메뉴 건너뛰기




Volumn 2, Issue 12, 2002, Pages 945-956

Regulation of B-cell fate by antigen-receptor signals

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 0036884819     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri955     Document Type: Review
Times cited : (535)

References (154)
  • 1
    • 0025852445 scopus 로고
    • A B-cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ-chain gene
    • Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A B-cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ-chain gene. Nature 350, 423-426 (1991).
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.4
  • 2
    • 0342711256 scopus 로고    scopus 로고
    • In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
    • Lam, K. P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997). This paper shows the requirement for surface B-cell receptor (BCR) for the maintenance of mature B-cell subsets.
    • (1997) Cell , vol.90 , pp. 1073-1083
    • Lam, K.P.1    Kuhn, R.2    Rajewsky, K.3
  • 3
    • 0037143733 scopus 로고    scopus 로고
    • Deletion of immunoglobulin-β in developing B cells leads to cell death
    • Meffre, E. & Nussenzweig, M. C. Deletion of immunoglobulin-β in developing B cells leads to cell death. Proc. Natl Acad. Sci. USA 99, 11334-11339 (2002). This paper proposes a requirement for surface BCR and signalling for immature B-cell survival.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11334-11339
    • Meffre, E.1    Nussenzweig, M.C.2
  • 5
    • 0033010661 scopus 로고    scopus 로고
    • Genetic analysis of B-cell antigen receptor signaling
    • Kurosaki, T. Genetic analysis of B-cell antigen receptor signaling. Annu Rev. Immunol. 17, 555-592 (1999).
    • (1999) Annu Rev. Immunol. , vol.17 , pp. 555-592
    • Kurosaki, T.1
  • 6
    • 0029786988 scopus 로고    scopus 로고
    • Knockouts of Src-family kinases: Stiff bones, wimpy T cells and bad memories
    • Lowell, C. A. & Soriano, P. Knockouts of Src-family kinases: stiff bones, wimpy T cells and bad memories. Genes Dev. 10, 1845-1857 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1845-1857
    • Lowell, C.A.1    Soriano, P.2
  • 7
    • 0033969955 scopus 로고    scopus 로고
    • The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation
    • Texido, G. et al. The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol. Cell. Biol. 20, 1227-1233 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1227-1233
    • Texido, G.1
  • 9
    • 0028180858 scopus 로고
    • 2- mobilization through distinct pathways
    • 2- mobilization through distinct pathways. EMBO J. 13, 1341-1349 (1994).
    • (1994) EMBO J. , vol.13 , pp. 1341-1349
    • Takata, M.1
  • 10
    • 0028889302 scopus 로고
    • Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
    • Turner, M. et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378, 298-302 (1995).
    • (1995) Nature , vol.378 , pp. 298-302
    • Turner, M.1
  • 11
    • 0036631548 scopus 로고    scopus 로고
    • VAV proteins as signal integrators for multi-subunit immune-recognition receptors
    • Turner, M. & Billadeau, D. D. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nature Rev. Immunol. 2, 476-486 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 476-486
    • Turner, M.1    Billadeau, D.D.2
  • 12
    • 0032493028 scopus 로고    scopus 로고
    • Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
    • Holsinger, L. Jr et al. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8, 563-572 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 563-572
    • Holsinger L., Jr.1
  • 13
    • 0028956337 scopus 로고
    • Defective antigen-receptor-mediated proliferation of B and T cells in the absence of Vav
    • Tarakhovsky, A. et al. Defective antigen-receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374, 467-470 (1995).
    • (1995) Nature , vol.374 , pp. 467-470
    • Tarakhovsky, A.1
  • 14
    • 0028915948 scopus 로고
    • Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the Vav protoonccgene
    • Zhang, R., Alt, F. W., Davidson, L., Orkin, S. H. & Swat, W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the Vav protoonccgene. Nature 374, 470-473 (1995).
    • (1995) Nature , vol.374 , pp. 470-473
    • Zhang, R.1    Alt, F.W.2    Davidson, L.3    Orkin, S.H.4    Swat, W.5
  • 15
    • 0035378223 scopus 로고    scopus 로고
    • Signal transduction through Vav-2 participates in humoral immune responses and B-cell maturation
    • Doody, G. M. et al. Signal transduction through Vav-2 participates in humoral immune responses and B-cell maturation. Nature Immunol. 2, 542-547 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 542-547
    • Doody, G.M.1
  • 16
    • 0035374589 scopus 로고    scopus 로고
    • Compensation between Vav-1 and Vav-2 in B-cell development and antigen-receptor signaling
    • Tedford, K. et al. Compensation between Vav-1 and Vav-2 in B-cell development and antigen-receptor signaling. Nature Immunol. 2, 548-555 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 548-555
    • Tedford, K.1
  • 17
    • 0037148505 scopus 로고    scopus 로고
    • Vav3 modulates B-cell receptor responses by regulating phosphoinositide 3-kinase activation
    • Inabe, K. et al. Vav3 modulates B-cell receptor responses by regulating phosphoinositide 3-kinase activation. J. Exp Med. 195, 189-200 (2002).
    • (2002) J. Exp Med. , vol.195 , pp. 189-200
    • Inabe, K.1
  • 18
    • 0033812082 scopus 로고    scopus 로고
    • Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cγ pathway
    • Marshall, A. J., Niiro, H., Yun, T. J. & Clark, E. A. Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cγ pathway. Immunol. Rev. 176, 30-46 (2000).
    • (2000) Immunol. Rev. , vol.176 , pp. 30-46
    • Marshall, A.J.1    Niiro, H.2    Yun, T.J.3    Clark, E.A.4
  • 19
    • 0032127159 scopus 로고    scopus 로고
    • BLNK: A central linker protein in B-cell activation
    • Fu, C., Turck, C. W., Kurosaki, T. & Chan, A. C. BLNK: a central linker protein in B-cell activation. Immunity 9, 93-103 (1998).
    • (1998) Immunity , vol.9 , pp. 93-103
    • Fu, C.1    Turck, C.W.2    Kurosaki, T.3    Chan, A.C.4
  • 20
    • 0033214220 scopus 로고    scopus 로고
    • Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - Functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
    • Hashimoto, S. et al. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK - functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 94, 2357-2364 (1999).
    • (1999) Blood , vol.94 , pp. 2357-2364
    • Hashimoto, S.1
  • 21
    • 0033056366 scopus 로고    scopus 로고
    • BLNK required for coupling Syk to PLCγ2 and Racl-JNK in B cells
    • Ishiai, M. et al. BLNK required for coupling Syk to PLCγ2 and Racl-JNK in B cells. Immunity 10, 117-125 (1999).
    • (1999) Immunity , vol.10 , pp. 117-125
    • Ishiai, M.1
  • 22
    • 0033521085 scopus 로고    scopus 로고
    • Requirement for B-cell linker protein (BLNK) in B-cell development
    • Pappu, R. et al. Requirement for B-cell linker protein (BLNK) in B-cell development. Science 286, 1949-1954 (1999).
    • (1999) Science , vol.286 , pp. 1949-1954
    • Pappu, R.1
  • 23
    • 0034090263 scopus 로고    scopus 로고
    • B-cell development and activation defects resulting in Xid-like immunodeficiency in BLNK/SLP-65-deficient mice
    • Xu, S. et al. B-cell development and activation defects resulting in Xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int. Immunol. 12, 397-404 (2000).
    • (2000) Int. Immunol. , vol.12 , pp. 397-404
    • Xu, S.1
  • 24
    • 0034646203 scopus 로고    scopus 로고
    • The B-cell-restricted adaptor BASH is required for normal development and antigen-receptor-mediated activation of B cells
    • Hayashi, K. et al. The B-cell-restricted adaptor BASH is required for normal development and antigen-receptor-mediated activation of B cells. Proc. Natl Acad. Sci. USA 97, 2755-2760 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2755-2760
    • Hayashi, K.1
  • 25
    • 0034663761 scopus 로고    scopus 로고
    • Cutting edge: Essential role of phospholipase Cγ2 in B-cell development and function
    • Hashimoto, A. et al. Cutting edge: essential role of phospholipase Cγ2 in B-cell development and function. J. Immunol. 165, 1738-1742 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1738-1742
    • Hashimoto, A.1
  • 26
    • 0033624638 scopus 로고    scopus 로고
    • Phospholipase Cγ2 is essential in the functions of B-cell and several Fc receptors
    • Wang, D. et al. Phospholipase Cγ2 is essential in the functions of B-cell and several Fc receptors. Immunity 13, 25-35 (2000).
    • (2000) Immunity , vol.13 , pp. 25-35
    • Wang, D.1
  • 27
    • 0034507903 scopus 로고    scopus 로고
    • BCAP the tyrosine kinase substrate that connects B-cell receptor to phosphoinositide 3-kinase activation
    • Okada, T, Maeda, A., Iwamatsu, A., Gotoh, K. & Kurosaki, T. BCAP: the tyrosine kinase substrate that connects B-cell receptor to phosphoinositide 3-kinase activation. Immunity 13, 817-827 (2000).
    • (2000) Immunity , vol.13 , pp. 817-827
    • Okada, T.1    Maeda, A.2    Iwamatsu, A.3    Gotoh, K.4    Kurosaki, T.5
  • 28
    • 0034678458 scopus 로고    scopus 로고
    • A novel B-lymphocyte-associated adaptor protein, Bam32, regulates antigen-receptor signaling downstream of phosphatidylinositol 3-kinase
    • Marshall, A. J. et al. A novel B-lymphocyte-associated adaptor protein, Bam32, regulates antigen-receptor signaling downstream of phosphatidylinositol 3-kinase. J. Exp. Med. 191, 1319-1332 (2000)
    • (2000) J. Exp. Med. , vol.191 , pp. 1319-1332
    • Marshall, A.J.1
  • 29
    • 0037033384 scopus 로고    scopus 로고
    • The B-lymphocyte adaptor molecule of 32 kD (Bam32) regulates B-cell antigen receptor signaling and cell survival
    • Niiro, H., Maeda, A., Kurosaki, T. & Clark, E. A. The B-lymphocyte adaptor molecule of 32 kD (Bam32) regulates B-cell antigen receptor signaling and cell survival. J. Exp. Med. 195, 143-149 (2002). References 28 and 29 show that after BCR ligation, BAM32 is recruited to the plasma membrane through its pleckstrin-homology domain, and that it binds and regulates the activation of PLC-2.
