Cloned transchromosomic calves producing human immunoglobulin

Nature Biotechnology

Volumn 20, Issue 9, 2002, Pages 889-894

  Kuroiwa, Yoshimi ^a   Kasinathan, Poothappillai ^b   Choi, Yoon J ^c   Naeem, Rizwan ^d   Tomizuka, Kazuma ^a   Sullivan, Eddie J ^b   Knott, Jason G ^b   Duteau, Anae ^c   Goldsby, Richard A ^c   Osborne, Barbara A ^e   Ishida, Isao ^a   Robl, James M ^b  

^a KIRIN BREWERY CO LTD   (Japan)

^b Hematech   (United States)

^c AMHERST COLLEGE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BLOOD; CELLS; CLONING; GENES; PROTEINS;

THERAPEUTICS;

BIOTECHNOLOGY;

IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; POLYCLONAL ANTIBODY; PROTEIN;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; ARTIFICIAL CHROMOSOME; CATTLE; CELL REGENERATION; CHROMOSOME TRANSLOCATION; FETUS (ANATOMY); GENE REARRANGEMENT; GENE TRANSFER; GENETIC SELECTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCING CELL; MICROCELL MEDIATED CHROMOSOME TRANSFER; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEQUENCE ANALYSIS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CATTLE; CHROMOSOMES, ARTIFICIAL, HUMAN; CLONING, MOLECULAR; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENES, IMMUNOGLOBULIN; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; TRANSGENES;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0036714713     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt727     Document Type: Article

References (31)

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