Ribosome-catalyzed peptide-bond formation with an A-site substrate covalently linked to 23S ribosomal RNA

Science

Volumn 280, Issue 5361, 1998, Pages 286-289

  Green, Rachel ^a,b   Switzer, Christopher ^c   Noller, Harry F ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDYLTRANSFERASE; RIBOSOME RNA; RNA 23S; TRANSFER RNA;

ARTICLE; CATALYSIS; CROSS LINKING; ENZYME SUBSTRATE; ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS; NONHUMAN; PRIORITY JOURNAL; RNA STRUCTURE;

ANTI-BACTERIAL AGENTS; BINDING SITES; CATALYSIS; ENZYME INHIBITORS; ESCHERICHIA COLI; NUCLEIC ACID CONFORMATION; PEPTIDYL TRANSFERASES; PUROMYCIN; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; RNA, TRANSFER, AMINO ACYL; RNA, TRANSFER, PHE;

ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS;

EID: 0032502997     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5361.286     Document Type: Article

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43. We thank B. Cormack, G. Culver, L. Holmberg, K. Fredrick, K. Lieberman, and E. Strauss for helpful comments on the manuscript and S. Joseph and C. Merryman for helpful discussions. Supported by grants from the National Institutes of Health, the National Science Foundation, the Lucille P. Markey Charitable Trust to the Center for Molecular Biology of RNA, and a Burroughs-Wellcome Career Award to R.G.