The GTPase Rho controls a p53-dependent survival checkpoint during thymopoiesis

Journal of Experimental Medicine

Volumn 192, Issue 1, 2000, Pages 77-85

  Costello, Patrick S ^a   Cleverley, Steve C ^a   Galandrini, Ricciarda ^a,b   Henning, Stefan W ^a,c   Cantrell, Doreen A ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Development; Pre T cell; Signaling; Thymus

Indexed keywords

CYTOKINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN BCL 2; PROTEIN P53; RHO FACTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADP RIBOSE TRANSFERASES; ANIMALS; APOPTOSIS; BOTULINUM TOXINS; CELL SURVIVAL; CLOSTRIDIUM BOTULINUM; GENES, BCL-2; GENES, P53; HUMANS; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; RHO GTP-BINDING PROTEINS; T-LYMPHOCYTES; THYMUS GLAND; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034601013     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.1.77     Document Type: Article

References (39)

1. Godfrey, D.I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today. 14:547-553.
2. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29-47.
3. Fehling, H.J., and H. von Boehmer. 1997. Early alpha beta T cell development in the thymus of normal and genetically altered mice. Curr. Opin. Immunol. 9:263-275.
4. Dudley, E.C., H.T. Petrie, L.M. Shah, M.J. Owen, and A.C. Hayday. 1994. T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. Immunity. 1:83-93.
5. Levelt, C.N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity. 3:667-672.
6. von Boehmer, H. 1992. Thymic selection: a matter of life and death. Immunol. Today. 13:454-458.
7. Sebzda, E., S. Mariathasan, T. Ohteki, R. Jones, M.F. Bachmann, and P.S. Ohashi. 1999. Selection of the T cell repertoire. Annu. Rev. Immunnol. 17:829-874.
8. Von Freeden-Jeffry, U., P. Vieira, L.A. Lucian, T. McNeil, S.E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519-1526.
9. DiSanto, J.P., and H.R. Rodewald. 1998. In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development. Curr. Opin. Immunol. 10:196-207.
10. Cao, X.Q., E.W. Shores, J. Huli, M.R. Anver, B.L. Kelsall, S.M. Russell, J. Drago, M. Noguchi, A. Grinberg, E.T. Bloom, et al. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor-γ chain. Immunity. 2:223-238.
11. Moore, T.A., and A. Zlotnik. 1995. T-cell lineage commitment and cytokine responses of thymic progenitors. Blood. 86:1850-1860.
12. Di Santo, J.P., and H.R. Rodewald. 1998. In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development. Curr. Opin. Immunol. 10:196-207.
13. Haks, M.C., M.A. Oosterwegel, B. Blom, H.M. Spits, and A.M. Kruisbeek. 1999. Cell-rate decisions in early T cell development: regulation by cytokine receptors and the pre-TCR. Semin. Immunol. 11:23-37.
14. Hoffman, E.S., L. Passoni, T. Crompton, T.M. Leu, D.G. Schatz, A. Koff, M.J. Owen, and A.C. Hayday. 1996. Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10:948-962.
15. Shinkai, Y., G. Rathbun, K.-P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.-M. Stall, et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
16. Di Santo, J.P., I. Aifantis, E. Rosmaraki, C. Garcia, J. Feinberg, H.J. Fehling, A. Fischer, H. von Boehmer, and B. Rocha. 1999. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. J. Exp. Med. 189:563-574.
17. von Freeden-Jeffry, U., N. Solvason, M. Howard, and R. Murray. 1997. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression. Immunity. 7:147-154.
18. Rothenberg, E.-V., D. Chen, and R.-A. Diamond. 1993. Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transition before and after the SCID arrest. J. Immunol. 151:3530-3536.
19. Bogue, M.A., C. Zhu, E. Aguilar-Cordova, L.A. Donehower, and D.B. Roth. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev. 10:553-565.
20. Guidos, C.J., C.J. Williams, I. Grandal, G. Knowles, M.T. Huang, and J.S. Danska. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in seid lymphocyte precursors. Genes Dev. 10:2038-2054.
21. Nacht, M., A. Strasser, Y.R. Chan, A.W. Harris, M. Schlissel, R.T. Bronson, and T. Jacks. 1996. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev. 10: 2055-2066.
22. + stage of thymocyte differentiation in the absence of T cell receptor rearrangement. J. Exp. Med. 183:1923-1928.
23. Haks, M.C., P. Krimpenfort, J.H. van den Brakel, and A.M. Kruisbeek. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity. 11:91-101.
24. Galandrini, R., S. Henning, and D.A. Cantrell. 1997. Different functions for the GTPase Rho in prothymocytes and late pre-T cells. Immunity. 7:163-174.
25. Henning, S.W., and D.A. Cantrell. 1998. p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function. J. Exp. Med. 188:931-939.
26. Henning, S., R. Galandrini, A. Hall, and D.A. Cantrell. 1997. The GTPase Rho has a critical regulatory role in thymocyte development. EMBO (Eur. Mol. Biol. Organ.) J. 16: 2397-2407.
27. Strasser, A., A.W. Harris, T. Jacks, and S. Cory. 1994. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79:329-339.
28. -/- mice. Cell. 89:1011-1019.
29. Vermes, I., C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J. Immunol. Methods. 184:39-51.
30. Schmid, I., C.H. Uittenbogaart, and J.V. Giorgi. 1994. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry. 15: 12-20.
31. Buer, J., I. Aifantis, J.P. DiSanto, H.J. Fehling, and H. von Boehmer. 1997. Role of different T cell receptors in the development of pre-T cells. J. Exp. Med. 185:1541-1547.
32. Veis, D.J., C.L. Sentman, E.A. Bach, and S.J. Korsmeyer. 1993. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J. Immunol. 151:2546-2554.
33. Kim, K., C.K. Lee, T.J. Savers, K. Muegge, and S.K. Durum. 1998. The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J. Immunol. 160:5735-5741.
34. Gomez, J., C. Martinez, M. Giry, A. Garcia, and A. Rebollo. 1997. Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction. Eur. J. Immunol. 27:2793-2799.
35. Newton, K., A.W. Harris, and A. Strasser. 2000. FADD/ MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor. EMBO (Eur. Mol. Biol. Organ.) J. 19:931-941.
36. - T cell progenitors. Int. Immunol. 9:1291-1301.
37. Cleverley, S.C. 1999. Exploring the role of the small GTPase Rho in T lymphocyte biology. Ph.D. thesis. University College London, UK. 145-147.
38. Clarke, A.R., C.A. Purdie, D.J. Harrison, R.G. Morris, C.C. Bird, M.L. Hooper, and A.H. Wyllie. 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:849-852.
39. Cleverley, S.C., S. Henning, and D.A. Cantrell. 1999. Temporal and cell subset specific elimination of Rho function in vivo gives different perspectives on Rho function. Curr. Biol. 9:657-660.