    • (2002) J. Exp. Med. , vol.195 , pp. 143-149
    • Niiro, H.1    Maeda, A.2    Kurosaki, T.3    Clark, E.A.4
  • 30
    • 0035340798 scopus 로고    scopus 로고
    • CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A
    • Shlapatska, L. M. et al. CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A. J. Immunol. 166, 5480-5487 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 5480-5487
    • Shlapatska, L.M.1
  • 31
    • 0142171489 scopus 로고    scopus 로고
    • Expression of the GrpL/Gads adaptor protein in B-cell subsets enhances BCR signaling through MAPK pathways
    • in the press
    • Yankee, T. M., Solow, S. A., Draves, K. E. & Clark, E. A. Expression of the GrpL/Gads adaptor protein in B-cell subsets enhances BCR signaling through MAPK pathways. J. Immunol. (in the press).
    • J. Immunol.
    • Yankee, T.M.1    Solow, S.A.2    Draves, K.E.3    Clark, E.A.4
  • 32
    • 0027169534 scopus 로고
    • CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase
    • Tuveson, D. A., Carter R. H., Soltoff, S. P. & Fearon, D. T. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260, 986-989 (1993).
    • (1993) Science , vol.260 , pp. 986-989
    • Tuveson, D.A.1    Carter, R.H.2    Soltoff, S.P.3    Fearon, D.T.4
  • 33
    • 0030587116 scopus 로고    scopus 로고
    • Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP
    • Chacko, G. W. et al. Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J. Immunol. 157, 2234-2238 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 2234-2238
    • Chacko, G.W.1
  • 34
    • 0028961264 scopus 로고
    • Protein tyrosine phosphatase 1C negatively regulates antigen-receptor signaling in B lymphocytes and determines thresholds for negative selection
    • Cyster, J. G. & Goodnow, C. C. Protein tyrosine phosphatase 1C negatively regulates antigen-receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2, 13-24 (1995).
    • (1995) Immunity , vol.2 , pp. 13-24
    • Cyster, J.G.1    Goodnow, C.C.2
  • 35
    • 0034625416 scopus 로고    scopus 로고
    • CD22 forms a quaternary complex with SHIP Grb2 and Shc. A pathway for regulation of B-lymphocyte antigen receptor-induced calcium flux
    • Poe, J. C., Fujimoto, M., Jansen, P. J., Miller, A. S. & Tedder, T. F. CD22 forms a quaternary complex with SHIP Grb2 and Shc. A pathway for regulation of B-lymphocyte antigen receptor-induced calcium flux. J. Biol. Chem 275, 17420-17427 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 17420-17427
    • Poe, J.C.1    Fujimoto, M.2    Jansen, P.J.3    Miller, A.S.4    Tedder, T.F.5
  • 36
    • 0035941215 scopus 로고    scopus 로고
    • CD22 regulates B-cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1
    • Otipoby, K. L., Draves, K. E. & Clark, E. A. CD22 regulates B-cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1. J. Biol. Chem. 276, 44315-44322 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 44315-44322
    • Otipoby, K.L.1    Draves, K.E.2    Clark, E.A.3
  • 37
    • 0033697266 scopus 로고    scopus 로고
    • Monomeric and oligomeric complexes of the B-cell antigen receptor
    • Schamel, W. W. & Reth, M. Monomeric and oligomeric complexes of the B-cell antigen receptor. Immunity 13, 5-14 (2000).
    • (2000) Immunity , vol.13 , pp. 5-14
    • Schamel, W.W.1    Reth, M.2
  • 38
    • 0036481264 scopus 로고    scopus 로고
    • Lipid rafts and B-cell activation
    • Pierce, S. K. Lipid rafts and B-cell activation. Nature Rev. Immunol. 2, 96-105 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 96-105
    • Pierce, S.K.1
  • 39
    • 0033695960 scopus 로고    scopus 로고
    • Engagement of the human pre-B-cell receptor generates a lipid raft-dependent calcium signaling complex
    • Guo, B., Kato, R. M., Garcia-Lloret, M., Wahl, M. L. & Rawlings, D. J. Engagement of the human pre-B-cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity 13, 243-253 (2000).
    • (2000) Immunity , vol.13 , pp. 243-253
    • Guo, B.1    Kato, R.M.2    Garcia-Lloret, M.3    Wahl, M.L.4    Rawlings, D.J.5
  • 40
    • 0035803539 scopus 로고    scopus 로고
    • Ligand-independent signaling functions for the B-lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis
    • Bannish, G., Fuentes-Panana, E. M., Cambier, J. C., Pear, W. S. & Monroe, J. G. Ligand-independent signaling functions for the B-lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J. Exp. Med. 194, 1583-1596 (2001). This paper shows that the plasma-membrane localization of immunoglobulin-associated protein-α (Igα) and Igβ cytoplasmic domains provides basal signalling that is sufficient for transition from the pro-B-cell to pre-B-cell stage, which indicates a role for antigen-independent BCR in B-cell development.
