Studies of the novel ketolide ABT-773: Transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 6, 2000, Pages 1562-1567

  Capobianco, John O ^a   Cao, Zhensheng ^a   Shortridge, Virginia D ^a   Ma, Zhenkun ^a   Flamm, Robert K ^a   Zhong, Ping ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETHROMYCIN; ERYTHROMYCIN; KETOLIDE; MACROLIDE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; DRUG BINDING; DRUG MECHANISM; DRUG UPTAKE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; DRUG RESISTANCE, MICROBIAL; ERYTHROMYCIN; KETOLIDES; RIBOSOMES; STREPTOCOCCUS PNEUMONIAE;

EID: 0034075717     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.6.1562-1567.2000     Document Type: Article

References (20)

1. Brueggemann, A. B., G. V. Doern, H. K. Huynh, E. M. Wingert, and P. R. Rhomberg, 2000. In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneunwniae, Haemophilus inftuenzae, and Moraxella catarrhalis. Antimicrob. Agents Chemother. 44:447-449.
2. Capobianco, J. O., and R. C. Goldman. 1990. Erythromycin and azithromycin transport into Haemophilus influenzae ATCC 19418 under conditions of depressed proton motive force (ΔμH), Antimicrob. Agents Chemother. 34: 1787-1791.
3. Capobianco, J. O., and R. C. Goldman. 1996. A concurrent study of macrolide transport, binding to ribosomes and inhibition of protein synthesis in Haemophilus influenzae, p. 95-102. In S. G. Pandalai and A. Gayathri (ed.), Recent research developments in antimicrobial agents and chemotherapy 1. Research Signpost, Trivandrum, India.
4. I4C)erythromycin uptake into Staphylococcus aureus - relation to antimicrobial activity. Zentbl. Bakteriol. Hyg. A 265:393-403.
5. Goldman, R. C., and S. K. Kadam. 1989. Binding of novel macrolide structures to macrolides-lincosamides-streptogramin B-resistant ribosomes inhibits protein synthesis and bacterial growth. Animicrob. Agents Chemother. 33:1058-1066.
6. Goldman, R. C., S. W. Fesik, and C. C. Doran. 1990. Role of the protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria. Antimicrob. Agents Chemother. 34:425-431.
7. Johnson, J. D., W. L. Hand, J. B. Francis, N. King-Thompson, and R. W. Corwin. 1980. Antibiotic uptake by alveolar macrophages. J. Lab. Clin. Med. 95:429-439.
8. Johnston, N. J., J. C. de Azavedo, J. D. Kellner, and D. E. Low. 1998. Prevalence and characterization of the mechanisms of macrolide, lincosamide, and streptogramin resistance in isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 42:2425-2426.
9. Mao, J. C. H., and M. Putterman. 1968. Accumulation in gram-positive and gram-negative bacteria as a mechanism of resistance to erythromycin. J. Bacteriol. 95:1111-1117.
10. Miller, J. H. 1972. Experiments in molecular genetics, p. 433. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
11. National Committee for Clinical Laboratory Standards. 1998. Performance standards for antimicrobial susceptibility testing. Supplemental tables: M100-S8. National Committee for Clinical Laboratory Standards, Wayne, Pa.
12. Or, Y., Z. Ma, and R. Clark. 1999. 6-0-Substituted ketolides having antibacterial activity. U.S. patent 5,866,549.
13. Paulsen, I. T., M. H. Brown, and R. A. Skurray. 1996. Proton-dependent multidrug efflux systems. Microbiol. Rev. 60:575-608.
14. Shortridge, V. D., G. V. Doern, A. B. Brueggemann, J. M. Beyer, and R. K. Flamm. 1999. Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995. Clin. Infect. Dis. 29: 1186-1188.
15. Shortridge, V. D., R. K. Flamm, N. Ramer, J. Beyer, and S. K. Tanaka. 1996. Novel mechanism of macrolide resistance in Streptococcus pneumoniae. Diagn. Microbiol. Infect. Dis. 26:73-78.
16. Sutclifft, J., A. Tait-Kamradt, and L. Wondrack. 1996. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob. Agents Chemother. 40:1817-1824.
17. Tait-Kamradt, A., J, Clancy, M. Cronan, F. Dib-Hajj, L. Wondrack, W. Yuan, and J. Sutcliffe. 1997. mefE is necessary for the erythromycin-resistant M phenotype in Streptococcus pneumuniae. Antimicrob. Agents Chemother. 41:2251-2255.
18. Weisblum, B. 1995. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39:577-585.
19. Williams, L. T. 1978. Theory of ligand-receptor interactions, p. 27-41. In L. T. Williams and R. J. Lefkowitz (ed.). Receptor binding studies in adrenergic pharmacology. Raven Press, New York, N.Y.
20. Zhong, P., Z. Cao, R. Hammond, Y. Chen, J. Beyer, V. D. Shortridge, L. Y. Phan, S. Pratt, J. Capobianco, K. A. Reich, R. K. Flamm, Y.-S. Or, and L. Katz. 1999. Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides. Microb. Drug Res. 5:183-188.