An anti-GD2 single chain Fv selected by phage display and fused to Pseudomonas exotoxin A develops specific cytotoxic activity against neuroblastoma derived cell lines.

International journal of molecular medicine

Volumn 8, Issue 5, 2001, Pages 579-584

  Tur, M K ^a   Sasse, S ^a   Stocker M ^a   Djabelkhir, K ^a   Huhn, M ^a   Matthey, B ^a   Gottstein, C ^a   Pfitzner, T ^a   Engert, A ^a   Barth, S ^a  

^a Pharmaceutical Product Development   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; EXOTOXIN; GANGLIOSIDE; GANGLIOSIDE, GD2; HYBRID PROTEIN; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN FV; IMMUNOTOXIN; MONOCLONAL ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TOXA PROTEIN, PSEUDOMONAS AERUGINOSA; VIRULENCE FACTOR;

ARTICLE; BINDING COMPETITION; CELL CULTURE; CELL MEMBRANE; CELL SURVIVAL; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR CLONING; NEUROBLASTOMA; PROTEIN BINDING;

ADP RIBOSE TRANSFERASES; ANTIBODIES, MONOCLONAL; BACTERIAL TOXINS; BINDING, COMPETITIVE; CELL MEMBRANE; CELL SURVIVAL; CLONING, MOLECULAR; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; EXOTOXINS; GANGLIOSIDES; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTOXINS; NEUROBLASTOMA; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; VIRULENCE FACTORS;

MLCS; MLOWN;

EID: 18344411909     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm.8.5.579     Document Type: Article

References (0)