Atypical protein kinase C is involved in the evolutionarily conserved PAR protein complex and plays a critical role in establishing epithelia-specific junctional structures

Journal of Cell Biology

Volumn 152, Issue 6, 2001, Pages 1183-1196

  Suzuki, Atsushi ^a   Yamanaka, Tomoyuki ^a   Hirose, Tomonori ^a   Manabe, Naoyuki ^a   Mizuno, Keiko ^a   Shimizu, Miki ^a   Akimoto, Kazunori ^a   Izumi, Yasushi ^a   Ohnishi, Tetsuo ^a   Ohno, Shigeo ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Atypical PKC; Epithelial cell polarity; PAR 3; PAR 6; Tight junction

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); PROTEIN KINASE C; PROTEINASE ACTIVATED RECEPTOR 3;

ARTICLE; BIOGENESIS; CAENORHABDITIS ELEGANS; CELL POLARITY; DIFFUSION; EMBRYO DEVELOPMENT; EPITHELIUM CELL; EXPRESSION VECTOR; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TIGHT JUNCTION; WESTERN BLOTTING;

ACTINS; ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; CADHERINS; CAENORHABDITIS ELEGANS PROTEINS; CALCIUM; CARRIER PROTEINS; CELL ADHESION MOLECULES; CELL LINE; CELL POLARITY; EPITHELIAL CELLS; FLUORESCENT DYES; GENE TRANSFER TECHNIQUES; HELMINTH PROTEINS; MACROMOLECULAR SUBSTANCES; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; NA(+)-K(+)-EXCHANGING ATPASE; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEIN KINASE C; PROTEINS; TIGHT JUNCTIONS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA; RICKETTSIA SP. PAR; STAPHYLOCOCCUS PHAGE 3A; VECTORS;

EID: 0035911955     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.6.1183     Document Type: Article

References (42)

1. A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells
2. EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase
3. Assembly of the tight junction: The role of diacylglycerol
4. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
5. Protein kinase C zeta isoform is critical for mitogenic signal transduction
6. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
7. Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells
8. Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber loss
9. Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis
10. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
11. Identification of isoforms of G proteins and PKC that colocalize with tight junctions
12. Origins of cell polarity
13. Occludin: A novel integral membrane protein localizing at tight junctions
14. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
15. Improved method for high efficiency transformation of intact yeast cells
16. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice
17. A functional assay for proteins involved in establishing an epithelial occluding barrier: Identification of a uvomorulin-like polypeptide
18. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo
19. Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta
20. Protein kinase C isoenzymes: Divergence in signal transduction?
21. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
22. An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
23. Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle
24. Requirement of atypical protein kinase C lambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes
25. Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity
26. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
27. Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta
28. UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily
29. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis
30. Expression, separation, and assay of protein kinase C subspecies
31. The polarized distribution of an apical cell surface glycoprotein is maintained by interactions with the cytoskeleton of Madin-Darby canine kidney cells
32. Use of fluorescent analogs of ceramide to study the Golgi apparatus of animal cells
33. Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
34. Regulated assembly of tight junctions by protein kinase C
35. Critical role for intracellular calcium in tight junction biogenesis
36. Mammalian alpha 1- and beta 1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus
37. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans
38. Signalling through the lipid products of phosphoinositide-3-OH kinase
39. Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton
40. The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells
41. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3
42. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts