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Volumn 7, Issue 5, 2001, Pages 293-300

The small GTPase rac suppresses apoptosis caused by serum deprivation in fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

ANTISERUM; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PHOSPHATIDYLINOSITOL 3 KINASE; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

EID: 0035346409     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03402212     Document Type: Article
Times cited : (28)

References (54)
  • 1
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 2
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • Van Aelst L, D'Souza-Schorey C. (1997) Rho GTPases and signaling networks. Genes Dev. 11: 2295-2322.
    • (1997) Genes Dev. , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 3
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski MS, McCormick F. (1993) Proteins regulating Ras and its relatives. Nature 366: 643-654.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 4
    • 0029968827 scopus 로고    scopus 로고
    • Rho family GTPases: The cytoskeleton and beyond
    • Symons M. (1996) Rho family GTPases: the cytoskeleton and beyond. Trends. Biochem. Sci. 21: 178-181.
    • (1996) Trends. Biochem. Sci. , vol.21 , pp. 178-181
    • Symons, M.1
  • 5
    • 0032541613 scopus 로고    scopus 로고
    • Rho family proteins and Ras transformation: The RHOad less traveled gets congested
    • Zohn IM, Campbell SL, Khosravi-Far R, Rossman KL, Der CJ. (1998) Rho family proteins and Ras transformation: the RHOad less traveled gets congested. Oncogene 17: 1415-1438.
    • (1998) Oncogene , vol.17 , pp. 1415-1438
    • Zohn, I.M.1    Campbell, S.L.2    Khosravi-Far, R.3    Rossman, K.L.4    Der, C.J.5
  • 6
    • 0033551698 scopus 로고    scopus 로고
    • Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation
    • Lin R, Cerione RA, Manor D. (1999) Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J Biol. Chem. 274: 23633-23641.
    • (1999) J Biol. Chem. , vol.274 , pp. 23633-23641
    • Lin, R.1    Cerione, R.A.2    Manor, D.3
  • 7
    • 0031456065 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
    • Shaw LM, Rabinovitz I, Wang HH, Toker A, Mercurio AM. (1997) Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion. Cell 91: 949-960.
    • (1997) Cell , vol.91 , pp. 949-960
    • Shaw, L.M.1    Rabinovitz, I.2    Wang, H.H.3    Toker, A.4    Mercurio, A.M.5
  • 8
    • 0031459917 scopus 로고    scopus 로고
    • Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
    • Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. (1997) Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390: 632-636.
    • (1997) Nature , vol.390 , pp. 632-636
    • Keely, P.J.1    Westwick, J.K.2    Whitehead, I.P.3    Der, C.J.4    Parise, L.V.5
  • 9
    • 0032935495 scopus 로고    scopus 로고
    • An essential part for Rho-associated kinase in the transcellular invasion of tumor cells
    • Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T, Narumiya S. (1999) An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat. Med. 5: 221-225.
    • (1999) Nat. Med. , vol.5 , pp. 221-225
    • Itoh, K.1    Yoshioka, K.2    Akedo, H.3    Uehata, M.4    Ishizaki, T.5    Narumiya, S.6
  • 10
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • Qiu RG, Chen J, Kirn D, McCormick F, Symons M. (1995) An essential role for Rac in Ras transformation. Nature 374: 457-459.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 12
    • 0028800305 scopus 로고
    • Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
    • Khosravi-Far R, Solski PA, Clark GJ, Kinch MS, Der CJ. (1995) Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell Biol. 15: 6443-6453.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 6443-6453
    • Khosravi-Far, R.1    Solski, P.A.2    Clark, G.J.3    Kinch, M.S.4    Der, C.J.5
  • 13
    • 0030911052 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
    • Rodriguez-Viciana P, Warne PH, Khwaja A, et al. (1997) Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras. Cell 89: 457-467.
    • (1997) Cell , vol.89 , pp. 457-467
    • Rodriguez-Viciana, P.1    Warne, P.H.2    Khwaja, A.3
  • 14
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • Joneson T, White MA, Wigler MH, Bar-Sagi D. (1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271: 810-812.
    • (1996) Science , vol.271 , pp. 810-812
    • Joneson, T.1    White, M.A.2    Wigler, M.H.3    Bar-Sagi, D.4
  • 17
    • 0034677549 scopus 로고    scopus 로고
    • NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis
    • Jo H, Zhang R, Zhang H, et al. (2000) NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis. Oncogene 19: 841-849.
    • (2000) Oncogene , vol.19 , pp. 841-849
    • Jo, H.1    Zhang, R.2    Zhang, H.3
  • 18
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. (2000) The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 19
    • 0029278739 scopus 로고
    • PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