    • (2001) J. Exp. Med. , vol.194 , pp. 1583-1596
    • Bannish, G.1    Fuentes-Panana, E.M.2    Cambier, J.C.3    Pear, W.S.4    Monroe, J.G.5
  • 41
    • 0032101348 scopus 로고    scopus 로고
    • Membrane compartmentation is required for efficient T-cell activation
    • Xavier, R., Brennan, T., Li, Q., McCormack, C. & Seed, B. Membrane compartmentation is required for efficient T-cell activation. Immunity 8, 723-732 (1998).
    • (1998) Immunity , vol.8 , pp. 723-732
    • Xavier, R.1    Brennan, T.2    Li, Q.3    McCormack, C.4    Seed, B.5
  • 42
    • 0033712984 scopus 로고    scopus 로고
    • Xid-like phenotypes: A B-cell signalosome takes shape
    • Fruman, D. A., Satterthwaite, A. B. & Witte, O. N. Xid-like phenotypes: a B-cell signalosome takes shape. Immunity 13, 1-3 (2000).
    • (2000) Immunity , vol.13 , pp. 1-3
    • Fruman, D.A.1    Satterthwaite, A.B.2    Witte, O.N.3
  • 43
    • 0034914677 scopus 로고    scopus 로고
    • Oligomeric antigen receptors: A new view on signaling for the selection of lymphocytes
    • Reth, M. Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes. Trends Immunol. 22, 356-360 (2001). Together with reference 37, this paper proposes an intriguing model in which in the absence of antigen ligation, oligomeric BCR complexes are formed and transduce basal BCR signalling.
    • (2001) Trends Immunol. , vol.22 , pp. 356-360
    • Reth, M.1
  • 45
    • 0034254193 scopus 로고    scopus 로고
    • Transient translocation of the B-cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: Evidence toward a role in calcium regulation
    • Petrie, R. J., Schnetkamp, P. P., Patel, K. D., Awasthi-Kalia, M. & Deans, J. P. Transient translocation of the B-cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation. J. Immunol. 165, 1220-1227 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1220-1227
    • Petrie, R.J.1    Schnetkamp, P.P.2    Patel, K.D.3    Awasthi-Kalia, M.4    Deans, J.P.5
  • 46
    • 0020075104 scopus 로고
    • Ligand-induced association of surface immunoglobulin with the detergent-insoluble cytoskeletal matrix of the B lymphocyte
    • Braun, J., Hochman, P. S. & Unanue, E. R. Ligand-induced association of surface immunoglobulin with the detergent-insoluble cytoskeletal matrix of the B lymphocyte. J. Immunol. 128, 1198-1204 (1982).
    • (1982) J. Immunol. , vol.128 , pp. 1198-1204
    • Braun, J.1    Hochman, P.S.2    Unanue, E.R.3
  • 47
    • 0026572982 scopus 로고
    • Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes
    • Pure, E. & Tardelli, L. Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes. Proc. Natl Acad. Sci. USA 89.114-117 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 114-117
    • Pure, E.1    Tardelli, L.2
  • 48
    • 0035253720 scopus 로고    scopus 로고
    • Visualization of Syk-antigen-receptor interactions using green fluorescent protein: Differential roles for Syk and Lyn in the regulation of receptor capping and internalization
    • Ma, H. et al. Visualization of Syk-antigen-receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J. Immunol. 166, 1507-1516 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 1507-1516
    • Ma, H.1
  • 49
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B-cell development and proliferation in absence of phosphoinositide 3-kinase p85α
    • Fruman, D. A. et al. Impaired B-cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 283, 393-397 (1999).
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1
  • 50
    • 0034254421 scopus 로고    scopus 로고
    • B-cell antigen receptor-induced activation of Akt promotes B-cell survival and is dependent on Syk kinase
    • Pogue, S. L., Kurosaki, T., Bolen, J. & Herbst, R. B-cell antigen receptor-induced activation of Akt promotes B-cell survival and is dependent on Syk kinase. J. Immunol. 165, 1300-1306 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1300-1306
    • Pogue, S.L.1    Kurosaki, T.2    Bolen, J.3    Herbst, R.4
  • 51
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B- and T-cell antigen receptor signaling in p110δ PI 3-kinase mutant mice
    • Okkenhaug, K. et al. Impaired B- and T-cell antigen receptor signaling in p110δ PI 3-kinase mutant mice. Science 297, 1031-1034 (2002).
    • (2002) Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1
  • 52
    • 0037119630 scopus 로고    scopus 로고
    • A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B-cell development and activation
    • Clayton, E. et al. A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B-cell development and activation. J. Exp. Med. 196, 753-763 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 753-763
    • Clayton, E.1
  • 53
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S. R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1
  • 54
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M. & Hemmings, B. A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789 (1995).
