The role of Rho GTPases in disease development

Gene

Volumn 286, Issue 2, 2002, Pages 155-174

  Boettner, Benjamin ^a   Van Aelst, Linda ^a  

^a Cold Spring Harbor Laboratories ^*  (United States)

Author keywords

Cancer; Disease; Neurological disorder; Rho GTPase; Signaling

Indexed keywords

ENZYME ACTIVATOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; BACTERIAL INFECTION; CANCER GROWTH; CYTOPATHOGENIC EFFECT; DEGENERATIVE DISEASE; DOWN SYNDROME; ENZYME ACTIVATION; ENZYME ACTIVITY; FACIOGENITAL DYSPLASIA; GENE MUTATION; HEARING IMPAIRMENT; HUMAN; MENTAL DEFICIENCY; MOLECULAR GENETICS; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TANGIER DISEASE; WISKOTT ALDRICH SYNDROME;

ANIMALS; DEAFNESS; HUMANS; NEOPLASMS; NEURODEGENERATIVE DISEASES; RHO GTP-BINDING PROTEINS; TANGIER DISEASE; WISKOTT-ALDRICH SYNDROME;

EID: 0037139607     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00426-2     Document Type: Review

References (196)

1. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
2. Structure and mutagenesis of the Dbl homology domain
3. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
4. PAK3 mutation in nonsyndromic X-linked mental retardation
5. Mind the GAP. Rho, Rab and GDI
6. Regulation of actin dynamics through phosphorylation of cofilin by LIM- kinase
7. FMR1 protein: Conserved RNP family domains and selective RNA binding
8. Pak to the future
9. A novel regulator of p21-activated kinases
10. A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins
11. Cyclin D1 protein expression and function in human breast cancer
12. Protein kinase C zeta isoform is critical for mitogenic signal transduction
13. Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation
14. Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
15. Bacterial toxins inhibiting or activating small GTP-binding proteins
16. The ras gene family and human carcinogenesis
17. Conformational switch and role of phosphorylation in PAK activation
18. Regulatory and signaling properties of the Vav family
19. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation
20. MRX review
21. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability
22. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
23. Regulation of c-myc expression by PDGF through Rho GTPases
24. Genomic analysis of metastasis reveals an essential role for RhoC
25. Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma
26. Rac1 protects epithelial cells against anoikis
27. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis
28. alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms
29. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
30. WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia
31. Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia
32. The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
33. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
34. Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer
35. Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes
36. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals
37. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
38. Tiam1 mutations in human renal-cell carcinomas
39. Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus
40. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
41. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation
42. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition
43. The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments
44. Rho GTPases are over-expressed in human tumors
45. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho
46. Multiple ras effector pathways contribute to G(1) cell cycle progression
47. Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining
48. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice
49. Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1→q22.2
50. Merlin: The neurofibromatosis 2 tumor suppressor
51. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2
52. Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins
53. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
54. Rho GTPases and the actin cytoskeleton
55. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
56. Analysis of neocortex in three males with the fragile X syndrome
57. Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease - The small G protein may play a role in cholesterol efflux
58. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling
59. RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity
60. Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP
61. Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1
62. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
63. The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts
64. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho
65. Understanding the molecular basis of fragile X syndrome
66. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
67. Suppression of Ras-induced apoptosis by the Rac GTPase
68. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
69. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors
70. Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases
71. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
72. Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour
73. Inhibition of cell motility after nm23 transfection of human and murine tumor cells
74. Cell cycle targets of Ras/Raf signalling
75. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
76. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
77. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
78. Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus
79. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia
80. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
81. Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation
82. Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene
83. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
84. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
85. Somatic allelic deletion of nm23 in human cancer
86. Bacterial protein toxins targeting rho GTPases
87. A novel Cdc42Hs mutant induces cellular transformation
88. Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1
89. RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage
90. RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells
91. Rho GTPases in neuronal morphogenesis
92. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
93. Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous
94. Site-directed mutagenesis of nm23-H1. Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells
95. A brain serine/threonine protein kinase activated by Cdc42 and Rac1
96. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
97. Postsynaptic actin and neuronal plasticity
98. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras
99. Determination of the prognostic value of cyclin D1 overexpression in breast cancer
100. A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system
101. Integrin-specific activation of rac controls progression through the G(1) phase of the cell cycle
102. A role for Rac in Tiam1-induced membrane ruffling and invasion
103. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
104. Induction of filopodium formation by a WASP-related actin- depolymerizing protein N-WASP
105. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway
106. Mechanisms that regulate mechanosensory hair cell differentiation
107. cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network
108. Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1
109. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
110. Mitogenesis and endocytosis: What's at the INTERSECTIoN?
111. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
112. A mutation in the pleckstrin homology (PH) domain of the FGD1 gene in an Italian family with faciogenital dysplasia (Aarskog-Scott syndrome)
113. Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1
114. mDia mediates Rho-regulated formation and orientation of stable microtubules
115. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
116. Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative Rho/Rac guanine nucleotide exchange factor
117. Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
118. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
119. Wnt signaling and cancer
120. Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP- binding protein, in non-Hodgkin's lymphoma and multiple myeloma
121. Regulation of the cytoskeleton by Rho-family GTPases: Implications for tumour cell invasion
122. Ras and Rho regulation of the cell cycle and oncogenesis
123. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis
124. The human intersectin genes and their spliced variants are differentially expressed
125. Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1
126. An essential role for Rac in Ras transformation
127. A role for Rho in Ras transformation
128. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
129. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation
130. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
131. Neuroanatomy of fragile X syndrome: The posterior fossa
132. Neuroanatomy of fragile X syndrome: The temporal lobe
133. Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA
134. A missense mutation in myosin VIIA prevents aminoglycoside accumulation in early postnatal cochlear hair cells
135. Rho proteins: Linking signaling with membrane trafficking
136. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
137. Adult fragile X syndrome. Clinico-neuropathologic findings
138. The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts
139. Transformation mediated by RhoA requires activity of ROCK kinases
140. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
141. Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
142. Inhibition of myosin light chain kinase by p21-activated kinase
143. A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
144. Rho GTPases: Signaling, migration, and invasion
145. Rac1 in human breast cancer: Overexpression, mutation analysis, and characterization of a new isoform, Rac1b
146. Two novel mutations confirm FGD1 is responsible for the Aarskog syndrome
147. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts
148. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
149. Interdomain binding mediates tumor growth suppression by the NF2 gene product
150. CDK inhibitors: Positive and negative regulators of G1-phase progression
151. The IL-1 receptor and Rho directly associate to drive cell activation in inflammation
152. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein
153. Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms
154. Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells
155. Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene
156. Structural mimicry in bacterial virulence
157. Transmembrane-4-superfamily proteins CD151 and CD81 associate with alpha 3 beta 1 integrin, and selectively contribute to alpha 3 beta 1-dependent neurite outgrowth
158. Rac1 is required for the formation of three germ layers during gastrulation
159. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
160. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
161. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures
162. Rho family GTPases: The cytoskeleton and beyond
163. Rho family GTPases: More than simple switches
164. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
165. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
166. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl
167. Junctophilins: A novel family of junctional membrane complex proteins
168. Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations
169. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts
170. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt- 1
171. Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF
172. OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes
173. Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes
174. Accumulation of RhoA, RhoB, RhoG, and Rac1 in fibroblasts from Tangier disease subjects suggests a regulatory role of Rho family proteins in cholesterol efflux
175. Rho GTPases and signaling networks
176. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
177. X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene
178. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
179. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
180. Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27
181. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation
182. The world according to Arp: Regulation of actin nucleation by the Arp2/3 complex
183. Timing of cyclin D1 expression within G1 phase is controlled by Rho
184. High prevalence of nonsense, frame shift, and splice-site mutations in 16 patients with full-blown Wiskott-Aldrich syndrome
185. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
186. Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation
187. The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation
188. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
189. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells
190. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
191. Specific protection against breast cancers by cyclin D1 ablation
192. A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation
193. The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs- specific guanine-nucleotide exchange factor
194. The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene