Optimizing radioimmunotherapy by matching dose distribution with tumor structure using 3D reconstructions of serial images

Cancer Biotherapy and Radiopharmaceuticals

Volumn 16, Issue 5, 2001, Pages 391-400

  Flynn, A A ^a   Pedley, R B ^a   Green, A J ^a   Boxer, G M ^a   Boden, R ^a   Begent, R H J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CARBON 14; IODINE 131; MONOCLONAL ANTIBODY; RADIOISOTOPE; YTTRIUM 90;

ANIMAL EXPERIMENT; ARTICLE; DOSIMETRY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGE RECONSTRUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION ABSORPTION; RADIATION DOSE DISTRIBUTION; RADIOIMMUNOTHERAPY; THREE DIMENSIONAL IMAGING; TUMOR NECROSIS; TUMOR VASCULARIZATION;

EID: 0035217960     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/108497801753354294     Document Type: Article

References (32)

1. 2 antibodies
2. 131I anti-CEA antibody in a colonic xenograft model
3. The impact of tumor cell proliferation in radioimmunotherapy
4. Proliferation and the advantage of longer-lived radionuclides in radioimmunotherapy
5. The effectiveness of radio-labelled antibodies for radioimmunotherapy in a colorectal xenograft model: A comparative study using the linear-quadratic formulation
6. Transport of molecules in the tumor interstitium: A review
7. Macroscopic dosimetry for radioimmunotherapy-nonuniform activity distributions in solid tumors
8. Calculation of radiation-doses for nonuniformly distributed beta-radionuclides and gamma-radionuclides in soft-tissue
9. Nonuniformity of tumor dose in radioimmunotherapy
10. Implications of nonuniform tumor doses for radioimmunotherapy
11. A novel technique, using radioluminography, for the measurement of uniformity of radiolabeled antibody distribution in a colorectal cancer xenograft model
12. Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
13. Absorbed doses for internal radiotherapy from 22 beta-emitting radionuclides: Beta dosimetry of small spheres
14. Autoradiography using phosphor technology
15. Preparation, characterisation and tumour targeting of cross-linked divalent and tri-valent anti-tumour Fab' fragments
16. Mapping epitope characteristics on carcinoembryonic antigen
17. Phage libraries for generation of clinically useful antibodies
18. Immunotherapy of human ovarian carcinoma with OVARIX™ Mab-B43.13 in a human PBL-SCID/PG mouse model
19. 131I-labelled human growth hormone of high specific radioactivity
20. Protein and cell membrane iodinations with a sparingly soluble chloramide, 1, 3, 6, 6-tetrachloro-3a, 6a-diphenylglycoluril
21. Human colonic adenocarcinoma cells
22. A comparison of image registration techniques for the correlation of radiolabelled antibody distribution with tumour morphology
23. 90Y labelled antibodies, including a method for managing heterogeneity in kidney and tumour
24. In vitro measurement of avidity of radioiodinated antibodies
25. Relationships between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides
26. Radiation physics and genetic targeting: New directions for radiotherapy
27. Towards multidimensional radiotherapy (MD-CRT): Biological imaging and biological conformality
28. Medical image registration
29. Mathematical model of antibody targeting: Important parameters defined using clinical data
30. A model based approach for the optimisation of radioimmunotherapy through antibody design and radionuclifle selection
31. MIRD pamphlet No. 17: The dosimetry of nonuniform activity distributions-radionuclide S values at the voxel level