Rho GTPases are over-expressed in human tumors

International Journal of Cancer

Volumn 81, Issue 5, 1999, Pages 682-687

  Fritz, Gerhard ^a,c   Just, Ingo ^b   Kaina, Bernd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Institute of Toxicology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CELL CYCLE PROTEIN; GUANOSINE TRIPHOSPHATASE; PHOSPHORUS 32; RHO FACTOR;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; BREAST TUMOR; CANCER GRADING; CARCINOGENESIS; COLON TUMOR; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LUNG TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR;

ADENOSINE DIPHOSPHATE RIBOSE; BREAST; BREAST NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CDC42 GTP-BINDING PROTEIN; CELL CYCLE PROTEINS; COLON; COLONIC NEOPLASMS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG NEOPLASMS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; RHOB GTP-BINDING PROTEIN;

EID: 0032939619     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990531)81:5<682::AID-IJC2>3.0.CO;2-B     Document Type: Article

References (32)

1. ADAMSON, P., PATERSON, H.F. and HALL, A., Intracellular localization of the p21rho proteins. J. Cell Biol., 119, 617-627 (1992).
2. AKTORIES, K., RÖSENER, S., BLASCHKE, U. and CHHATWAL, G.S., Botulinum ADP-ribosyltransferase C3. Purification of the enzyme and characterization of the ADP-ribosylation reaction in platelet membranes. Europ. J. Biochem., 172, 445-450 (1988).
3. ALITALO, K., KOSKINEN, P., MÄKELÄ, T.P., SAKSELA, K., SISTONEN, L. and WINQVIST, R., myc oncogenes: activation and amplification. Biochim. biophys. Acta, 907, 1-32 (1987).
4. AMANO, M., ITO, M., KIMURA, K., FUKUTA, Y., CHIHARA, K., NAKANO, T., MATSUURA, Y. and KAIBUCHI, K., Phosphorylation and activation of myosin by Rho-associated kinase (Rho kinase). J. biol. Chem., 271, 20246-20249 (1996).
5. AVRAHAM, H. and WEINBERG, R.A., Characterization and expression of the human rhoH12 gene product. Mol. cell. Biol., 9, 2058-2066 (1989).
6. Bos, J.L., The ras gene family and human carcinogenesis. Mutat. Res., 195, 255-271 (1988).
7. BOURMEYSTER, N., STASIA, M.J., GARIN, J., GAGNON, J., BOQUET, P. and VIGNAIS, P.V., Copurification of Rho protein and the Rho GDI dissociation inhibitor from bovine neutrophil cytosol. Effect of phosphoinositides on Rho ADP-ribosylation by the C3 exoenzyme of Clostridium botulinum. Biochemistry, 31, 12863-12869 (1992).
8. BRAGA, V.M., MACHESKY, L.M., HALL, A. and HOTCHIN, N.A., The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol., 137, 1421-1431 (1997).
9. CHARDIN, P., BOQUET, P., MADAULE, P., POPOFF, M., RUBIN, E.J. and GILL, D.M., The mammalian G protein RhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilament in Vero cells. EMBO J., 8, 1087-1092 (1989).
10. CHARDIN, P., MADAULE, P. and TAVITIAN, A., Coding sequence of human rho cDNA's clone 6 and clone 9. Nucleic Acids Res., 16, 2717 (1988).
11. COSO, A.A., CHIARIELLO, M., YU, J.-C., TERAMOTO, H., CRESPO, P., XU, N., MIKI, T. and GUTKIND, J.S., The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK-signaling pathway. Cell, 81, 1137-1146 (1995).
12. DEL PESO, L., HERNANDEZ-ALCOCEBA, R., EMBADE, N., CARNERO, A., ESTEVE, P., PAJE, C. and LACAL, J.C., Rho proteins induce metastatic properties in vivo. Oncogene, 15, 3047-3057 (1997).
13. FRITZ, G. and AKTORIES, K., ADP-ribosylation of Rho proteins by Clostridium botulinum exoenzyme C3 is influenced by phosphorylation of Rho-associated factors. Biochem. J., 300, 133-139 (1994).
