A missense mutation in myosin VIIA prevents aminoglycoside accumulation in early postnatal cochlear hair cells

Annals of the New York Academy of Sciences

Volumn 884, Issue , 1999, Pages 110-124

  Richardson, G P ^a   Forge, A ^b   Kros, C J ^c   Marcotti, W ^a,c   Becker, D ^d   Williams, D S ^e   Thorpe, J ^a   Fleming, J ^f   Brown, S D M ^g   Steel, K P ^f  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f MRC INSTITUTE OF HEARING RESEARCH   (United Kingdom)

^g MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; GENTAMICIN; MYOSIN;

ANIMAL CELL; CELL CULTURE; CELL STRUCTURE; COCHLEA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACCUMULATION; GENETIC TRANSDUCTION; HAIR CELL; HETEROZYGOTE; HOMOZYGOTE; MISSENSE MUTATION; MOUSE; NEWBORN; NONHUMAN;

EID: 0032806387     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (42)

1. 1. Hawkins, J. E., Jr. 1976. Drug ototoxicity. In Handbook of Sensory Physiology, Vol. 5, S.D. Keidel and W.D. Neff, Eds.: 707-748. Springer-Verlag. New York.
2. 2. Kaloyanides, G. J. & E. Pastoriza-Munoz. 1980. Aminoglycoside nephrotoxicity. Kidney Int. 18: 571-582.
3. 3. Cojecel, C. & J. B. Hook. 1983. Aminoglycoside nephrotoxicity. Trends Pharm. Sci. 4: 174-179.
4. 4. Hiel, H., A. Schamel, J.-P. Erre, T. Hayashida, D. Dulon, & J.-M. Aran. 1992. Cellular and subcellular localisation of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid. Hear. Res. 57: 157-165.
5. 5. Silverblatt, F. J. & C. Kuehn. 1979. Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney Int. 15: 335-345.
6. 6. Silverblatt, F. J. 1982. Autoradiographic studies of intracellular aminoglycoside disposition in the kidney. In The Aminoglycosides. Microbiology, Clinical Use, and Toxicology, A. Whelton and H.C. Neu, Eds.: 223-233. Dekker. New York.
7. 7. Hasson, T., M. B. Heinzelman, J. Santos-Sacchi, D. P. Corey & M. S. Mooseker. 1995. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type IB. Proc. Natl. Acad. Sci. U.S.A. 92: 9815-9819.
8. 8. Hasson, T., J. Walsh, J. Cable, M. S. Mooseker, S. D. M. Brown & K. P. Steel. 1997. Effects of shaker-1 mutations on myosin VIIa protein and mRNA expression. Cell Motil. Cytoskeleton 37: 127-138.
9. 9. Hasson, T., P. G. Gillespie, J. A. Garcia, R. B. MacDonald, Y. Zhao, A. G. Yee, M. S. Mooseker & D. P. Corey. 1997. Unconventional myosins in inner-ear sensory epithelia. J. Cell Biol. 137: 1287-1307.
10. 10. El-Amraoui, A., I. Sahly, S. Picaud, J. Sahel, M. Abitol & C. Petit. 1996. Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells. Hum. Mol. Genet. 5: 1171-1178.
11. 11. Wolfrum, U., X. Liu, A. Schmitt, I. P. Udovinchenko & D. S. Williams. 1998. Myosin VIIa as a common component of cilia and micovilli. Cell Motil. Cytoskeleton 40: 261-271.
12. 12. Gibson, F., J. Walsh, P. Mburu, A. Varela, K. A. Brown, M. Antonio, K. W. Beisel, K. P. Steel & S. D. M. Brown. 1995. A type VII myosin encoded by the mouse deafness gene shaker-1. Nature (Lond.) 374: 62-64.
13. 13. Self, T., M. Mahony, J. Fleming, J. Walsh, S. D. M. Brown & K. P. Steel. 1998. Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells. Development 125: 557-566.
14. 14. Chen, Z.-Y., T. Hasson, P. M. Kelley, B. J. Schwender, M. F. Schwartz, M. Ramakrishnan, W. J. Kimberling, M. S. Mooseker & D. P. Corey. 1996. Molecular cloning and domain structure of human myosin-VIIA, the gene product defective in Usher syndrome 1B. Genomics 36: 440-448.
15. 15. Weil, D., G. Levy, I. Sahly, F. Levi-Acobas, S. Blanchard, A. El-Amroui, F. Crozet, H. Philippe, M. Abitbol & C. Petit. 1996. Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia. Proc. Natl. Acad. Sci. U.S.A. 93: 3232-3237.
16. 16. Mburu, P., X. Liu, J. Walsh, D. Saw, Jr., M. J. T. V. Cope, F. Gibson, J. Kendrick-Jones, K. P. Steel & S. D. M. Brown. 1977. Mutation analysis of the mouse myosin VIIa deafness gene. Genes & Funct. 1: 191-203.
17. 17. Richardson, G. P., A. Forge, C. J. Kros, J. Fleming, S. D. M. Brown & K. P. Steel. 1997. Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells. J. Neurosci. 17: 9506-9519.
18. 18. Kros, C. J., A. Rüsch & G. P. Richardson. 1992. Mechano-electrical transducer currents in hair cells of the cultured neonatal mouse cochlea. Proc. Roy. Soc. Lond. B 249: 185-193.
