-
4
-
-
0018878954
-
Structural and functional differentiation of microvascular endothelium
-
Blood Cells and Vessel Walls: Functional Interactions, Excerpta Medica, Amsterdam
-
(1980)
CIBA Foundation Symposium 71
, pp. 39-60
-
-
Simionescu, M.1
-
21
-
-
0026599425
-
A quantitative analysis of tumour specific monoclonal antibody uptake by human melanoma xenografts: Effects of antibody immunological properties and tumour expression levels
-
(1992)
Cancer Res.
, vol.52
, pp. 357-366
-
-
Shockley, T.R.1
Lin, K.2
Sung, C.3
Nagy, J.A.4
Tompkins, R.G.5
Dedrick, R.L.6
Dvorak, H.F.7
Yarmush, M.L.8
-
28
-
-
0022380126
-
Characterisation of immunotoxins active against ovarian cancer cell lines
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 1261-1267
-
-
Pirker, R.1
Fitzgerald, D.J.P.2
Hamilton, T.C.3
Ozols, R.F.4
Laird, W.5
Frankel, A.E.6
Willingham, M.C.7
Pastan, I.8
-
37
-
-
0018115212
-
Protein thiolation and reversible protein-protein conjugation, N-succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent
-
(1978)
Biochem. J.
, vol.173
, pp. 723-737
-
-
Carlsson, J.1
Drevin, H.2
Axén, R.3
-
40
-
-
0029997822
-
Synthesis and antitumour activity of the immunoconjugate BR96-Dox
-
(1996)
J. Control. Release
, vol.39
, pp. 251-259
-
-
Firestone, R.A.1
Willner, D.2
Hofstead, S.J.3
King, H.D.4
Kaneko, T.5
Braslawsky, G.R.6
Greenfield, R.S.7
Trail, P.A.8
Lasch, S.J.9
Henderson, A.J.10
Casazza, A.M.11
Hellström, K.E.12
Hellström, I.13
-
43
-
-
0542424044
-
Site-specific covalent modification of monoclonal antibodies: In vitro and in vivo evaluations
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 2632-2636
-
-
Rodwell, J.D.1
Alvarez, V.L.2
Lee, C.3
Lopes, A.D.4
Goers, J.W.F.5
King, H.D.6
Powsner, H.J.7
McKearn, T.J.8
-
45
-
-
0031854381
-
Carbohydrates engineered at antibody constant domains can be used for site-specific conjugation of drugs and chelates
-
(1998)
J. Immunol. Methods
, vol.213
, pp. 131-144
-
-
Qu, Z.1
Sharkey, R.M.2
Hansen, H.J.3
Shih, L.B.4
Govindan, S.V.5
Shen, J.6
Goldenberg, D.M.7
Leung, S.-O.8
-
46
-
-
0027134326
-
(6-Maleimidocaproly)hydrazone of doxorubicin - A new derivative for the preparation of immunoconjugates of doxorubicin
-
(1993)
Bioconjug. Chem.
, vol.4
, pp. 521-527
-
-
Willner, D.1
Trail, P.A.2
Hofstead, S.J.3
King, H.D.4
Lasch, S.J.5
Braslawsky, G.R.6
Greenfield, R.S.7
Kaneko, T.8
Firestone, R.A.9
-
47
-
-
0033106074
-
Monoclonal antibody conjugates of doxorubicin prepared with branched linkers: A novel method for increasing the potency of doxorubicin immunoconjugates
-
(1999)
Bioconjug. Chem.
, vol.10
, pp. 279-288
-
-
King, H.D.1
Yurgaitis, D.2
Willner, D.3
Firestone, R.A.4
Yang, M.B.5
Lasch, S.J.6
Hellström, K.E.7
Trail, P.A.8
-
49
-
-
0018828092
-
Conjugation of methotrexate to poly (L-lysine) as a potential way to overcome drug resistance
-
(1980)
Cancer
, vol.45
, pp. 1207-1211
-
-
Ryser, H.J.-P.1
Shen, W.-C.2
-
52
-
-
0023890683
-
Nature of linkage and mode of action of methotrexate conjugated with antitumor antibodies: Implication for future preparation of conjugates
-
(1988)
Cancer Res.
, vol.48
, pp. 3330-3335
-
-
Endo, N.1
Takeda, Y.2
Umemoto, N.3
Kishida, K.4
Watanabe, K.5
Saito, M.6
Kato, Y.7
Hara, T.8
-
63
-
-
0023554984
-
New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo
-
(1987)
Cancer Res.
