메뉴 건너뛰기




Volumn 5, Issue 1, 1996, Pages 95-102

Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOPLASM PROTEIN; ISOPROTEIN; NUCLEAR PROTEIN; RNA BINDING PROTEIN;

EID: 0030051618     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/5.1.95     Document Type: Article
Times cited : (155)

References (34)
  • 3
    • 0025905795 scopus 로고
    • Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
    • Verkerk, A.J.M.H., Pieretti, M., Sutcliffe, J.S., et al. (1991) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65, 905-914.
    • (1991) Cell , vol.65 , pp. 905-914
    • Verkerk, A.J.M.H.1    Pieretti, M.2    Sutcliffe, J.S.3
  • 5
    • 84942947953 scopus 로고
    • Advances in molecular analysis of fragile X syndrome
    • Warren, S.T. and Nelson, D.L. (1994) Advances in molecular analysis of fragile X syndrome [see comments]. JAMA, 271, 536-542.
    • (1994) JAMA , vol.271 , pp. 536-542
    • Warren, S.T.1    Nelson, D.L.2
  • 7
    • 0028239232 scopus 로고
    • Male with typical fragile X phenotype is deleted for part of the FMR1 gene and for about 100 kb of upstream region
    • Trottier, Y., Imbert G., Poustka, A., Fryns, J.P. and Mandel, J.L. (1994) Male with typical fragile X phenotype is deleted for part of the FMR1 gene and for about 100 kb of upstream region. Am. J. Med. Genet., 51, 454-457.
    • (1994) Am. J. Med. Genet. , vol.51 , pp. 454-457
    • Trottier, Y.1    Imbert, G.2    Poustka, A.3    Fryns, J.P.4    Mandel, J.L.5
  • 8
    • 0028246435 scopus 로고
    • Fmr1 knockout mice: A model to study fragile X mental retardation
    • The Dutch-Belgian fragile X consortium, (1994) Fmr1 knockout mice: a model to study fragile X mental retardation. Cell, 78, 23-33.
    • (1994) Cell , vol.78 , pp. 23-33
  • 10
    • 0027300283 scopus 로고
    • Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain
    • Abitbol, M., Menini, C., Delezoide, A.L., Rhyner, T., Vekemans, M. and Mallet, J. (1993) Nucleus basalis magnocellularis and hippocampus are the major sites of FMR-1 expression in the human fetal brain. Nature Genet., 4, 147-153
    • (1993) Nature Genet. , vol.4 , pp. 147-153
    • Abitbol, M.1    Menini, C.2    Delezoide, A.L.3    Rhyner, T.4    Vekemans, M.5    Mallet, J.6
  • 11
    • 0027176361 scopus 로고
    • The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation
    • Devys, D., Lutz, Y., Rouyer, N., Bellocq, J.P. and Mandel, J.L. (1993) The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation. Nature Genet, 4, 335-340.
    • (1993) Nature Genet , vol.4 , pp. 335-340
    • Devys, D.1    Lutz, Y.2    Rouyer, N.3    Bellocq, J.P.4    Mandel, J.L.5
  • 18
    • 0027260844 scopus 로고
    • KH domains within the FMR1 sequence suggest that fragile X syndrome stems from a defect in RNA metabolism
    • Gibson, T.J., Rice, P.M., Thompson, J.D. and Heringa, J. (1993) KH domains within the FMR1 sequence suggest that fragile X syndrome stems from a defect in RNA metabolism. Trends. Biochem. Sci., 18, 331-333.
    • (1993) Trends. Biochem. Sci. , vol.18 , pp. 331-333
    • Gibson, T.J.1    Rice, P.M.2    Thompson, J.D.3    Heringa, J.4
  • 19
    • 0027327486 scopus 로고
    • The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein
    • Siomi, H., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. (1993) The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell, 74, 291-298.
    • (1993) Cell , vol.74 , pp. 291-298
    • Siomi, H.1    Siomi, M.C.2    Nussbaum, R.L.3    Dreyfuss, G.4
  • 20
    • 0027377580 scopus 로고
    • FMR1 protein: Conserved RNP family domains and selective RNA binding
    • Ashley, C.T., Jr, Wilkinson, K.D., Reines, D. and Warren, S.T. (1993) FMR1 protein: conserved RNP family domains and selective RNA binding. Science, 262, 563-566.
    • (1993) Science , vol.262 , pp. 563-566
