Structural mimicry in bacterial virulence

Nature

Volumn 412, Issue 6848, 2001, Pages 701-705

  Stebbins, C Erec ^a   Galaán, Jorge E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; PROTEINS;

MIMICRY;

BACTERIA;

VIRULENCE FACTOR;

BACTERIUM; MIMICRY; VIRULENCE;

AMINO ACID SEQUENCE; BACTERIAL VIRULENCE; CELL FUNCTION; CONTROLLED STUDY; IMMUNE RESPONSE; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

ADHESINS, BACTERIAL; BACTERIA; BACTERIAL PROTEINS; EVOLUTION, MOLECULAR; FIBRONECTINS; GTPASE-ACTIVATING PROTEINS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; SALMONELLA; SIGNAL TRANSDUCTION; VIRULENCE;

BACTERIA (MICROORGANISMS);

EID: 0035899360     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35089000     Document Type: Review

References (44)

1. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia
2. Salmonella typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
3. Crystal structure of invasin: A bacterial integrin-binding protein
4. A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
5. Modulation of host signaling by a bacterial mimic. Structure of the Salmonella effector SptP bound to Rac1
6. A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant
7. SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase
8. Role ofthe S. Typhimurium actin-binding protein SipA in bacterial internalization
9. Bacterial protein toxins targeting rho GTPases
10. Bacterial protein toxins. An overview
11. Bacterial protein toxins and cell vesicle trafficking
12. Endogenous relatives of ADP-ribosylating bacterial toxins in mice and men: Potential regulators of immune cell function
13. Type III secretion machines: Bacterial devices for protein delivery into host cells
14. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate
15. A secreted tyrosine phosphatase with modular effector domains encoded by the bacterial pathogen Salmonella typhimurium
16. The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions
17. Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions
18. Disruption of signaling by the Yersinia effector Yopj, a ubiquitin-like protein protease
19. Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells
20. The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases
21. GAP activity of the Yersinia YopE cytotoxin specifically targets the rho pathway: A mechanism for disruption of actin microfilament structure
22. How the Pseudomonas aeruginosa ExoS toxin downregulates Rac
23. Striking a balance: Modulation of the actin cytoskeleton by Salmonella
24. Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell
25. Structures of Cde42 bound to the active and catalytically compromised forms of Cdc42GAP
26. Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
27. The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
28. GTPase-activating proteins: Helping hands to complement an active site
29. Signaling and invasin-promoted uptake via integrin receptors
30. The Yersinia pseudotuberculosis invasin protein and human fibronectin bind to mutually exclusive sites on the alpha 5 beta 1 integrin receptor
31. Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density
32. 2.0 Å crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region
33. Towards deciphering the Helicobacter pylori cytotoxin
34. Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: Bacterial factors, cellular ligands and signaling
35. Gclq-R/p32, a Clq-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes
36. InlB-dependent internalization of Listeria is mediated by the met receptor tyrosine kinase
37. The leucine-rich repeat: A versatile binding motif
38. Structure of the InlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen Listeria monocytogenes
39. A target of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage
40. Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella
41. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin
42. A bacterial invasin induces macrophage apoptosis by binding directly to ICE
43. Diversion of cytoskeletal processes by Shigella during invasion of epithelial cells
44. Gut feelings: Enteropathogenic E. Coli (EPEC) interactions with the host