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 55
    • 0032748581 scopus 로고    scopus 로고
    • Syk and Bruton's tyrosine kinase are required for B-cell antigen receptor-mediated activation of the kinase Akt
    • Craxton, A., Jiang, A., Kurosaki, T. & Clark, E. A. Syk and Bruton's tyrosine kinase are required for B-cell antigen receptor-mediated activation of the kinase Akt. J. Biol. Chem. 274, 30644-30650 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 30644-30650
    • Craxton, A.1    Jiang, A.2    Kurosaki, T.3    Clark, E.A.4
  • 56
    • 0033566911 scopus 로고    scopus 로고
    • The B-cell antigen receptor activates the Akt (protein kinase B)/ glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
    • Gold, M. R. et al. The B-cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase. J Immunol. 163, 1894-1905 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 1894-1905
    • Gold, M.R.1
  • 57
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • Sears, R. C. & Nevins, J. R. Signaling networks that link cell proliferation and cell fate. J Biol. Chem. 277, 11617-11620 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 58
    • 0032487507 scopus 로고    scopus 로고
    • Involvement of guanosine triphosphatases and phospholipase C-y2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B-cell antigen receptor
    • Hashimoto, A. et al. Involvement of guanosine triphosphatases and phospholipase C-y2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B-cell antigen receptor. J. Exp. Med. 188, 1287-1295 (1998).
    • (1998) J. Exp. Med. , vol.188 , pp. 1287-1295
    • Hashimoto, A.1
  • 59
    • 0034881019 scopus 로고    scopus 로고
    • Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell-survival signals
    • Ballif, B. A. & Blenis, J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell-survival signals. Cell Growth Differ. 12, 397-408 (2001).
    • (2001) Cell Growth Differ. , vol.12 , pp. 397-408
    • Ballif, B.A.1    Blenis, J.2
  • 60
    • 0035869267 scopus 로고    scopus 로고
    • Inhibition of the MEK/ERK signaling pathway blocks a subset of B-cell responses to antigen
    • Richards, J. D., Dave, S. H., Chou, C. H., Mamchak, A. A. & DeFranco, A. L. Inhibition of the MEK/ERK signaling pathway blocks a subset of B-cell responses to antigen. J. Immunol. 166, 3855-3864 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3855-3864
    • Richards, J.D.1    Dave, S.H.2    Chou, C.H.3    Mamchak, A.A.4    DeFranco, A.L.5
  • 61
    • 0037023741 scopus 로고    scopus 로고
    • Requirement for HSP90 chaperone-dependent MEK1/2-ERK pathway for B-cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes
    • Piatelli, M. J., Doughty, C. & Chiles, T. C. Requirement for HSP90 chaperone-dependent MEK1/2-ERK pathway for B-cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. J. Biol. Chem. 277, 12144-12150 (2002). References 60 and 61 show that the RAF-MEK-ERK pathway has a crucial role in BCR-induced proliferation of mature B cells.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12144-12150
    • Piatelli, M.J.1    Doughty, C.2    Chiles, T.C.3
  • 62
    • 17744378364 scopus 로고    scopus 로고
    • MEK kinase activity is not necessary for Raf-1 function
    • Huser, M. et al. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940-1951 (2001).
    • (2001) EMBO J. , vol.20 , pp. 1940-1951
    • Huser, M.1
  • 63
    • 17744384002 scopus 로고    scopus 로고
    • Embryonic lethality and fetal-liver apoptosis in mice lacking the c-raf-1 gene
    • Mikula, M. et al. Embryonic lethality and fetal-liver apoptosis in mice lacking the c-raf-1 gene. EMBO J. 20, 1952-1962 (2001).
    • (2001) EMBO J. , vol.20 , pp. 1952-1962
    • Mikula, M.1
  • 64
    • 0345498292 scopus 로고    scopus 로고
    • Bcl-2 targets the protein kinase Raf-1 to mitochondria
    • Wang, H. G., Rapp, U. R. & Reed, J. C. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87, 629-638 (1996).
    • (1996) Cell , vol.87 , pp. 629-638
    • Wang, H.G.1    Rapp, U.R.2    Reed, J.C.3
  • 65
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-κB transcription factors
    • Barkett, M. & Gilmore, T. D. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18, 6910-6924 (1999).
    • (1999) Oncogene , vol.18 , pp. 6910-6924
    • Barkett, M.1    Gilmore, T.D.2
  • 66
    • 0035910742 scopus 로고    scopus 로고
    • IκB kinase-α is essential for mature B-cell development and function
    • Kaisho, T. et al. IκB kinase-α is essential for mature B-cell development and function. J. Exp. Med. 193, 417-426 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 417-426
    • Kaisho, T.1
  • 67
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
    • Senftleben, U. et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293, 1495-1499 (2001).
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1
  • 68
    • 0037119628 scopus 로고    scopus 로고
    • IκB kinase signaling is essential for maintenance of mature B cells
    • Pasparakis, M., Schmidt-Supprian, M. & Raiewsky, K. IκB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196, 743-752 (2002). This paper shows that IKK-mediated NF-κB activation is crucial for the maintenance of mature B-cell subsets.
    • (2002) J. Exp. Med. , vol.196 , pp. 743-752
    • Pasparakis, M.1    Schmidt-Supprian, M.2    Raiewsky, K.3
  • 69
    • 0035910580 scopus 로고    scopus 로고
    • Phospholipase C-y2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes
    • Petro, J. B. & Khan, W. N. Phospholipase C-y2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes. J. Biol. Chem. 276, 1715-1719 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 1715-1719
    • Petro, J.B.1    Khan, W.N.2
  • 70
    • 0034657307 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor-κB in response to B-cell receptor engagement
    • Petro, J. B., Rahman, S. M., Ballard, D W & Khan, W. N. Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor-κB in response to B-cell receptor engagement. J Exp. Med 191, 1745-1754 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1745-1754
    • Petro, J.B.1    Rahman, S.M.2    Ballard, D.W.3    Khan, W.N.4
  • 71
    • 0035827623 scopus 로고    scopus 로고
    • The adaptor protein BLNK is required for B-cell antigen receptor-induced activation of nuclear factor-κB and cell-cycle entry and survival of B lymphocytes
    • Tan, J. E., Wong, S. C., Gan, S. K., Xu, S. & Lam, K. P. The adaptor protein BLNK is required for B-cell antigen receptor-induced activation of nuclear factor-κB and cell-cycle entry and survival of B lymphocytes. J. Biol. Chem. 276, 20055-20063 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 20055-20063
    • Tan, J.E.1    Wong, S.C.2    Gan, S.K.3    Xu, S.4    Lam, K.P.5
  • 72
    • 0034651539 scopus 로고    scopus 로고
    • Multiple pathways control protein kinase C phosphorylation
    • Parekh, D. B., Ziegler, W. & Parker, P. J. Multiple pathways control protein kinase C phosphorylation. EMBO J. 19, 496-503 (2000).
    • (2000) EMBO J. , vol.19 , pp. 496-503
    • Parekh, D.B.1    Ziegler, W.2    Parker, P.J.3
  • 73
    • 0034031401 scopus 로고    scopus 로고
    • Protein kinase Cθ participates in NF-κB activation induced by CD3-CD28 costimulation through selective activation of IκB kinase-β
    • Lin, X., O'Mahony, A., Mu, Y., Geleziunas, R. & Greene, W. C. Protein kinase Cθ participates in NF-κB activation induced by CD3-CD28 costimulation through selective activation of IκB kinase-β. Mol. Cell. Biol. 20, 2933-2940 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2933-2940
    • Lin, X.1    O'Mahony, A.2    Mu, Y.3    Geleziunas, R.4    Greene, W.C.5
  • 74
    • 0037171439 scopus 로고    scopus 로고
    • Protein kinase Cδ controls self-antigen-induced B-cell tolerance
    • Mecklenbrauker, I., Saijo, K., Zheng, N. Y., Leitges, M. & Tarakhovsky, A. Protein kinase Cδ controls self-antigen-induced B-cell tolerance. Nature 416, 860-865 (2002).
    • (2002) Nature , vol.416 , pp. 860-865
    • Mecklenbrauker, I.1    Saijo, K.2    Zheng, N.Y.3    Leitges, M.4    Tarakhovsky, A.5
  • 75
    • 0037171731 scopus 로고    scopus 로고
    • Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ
    • Miyamoto, A. et al. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ. Nature 416, 865-869 (2002).
    • (2002) Nature , vol.416 , pp. 865-869
    • Miyamoto, A.1
  • 76
    • 0037124307 scopus 로고    scopus 로고
    • Protein kinase Cβ controls nuclear factor-κB activation in B cells through selective regulation of the IκB kinase-α
    • Saijo, K. et al. Protein kinase Cβ controls nuclear factor-κB activation in B cells through selective regulation of the IκB kinase-α. J. Exp. Med. 195, 1647-1652 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1647-1652
    • Saijo, K.1
  • 77
    • 0036344276 scopus 로고    scopus 로고
    • PKC-β controls IκB kinase lipid-raft recruitment and activation in response to BCR signaling
    • Su, T. T. et al. PKC-β controls IκB kinase lipid-raft recruitment and activation in response to BCR signaling. Nature Immunol. 3, 780-786 (2002). References 76 and 77 show the importance of PKCβ for BCR-induced NF-κB activation, and reference 77 also shows that BTK and PKCβ have distinct roles in the maturation of follicular B cells.
    • (2002) Nature Immunol. , vol.3 , pp. 780-786
    • Su, T.T.1
  • 78
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin, A. S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683 (1996).
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649-683
    • Baldwin A.S., Jr.1
  • 79
    • 0028154853 scopus 로고
    • The subunit composition of NF-κB complexes changes during B-cell development
    • Grumont, R. J. & Gerondakis, S. The subunit composition of NF-κB complexes changes during B-cell development. Cell. Growth Differ. 5, 1321-1331 (1994).
    • (1994) Cell. Growth Differ. , vol.5 , pp. 1321-1331
    • Grumont, R.J.1    Gerondakis, S.2
  • 80
    • 0030267068 scopus 로고    scopus 로고
    • An essential role for Bruton's tyrosine kinase in the regulation of B-cell apoptosis
    • Anderson, J. S., Teutsch, M., Dong, Z. & Wortis, H. H. An essential role for Bruton's tyrosine kinase in the regulation of B-cell apoptosis. Proc. Natl Acad. Sci USA 93, 10966-10971 (1996).
    • (1996) Proc. Natl. Acad. Sci USA , vol.93 , pp. 10966-10971
    • Anderson, J.S.1    Teutsch, M.2    Dong, Z.3    Wortis, H.H.4
  • 81
    • 0032473405 scopus 로고    scopus 로고
    • B lymphocytes differentially use the Rel and nuclear factor-κB1 (NF-κB1) transcription factors to regulate cell-cycle progression and apoptosis in quiescent and mitogen-activated cells
    • Grumont, R. J. et al. B lymphocytes differentially use the Rel and nuclear factor-κB1 (NF-κB1) transcription factors to regulate cell-cycle progression and apoptosis in quiescent and mitogen-activated cells. J. Exp. Med. 187, 663-674 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 663-674
    • Grumont, R.J.1
  • 82
    • 0033557805 scopus 로고    scopus 로고
    • Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
    • Grumont, R. J., Rourke, I. J. & Gerondakis, S. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. 13, 400-411 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 400-411
    • Grumont, R.J.1    Rourke, I.J.2    Gerondakis, S.3
  • 83
    • 0037162528 scopus 로고    scopus 로고
    • 2- homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors
    • 2- homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors. Proc. Natl Acad. Sci. USA 99, 9830-9835 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9830-9835
    • Li, C.1
  • 84
    • 0034744949 scopus 로고    scopus 로고
    • NF-κB and cell-cycle regulation: The cyclin connection
    • Joyce, D. et al. NF-κB and cell-cycle regulation: the cyclin connection. Cytokine Growth Factor Rev. 12, 73-90 (2001).
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 73-90
    • Joyce, D.1
  • 85
    • 0035798691 scopus 로고    scopus 로고
    • Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen receptor
    • Glassford, J. et al. Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen receptor. J. Biol. Chem. 276, 41040-41048 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 41040-41048
    • Glassford, J.1
  • 86
    • 0029156724 scopus 로고
    • Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in lonomycin-induced apoptosis
    • Aagaard-Tillery, K. M. & Jelinek, D. F. Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in lonomycin-induced apoptosis. J. Immunol. 155, 3297-3307 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 3297-3307
    • Aagaard-Tillery, K.M.1    Jelinek, D.F.2
  • 87
    • 0031007450 scopus 로고    scopus 로고
    • Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor
    • Sugawara, H., Kurosaki, M., Takata, M. & Kurosaki, T. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J. 16, 3078-3088 (1997).
    • (1997) EMBO J. , vol.16 , pp. 3078-3088
    • Sugawara, H.1    Kurosaki, M.2    Takata, M.3    Kurosaki, T.4
  • 88
    • 0035808769 scopus 로고    scopus 로고
    • 1 and JNK2 have similar and stage-dependent roles in regulating T-cell apoptosis and proliferation
    • 1 and JNK2 have similar and stage-dependent roles in regulating T-cell apoptosis and proliferation. J. Exp. Med. 193, 317-328 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 317-328
    • Sabapathy, K.1
  • 89
    • 0344563442 scopus 로고    scopus 로고
    • Mitochondria connects the antigen receptor to effector caspases during B-cell receptor-induced apoptosis in normal human B cells
    • Berard, M. et al. Mitochondria connects the antigen receptor to effector caspases during B-cell receptor-induced apoptosis in normal human B cells. J. Immunol. 163, 4655-4662 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 4655-4662
    • Berard, M.1
  • 90
    • 0033989684 scopus 로고    scopus 로고
    • Critical role for mitochondna in B-cell receptor-mediated apoptosis
    • Bouchon, A., Krammer, P. H. & Walczak, H. Critical role for mitochondna in B-cell receptor-mediated apoptosis. Eur. J. Immunol. 30, 69-77 (2000).
    • (2000) Eur. J. Immunol. , vol.30 , pp. 69-77
    • Bouchon, A.1    Krammer, P.H.2    Walczak, H.3
  • 91
    • 0037090159 scopus 로고    scopus 로고
    • Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells
    • Herold, M. J., Kuss, A. W., Kraus, C. & Berberich, I. Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells. J. Immunol. 168, 3902-3909 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3902-3909
    • Herold, M.J.1    Kuss, A.W.2    Kraus, C.3    Berberich, I.4
  • 92
    • 0033103016 scopus 로고    scopus 로고
    • Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
    • Sandel, P. C. & Monroe, J. G. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 10, 289-299 (1999).
    • (1999) Immunity , vol.10 , pp. 289-299
    • Sandel, P.C.1    Monroe, J.G.2
  • 93
    • 0033526816 scopus 로고    scopus 로고
    • B-cell development in the spleen takes place in discrete steps and is determined by the quality of B-cell receptor-derived signals
    • Loder, F. et al. B-cell development in the spleen takes place in discrete steps and is determined by the quality of B-cell receptor-derived signals. J. Exp. Med. 190, 75-89 (1999). The authors characterize T1 and T2 cells in the spleen, and also show that the strength of BCR signalling affects the generation of transitional and follicular B cells.