    • Ashley Jr., C.T.1    Wilkinson, K.D.2    Reines, D.3    Warren, S.T.4
  • 22
    • 0028236525 scopus 로고
    • Essential role for KH domains in RNA binding: Impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome
    • Siomi, H., Choi, M., Siomi, M.C., Nussbaum, R.L. and Dreyfuss, G. (1994) Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. Cell, 77, 33-39.
    • (1994) Cell , vol.77 , pp. 33-39
    • Siomi, H.1    Choi, M.2    Siomi, M.C.3    Nussbaum, R.L.4    Dreyfuss, G.5
  • 23
    • 0028609253 scopus 로고
    • A eukaryotic expression vector for the study of nuclear localization signals
    • Schreiber, V., de Murcia, G. and Ménissier de Murcia, J. (1994) A eukaryotic expression vector for the study of nuclear localization signals. Gene, 150, 411-112.
    • (1994) Gene , vol.150 , pp. 411-1112
    • Schreiber, V.1    De Murcia, G.2    De Ménissier Murcia, J.3
  • 25
    • 0026662651 scopus 로고
    • The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity
    • Schreiber, V., Molinete, M., Boeuf, H., de Murcia, G. and Ménissier -de Murcia, J. (1992) The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity. EMBO J., 11, 3263-3269
    • (1992) EMBO J. , vol.11 , pp. 3263-3269
    • Schreiber, V.1    Molinete, M.2    Boeuf, H.3    De Murcia, G.4    Ménissier -de Murcia, J.5
  • 26
    • 0028040020 scopus 로고
    • Cytoplasmic retention of Xenopus nuclear factor 7 before the mid blastula transition uses a unique anchoring mechanism involving a retention domain and several phosphorylaoon sites
    • Li, X., Shou, W., Kloc, M., Reddy, B.A. and Etkin, L.D. (1994) Cytoplasmic retention of Xenopus nuclear factor 7 before the mid blastula transition uses a unique anchoring mechanism involving a retention domain and several phosphorylaoon sites J. Cell Biol., 124, 7-17.
    • (1994) J. Cell Biol. , vol.124 , pp. 7-17
    • Li, X.1    Shou, W.2    Kloc, M.3    Reddy, B.A.4    Etkin, L.D.5
  • 27
    • 0027933911 scopus 로고
    • The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B
    • Pines, J. and Hunter, T. (1994) The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J., 13, 3772-3781.
    • (1994) EMBO J. , vol.13 , pp. 3772-3781
    • Pines, J.1    Hunter, T.2
  • 28
    • 0028986193 scopus 로고
    • NK-κB: A lesson in family values
    • Thanos, D. and Maniatis, T. (1995) NK-κB: a lesson in family values. Cell, 80, 529-532.
    • (1995) Cell , vol.80 , pp. 529-532
    • Thanos, D.1    Maniatis, T.2
  • 29
    • 0017363847 scopus 로고
    • A cytoskeletal structure with associated polyribosomes obtained from HeLa cells
    • Lenk, R., Ransom, L., Kaufmann, Y. and Penman, S. (1977) A cytoskeletal structure with associated polyribosomes obtained from HeLa cells Cell, 10, 67-78.
    • (1977) Cell , vol.10 , pp. 67-78
    • Lenk, R.1    Ransom, L.2    Kaufmann, Y.3    Penman, S.4
  • 30
    • 0019944957 scopus 로고
    • Intermediate filament systems are collapsed onto the nuclear surface after isolation of nuclei from tissue culture cells
    • Staufenbiel, M. and Deppert, W. (1982) Intermediate filament systems are collapsed onto the nuclear surface after isolation of nuclei from tissue culture cells. Exp. Cell Res., 138, 207-214.
    • (1982) Exp. Cell Res. , vol.138 , pp. 207-214
    • Staufenbiel, M.1    Deppert, W.2
  • 33
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., Lebovitz, R.M. and Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 34
    • 0023895357 scopus 로고
    • A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing
    • Lee, K.A.W., Bindereif, A. and Green, M.R. (1988) A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal. Techn., 5, 22-31
    • (1988) Gene Anal. Techn. , vol.5 , pp. 22-31
    • Lee, K.A.W.1    Bindereif, A.2    Green, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.