19. 19. Géléoc, G. S. G., G. W. T. Lennan, G. P. Richardson & C. J. Kros. 1997. A quantitative comparison of mechanoelectrical transduction in vestibular and auditory hair cells of neonatal mice. Proc. Roy. Soc. Lond. B 264: 611-621.
20. 20. Rüsch, A., C. J. Kros, G. P. Richardson & I. J. Russell. 1991. Potassium and calcium currents in outer hair cells in organotypic cultures of the neonatal mouse cochlea. J. Physiol. 434: 52P.
21. 21. Kros, C. J., A. Rüsch, G. P. Richardson & I. J. Russell. 1993. Sodium and calcium currents in cultured cochlear hair cells of neonatal mice. J. Physiol. 473: 231P.
22. 22. Forge, A. & G. Richardson. 1993. Freeze fracture analysis of apical membranes in cochlear cultures: differences between basal and apical-coil outer hair cells and effects of neomycin. J. Neurocytol. 22: 854-867.
23. 23. Liu, X., G. Vansant, I. P. Udovinchenko, E. Wolfrum & D. S. Williams. 1997. Myosin VIIA, the product of the Usher 1B syndrome gene is concentrated in the connecting cilium of photoreceptor cells. Cell Motil. Cytoskeleton 37: 240-252.
24. 24. Hashino, E. & M. Shero. 1995. Endocytosis of aminoglycoside antibiotics in sensory hair cells. Brain Res. 704: 135-140.
25. 25. Mooseker, M. S. & R. E. Cheney. 1995. Unconventional myosins. Annu. Rev. Cell Dev. Biol. 11: 633-675.
26. 26. Titus, M. A. 1997. Unconventional myosins: new frontiers in actin-based motors. Trends Cell Biol. 7: 119-123.
27. 27. Novak, K. D., M. D. Peterson, M. C. Reedy & M. A. Titus. 1995. Dictyostelium myosin I double mutants exhibit conditional defects in pinocytosis. J. Cell Biol. 131: 1205-1221.
28. 28. Durrbach, A., K. Collins, P. Matsudaira, D. Louvard & E. Coudrier. 1996. Brush border myosin-I truncated in the motor domain impairs the distribution and function of endocytotic compartments in a hepatoma cell line. Proc. Natl. Acad. Sci. U.S.A. 93: 7053-7058.
29. 29. Geli, M. I. & H. Reizman. 1996. Role of type I myosins in receptor-mediated endocytosis in yeast. Science 272: 533-535.
30. 30. Jung, G., X. Wu & J. A. Hammer III. 1996. Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions. J. Cell Biol. 133: 305-323.
31. 31. DeGroot, J. C. M. J., F. Meeuwesen, W. E. Ruizendaai. & J. E. Veldman. 1990. Ultra-structural localisation of gentamicin in the cochlea. Hear. Res. 50: 35-42.
32. 32. Williams, S. E., D. E. Smith & J. Schacht. 1987. Characteristics of gentamicin uptake in the crista ampullaris of the inner ear of the guinea pig. Biochem. Pharmacol. 36: 89-95
33. 33. Richardson, G. P. & I. J. Russell. 1991. Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity. Hear. Res. 53: 293-311.
34. 34. Santi, P. A. & C. B. Anderson. 1986. Alcian blue staining of cochlea hair cell stereocilia and other cochlear tissues. Hear. Res. 23: 153-160.
35. 35. Santi, P. A. & C. B. Anderson. 1987. A newly identified surface coat on cochlear hair cells. Hear. Res. 27: 47-65.
36. 36. Slepecky, N. & S. C. Chamberlain. 1985. The cell coat of inner ear sensory and supporting cells as demonstrated by ruthenium red. Hear. Res. 17: 281-288.
37. 37. Prieto, J. J. & J. A. Merchan. 1987. Regional specialisation of the cell coat in the hair cells of the organ of Corti. Hear. Res. 31: 223-228.
38. 38. Goodyear, R. & G. Richardson. 1992. Distribution of the 275 kD hair cell antigen and cell surface specialisations on auditory and vestibular hair bundles in the chicken inner ear. J. Comp. Neurol. 325: 243-256.
39. 39. Bosher, S. K. & R. L. Warren. 1978. Very low calcium content of cochlear endolymph, an extracellular fluid. Nature 273: 377-379.
40. 40. Sterkers, O., E. Ferrary & C. Amiel. 1988. Production of inner ear fluids. Physiol. Rev. 68: 1083-1128.
41. 41. Moestrup, S. K., S. Cui, H. Vorum, C. Bregengard, S. E. Bjorn, K. Norris, J. Gliemann & E. U. Christensen. 1995. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J. Clin. Invest. 96: 1404-1413.
42. 42. Ylikoski, J., U. Pirvola, S. Zhai, U. Eriksson, M. L. Solin & A. Miettinen. 1997. Aminoglycoside ototoxicity: high affinity receptors are expressed in secretory epithelia. Audiol. Neurosci. 3: 415-424.