Enhanced tumor cell selectivity of adriamycin-monoclonal antibody conjugate via a poly(ethylene glycol)-based cleavable linker

Journal of Controlled Release

Volumn 79, Issue 1-3, 2002, Pages 229-242

  Suzawa, T ^a   Nagamura, S ^a   Saito, H ^a   Ohta, S ^a   Hanai, N ^a   Kanazawa, J ^a   Okabe, M ^a   Yamasaki, M ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Adriamycin; Immunoconjugate; Linker; Poly(ethylene glycol); Tumor targeting

Indexed keywords

ADRIAMYCIN MONOCLONAL ANTIBODY NL 1 CONJUGATE; ALANINE; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DIPEPTIDE; GLYCINE; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NL 1; PROLINE; PROLYL ENDOPEPTIDASE; PROTEINASE; THERMOLYSIN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; ARTICLE; CANCER INHIBITION; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DAUDI CELL; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PURIFICATION; DRUG RELEASE; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; TUMOR CELL;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; IMMUNOTOXINS; POLYETHYLENE GLYCOLS; SOLVENTS; TUMOR CELLS, CULTURED;

EID: 0037133109     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00554-5     Document Type: Article

References (36)

1. Relationship between activity and amino sugar stereochemistry of daunorubicin and adriamycin derivatives
2. The anthracycline antineoplastic drugs
3. Cardiac effects of anthracyclines used in the treatment of childhood acute lymphoblastic leukemia: A 10-year experience
4. Daunomycin metabolism by rat tissue preparations
5. Antibodies and dextran as an anti-tumor drug carrier
6. Poly-L-aspartic acid as a carrier for doxorubicin: A comparative in vivo study of free and polymer-bound drug
7. Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro
8. Poly(ethylene glycol)-doxorubicin conjugates containing β-lactamase-sensitive linkers
9. A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug carrier conjugate: In vitro and in vivo studies
10. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
11. General mechanism of intratumor accumulation of macromolecules: Advantage of macromolecular therapeutics
12. Application of monoclonal antibody for drug delivery system - Missile therapy for cancer
13. Immunotoxins of pseudomonas exotoxin A (PE): Effect of linkage on conjugate yield, potency, selectivity and toxicity
14. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
15. Synthesis and HPLC analysis of enzymatically cleavable linker consisting of poly(ethylene glycol) and dipeptide for the development of immunoconjugate
16. PEG-modified proteins
17. New PEG2 type polyethylene glycol derivatives for protein modification
18. Preparation and characterization of conjugates of monoclonal antibodies and staphylococcal enterotoxin A using a new hydrophilic cross-linker
19. Serological analysis of cell surface antigens of null cell acute lymphocyte leukemia by mouse monoclonal antibodies
20. The common acute lymphoblastic leukemia antigen (CD10) - Emancipation from a functional enigma
21. Tumor formation by a human pre-B leukemia cell line in scid mice is enhanced by matrigel and is associated with induction of CD10 expression
22. Increased expression of neprilysin (neutral endopeptidase 24.11) in rat and human hepatocellular carcinomas
23. In vivo and in vitro antitumor activity of mitomycin C conjugates at 7-N position through a linker containing thiocarbamate bond with CD10 monoclonal antibody
24. Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker
25. FITC derivatives in amino acid analysis
26. Calicheamicin derivatives conjugated to monoclonal antibodies: Determination of loading values and distributions by infrared and UV matrix-assisted laser desorption/ionization mass spectrometry and electrospray ionization mass spectrometry
27. Inhibition of transplasma membrane electron transport by transferrin-adriamycin conjugates
28. Cell surface effects of adriamycin and carminomycin immobilized on cross-linked polyvinyl alcohol
29. A novel amplicon at 8p-22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma
30. Matrix metalloproteases: Variations on a theme
31. Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA
32. Lysosomal cystein peptidases and malignant tumors
33. Serum activities of dipeptidyl-aminopeptidase II and dipeptidyl-aminopeptidase IV in tumor-bearing animals and in cancer patients
34. Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic antigen
35. Fate of a common acute lymphoblastic leukemia antigen during modulation by monoclonal antibody
36. Flow cytometry studies of intracellular adriamycin in single cells in vitro