, vol.47
, pp. 5924-5931
-
-
Thorpe, P.E.1
Wallace, P.M.2
Knowles, P.P.3
Relf, M.G.4
Brown, A.N.F.5
Watson, G.J.6
Knyba, R.E.7
Wawrzynczak, E.J.8
Blakey, D.C.9
-
72
-
-
0024561482
-
New antitumor monoclonal antibody-vinca conjugates LY203725 and related compounds: Design, preparation, and representative in vivo activity
-
(1989)
J. Med. Chem.
, vol.32
, pp. 548-555
-
-
Laguzza, B.C.1
Nichols, C.L.2
Briggs, S.L.3
Cullinan, G.J.4
Johnson, D.A.5
Staarling, J.J.6
Baker, A.L.7
Bumol, T.F.8
Corvalan, J.R.F.9
-
73
-
-
0025185802
-
Evaluation in vitro of adriamycin immunoconjugates synthesis using an acid-sensitive hydrazone linker
-
(1990)
Cancer Res.
, vol.50
, pp. 6600-6607
-
-
Greenfield, R.S.1
Kaneko, T.2
Dues, A.3
Edson, M.A.4
Fitzgerald, K.A.5
Olech, L.J.6
Grattan, J.A.7
Spitalny, G.L.8
Braslawsky, G.R.9
-
86
-
-
84961023030
-
Effet sur la leucémie 1210 de la souris d'une combinaison par diazotation d'améthoptérine et de γ-globulines de hamsters porteurs de cette leucémie par hétérogreffe
-
(1958)
C.R. Acad. Sci.
, vol.246
, pp. 1626-1628
-
-
Mathé, G.1
Ba Loc, T.2
Bernard, J.3
-
91
-
-
0023770023
-
Preclinical trials using an immunoconjugate of T101 and methotrexate in an athymic mouse/human T-cell tumor model
-
(1988)
J. Biol. Response Modifiers
, vol.7
, pp. 608-618
-
-
Shawler, D.L.1
Johnson, D.E.2
Sweet, M.D.3
Myers, L.J.4
Tudor, S.D.5
Beidler, D.E.6
Koziol, J.A.7
Dillman, R.O.8
-
95
-
-
0023581615
-
Sensitivity of newly established colorectal cell lines to cytotoxic drugs and monoclonal antibody drug conjugates
-
(1987)
Br. J. Cancer
, vol.56
, pp. 722-726
-
-
Durrant, L.G.1
Garnett, M.C.2
Gallego, J.3
Armitage, N.C.4
Ballantyne, K.C.5
Marksman, R.A.6
Hardcastle, J.D.7
Baldwin, R.W.8
-
101
-
-
0025288274
-
Phase 1 clinical comparative study of monoclonal antibody KS1/4 and KS1/4-methotrexate immunoconjugate in patients with non-small cell lung carcinoma
-
(1990)
Cancer Res.
, vol.50
, pp. 4154-4159
-
-
Elias, D.J.1
Horosowitz, L.2
Kline, L.E.3
Kroener, J.F.4
Dillman, R.O.5
Walker, L.E.6
Robb, J.A.7
Timms, R.M.8
-
107
-
-
0021959832
-
Antitumour properties of vindesine-monoclonal antibody conjugates
-
(1985)
Cancer Immunol. Immunother.
, vol.19
, pp. 1-7
-
-
Rowland, G.F.1
Axton, C.A.2
Baldwin, R.W.3
Brown, J.P.4
Corvalan, J.R.F.5
Embleton, M.J.6
Gore, V.A.7
Hellström, I.8
Hellström, K.E.9
Jacobs, E.10
Marsden, C.H.11
Pimm, M.V.12
Simmonds, R.G.13
Smith, W.14
-
113
-
-
0025688250
-
In vivo selection of human tumour cells resistant to monoclonal antibody-vinca alkaloid immunoconjugates
-
(1990)
Cancer Res.
, vol.50
, pp. 7634-7640
-
-
Starling, J.J.1
Maciak, R.S.2
Hinson, N.A.3
Hoskins, J.4
Laguzza, B.C.5
Gadski, R.A.6
Strnad, J.7
Rittman-Grauer, L.8
DeHerdt, S.V.9
Bumol, T.F.10
Moore, R.E.11
-
115
-
-
0025095672
-
Disposition of a murine monoclonal antibody vinca conjugate (KS1/4-DAVLB) in patients with adenocarcinomas
-
(1990)
Clin. Pharmacol. Exp.
