Integrin-specific activation of Rac controls progression through the G1 phase of the cell cycle

Molecular Cell

Volumn 8, Issue 1, 2001, Pages 115-127

  Mettouchi, Amel ^a   Klein, Sharon ^a   Guo, Wenjun ^a,b   Lopez Lago, Miguel ^a   Lemichez, Emmanuel ^c   Westwick, John K ^d   Giancotti, Filippo G ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d Signal Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; FIBRONECTIN; FOCAL ADHESION KINASE; GROWTH FACTOR; INTEGRIN; LAMININ; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGENIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SHC; RAC PROTEIN; SOS PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2; VERY LATE ACTIVATION ANTIGEN 5;

ARTICLE; BIOSYNTHESIS; CELL ADHESION; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; RNA TRANSLATION; SIGNAL TRANSDUCTION;

EID: 0034886701     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00285-4     Document Type: Article

References (55)

1. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK
2. Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression
3. Integrin-mediated signal transduction pathways
4. Geometric control of cell life and death
5. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
6. Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes
7. Dual stimulation of Ras/mitogen-activated protein kinase and Rho by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression
8. Control of intramolecular interactions between the Pleckstrin-homology and Dbl-homology domains of Vav and Sos1 regulate Rac binding
9. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
10. The role of αv integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
11. Dependence of cyclin E-CDK2 kinase activity on cell anchorage
12. Integrin signaling
13. Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling
14. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
15. 1/S control of anchorage-independent growth in the fibroblast cell cycle
16. Rho GTPases and the actin cytoskeleton
17. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
18. Kip1, and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension
19. Integrins in vascular development
20. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
21. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
22. Alpha 2 beta 1 integrins from different cell types show different binding specificities
23. Activation of Rac1 by a Crk SH3-binding protein, DOCK180
24. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures
25. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
26. PAK and the JNK/SAPK MAP kinase cascade
27. Endothelial cells use α2β1 integrin as a laminin receptor
28. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
29. Cell anchorage permits efficient signal transduction between Ras and its downstream kinases
30. The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation
31. Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
32. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1
33. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
34. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
35. 1
36. Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways
37. Protein modules and signalling networks
38. Integrin α1β1 mediates a unique collagen-dependent proliferation pathway in vivo
39. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
40. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
41. Mechanisms of angiogenesis
42. Role of Phosphoinositide 3-OH Kinase in cell transformation and control of the actin cytoskeleton by Ras
43. Alpha 5 beta 1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
44. Integrin signaling and tyrosine phosphorylation; Just the FAKs?
45. Focal adhesion targeting: The critical determinant of FAK regulation and substrate phosphorylation
46. 1-phase progression
47. Crystal structure of the Dbl and Pleckstrin Homology domains from the human Son Of Sevenless protein
48. Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Y14) via activation of p38 Mitogen-activated Protein (MAP) kinase and c-Src kinase
49. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
50. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
51. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
52. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
53. Integrin transmembrane signaling and cytoskeletal control
54. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
55. Rho family proteins and Ras transformation: The RHOad less traveled gets congested