Activation of the small GTPase Cdc42 by the inflammatory cytokines TNFα and IL-1, and by the Epstein-Barr virus transforming protein LMP1

Journal of Cell Science

Volumn 112, Issue 17, 1999, Pages 2983-2992

  Puls, Axel ^a   Eliopoulos, Aristides G ^b   Nobes, Catherine D ^a   Bridges, Tina ^a   Young, Lawrence S ^b   Hall, Alan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

Cdc42; Epstein Barr virus; Inflammatory cytokine; LMP1; Rho GTPase

Indexed keywords

CYTOKINE; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; LATENT MEMBRANE PROTEIN 1; RHO FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; VIRUS PROTEIN;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; EPSTEIN BARR VIRUS; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

3T3 CELLS; ACTINS; ANIMALS; BACTERIAL PROTEINS; BIOPOLYMERS; CDC42 GTP-BINDING PROTEIN; CULTURE MEDIA, SERUM-FREE; CYTOSKELETON; ENZYME ACTIVATION; FIBROBLASTS; HERPESVIRUS 4, HUMAN; INFLAMMATION; INTERLEUKIN-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICROFILAMENTS; MICROINJECTIONS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PLATELET-DERIVED GROWTH FACTOR; PROTEINS; PSEUDOPODIA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; VIRAL MATRIX PROTEINS;

ANIMALIA; HUMAN HERPESVIRUS 4;

EID: 0032841725     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Arezana-Seisdedos, F., Fernandez, B., Dominguez, I., Jacque, J. M., Thomas, D., Diaz-Meco, M. T., Moscat, J. and Virelizier, J. L. (1993). Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J. Virol. 67, 6596-6604.
2. Baeuerle, P. A. (1998). Last pieces in the NF-kappaB puzzle? Curr. Biol. 8, R19-R22.
3. Bagrodia, S., Derijard, B., Davis, R. J. and Cerione, R. A. (1995). Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270, 27995-27998.
4. Beg, A. A. and Baltimore, D. (1996). An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274, 782-784.
5. Beyaert, R. and Fiers, W. (1994). Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not. FEBS Lett. 340, 9-16.
6. Brown, J. L., Stowers, L., Baer, M., Trejo, J., Coughlin, S. and Chant, J. (1996). Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol. 6, 598-605.
7. Brown, T. L. and Howe, P. H. (1998). MADD is highly homologous to a Rab3 guanine-nucleotide exchange protein (Rab3-GEP). Curr. Biol. 8, R191-R193.
8. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T. and Goeddel, D. V. (1996). TRAF6 is a signal transducer for interleukin-1. Nature 383, 443-446.
9. Coso, O. A., Chiariello, M., Yu, J. C., Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J. S. (1995). The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81, 1137-1146.
10. Devergne, O., Hatzivassiliou, E., Izumi, K. M., Kaye, K. M., Kleijnen, M. F., Kieff, E. and Mosialos, G. (1996). Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation. Mol. Cell. Biol. 16, 7098-7108.
11. Dinarello, C. A. (1996). Biologic basis for interleukin-1 in disease. Blood 87, 2095-2147.
12. Eliopoulos, A. G., Stack, M., Dawson, C. W., Kaye, K. M., Hodgkin, L., Sihota, S., Rowe, M. and Young, L. S. (1997). Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors. Oncogene 14, 2899-2916.
13. Eliopoulos, A. G. and Rickinson, A. B. (1998). Epstein-Barr virus: LMP1 masquerades as an active receptor. Curr. Biol. 8, R196-R198.
14. Eliopoulos, A. G. and Young, L. S. (1998). Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 16, 1731-1742.
15. Eliopoulos, A. G., Blake, S. M. S., Floettmann, J. E., Rowe, M. and Young, L. S. (1999). Epstein-Barr virus-encoded Latent Mambrane Protein 1 activates the JNK pathway through its extrene C-terminus via a mechanism involving TRADD and TRAF2. J. Virol. 73, 1023-1035.
16. Fanger, G. R., Johnson, N. L. and Johnson, G. L. (1997). MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16, 4961-4972.
17. Floettmann, J. E., Eliopoulos, A. G., Jones, M., Young, L. S. and Rowe, M. (1998). Epstein-Barr virus latent membrane protein-1 (LMP1) signalling is distinct from CD40 and involves physical cooperation of its two C-terminus functional regions. Oncogene 17, 2383-2392.
18. Gires, O., Zimber-Strobl, U., Gonnella, R., Ueffing, M., Marschall, G., Zeidler, R., Pich, D. and Hammerschmidt, W. (1997). Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J. 16, 6131-6140.
19. Glise, B. and Noselli, S. (1997). Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes Dev. 11, 1738-1747.
20. Hall, A. (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.
21. Hammarskjold, M. L. and Simurda, M. C. (1992). Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity. J. Virol. 66, 6496-6501.
22. Hirai, S., Katoh, M., Terada, M., Kyriakis, J. M., Zon, L. I., Rana, A., Avruch, J. and Ohno, S. (1997). MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 272, 15167-15173.
23. Hsu, H., Xiong, J. and Goeddel, D. V. (1995). The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81, 495-504.
24. Hsu, H., Huang, J., Shu, H. B., Baichwal, V. and Goeddel, D. V. (1996). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396.
25. Huen, D. S., Henderson, S. A., Croom-Carter, D. and Rowe, M. (1995). The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene 10, 549-560.
26. Ip, Y. T. and Davis, R. J. (1998). Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell Biol. 10, 205-219.
27. Izumi, K. M. and Kieff, E. D. (1997). The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. Proc. Nat. Acad. Sci. USA 94, 12592-12597.
28. Jefferies, W. A., Green, J. R. and Williams, A. F. (1985). Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. J. Exp. Med. 162, 117-127.
29. Just, I., Selzer, J., Wilm, M., von Eichel-Streiber, C., Mann, M. and Aktories, K. (1995). Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375, 500-503.
30. Kaye, K. M., Izumi, K. M., Mosialos, G. and Kieff, E. (1995). The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues. J. Virol. 2, 675-683.
31. Kheradmand, F., Werner, E., Tremble, P., Symons, M. and Werb, Z. (1998). Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science 280, 898-902.
32. Kieser, A., Kilger, E, Gires, O., Ueffing, M., Kolch, W. and Hammerschmidt, W. (1997). Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J. 16, 6478-6485.
33. Kozma, R., Ahmed, S., Best, A. and Lim, L. (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15, 1942-1952.
34. Laherty, C. D., Hu, H. M., Opipari, A. W., Wang, F. and Dixit, V. M. (1992). The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B. J. Biol. Chem. 267, 24157-24160.
