Improved renal clearance and tumor targeting of 99mTc-labeled anti-Tac monoclonal antibody Fab by chemical modifications

Nuclear Medicine and Biology

Volumn 29, Issue 2, 2002, Pages 139-146

  Kim, Meyoung kon ^a   Jeong, Hyeh Jean ^a   Kao, Chih Hao K ^a   Yao, Zhengsheng ^a   Paik, David S ^a   Pie, Jae Eun ^a   Kobayashi, Hisataka ^a   Waldmann, Thomas A ^b   Carrasquillo, Jorge A ^a   Paik, Chang H ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

99mTc MAG3 Antibody Fragments; Acylation; Rapid Renal Clearance; Tumor Targeting

Indexed keywords

ESTER DERIVATIVE; GLYCOLIC ACID DERIVATIVE; MERTIATIDE TC 99M; MONOCLONAL ANTIBODY; TRIFLUOROPHENYLGLYCOLIC ACID ESTER; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ARTICLE; CHEMICAL LABELING; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; DRUG EXCRETION; DRUG RETENTION; DRUG UPTAKE; FEMALE; GLYCOSYLATION; IMMUNOREACTIVITY; ISOELECTRIC POINT; KIDNEY CLEARANCE; MOUSE; NONHUMAN; NUDE MOUSE; TUMOR LOCALIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; GLYCOLATES; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN FAB FRAGMENTS; IODINE RADIOISOTOPES; KIDNEY; LYSINE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M MERTIATIDE; TISSUE DISTRIBUTION;

EID: 0036165832     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00296-7     Document Type: Article

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