Synthesis and antibacterial activity of ketolides (6-O-methyl-3- oxoerythromycin derivatives): A new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens

Journal of Medicinal Chemistry

Volumn 41, Issue 21, 1998, Pages 4080-4100

  Agouridas, Constantin ^b   Denis, Alexis ^a   Auger, Jean Michel ^a   Benedetti, Yannick ^a   Bonnefoy, Alain ^c   Bretin, François ^a   Chantot, Jean François ^c   Dussarat, Arlette ^a   Fromentin, Claude ^a   D'Ambrières, Solange Gouin ^a   Lachaud, Sylvette ^a   Laurin, Patrick ^a   Martret, Odile Le ^a   Loyau, Véronique ^a   Tessot, Nicole ^a  

^a Medicinal Chemistry   (France)

^b NONE   (France)

^c Hoechst Marion Roussel   (France)

Author keywords

[No Author keywords available]

Indexed keywords

11,12 DIDEOXY 3 DESCLADINOSYL 6 O METHYL 3 OXO 12,11 (OXYCARBONYL(2 (3 (4 QUINOLINYL)PROPYL)HYDRAZONO))ERYTHROMYCIN; 3 O DESCLADINOSYL 6 O METHYL 3 OXOERYTHROMYCIN 9 O (3 PIPERIDINYL)OXIME; 6 O METHYL 3 OXOERYTHROMYCIN DERIVATIVE; A 66321; ANTIBIOTIC AGENT; AZITHROMYCIN; CLARITHROMYCIN; ERYTHROMYCIN; ERYTHROMYCIN DERIVATIVE; HMR 3004; MACROLIDE; NARBOMYCIN; PIKROMYCIN; ROXITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL INFECTION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; MYCOPLASMA; NONHUMAN; RESPIRATORY TRACT INFECTION; STREPTOCOCCUS GROUP A;

ANIMALS; ANTI-BACTERIAL AGENTS; COLONY COUNT, MICROBIAL; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; ENTEROCOCCUS; ERYTHROMYCIN; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; KETOLIDES; MACROLIDES; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RESPIRATORY TRACT INFECTIONS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 15644366975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980240d     Document Type: Article

References (103)

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