14. FRITZ, G., JUST, I., WOLLENBERG, P. and AKTORIES, K., Differentiation-induced increase in Clostridium botulinum C3 exoenzyme-catalyzed ADP-ribosylation of the small GTP-binding protein Rho. Europ. J. Biochem., 223, 909-916 (1994).
15. FRITZ, G., KAINA, B. and AKTORIES, K., The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA-damaging treatments. J. biol. Chem., 270, 25172-25177 (1995).
16. HABETS, G.G., SCHOLTES, E.H., ZUYDGEEST, D., VAN DER KAMMEN, R.A., STAM, J.C., BERNS, A. and COLLARD, J.G., Identification of an invasion-inducing gene, Tiam-l, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell, 77, 537-549 (1994).
17. HOLLSTEIN, M., SIDRANSKY, D., VOGELSTEIN, B. and HARRIS, C.C., p53 mutations in human cancer. Science, 253, 49-53 (1991).
18. LAUDANNA, C., CAMPBELL, J.J. and BUTCHER, E.G., Role of Rho in chemo-attractant-activated leukocyte adhesion through integrins. Science, 271, 981-983 (1996).
19. LEUNG, T., MANSER, E., TAN, L. and LIM, L., A novel serine/threonine kinase binding the ras related rhoA GTPase which translocates the kinase to peripheral membranes. J. biol. Chem., 270, 29051-29054 (1995).
20. MARSHALL, C., Functions of ras oncogenes. Nature (Lond), 310, 448 (1984).
21. NOBES, C.D. and HALL, A., Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibres, lamellipodia and filopodia. Cell, 81, 53-62 (1995).
22. OHTSUKA, T., NAGATA, K., IIRI, T., NOZAWA, Y., UENO, K., UI, M. and KATADA, T., Activator protein supporting the botulinum ADP-ribosyltransferase reaction. J. biol. Chem., 264, 15000-15005 (1998).
23. OLSON, M.F., ASHWORTH, A. and HALL, A., An essential role for Rho, Rac and Cdc42 GTPases in cell cycle progression through G1. Science, 269, 1270-1272 (1995).
24. PREUSS, I. and 12 OTHERS, Activity of the DNA repair protein O6-methylguanin-DNA methyltransferase in human tumor and corresponding normal tissue. Cancer Detect. Prev., 20, 130-136 (1996).
25. QIU, R.-G., CHEN, J., KIRN, D., MCCORMICK, F. and SYMONS, M., An essential role for Rac in Ras transformation. Nature (Lond.), 374, 457-459 (1995).
26. RUBIN, E.J., GILL, M., BOQUET, P. and POPOFF, M.P., Functional modification of a 21-kDa G protein when ADP-ribosylated by exo-enzyme C3 of Clostridium botulinum. Mol. cell. Biol., 8, 418-426 (1988).
27. SIVARAMAN, V.S., WANG, H.-Y., NUOVO, G.J. and MALBON, C.C., Hyperexpression of mitogen-activated protein kinase in human breast cancer. J. clin. Invest., 99, 1478-1483 (1997).
28. TOLIAS, K.F., CANTLEY, L.C. and CARPENTER, C.L., Rho family GTPases bind to phosphoinositide kinases. J. biol. Chem., 270, 17656-17659 (1995).
29. WATANABE, G., SAITO, Y., MADAULE, P., ISHIZAKI, T., FUJISAWA, K., MORII, N., MUKAI, H., ONO, Y., KAKIZUKA, A. and NARUMIYA, S., Protein kinase N(PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science, 271, 645-648 (1996).
30. YERAMIAN, P., CHARDIN, P., MADAULE, P. and TAVITIAN, A., Nucleotide sequence of human rho cDNA clone 12. Nucleic Acids Res., 15, 1869 (1987).
31. ZACHARY, J.M., CLEVELAND, G., KWOCK, L., LAWRENCE, T., WEISSMAN, R.M., NABELL, L., FRIED, F.A., STAAB, E.V., RISINGER, M.A. and LIN, S., Actin filament organization of the Dunning R3327 rat prostatic adenocarcinoma system: correlation with metastatic potential. Cancer Res., 46, 926-932 (1986).
32. ZALCMAN, G., CLOSSON, V., CAMONIS, J., HONORE, N., ROUSSEAU-MERCK, M.F., TAVITIAN, A. and OLOFSSON, B., RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J. biol. Chem., 271, 30366-30374 (1996).