35. Lamarche, N., Tapon, N., Stowers, L., Burbelo, P. D., Aspenstrom, P., Bridges, T., Chant, J. and Hall, A. (1996). Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.
36. Leberer, E., Wu, C., Leeuw, T., Fourest-Lieuvin, A., Segall, J. E. and Thomas, D. Y. (1997). Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 16, 83-97.
37. Liu, Z. G., Hsu, H., Goeddel, D. V. and Karin, M. (1996). Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87, 565-576.
38. Minden, A., Lin, A., Claret, F. X., Abo, A. and Karin, M. (1995). Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81, 1147-1157.
39. Mosialos, G., Birkenbach, M., Yalamanchili, R., Van Arsdale, T., Ware, C. and Kieff, E. (1995). The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80, 389-399.
40. Nagata, K., Puls, A., Futter, C., Aspenstrom, P., Schaefer, E., Nakata, T., Hirokawa, N. and Hall, A. (1998). The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J. 17, 149-158.
41. Nobes, C. D. and Hall, A. (1995). Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 81, 53-62.
42. Olson, M. F., Ashworth, A. and Hall, A. (1995). An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269, 1270-1272.
43. Peppelenbosch, M. P., Qiu, R. G., de Vries-Smits, A, M., Tertoolen, L. G., de Laat, S. W., McCormick, F., Hall, A., Symons, M. H. and Bos, J. L. (1995). Rac mediates growth factor-induced arachidonic acid release. Cell 81, 849-856.
44. Perona, R., Montaner, S., Saniger, L., Sanchez-Perez, I., Bravo, R. and Lacal, J. C. (1997). Activation of the nuclear factor-kappaB by Rho, Cdc42, and Rac-1 proteins. Genes Dev. 11, 463-475.
45. Peter, M., Neiman, A. M., Park, H. O., van Lohuizen, M. and Herskowitz, I. (1996). Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J. 15, 7046-7059.
46. Prepens, U., Just, I., von Eichel-Streiber, C. and Aktories, K. (1996). Inhibition of Fc epsilon-R1-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B. J. Biol. Chem. 271, 7324-7329.
47. Rana, A., Gallo, K., Godowski, P., Hirai, S., Ohno, S., Zon, L., Kyriakis, J. M. and Avruch, J. (1996). The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem. 271, 19025-19028.
48. Reinhard, C., Shamoon, B., Shyamala, V. and Williams, L. T. (1997) Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 16, 1080-1092.
49. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
50. Rothe, M., Sarma, V., Dixit, V. M. and Goeddel, D. V. (1995). TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 269, 1424-1427.
51. Rowe, M., Evans, H. S., Young, L. S., Hennessy, K., Kieff, E. and Rickinson, A. B. (1987). Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells. J. Gen. Virol. 68, 1575-1586.
52. Schievella, A. R., Chen, J. H., Graham, J. R. and Lin, L. L. (1997). MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. J. Biol. Chem. 272, 12069-12075.
53. Self, A. J. and Hall, A. (1995). Purification of recombinant Rho/Rac/G25K from Escherichia coli. Meth. Enzymol. 256, 3-10.
54. Song, H. Y., Regnier, C. H., Kirschning, C. J., Goeddel, D. V. and Rothe, M. (1997). Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Nat. Acad. Sci. USA 94, 9792-9796.
55. Stancovski, I. and Baltimore, D. (1997). NF-κB activation: The IκB kinase revealed? Cell 91, 299-301.
56. Stanger, B. Z., Leder, P., Lee, T. H., Kim, E. and Seed, B. (1995). RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81, 513-523.
57. Sulciner, D. J, Irani, K., Yu, Z. X., Ferrans, V. J., Goldschmidt-Clermont, P. and Finkel, T. (1996). Rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation. Mol. Cell. Biol. 16, 7115-7121.
58. Tapon, N., Nagata, K., Lamarche, N. and Hall, A. (1998). A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NFkappaB signalling pathways. EMBO J. 17, 1395-1404.
59. Teramoto, H., Coso, O. A., Miyata, H., Igishi, T., Miki, T. and Gutkind, J. S. (1996). Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J. Biol. Chem. 271, 27225-27228.
60. Thanos, D. and Maniatis, T. (1995). NF-kappa B: a lesson in family values. Cell 4, 529-532.
61. van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R. and Verma, I. M. (1996). Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274, 787-789.
62. Vandenabeele, P., Declercq, W., Beyaert, R. and Fiers, W. (1995). Two tumor necrosis factor receptors: structure and function. Trends Cell Biol. 5, 392-399.
63. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D. and Miyamoto, S. (1995). Re1/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 9, 2723-2735.
64. Wang, C. Y., Mayo, M. W. and Baldwin, A. S. Jr. (1996). TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274, 784-787.
65. Wang, D., Liebowitz, D. and Kieff, E. (1985). An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43, 831-40.
66. Wang, D., Liebowitz, D., Wang, F., Gregory, C., Rickinson, A., Larson, R., Springer, T. and Kieff, E. (1988). Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity. J. Virol. 62, 4173-84.
67. Wesselborg, S., Bauer, M. K. A., Vogt, M., Schmitz, M. L. and Schulze-Osthoff, K. (1997). Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways. J. Biol. Chem. 272, 12422-12429.
68. Whitmarsh, A. J. and Davis, R. J. (1996). Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 74, 589-607.