, vol.47
, pp. 36-41
-
-
Schneck, D.1
Butler, R.2
Dugan, W.3
Littrel, D.4
Petersen, B.5
Bowsher, R.6
DeLong, A.7
Dorrbecker, S.8
-
116
-
-
0027229426
-
Murine monoclonal antibody-vinca conjugate KA1/4-DAVLB hydrazide: Phase I studies in patients with adenocarcinoma
-
(1993)
Antibody Immunoconjugates Radiopharm.
, vol.6
, pp. 127-139
-
-
Petersen, B.H.1
Barrett, P.2
Labus, J.3
Woodworth, J.4
Zimmerman, J.5
Butler, F.6
Dugan, W.7
Schneck, D.W.8
-
118
-
-
0022360180
-
Properties of antitumour anthracyclines and new developments in their application: Cain memorial award lecture
-
(1985)
Cancer Res.
, vol.45
, pp. 5995-5999
-
-
Arcamone, F.1
-
126
-
-
0019986638
-
The anticancer agent adriamycin can be actively cytotoxic without entering cells
-
(1983)
Science
, vol.217
, pp. 248-250
-
-
Tritton, T.R.1
Yee, G.2
-
129
-
-
0026671282
-
Antigen specific activity of carcinoma reactive BR64-doxorubicin conjugates evaluated in vitro and in human tumour xenograft models
-
(1992)
Cancer Res.
, vol.52
, pp. 5693-5700
-
-
Trail, P.A.1
Willner, D.2
Lasch, S.J.3
Henderson, A.J.4
Greenfield, R.S.5
King, D.6
Zoeckler, M.E.7
Braslawsky, G.R.8
-
130
-
-
0031031895
-
Effect of linker variation on the stability, potency, and efficacy of carcinoma reactive BR64-doxorubicin immunoconjugates
-
(1997)
Cancer Res.
, vol.57
, pp. 100-105
-
-
Trail, P.A.1
Willner, D.2
Knipe, J.3
Henderson, A.J.4
Lasch, S.J.5
Zoeckler, M.E.6
TrailSmith, M.D.7
Doyle, T.W.8
King, H.D.9
Casazza, A.M.10
Braslawsky, G.R.11
Brown, J.12
Hofstead, S.J.13
Greenfield, R.S.14
Firestone, R.A.15
Mosure, K.16
Kadow, K.F.17
Yang, M.B.18
Hellström, K.E.19
Hellström, I.20
more..
-
131
-
-
0027218284
-
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
-
(1993)
Science
, vol.261
, pp. 212-215
-
-
Trail, P.A.1
Willner, D.2
Lasch, S.J.3
Henderson, A.J.4
Hofstead, S.5
Casazza, A.M.6
Firestone, R.A.7
Hellström, K.E.8
Hellström, I.9
-
135
-
-
0034077405
-
Phase I trial of the anti-lewis Y drug immunoconjugate BR96-doxorubicin in patients with Lewis Y-expressing epithelial tumors
-
(2000)
J. Clin. Oncol.
, vol.11
, pp. 2282-2292
-
-
Saleh, M.N.1
Sugarman, S.2
Murray, J.3
Ostroff, J.B.4
Healey, D.5
Jones, D.6
Daniel, C.R.7
Lebherz, D.8
Onetto, N.9
LoBuglio, A.F.10
-
136
-
-
0032975042
-
Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 478-484
-
-
Tolcher, A.W.1
Sugarman, S.2
Gelmon, K.A.3
Cohen, R.4
Saleh, M.5
Isaacs, C.6
Young, L.7
Healey, D.8
Onetto, N.9
Slichmeyer, W.10
-
163
-
-
0022587036
-
An improved synthesis of a methotrexate-albumin, 791T/36 monoclonal antibody conjugate cytotoxic to human osteogenic sarcoma cell lines
-
(1986)
Cancer Res.
