Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action

Journal of Bacteriology

Volumn 182, Issue 19, 2000, Pages 5325-5331

  Xiong, L ^a   Kloss, P ^a   Douthwaite, S ^a   Andersen, N M ^a   Swaney, S ^a   Shinabarger, D L ^a   Mankin, A S ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXAZOLIDINONE DERIVATIVE; RIBOSOME RNA;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM MUTANT; BINDING SITE; CELL FREE SYSTEM; ESCHERICHIA COLI; GENE TARGETING; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SYNTHESIS INHIBITION; RIBOSOME SUBUNIT; RNA TRANSLATION; SITE DIRECTED MUTAGENESIS;

ACETAMIDES; AMINO ACID SUBSTITUTION; ANTIBIOTICS; BASE SEQUENCE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; GENES, BACTERIAL; GENETIC ENGINEERING; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS; NUCLEIC ACID CONFORMATION; OXAZOLIDINONES; PEPTIDYLTRANSFERASE; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0033797686     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.19.5325-5331.2000     Document Type: Article

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