    • Hawkins PT, Eguinoa A, Qiu RG, et al. (1995) PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol. 5: 393-403.
    • (1995) Curr Biol. , vol.5 , pp. 393-403
    • Hawkins, P.T.1    Eguinoa, A.2    Qiu, R.G.3
  • 20
    • 0030293886 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
    • Reif K, Nobes CD, Thomas G, Hall A, Cantrell DA. (1996) Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6: 1445-1455.
    • (1996) Curr. Biol. , vol.6 , pp. 1445-1455
    • Reif, K.1    Nobes, C.D.2    Thomas, G.3    Hall, A.4    Cantrell, D.A.5
  • 21
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT. (1996) Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell Biol. 16: 4117-4127.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.A.5    Williams, L.T.6
  • 22
    • 0030772153 scopus 로고    scopus 로고
    • Enhanced apoptosis in the thymus of transgenic mice expressing constitu- Lively activated forms of human Rac2GTPase
    • Lores P, Morin L, Luna R, Gacon G. (1997) Enhanced apoptosis in the thymus of transgenic mice expressing constitu- lively activated forms of human Rac2GTPase. Oncogene 15: 601-605.
    • (1997) Oncogene , vol.15 , pp. 601-605
    • Lores, P.1    Morin, L.2    Luna, R.3    Gacon, G.4
  • 23
    • 0033561622 scopus 로고    scopus 로고
    • Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells
    • Kawazoe N, Watabe M, Masuda Y, Nakajo S, Nakaya K. (1999) Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Oncogene 18: 2413-2421.
    • (1999) Oncogene , vol.18 , pp. 2413-2421
    • Kawazoe, N.1    Watabe, M.2    Masuda, Y.3    Nakajo, S.4    Nakaya, K.5
  • 24
    • 0034737484 scopus 로고    scopus 로고
    • Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas
    • Subauste MC, Von Herrath M, Benard V, et al. (2000) Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J. Biol Chem. 275: 9725-9733.
    • (2000) J. Biol Chem. , vol.275 , pp. 9725-9733
    • Subauste, M.C.1    Von Herrath, M.2    Benard, V.3
  • 25
    • 0033552910 scopus 로고    scopus 로고
    • Anti-apoptotic function of Rac in hematopoietic cells
    • Nishida K, Kaziro Y, Satoh T. (1999) Anti-apoptotic function of Rac in hematopoietic cells. Oncogene 18: 407-415.
    • (1999) Oncogene , vol.18 , pp. 407-415
    • Nishida, K.1    Kaziro, Y.2    Satoh, T.3
  • 26
    • 0032497699 scopus 로고    scopus 로고
    • Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway
    • Esteve P, Embade N, Perona R, et al. (1998) Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway. Oncogene 17: 1855-1869.
    • (1998) Oncogene , vol.17 , pp. 1855-1869
    • Esteve, P.1    Embade, N.2    Perona, R.3
  • 27
    • 0033215188 scopus 로고    scopus 로고
    • Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain
    • Boehm JE, Chaika OV, Lewis RE. (1999) Rac-dependent anti-apoptotic signaling by the insulin receptor cytoplasmic domain. J. Biol. Chem . 274: 28632-28636.
    • (1999) J. Biol. Chem . , vol.274 , pp. 28632-28636
    • Boehm, J.E.1    Chaika, O.V.2    Lewis, R.E.3
  • 28
    • 0032803236 scopus 로고    scopus 로고
    • Suppression of Ras-induced apoptosis by the Rac GTPase
    • Joneson T, Bar-Sagi D. (1999) Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell Biol. 19: 5892-5901.
    • (1999) Mol. Cell Biol. , vol.19 , pp. 5892-5901
    • Joneson, T.1    Bar-Sagi, D.2
  • 29
    • 0028263811 scopus 로고
    • C-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington EA, Bennett MR, Fanidi A, Evan GI. (1994) c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13: 3286-3295.
    • (1994) EMBO J. , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 30
    • 0025775062 scopus 로고
    • Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
    • Monks A, Scudiero D, Skehan P, et al. (1991) Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J. Natl. Cancer Inst. 83: 757-766.
    • (1991) J. Natl. Cancer Inst. , vol.83 , pp. 757-766
    • Monks, A.1    Scudiero, D.2    Skehan, P.3
  • 31
    • 0029861463 scopus 로고    scopus 로고
    • The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase
    • Beltman J, McCormick F, Cook SJ. (1996) The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. J. Biol. Chem. 271: 27018-27024.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27018-27024
    • Beltman, J.1    McCormick, F.2    Cook, S.J.3
  • 32
    • 0028168798 scopus 로고
    • Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression
    • Schindler U, Baichwal VR. (1994) Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression. Mol. Cell Biol. 14: 5820-5831.
    • (1994) Mol. Cell Biol. , vol.14 , pp. 5820-5831
    • Schindler, U.1    Baichwal, V.R.2
  • 33
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden A, Lin A, Claret FX, Abo A, Karin M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs, Cell 81: 1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 34
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • Coso OA, Chiariello M, Yu JC, et al. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.C.3
  • 35
    • 0029101360 scopus 로고
    • An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1
