Reversible dimer formation and stability of the anti-tumour single-chain Fv antibody MFE-23 by neutron scattering, analytical ultracentrifugation, and NMR and FT-IR spectroscopy

Journal of Molecular Biology

Volumn 320, Issue 1, 2002, Pages 107-127

  Lee, Yie Chia ^a,b   Boehm, Mark K ^a,b   Chester, Kerry A ^b   Begent, Richard H J ^b   Perkins, Stephen J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

1H NMR spectroscopy; Analytical ultracentrifuge; Neutron scattering; Single chain Fv antibody; Size exclusion chromatography

Indexed keywords

CANCER ANTIBODY; CARCINOEMBRYONIC ANTIGEN; DIMER; MONOMER; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIBODY BLOOD LEVEL; ARTICLE; CALCULATION; COLORECTAL CANCER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENATURATION; DIMERIZATION; GEL PERMEATION CHROMATOGRAPHY; INFRARED SPECTROMETRY; NEUTRON SCATTERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SEDIMENTATION; SEDIMENTATION RATE; THERMOSTABILITY; ULTRACENTRIFUGATION;

EID: 0036290860     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00403-5     Document Type: Article

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