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VEREL I, HEIDER KH, SIEGMUND M et al.: Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts. Int. J. Cancer (2002) 99:396-402.
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Verel, I.1
Heider, K.H.2
Siegmund, M.3
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150
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High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules
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ADAMS GP, SCHIER R, MCCALL AM et al.: High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Cancer Res. (2001) 61:4750-4755. An important observation which suggests that high affinity can also be a limitation for tumour targeting and particularly for tumour penetration.
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Adams, G.P.1
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