, vol.46
, pp. 2407-2412
-
-
Garnett, M.C.1
Baldwin, R.W.2
-
166
-
-
0006783735
-
Human tumour xenografts in anticancer drug development: Iodistribution and therapeutic efficacy of a monoclonal antibody-methotrexate conjugate
-
B. Winograd, M.J. Peckham, H.M. Pinedo (Eds.), Springer, Heidelberg
-
(1988)
European School of Oncology Monographs
, pp. 95-98
-
-
Pimm, M.V.1
Clegg, J.A.2
Garnett, M.C.3
Perkins, A.C.4
Baldwin, R.W.5
-
177
-
-
0026584015
-
Polymers containing enzymatically degradable bonds, XII. Effect of spacer structure on the rate of release of daunomycin and adriamycin from poly[N-(2-hydroxypropyl)-methacrylamide] copolymer drug carriers in vitro and antitumour activity measured in vivo
-
(1992)
J. Control. Release
, vol.18
, pp. 123-132
-
-
Subr, V.1
Strohalm, J.2
Ulbrich, K.3
Duncan, R.4
Hume, I.C.5
-
182
-
-
0041962221
-
2-targeted conjugates and combined therapy with immunomodulators
-
(2000)
J. Control. Release
, vol.64
, pp. 241-261
-
-
Ríhová, B.1
Jelínková, M.2
Strohalm, J.3
Šubr, V.4
Plocová, D.5
Hovorka, O.6
Novák, M.7
Plundrová, D.8
Germano, Y.9
Ulbrich, K.10
-
183
-
-
0029872673
-
5-(2-hydroxyethyl)-l-glutamine]
-
(1996)
J. Control. Release
, vol.38
, pp. 245-266
-
-
Hoes, C.J.T.1
Ankoné, M.2
Grootoonk, J.3
Feijen, J.4
Van der Struik, E.5
Van Doornmalen, A.6
Pham, D.7
De Man, A.8
Van Ettekowen, A.9
Schlachter, I.10
Boon, P.J.11
Kaspersen, F.12
Bos, E.S.13
-
188
-
-
0022959735
-
Antitumour activity and biochemistry of novel analogs of the antibiotic CC-1065
-
(1986)
Adv. Enzyme Regul.
, vol.25
, pp. 141-155
-
-
Wierenga, W.1
Bhuyen, B.K.2
Kelly, R.C.3
Krueger, W.C.4
Li, L.H.5
McGovren, J.P.6
Swenson, D.H.7
Warpehoski, M.A.8
-
189
-
-
0029093035
-
Enhancement of the selectivity and antitumour efficacy of a CC-10-65 analogue through immunoconjugate formation
-
(1995)
Cancer Res.
, vol.55
, pp. 4079-4084
-
-
Chari, R.V.J.1
Jackel, K.A.2
Bourret, L.A.3
Derr, S.M.4
Tadayoni, B.M.5
Mattocks, K.M.6
Shah, S.A.7
Liu, C.8
Blättler, W.A.9
Goldmacher, V.S.10
-
194
-
-
0026118760
-
SMANCS and polymer conjugated macromolecular drugs: Advantages in cancer chemotherapy
-
(1991)
Adv. Drug Deliv. Rev.
, vol.6
, pp. 181-202
-
-
Maeda, H.1
-
196
-
-
0023860834
-
Clinical application of monoclonal antibody-drug conjugates for immunotargeting chemotherapy of colorectal carcinoma
-
(1988)
Cancer
, vol.61
, pp. 881-888
-
-
Takahashi, T.1
Yamaguchi, T.2
Kitamura, K.3
Suzuyama, H.4
Honda, M.5
Yokata, T.6
Kotonagi, H.7
Takahashi, M.8
Hashimoto, Y.9
-
200
-
-
0025055373
-
Kinetics of internalisation and cytotoxicity of transferrin-neocarzinostatin conjugate in human leukemia cell line K562
-
(1990)
Jpn. J. Cancer Res.
, vol.81
, pp. 91-99
-
-
Kohgo, Y.1
Kondo, H.2
Kat, J.3
Sasaki, K.4
Tsushima, N.5
Nishisato, T.6
Hirayama, M.7
Fujikawa, K.8
Shintani, N.9
Mogi, Y.10
Niitsu, Y.11
-
202
-
-
0026492823
-
Local administration of monoclonal antibody-drug conjugate: A new strategy to reduce the local recurrence of colorectal cancer
-
(1992)
Cancer Res.
