A recombinant CD7-specific single-chain immunotoxin is a potent inducer of apoptosis in acute leukemic T cells

Cancer Research

Volumn 62, Issue 10, 2002, Pages 2848-2855

  Peipp, Matthias ^a   Küpers, Heide ^a   Saul, Domenica ^a   Schlierf, Beate ^a   Greil, Johann ^b   Zunino, Susan J ^a   Gramatzki, Martin ^a   Fey, Georg H ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD7 ANTIGEN; IMMUNOTOXIN; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEOCHONDROITIN SULFATE; PSEUDOMONAS EXOTOXIN;

ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL CULTURE; CELL KILLING; CYTOLYSIS; HUMAN; HUMAN CELL; HYBRIDOMA; LEUKEMIA CELL LINE; MELANOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PSEUDOMONAS; T CELL LEUKEMIA;

ADP RIBOSE TRANSFERASES; ANIMALS; ANTIBODY SPECIFICITY; ANTIGENS, CD7; APOPTOSIS; BACTERIAL TOXINS; CHILD; COS CELLS; EPITOPES; EXOTOXINS; FEMALE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTOXINS; INFANT; JURKAT CELLS; LEUKEMIA, T-CELL; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TUMOR CELLS, CULTURED; VIRULENCE FACTORS;

EID: 0037093199     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Treatment of B-cell non-Hodgkin's lymphoma with anti-CD20 monoclonal antibody Rituximab
2. Baselga II clinical trials of trastuzumab
3. Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: A Phase I study of an anti-CD33 calicheamicin immunoconjugate
4. The Non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma
5. High remission rate in T-cell prolymphocytic leukemia with CAMPATH-1H
6. Outcome after first relapse in children with acute lymphoblastic leukemia: A population-based study of 315 patients from the Nordic Society of Pediatric Hematology and Oncology
7. Biological characteristics of CD7(+) acute leukemia
8. The reliability of cytoplasmic CD3 and CD22 antigen expression in the immunodiagnosis of acute leukemia: A study of 500 cases
9. Clinical and biological characteristics of CD7+ acute myeloid leukemia. Our experience and literature review
10. CD7 expression in acute myeloid leukemia
11. Structure and function of the CD7 molecule
12. CD7 delivers a proapoptotic signal during galectin-l-induced T cell death
13. CD7-mediated regulation of integrin adhesiveness on human T-cells involves tyrosine phosphorylation-dependent activation of phosphatidylinositol 3-kinase
14. Cross-linking of the T-cell specific accessory molecules CD7 and CD28 modulates T-cell adhesion
15. Production and characterization of the extracellular domain of human CD7 antigen: Further evidence that CD7 has a role in T-cell signaling
16. Identification of a novel, human multilymphoid progenitor in cord blood
17. - lymphoid progenitor in umbilical cord blood
18. Ontogeny of T-cell precursors: A model for the initial stages of human T-cell development
19. Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus
20. Expression of CD7 on normal human myeloid progenitors
21. Expression and function of CD7 molecule on human natural killer cells
22. A novel population of natural killer progenitor cells isolated from human umbilical cord blood
23. CD7-negative T-cells represent a separate differentiation pathway in a subset of postthymic helper T-cells
24. Construction and characterization of human CD7-specific single-chain Fv immunotoxins
25. T-cell section report CD7
26. Therapy with CD7 monoclonal antibody TH-69 is highly effective for xenografted human T-cell ALL
27. CD7-specific single-chain Fv immunotoxins. Design and expression
28. In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed anti-viral protein immunotoxin
29. Immunotoxins in cancer therapy
30. Therapy of patients with T-cell lymphomas and leukemias using an anti-CD7 monoclonal antibody-ricin A chain immunotoxin
31. Laboratory preparation of a deglycosylated ricin toxin A chain containing immunotoxin directed against a CD7 T lineage differentiation antigen for Phase I human clinical studies involving T-cell malignancies
32. Host-mediated antibody-dependent cellular cytotoxicity contributes to the in vivo therapeutic efficacy of an anti-CD7-saporin immunotoxin in a severe combined immunodeficient mouse model of human T-cell acute lymphoblastic leukemia
33. In vitro activity of immunoconjugates between cis-platinum and monoclonal antibodies
34. Pseudomonas exotoxin: Chimeric toxins
35. Toxin entry: How bacterial proteins get into mammalian cells
36. Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome
37. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia
38. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies
39. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system
40. The acute lymphoblastic leukemia cell line SEMM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin 7
41. Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia
42. Characterization of EBV-genome negative null and T-cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma
43. Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells
44. Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): The DNA damage-repair model of translocation
45. An improved procedure for the generation of recombinant single-chain Fv antibody fragments reacting with human CD13 on intact cells
46. 185erbB 2-specific single-chain antibody toxins differ in their cell-killing activity on tumor cells expressing both receptor proteins
47. Ki-4(SeFv)-ETA′, a new recombinant anti-CD30 immunotoxin with highly specific cytotoxic activity against disseminated Hodgkin tumors in SCID mice
48. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells
49. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
50. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein-labelled Annexin V
51. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
52. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
53. Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4 (dsFv)-PE38(BL22) toward fresh malignant cells from patients with B-cell leukemias