Structure-function relationships for human antibodies to pneumococcal capsular polysaccharide from transgenic mice with human immunoglobulin loci

Infection and Immunity

Volumn 70, Issue 9, 2002, Pages 4977-4986

  Chang, Q ^a   Zhong, Z ^a   Lees, A ^a   Pekna, M ^a   Pirofski, L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; BACTERIUM ANTIBODY; EPITOPE; MONOCLONAL ANTIBODY; PNEUMOCOCCUS VACCINE; STREPTOCOCCUS ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; GENE LOCUS; HUMAN; IMMUNOGLOBULIN GENE; INFECTION RESISTANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLEEN CELL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BASE SEQUENCE; COMPLEMENT ACTIVATION; COMPLEMENT C4; COMPLEMENT FACTOR B; DNA, RECOMBINANT; EPITOPES; GENES, IMMUNOGLOBULIN; HUMANS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR STRUCTURE; PNEUMOCOCCAL INFECTIONS; POLYSACCHARIDES, BACTERIAL; STREPTOCOCCUS PNEUMONIAE;

EID: 0036717716     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.9.4977-4986.2002     Document Type: Article

References (63)

1. H3 gene segment usage
2. Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations
3. Effect of human immunodeficiency virus type 1 infection on the antibody response to a glycoprotein conjugate pneumococcal vaccine: Results from a randomized trial
4. H3 gene products: Natural ligands for HIV gp120
5. Lack of a requirement for the Fc region of IgG in restoring pneumococcal opsonization via the alternative complement pathway in sickle cell anemia
6. Direct evidence that decreased opsonization of Streptococcus pneumoniae via the alternative complement pathway in sickle cell disease is related to antibody deficiency
7. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
8. A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection
9. Discrepancy between effects of in vivo and in vitro administration of gammaglobulin on phagocytic killing of Streptococcus pneumoniae in an antibody-deficient serum
10. A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia
11. Localization of complement component 3 on Streptococcus pneumoniae: Anti-capsular antibody causes complement deposition on the pneumococcal capsule
12. Pneumococcal vaccine efficacy
13. Antibody class and subclass responses to pneumococcal polysaccharides following immunization of human immunodeficiency virus-infected patients
14. Serum therapy revisited: Animal models of infection and development of passive antibody therapy
15. Return to the past: The case for antibody-based therapies in infectious diseases
16. H3 expression in peripheral B cells from HIV-uninfected, but not HIV-infected individuals
17. Immunoglobulin VH gene analysis in rat: Most marginal zone B cells express germline encoded VH genes and are ligand selected
18. The occurrence and virulence of pneumococci in the circulating blood during lobar pneumonia and the susceptibility of pneumococcus strains to univalent antipneumococcus serum
19. Analysis of humoral and phagocytic defenses against Streptococcus pneumoniae serotypes 1 and 3
20. Regulation of the B cell response to T-dependent antigens by classical pathway of complement
21. A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Cryptococcus neoformans infection
22. A human IgM monoclonal antibody prolongs survival of mice with lethal cryptococcosis
23. The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans
24. Polysaccharide conjugate vaccine responses in bone marrow transplant patients
25. Complement is essential for protection by an IgM and an IgG3 monoclonal antibody against experimental, hematogenously disseminated candidiasis
26. In vitro complement-dependent binding and in vivo kinetics of pneumococcal polysaccharide TI-2 antigens in the rat spleen marginal zone and follicle
27. Human monoclonal antibodies against Pseudomonas aeruginosa lipopolysaccharide derived from transgenic mice containing megabase human immunoglobulin loci are opsonic and protective against fatal pseudomonas sepsis
28. Involvement of antilipoarabinomannan antibodies in classical complement activation in tuberculosis
29. Influence of patient age on Streptococcus pneumoniae serotypes causing invasive disease
30. H clan and family identity predicts variable domain structure and may influence antigen binding
31. Antibody-antigen recognition: A canonical structure paradigm
32. Mechanism for the isotype dependence of antibody-mediated toxicity in Cryptococcus-neoformans-infected mice
33. Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination
34. Oligoclonality of serum immunoglobulin G antibody responses to Streptococcus pneumoniae capsular polysaccharide serotypes 6B, 14, and 23F
35. Streptococcus pneumoniae in community-acquired respiratory tract infections in Spain: The impact of serotype and geographical, seasonal and clinical factors on its susceptibility to the most commonly prescribed antibiotics
36. B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a "natural immune memory."
37. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
38. Molecular characterization of the antibody responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization
39. Quantitative relationship between anticapsular antibody measured by enzyme-linked immunoabsorbant assay or radioimmunoassay and protection of mice against challenge with Streptococcus pneumoniae serotype 4
40. Direct measurement of antibody affinity distribution by hapten-inhibition enzyme immunoassay
41. Mice deficient for the complement factor B develop and reproduce normally
42. Human immune response to pneumococcal polysaccharides: Complement-mediated localization preferentially on CD21-positive splenic marginal zone B cells and follicular dendritic cells
43. Polysaccharides, mimotopes and vaccines for encapsulated pathogens
44. The use of licensed vaccines for active immunization of the immunocompromised host
45. Traitment anti-infectieux par anticorps
46. Analysis of human monoclonal antibodies elicited by vaccination with a Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide vaccine
47. Reactogenicity and immunogenicity of a protein-conjugated pneumococcal oligosaccharide vaccine in older adults
48. Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes
49. Determination of antibody responses of elderly adults to all 23 capsular polysaccharides after pneumococcal vaccination
50. Magnitude, duration, quality, and function of pneumococcal vaccine responses in elderly adults
51. Production of protective human anti-pneumococcal antibodies by transgenic mice with human immunoglobulin loci
52. Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse
53. Structure-function studies of human monoclonal antibodies to pneumococcus type 3 polysaccharide
54. IgG response to pneumococcal polysaccharide-protein conjugate appears similar to IgG response to polysaccharide in bone marrow transplant recipients and healthy adults
55. Repertoire of human antibodies against the polysaccharide capsule of Streptococcus pneumoniae serotype 6B
56. Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice
57. Canonical structure repertoire of the antigen-binding site of immunoglobulins suggests strong geometrical restrictions associated to the mechanism of immune recognition
58. A brief history of the pneumococcus in biomedical research: A panoply of scientific discovery
59. The role of complement in the host's defense against Streptococcus pneumoniae
60. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities
61. Slow recovery of follicular B cells and marginal zone B cells after chemotherapy: Implications for humoral immunity
62. Molecular and functional characteristics of a protective human monoclonal antibody to serotype 8 Streptococcus pneumoniae capsular polysaccharide
63. Antifungal activity of a human antiglucuronoxylomannan antibody