    • Olson MF, Ashwonh A, Hall A. (1995) An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269: 1270-1272.
    • (1995) Science , vol.269 , pp. 1270-1272
    • Olson, M.F.1    Ashwonh, A.2    Hall, A.3
  • 36
    • 0030703604 scopus 로고    scopus 로고
    • Regulation and function of the JNK subgroup of MAP kinases
    • Minden A, Karin M. (1997) Regulation and function of the JNK subgroup of MAP kinases. Biochim. Biophys. Acta 1333: F85-F104.
    • (1997) Biochim. Biophys. Acta , vol.1333
    • Minden, A.1    Karin, M.2
  • 38
    • 0034719680 scopus 로고    scopus 로고
    • The transcription factor NF-κB: Control of oncogenesis and cancer therapy resistance
    • Mayo MW, Baldwin AS. (2000) The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance. Biochim. Biophys. Acta 1470: M55-M62.
    • (2000) Biochim. Biophys. Acta , vol.1470
    • Mayo, M.W.1    Baldwin, A.S.2
  • 39
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Re1/NF-κB transcription factors
    • Barkett M, Gilmore TD. (1999) Control of apoptosis by Re1/NF-κB transcription factors. Oncogene 18: 6910-6924
    • (1999) Oncogene , vol.18 , pp. 6910-6924
    • Barkett, M.1    Gilmore, T.D.2
  • 40
    • 0031806711 scopus 로고    scopus 로고
    • Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes
    • D'Souza-Schorey C, Boettner B, Van Aelst L. (1998) Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes. Mol. Cell Biol. 18: 3936-3946.
    • (1998) Mol. Cell Biol. , vol.18 , pp. 3936-3946
    • D'Souza-Schorey, C.1    Boettner, B.2    Van Aelst, L.3
  • 41
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-mor pholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos CJ, Matter WF, Hui KY, Brown RF. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-mor pholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269: 5241-5248
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 42
    • 0031239882 scopus 로고    scopus 로고
    • The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells
    • Roux P, Gauthier-Rouviere C, Doucet-Brutin S, Fort P. (1997) The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells. Curr. Biol. 7: 629-637.
    • (1997) Curr. Biol. , vol.7 , pp. 629-637
    • Roux, P.1    Gauthier-Rouviere, C.2    Doucet-Brutin, S.3    Fort, P.4
  • 45
    • 0031936353 scopus 로고    scopus 로고
    • Ras signalling and apoptosis
    • Downward J. (1998) Ras signalling and apoptosis. Curr. Opin. Genet. Dev. 8: 49-54.
    • (1998) Curr. Opin. Genet. Dev. , vol.8 , pp. 49-54
    • Downward, J.1
  • 46
    • 0030803278 scopus 로고    scopus 로고
    • Fas- Or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
    • Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Lang F, Gulbins E. (1997) Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J. Biol. Chem. 272: 22173-22181.
    • (1997) J. Biol. Chem. , vol.272 , pp. 22173-22181
    • Brenner, B.1    Koppenhoefer, U.2    Weinstock, C.3    Linderkamp, O.4    Lang, F.5    Gulbins, E.6
  • 47
    • 0032584083 scopus 로고    scopus 로고
    • The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death
    • Bazenet CE, Mota MA, Rubin LL. (1998) The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc. Natl. Acad. Sci. U.S.A. 95: 3984-3989.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3984-3989
    • Bazenet, C.E.1    Mota, M.A.2    Rubin, L.L.3
  • 48
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. (1999) Cellular survival: a play in three Akts. Genes Dev. 13: 2905-2927.
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 49
    • 0029999656 scopus 로고    scopus 로고
    • Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis
    • Grimm S, Bauer MK, Baeuerle PA, Schulze-Osthoff K. (1996) Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J. Cell Biol. 134: 13-23.
    • (1996) J. Cell Biol. , vol.134 , pp. 13-23
    • Grimm, S.1    Bauer, M.K.2    Baeuerle, P.A.3    Schulze-Osthoff, K.4
  • 50
    • 0027688564 scopus 로고
    • Nuclear factor kappa B binding activity in mouse L1210 cells following photofrin II-mediated photosensitization
    • Ryter SW, Gomer CJ. (1993) Nuclear factor kappa B binding activity in mouse L1210 cells following photofrin II-mediated photosensitization. Photochem. Photobiol. 58: 753-756.
    • (1993) Photochem. Photobiol. , vol.58 , pp. 753-756
    • Ryter, S.W.1    Gomer, C.J.2
  • 52
    • 0000154443 scopus 로고    scopus 로고
    • Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. 3
    • Johnson NL, Gardner AM, Diener KM, et al. (1996) Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. 3. Biol. Chem. 271: 3229-3237.
    • (1996) Biol. Chem. , vol.271 , pp. 3229-3237
    • Johnson, N.L.1    Gardner, A.M.2    Diener, K.M.3
  • 53
    • 0347537940 scopus 로고    scopus 로고
    • Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
    • Verheij M, Bose R, Lin XH, et al. (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380: 75-79.
    • (1996) Nature , vol.380 , pp. 75-79
    • Verheij, M.1    Bose, R.2    Lin, X.H.3
  • 54


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