Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood - Brain barrier drug delivery system

Journal of Drug Targeting

Volumn 10, Issue 3, 2002, Pages 239-245

  Wu, Dafang ^a   Song, Bi Wei ^a   Vinters, Harry V ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain transport; Drug targeting; Ischemia; Neurotrophin

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; DRUG VEHICLE; FIBROBLAST GROWTH FACTOR RECEPTOR; IODINE 125; KETAMINE; MONOCLONAL ANTIBODY; NEUROPROTECTIVE AGENT; NEUROTROPHIN; P 8504; PEPTIDE; RECOMBINANT PROTEIN; STREPTAVIDIN; TRANSFERRIN RECEPTOR; XYLAZINE;

ANIMAL EXPERIMENT; ARTICLE; BIOTINYLATION; BLOOD BRAIN BARRIER; BOLUS INJECTION; BRAIN TISSUE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG SYNTHESIS; DRUG TRANSPORT; DRUG UPTAKE; IC 50; MALE; NEUROPROTECTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RADIORECEPTOR ASSAY; RAT; RECEPTOR AFFINITY; TRANSCYTOSIS;

ALGORITHMS; ANIMALS; ANTIBODIES, MONOCLONAL; AREA UNDER CURVE; BINDING SITES; BIOTINYLATION; BLOOD-BRAIN BARRIER; BRAIN; CAROTID ARTERIES; DRUG DELIVERY SYSTEMS; FIBROBLAST GROWTH FACTOR 2; HUMANS; INFUSIONS, INTRA-ARTERIAL; IODINE RADIOISOTOPES; KIDNEY; LIVER; LUNG; MALE; MICE; MYOCARDIUM; NERVE GROWTH FACTORS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; STREPTAVIDIN; TISSUE DISTRIBUTION;

EID: 0036245040     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860290022679     Document Type: Article

References (29)

1. "Neutrophic effect of basic fibroblasts growth factor is mediated by the p42/p44 mitogen-activates protein kinase cascade in cultured rat cortical neurons"
2. "Biological roles of fibroblasts growth factor-2"
3. "Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in granule cells"
4. "Trafermin in acute ischemic stroke: Results of a phase II/III randomized efficacy study"
5. "Epidermal growth factor and basic fibroblast growth factor protect dopaminergic neurons from glutamate toxicity in cultures"
6. 125I-labeled fibroblast growth factor"
7. "Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats"
8. "Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PSI mutation"
9. "Potential usefulness of basic fibroblast growth factor as a treatment for stroke"
10. "Delayed intravenous administration of basic fibroblast growth (bFGF) reduces infarct volume in a model of focal cerebral ischemia/reperfusion in the rat"
11. "Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate"
12. "Pretreatment with intraventricular basic fibroblast growth factor (bFGF) decreases infarct size following focal cerebral ischemia in rats"
13. "Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemia heart disease: Results of a Phase-I open-labeled close escalation study"
14. "Nerve growth factor and basic fibroblast growth factor protect rat cerebellar granule cells in culture against ethanol-induced cell death"
15. "Programmed cell life: Neuroprotective signal transduction and ischemic brain injury"
16. "Experience with the preclinical assessment of basic fibroblast growth factor (bFGF)"
17. "The histopathology of kidney changes in rats and monkeys following intravenous administration of massive doses of FCE 26184, human basic fibroblast growth factor"
18. "Basic fibroblast growth factor and brain-derived neurotrophic factor promote survival and neuronal circuit"
19. "The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells"
20. "Basic and acidic fibroblast growth factors interact with the same cell surface receptors"
21. Peptide Drug Delivery to the Brain
22. "Transport of human recombinant brain derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery"
23. "Time window of infarct reduction by intravenous basic fibroblast growth factor in focal cerebral ischemia"
24. "Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms"
25. "Effect of basic fibroblast growth factor on experimental focal ischemia studied by diffusion-weighted and perfusion imaging"
26. "Capillary depletion method quantification of blood-brain barrier transport of circulating peptides and plasma proteins"
27. 3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system"
28. "Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction"