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Volumn 19, Issue 9, 1999, Pages 5892-5901

Suppression of Ras-induced apoptosis by the Rac GTPpase

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

EID: 0032803236     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.9.5892     Document Type: Article
Times cited : (155)

References (54)
  • 1
    • 0030898311 scopus 로고    scopus 로고
    • Apoptosis: Activate NF-κB or die?
    • Baichwal, V. R., and P. A. Baeuerle. 1997. Apoptosis: activate NF-κB or die? Curr. Biol. 7:R94-R96.
    • (1997) Curr. Biol. , vol.7
    • Baichwal, V.R.1    Baeuerle, P.A.2
  • 2
    • 0029874138 scopus 로고    scopus 로고
    • The KF-kappaB and I kappaB proteins: New discoveries and insights
    • Baldwin, A. S. 1996. The KF-kappaB and I kappaB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin, A.S.1
  • 4
    • 0028971751 scopus 로고
    • Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2
    • Chen, C. Y., and D. V. Fallen. 1995. Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene 11:1487-1498.
    • (1995) Oncogene , vol.11 , pp. 1487-1498
    • Chen, C.Y.1    Fallen, D.V.2
  • 5
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-jun activation domain
    • Derijard, M. Hibi, I. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-jun activation domain. Cell 76:1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Derijard1    Hibi, M.2    Wu, I.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.8
  • 6
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
    • DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388:548-554.
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 7
    • 0028485768 scopus 로고
    • PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation
    • Dikic, I., J. Schlessinger, and I. Lax. 1994. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr. Biol. 4:702-708.
    • (1994) Curr. Biol. , vol.4 , pp. 702-708
    • Dikic, I.1    Schlessinger, J.2    Lax, I.3
  • 8
    • 0031936353 scopus 로고    scopus 로고
    • Ras signaling and apoptosis
    • Downward, J. 1998. Ras signaling and apoptosis. Curr. Opin. Genet. Dev. 8:49-54.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 49-54
    • Downward, J.1
  • 9
    • 0032502772 scopus 로고    scopus 로고
    • Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli
    • Foltz, I. N., R. E. Gerl, J. S. Wieler, M. Luckach, R. A. Salmon, and J. W. Schrader. 1998. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. J. Biol. Chem. 273:9344-9351.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9344-9351
    • Foltz, I.N.1    Gerl, R.E.2    Wieler, J.S.3    Luckach, M.4    Salmon, R.A.5    Schrader, J.W.6
  • 10
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke, T. F., D. R. Kaplan, and L. C. Cantley. 1997. PI3K: Downstream AKTion blocks apoptosis. Cell 88:435-437.
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 11
    • 0029814413 scopus 로고    scopus 로고
    • Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65
    • Freeman, J., A. Abo, and J. Lambeth. 1996. Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65. J. Biol. Chem. 271:19794-19801.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19794-19801
    • Freeman, J.1    Abo, A.2    Lambeth, J.3
  • 12
    • 0028852770 scopus 로고
    • Overexpression of Mos oncogene product in Swiss 3T3 cells induces apoptosis preferentially during S-phase
    • Fukasawa, K., S. Rulong, J. Resau, P. Pinto da Silva, and G. F. Van de Woude. 1995. Overexpression of Mos oncogene product in Swiss 3T3 cells induces apoptosis preferentially during S-phase. Oncogene 10:1-8.
    • (1995) Oncogene , vol.10 , pp. 1-8
    • Fukasawa, K.1    Rulong, S.2    Resau, J.3    Pinto Da Silva, P.4    Van De Woude, G.F.5
  • 13
    • 0031035639 scopus 로고    scopus 로고
    • Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability
    • Fukasawa, K., and G. F. Van de Woude. 1997. Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Mol. Cell. Biol. 17:506-518.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 506-518
    • Fukasawa, K.1    Van De Woude, G.F.2
  • 14
    • 0029905354 scopus 로고    scopus 로고
    • Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase
    • Groom, L. A., A. A. Sneddon, D. R. Alessi, S. Dowd, and S. M. Keyse. 1996. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J. 15:3621-3632.
    • (1996) EMBO J. , vol.15 , pp. 3621-3632
    • Groom, L.A.1    Sneddon, A.A.2    Alessi, D.R.3    Dowd, S.4    Keyse, S.M.5
  • 15
    • 0022602017 scopus 로고
    • Inhibition of growth factor induced differentiation of PC12 cells by microinjection of antibody to ras p21
    • Hagag, N., S. Halegoua, and M. Viola. 1986. Inhibition of growth factor induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature 319:680-682.
    • (1986) Nature , vol.319 , pp. 680-682
    • Hagag, N.1    Halegoua, S.2    Viola, M.3
  • 16
    • 0031058730 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo
    • Hirsch, D. D., and P. J. S. Stork. 1997. Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo. J. Biol. Chem. 272:4568-4575.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4568-4575
    • Hirsch, D.D.1    Stork, P.J.S.2
  • 17
    • 0029802561 scopus 로고    scopus 로고
    • Rac regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
    • Joneson, T., M. McDonongh, D. Bar-Sagi, and L. Van Aelst. 1996. Rac regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. Science 274:1374-1376.
    • (1996) Science , vol.274 , pp. 1374-1376
    • Joneson, T.1    McDonongh, M.2    Bar-Sagi, D.3    Van Aelst, L.4
  • 18
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • Joneson, T., M. White, M. Wigler, and D. Bar-Sagi. 1996. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271:810-812.
    • (1996) Science , vol.271 , pp. 810-812
    • Joneson, T.1    White, M.2    Wigler, M.3    Bar-Sagi, D.4
  • 19
    • 0030771387 scopus 로고    scopus 로고
    • Ras effectors and their role in mitogenesis and oncogenesis
    • Joneson, T., and D. Bar-Sagi. 1997. Ras effectors and their role in mitogenesis and oncogenesis. J. Mol. Med. 75:587-593.
    • (1997) J. Mol. Med. , vol.75 , pp. 587-593
    • Joneson, T.1    Bar-Sagi, D.2
  • 20
    • 0032541085 scopus 로고    scopus 로고
    • A Rac1 effector site controlling mitogenesis through superoxide production
    • Joneson, T., and D. Bar-Sagi. 1998. A Rac1 effector site controlling mitogenesis through superoxide production. J. Biol. Chem. 273:17991-17994.
    • (1998) J. Biol. Chem. , vol.273 , pp. 17991-17994
    • Joneson, T.1    Bar-Sagi, D.2
  • 21
    • 0031964429 scopus 로고    scopus 로고
    • Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues
    • Karim, F. D., and G. M. Rubin. 1998. Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development 125:1-9.
    • (1998) Development , vol.125 , pp. 1-9
    • Karim, F.D.1    Rubin, G.M.2
  • 24
    • 0028800305 scopus 로고
    • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosrovi-Far, R., P. Solkki, G. Clark, M. Kinch, and C. Der. 1995. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15:6443-6453.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6443-6453
    • Khosrovi-Far, R.1    Solkki, P.2    Clark, G.3    Kinch, M.4    Der, C.5
  • 25
    • 0032582793 scopus 로고    scopus 로고
    • Ras promotes cell survival in Drosophila by downregulating hid expression
    • Kurada, P., and K. White. 1998. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95:319-329.
    • (1998) Cell , vol.95 , pp. 319-329
    • Kurada, P.1    White, K.2
  • 27
    • 0030298138 scopus 로고    scopus 로고
    • Rac and Cdc42 induce actin polymerization and G1 cell progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
    • Lamarche, N., N. Tapon, L. Stowers, P. D. Burbelo, P. Aspenstrom, T. Bridges, J. Chant, and A. Hall. 1996. Rac and Cdc42 induce actin polymerization and G1 cell progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87:519-529.
    • (1996) Cell , vol.87 , pp. 519-529
    • Lamarche, N.1    Tapon, N.2    Stowers, L.3    Burbelo, P.D.4    Aspenstrom, P.5    Bridges, T.6    Chant, J.7    Hall, A.8
  • 29
    • 0030612937 scopus 로고    scopus 로고
    • Requirement of NF-KB activation to suppress p53-independent apoptosis induced by oncogenic Ras
    • Mayo, M., C.-Y. Wang, P. Cogswell, K. Rogers-Graham, S. Lowe, C. Der, and A. Baldwin. 1997. Requirement of NF-KB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science 278:1812-1815.
    • (1997) Science , vol.278 , pp. 1812-1815
    • Mayo, M.1    Wang, C.-Y.2    Cogswell, P.3    Rogers-Graham, K.4    Lowe, S.5    Der, C.6    Baldwin, A.7
  • 30
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting PI3-kinase to cell survival and beyond
    • Marte, B. M., and J. Downward. 1997. PKB/Akt: connecting PI3-kinase to cell survival and beyond. Trends Biochem. Sci. 22:355-358.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 355-358
    • Marte, B.M.1    Downward, A.J.2
  • 32
    • 0027269781 scopus 로고
    • 2 and antioxidants have opposite effects on activation of NF-kappaB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
    • 2 and antioxidants have opposite effects on activation of NF-kappaB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO 12:2005-2015.
    • (1993) EMBO , vol.12 , pp. 2005-2015
    • Meyer, M.1    Schreck, R.2    Baenerle, P.A.3
  • 33
    • 0029910140 scopus 로고    scopus 로고
    • The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases
    • Muda, M., A. Theodosiou, N. Rodrigues, U. Boschert, M. Camps, C. Gillieron, K. Davies, A. Ashworth, and S. Arkinstall. 1996. The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. J. Biol. Chem. 271:27205-27208.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27205-27208
    • Muda, M.1    Theodosiou, A.2    Rodrigues, N.3    Boschert, U.4    Camps, M.5    Gillieron, C.6    Davies, K.7    Ashworth, A.8    Arkinstall, S.9
  • 34
    • 0021970413 scopus 로고
    • Requirement for ras protooncogene function during serum stimulated growth of NIH 3T3 cells
    • Mulchay, L. S., M. R. Smith, and D. W. Stacey. 1985. Requirement for ras protooncogene function during serum stimulated growth of NIH 3T3 cells. Nature 313:241-243.
    • (1985) Nature , vol.313 , pp. 241-243
    • Mulchay, L.S.1    Smith, M.R.2    Stacey, D.W.3
  • 36
    • 0000552751 scopus 로고
    • The GTPase Rac1 controls cell proliferation and cooperates with the MAP kinase pathway in fibroblast transformation
    • Qui, R., F. McCormick, and M. Symons. 1995. The GTPase Rac1 controls cell proliferation and cooperates with the MAP kinase pathway in fibroblast transformation. Nature 374:457-459.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qui, R.1    McCormick, F.2    Symons, M.3
  • 38
    • 0031586174 scopus 로고    scopus 로고
    • Identification and characterization of an I kappaB kinase
    • Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an I kappaB kinase. Cell 90:373-383.
    • (1997) Cell , vol.90 , pp. 373-383
    • Regnier, C.H.1    Song, H.Y.2    Gao, X.3    Goeddel, D.V.4    Cao, Z.5    Rothe, M.6
  • 39
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley, A. J., H. F. Paterson, C. Johnston, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.3    Diekmann, D.4    Hall, A.5
  • 41
    • 0028344541 scopus 로고
    • Distinct effects of thioredoxin and other antioxidants on the activation of NF-κB and AP-1
    • Schenk, H., M. Klein, W. Erdbrugger, W. Droge, and K. Schulze-Osthoff. 1994. Distinct effects of thioredoxin and other antioxidants on the activation of NF-κB and AP-1. Proc. Natl. Acad. Sci. USA 91:1672-1676.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1672-1676
    • Schenk, H.1    Klein, M.2    Erdbrugger, W.3    Droge, W.4    Schulze-Osthoff, K.5
  • 42
    • 0027974133 scopus 로고
    • Assessing oxegen radicals as mediators in activation of indudble eukaryotic transcription factor NF-κB
    • Schreck, R., and P. A. Baeuerle. 1994. Assessing oxegen radicals as mediators in activation of indudble eukaryotic transcription factor NF-κB. Methods Enzymol. 234:151-163.
