In vivo recombination as a tool to generate molecular diversity in phage antibody libraries

Journal of biotechnology

Volumn 74, Issue 4, 2001, Pages 303-315

  Sblattero, Daniele ^a   Lou, Jianlong ^b,c   Marzari, Roberto ^a   Bradbury, Andrew ^d,e  

^a UNIVERSITY OF TRIESTE   (Italy)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LOS ALAMOS NATIONAL LABORATORY   (United States)

^e SISSA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CRE RECOMBINASE; INTEGRASE; PEPTIDE LIBRARY; VIRUS PROTEIN;

ANIMAL; BIOTECHNOLOGY; GENE VECTOR; GENETIC RECOMBINATION; GENETIC VARIABILITY; GENETICS; GENOMICS; HUMAN; PROTEIN ENGINEERING; REVIEW;

ANIMALS; ANTIBODIES; BIOTECHNOLOGY; GENETIC VECTORS; GENOMICS; HUMANS; INTEGRASES; PEPTIDE LIBRARY; PROTEIN ENGINEERING; RECOMBINATION, GENETIC; VARIATION (GENETICS); VIRAL PROTEINS;

EID: 0035715878     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1389-0352(01)00022-8     Document Type: Article

References (36)

1. D.E Adams J.B Bliska N.R Cozzarelli Cre–lox recombination in Escherichia coli cells. Mechanistic differences from the in vitro reaction J. Mol. Biol. 226 3 1992 661 673
2. C.F Barbas T.A Collet W Amberg Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries J. Mol. Biol. 230 1993 812 823
3. L Bjorck Protein L. A novel bacterial cell wall protein with affinity for Ig L chains J. Immunol. 140 4 1988 1194 1197
4. J.D Boeke P Model N.D Zinder Effects of bacteriophage f1 gene III protein on the host cell membrane Mol. Gen. Genet. 186 2 1982 185 192
5. T Clackson J.A Wells In vitro selection from protein and peptide libraries Trends Biotechnol. 12 1994 173 184
6. N.L Craig The mechanism of conservative site-specific recombination Annu. Rev. Genet. 22 1988 77 105
7. J Davies L Riechmann An antibody VH domain with a lox–Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain FEBS Lett. 377 1 1995 92 96
8. H.J de Haard N van Neer A Reurs A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies J. Biol. Chem. 274 26 1999 18218 18230
9. I Fisch R.E Kontermann R Finnern A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage Proc. Natl. Acad. Sci. USA 93 15 1996 7761 7766
10. F Geoffroy R Sodoyer L Aujame A new phage display system to construct multicombinatorial libraries of very large antibody repertoires Gene 151 1/2 1994 109 113
11. A.D Griffiths S.C Williams O Hartley Isolation of high affinity human antibodies directly from large synthetic repertoires EMBO J. 13 14 1994 3245 3260
12. F Guo D.N Gopaul G.D van Duyne Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse Nature 389 6646 1997 40 46
13. J Hanes L Jermutus S Weber-Bornhauser Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries Proc. Natl. Acad. Sci. USA 95 24 1998 14130 14135
14. J Hanes A Plückthun In vitro selection and evolution of functional proteins by using ribosome display Proc. Natl. Acad. Sci. USA 94 10 1997 4937 4942
15. R Hoess A Wierzbicki K Abremiski The role of the loxP spacer region in P1 site-specific recombination Nucleic Acids Res. 14 1986 2287 2300
16. R.H Hoess K Abremski Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP Proc. Natl. Acad. Sci. USA 81 4 1984 1026 1029
17. A.S Kang T.M Jones D.R Burton Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries Proc. Natl. Acad. Sci. USA 88 1991 11120 11123
18. A Knappik L Ge A Honegger Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides J. Mol. Biol. 296 1 2000 57 86
19. A Landy Dynamic, structural, and regulatory aspects of lambda site-specific recombination Annu. Rev. Biochem. 58 1989 913 949
20. S Lofdahl B Guss M Uhlen Gene for staphylococcal protein A Proc. Natl. Acad. Sci. USA 80 3 1983 697 701
21. J.D Marks H.R Hoogenboom T.P Bonnert By-passing immunization. Human antibodies from V-gene libraries displayed on phage J. Mol. Biol. 222 1991 581 597
22. D.A Marvin B Hohn Filamentous bacterial viruses Bacteriol. Rev. 33 2 1969 172 209
23. A Nissim H.R Hoogenboom I.M Tomlinson Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents Embo J. 13 1994 692 698
24. A.S Perelson G.F Oster Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self non-self discrimination J. Theor. Biol. 81 1979 645 670
25. R.W Roberts J.W Szostak RNA-peptide fusions for the in vitro selection of peptides and proteins Proc. Natl. Acad. Sci. USA 94 23 1997 12297 12302
26. J Sambrook E.F Fritsch T Maniatis Molecular Cloning: a Laboratory Manual, Cold Spring Harbour Laboratory Press 1989
27. D Sblattero A Bradbury Exploiting recombination in single bacteria to make large phage antibody libraries Nat. Biotechnol. 18 2000 75 80
28. R Schier J Bye G Apell Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection J. Mol. Biol. 255 1 1996 28 43
29. M.D Sheets P Amersdorfer R Finnern Efficient construction of a large nonimmune phage antibody library; the production of panels of high affinity human single-chain antibodies to protein antigens Proc. Natl. Acad. Sci. USA 95 1998 6157 6162
30. W.M Stark M.R Boocock D.J Sherratt Catalysis by site-specific recombinases [published erratum appears in Trends Genet 1993 Feb;9(2):45] Trends Genet. 8 12 1992 432 439
31. N Sternberg Bacteriophage P1 site-specific recombination. III. Strand exchange during recombination at lox sites J. Mol. Biol. 150 4 1981 603 608
32. H.G Svensson H.R Hoogenboom U Sjobring Protein LA, a novel hybrid protein with unique single-chain Fv antibody- and Fab-binding properties Eur. J. Biochem. 258 2 1998 890 896
33. N Tsurushita H Fu C Warren Phage display vectors for in vivo recombination if immunoglobulin heavy and light chain genes to make large combinatorial libraries Gene 172 1996 59 63
34. T.J Vaughan A.J Williams K Pritchard Human antibodies with sub-nanomolar affinities isolated from a large non-immunised phage display library Nat. Biotechnol. 14 1996 309 314
35. P Waterhouse A.D Griffiths K.S Johnson Combinatorial infection and in vivo recombination: a strategy for making large phage antibody repertoires Nucleic Acids Res. 21 9 1993 2265 2266
36. D.G Zahra T Vancov J.M Dunn Selectable in-vivo recombination to increase antibody library size — an improved phage display vector system Gene 227 1 1999 49 54