, vol.52
, pp. 6323-6328
-
-
Kitamura, K.1
Takahashi, T.2
Kotani, T.3
Miyagaki, T.4
Yamaoka, N.5
Tsurumi, H.6
Noguchi, A.7
Yamaguchi, T.8
-
204
-
-
9344265213
-
Effects of neocarzinostatin-chimeric Fab conjugates on the growth of human pancreatic carcinoma xenografts
-
(1996)
Br. J. Cancer
, vol.73
, pp. 1178-1182
-
-
Otsuji, E.1
Yamaguchi, T.2
Tsurata, H.3
Yata, Y.4
Nishi, H.5
Okamoto, K.6
Taniguchi, T.7
Kato, M.8
Kotani, T.9
Kitamura, K.10
Takahashi, T.11
-
205
-
-
9444221932
-
Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragment after administration of avidin
-
(1996)
Br. J. Cancer
, vol.74
, pp. 597-602
-
-
Otsuji, E.1
Yamaguchi, T.2
Matsumura, H.3
Yamamoto, K.4
Tsurata, H.5
Yata, Y.6
Nishi, H.7
Okamoto, K.8
Kitamura, K.9
Takahashi, T.10
-
207
-
-
0033526833
-
Tumor vascular targeting using a tumor-tissue endothelium-specific monoclonal antibody as an effective strategy for cancer chemotherapy
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.260
, pp. 346-350
-
-
Makimoto, H.1
Loizumi, K.2
Tsunoda, S.3
Wakai, Y.4
Matsui, J.5
Tsutsumi, Y.6
Nakagawa, S.7
Ohzumi, I.8
Taniguchi, K.9
Saito, H.10
Utoguchi, N.11
Ohsugi, Y.12
Mayumi, T.13
-
210
-
-
0033852105
-
Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD-33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines
-
(2000)
Leukemia
, vol.14
, pp. 1436-1443
-
-
Naito, K.1
Takeshita, A.2
Shigeno, K.3
Nakamura, S.4
Fujisawa, S.5
Shinjo, K.6
Yoshida, H.7
Ohnishi, K.8
Mori, M.9
Terakawa, S.10
Ohno, R.11
-
211
-
-
0033151526
-
Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: A phase I study of an anti-CD33 calicheamicin immunoconjugate
-
(1999)
Blood
, vol.93
, pp. 3678-3684
-
-
Sievers, E.L.1
Appelbaum, F.R.2
Spielberger, R.T.3
Forman, S.J.4
Flowers, D.5
Smith, F.O.6
Shannon-Dorcy, K.7
Berger, M.S.8
Bernstein, I.D.9
-
214
-
-
0003298386
-
Comparison of the efficacy and safety of gemtuzumab ozogamycin (CMA-676) in patients <60 and >60 years of age with AML in first relapse
-
(2000)
Proc. Am. Soc. Clin. Oncol.
, vol.19
-
-
Sievers, E.L.1
Larson, R.A.2
Estey, E.3
Stadmauer, E.A.4
Karanes, C.5
Spielberger, R.6
Berger, M.S.7
Eten, C.8
Stone, A.9
Munteanu, M.10
Bernstein, I.11
Appelbaum, F.12
-
218
-
-
0034605438
-
Immunoconjugates of Geldanamycin and Anti-HER2 monoclonal antibodies: Antiproliferative activity on Human breast carcinoma cell lines
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1573-1581
-
-
Mandler, R.1
Wu, C.2
Sausville, E.A.3
Roettinger, A.J.4
Newman, D.J.5
Ho, D.K.6
King, R.7
Yang, D.8
Lippman, M.E.9
Landolfi, N.F.10
Dadachova, E.11
Brechbiel, M.W.12
Waldmann, T.A.13
-
219
-
-
0029123128
-
erbB2 oncogene inhibition by geldanamycin derivatives: Synthesis, mechanism of action and structure activity relationships
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3813-3820
-
-
Schnur, R.C.1
Corman, M.L.2
Gallaschun, R.J.3
Cooper, B.A.4
Dee, M.F.5
Doty, J.L.6
Muzzi, M.L.7
DiOrio, C.I.8
Barbacci, E.G.9
Miller, P.E.10
Pollack, V.A.11
Savage, D.M.12
Sloan, D.E.13
Pustilnik, L.R.14
Moyer, J.D.15
Moyer, M.P.16
-
220
-
-
0017927423
-
Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids
-
(1978)
J. Med. Chem.
, vol.21
, pp. 31-37
-
-
Kupchan, S.M.1
Sneden, A.T.2
Branfman, A.R.3
Howie, G.A.4
Rebhun, L.I.5
McIver, W.E.6
Wang, R.W.7
Schnaitman, T.C.8
-
221
-
-
0026593928
-
Immunoconjugates containing novel maytansinoids: Promising anticancer drugs
-
(1992)
Cancer Res.
, vol.52
, pp. 127-131
-
-
Chari, R.V.J.1
Martell, B.A.2
Gross, J.L.3
Cook, S.B.4
Shah, S.A.5
Blättler, W.A.6
Mackenzie, S.J.7
Goldmacher, V.S.8
-
222
-
-
9444235053
-
Eradication of large colon tumor xenografts by targeted delivery of maytansinoids
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 8618-8623
-
-
Liu, B.1
Tadayoni, B.M.2
Bourret, L.A.3
Mattocks, K.M.4
Derr, S.M.5
Widdison, W.C.6
Kedersha, N.L.7
Ariniello, P.D.8
Goldmacher, V.S.9
Lambert, J.M.10
Blättler, W.A.11
Chari, R.V.J.12
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