Single-chain antibody-based gene therapy: Inhibition of tumor growth by in situ production of phage-derived human antibody fragments blocking functionally active sites of cell-associated matrices

Gene Therapy

Volumn 9, Issue 15, 2002, Pages 1049-1053

  Sanz, L ^a   Kristensen, P ^b   Blanco, B ^a   Facteau, S ^c   Russell, S J ^c   Winter, G ^d   AAlvarez Vallina L ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b AARHUS UNIVERSITY   (Denmark)

^c MAYO CLINIC   (United States)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Cancer; Extracellular matrix; Gene therapy; Laminin; Single chain antibody

Indexed keywords

ANGIOGENESIS INHIBITOR; LAMININ; PROTEIN ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY SCREENING; ARTICLE; BACTERIOPHAGE; BASEMENT MEMBRANE; BIOASSAY; BLOOD VESSEL; CANCER INHIBITION; CANCER PREVENTION; CANCER THERAPY; CAPILLARY; CELL INTERACTION; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; DNA MODIFICATION; EMBRYO; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE DELIVERY SYSTEM; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN FUNCTION; SUBCUTANEOUS TISSUE TUMOR; TUMOR CELL;

ANIMALS; CELL LINE; CHICK EMBRYO; CULTURE TECHNIQUES; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; GENE THERAPY; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN FRAGMENTS; LAMININ; MICE; MICE, INBRED C57BL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

ANIMALIA; GALLUS GALLUS; MAMMALIA;

EID: 0036053161     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301725     Document Type: Article

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