Conformations in solution and bound to bacterial ribosomes of ketolides, HMR 3647 (telithromycin) and RU 72366: A new class of highly potent antibacterials

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 7, 2000, Pages 1579-1597

  Evrard Todeschi, Nathalie ^a   Gharbi Benarous, Josyane ^a   Gaillet, Christine ^a   Verdier, Laurent ^a   Bertho, Gildas ^a   Lang, Catherine ^b   Parent, Annick ^b   Girault, Jean Pierre ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

KETOLIDE; RU 72366; TELITHROMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; ESCHERICHIA COLI; ISOMERISM; KETOLIDES; LIGANDS; MACROLIDES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RIBOSOMES; SOLVENTS; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 0033948620     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00091-2     Document Type: Article

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