    • (1994) Methods Enzymol. , vol.234 , pp. 151-163
    • Schreck, R.1    Baeuerle, P.A.2
  • 45
    • 0032473569 scopus 로고    scopus 로고
    • A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signaling pathways
    • Tapon, N., K. Nagata, N. Lamarche, and A. Hall. 1998. A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signaling pathways. EMBO J. 17:1395-1404.
    • (1998) EMBO J. , vol.17 , pp. 1395-1404
    • Tapon, N.1    Nagata, K.2    Lamarche, N.3    Hall, A.4
  • 46
    • 0028986193 scopus 로고
    • NF-kappaB: A lesson in family values
    • Thanos, D., and T. Maniatis. 1995. NF-kappaB: a lesson in family values. Cell 80:529-532.
    • (1995) Cell , vol.80 , pp. 529-532
    • Thanos, D.1    Maniatis, T.2
  • 47
    • 0028483678 scopus 로고
    • EGF triggers neural differentiation of PC12 cells that overexpress the EGF receptor
    • Traverse, S., K. Seedorf, H. Paterson, C. J. Marshall, P. Cohen, and A. Ulrich. 1994. EGF triggers neural differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4:694-701.
    • (1994) Curr. Biol. , vol.4 , pp. 694-701
    • Traverse, S.1    Seedorf, K.2    Paterson, H.3    Marshall, C.J.4    Cohen, P.5    Ulrich, A.6
  • 48
    • 0031948845 scopus 로고    scopus 로고
    • Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras
    • Van Weering, D. H. J., J. de Rooij, B. Marte, J. Downward, J. L. Box, and B. M. T. Burgering. 1998. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. Mol. Cell. Biol. 18:1802-1811.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1802-1811
    • Van Weering, D.H.J.1    De Rooij, J.2    Marte, B.3    Downward, J.4    Box, J.L.5    Burgering, B.M.T.6
  • 49
    • 0030900653 scopus 로고    scopus 로고
    • The cat and mouse games that genes, viruses, and cells play
    • Weinberg, R. A. 1997. The cat and mouse games that genes, viruses, and cells play. Cell 88:573-575.
    • (1997) Cell , vol.88 , pp. 573-575
    • Weinberg, R.A.1
  • 50
    • 0032079523 scopus 로고    scopus 로고
    • Protein kinase B and Rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
    • Welch, H., A. Eguinoa, L. R. Stephens, and P. T. Hawkins. 1998. Protein kinase B and Rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway. J. Biol. Chem. 273:11248-11256.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11248-11256
    • Welch, H.1    Eguinoa, A.2    Stephens, L.R.3    Hawkins, P.T.4
  • 52
    • 0021170342 scopus 로고
    • The p21 ras C-terminus is required for transformation and membrane association
    • Willumsen, B., A. Christensen, N. Hubbert, A Papageorge, and D. Lowy. 1984. The p21 ras C-terminus is required for transformation and membrane association. Nature 310:583-586.
    • (1984) Nature , vol.310 , pp. 583-586
    • Willumsen, B.1    Christensen, A.2    Hubbert, N.3    Papageorge, A.4    Lowy, D.5
  • 53
    • 0030611595 scopus 로고    scopus 로고
    • IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
    • Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278:866-869.
    • (1997) Science , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel, D.V.5
  • 54
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5


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