    • (1999) J. Exp. Med. , vol.190 , pp. 75-89
    • Loder, F.1
  • 94
    • 0029003671 scopus 로고
    • Transitional B cells are the target of negative selection in the B-cell compartment
    • Carsetti, R., Kohler, G. & Lamers, M. C. Transitional B cells are the target of negative selection in the B-cell compartment. J. Exp. Med. 181, 2129-2140 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 2129-2140
    • Carsetti, R.1    Kohler, G.2    Lamers, M.C.3
  • 95
    • 0036498795 scopus 로고    scopus 로고
    • Transitional B-lymphocyte subsets operate as distinct checkpoints in murine splenic B-cell development
    • Su, T. T. & Rawlings, D. J. Transitional B-lymphocyte subsets operate as distinct checkpoints in murine splenic B-cell development. J. Immunol. 168, 2101-2110 (2002). This paper shows that there are distinct profiles of BCR-induced signalling in transitional and follicular B cells.
    • (2002) J. Immunol. , vol.168 , pp. 2101-2110
    • Su, T.T.1    Rawlings, D.J.2
  • 96
    • 0035892228 scopus 로고    scopus 로고
    • Resolution of three nonproliferative immature splenic B-cell subsets reveals multiple selection points during peripheral B-cell maturation
    • Allman, D. et al. Resolution of three nonproliferative immature splenic B-cell subsets reveals multiple selection points during peripheral B-cell maturation. J. Immunol 167, 6834-6840 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 6834-6840
    • Allman, D.1
  • 97
    • 0036163380 scopus 로고    scopus 로고
    • CD23 defines two distinct subsets of immature B cells which differ in their responses to T-cell help signals
    • Chung, J. B., Sater, R. A., Fields, M. L., Erikson, J. & Monroe, J. G. CD23 defines two distinct subsets of immature B cells which differ in their responses to T-cell help signals. Int. Immunol. 14, 157-166 (2002).
    • (2002) Int. Immunol. , vol.14 , pp. 157-166
    • Chung, J.B.1    Sater, R.A.2    Fields, M.L.3    Erikson, J.4    Monroe, J.G.5
  • 98
    • 0032479526 scopus 로고    scopus 로고
    • Visualization of specific B- and T-lymphocyte interactions in the lymph node
    • Garside, P. et al. Visualization of specific B- and T-lymphocyte interactions in the lymph node. Science 281, 96-99 (1998).
    • (1998) Science , vol.281 , pp. 96-99
    • Garside, P.1
  • 99
    • 0030058466 scopus 로고    scopus 로고
    • Aberrant B-cell development and immune response in mice with a compromised BCR complex
    • Torres, R. M., Flaswinkel, H., Reth, M. & Rajewsky, K. Aberrant B-cell development and immune response in mice with a compromised BCR complex. Science 272, 1802-1804 (1996).
    • (1996) Science , vol.272 , pp. 1802-1804
    • Torres, R.M.1    Flaswinkel, H.2    Reth, M.3    Rajewsky, K.4
  • 100
    • 0035186661 scopus 로고    scopus 로고
    • B-cell development is arrested at the immature B-cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin-β
    • Reichlin, A. et al. B-cell development is arrested at the immature B-cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin-β. J. Exp. Med. 193, 13-23 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 13-23
    • Reichlin, A.1
  • 101
    • 0031456145 scopus 로고    scopus 로고
    • Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B-cell pool
    • Turner, M. et al. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B-cell pool. J. Exp. Med. 186, 2013-2021 (1997).
    • (1997) J. Exp. Med. , vol.186 , pp. 2013-2021
    • Turner, M.1
  • 103
    • 0034694088 scopus 로고    scopus 로고
    • BAFF mediates survival of peripheral immature B lymphocytes
    • Batten, M. et al. BAFF mediates survival of peripheral immature B lymphocytes. J. Exp. Med. 192, 1453-1466 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1453-1466
    • Batten, M.1
  • 104
    • 0035860559 scopus 로고    scopus 로고
    • An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    • Schiemann, B. et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293, 2111-2114 (2001). This paper shows a crucial role for BAFF in transition from the T1 to T2 stage, and also shows that Baff-deficient mice have a similar phenotype to A/WySnJ mice, which have a mutation of the Baff receptor.
    • (2001) Science , vol.293 , pp. 2111-2114
    • Schiemann, B.1
  • 105
    • 0033538468 scopus 로고    scopus 로고
    • BLyS: Member of the tumor-necrosis factor family and B-lymphocyte stimulator
    • Moore, P. A. et al. BLyS: member of the tumor-necrosis factor family and B-lymphocyte stimulator. Science 285, 260-263 (1999).
    • (1999) Science , vol.285 , pp. 260-263
    • Moore, P.A.1
  • 106
    • 0033532634 scopus 로고    scopus 로고
    • BAFF, a novel ligand of the tumor-necrosis factor family, stimulates B-cell growth
    • Schneider, P. et al. BAFF, a novel ligand of the tumor-necrosis factor family, stimulates B-cell growth. J. Exp. Med. 189, 1747-1756 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1747-1756
    • Schneider, P.1
  • 107
    • 0037097665 scopus 로고    scopus 로고
    • Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators
    • Hsu, B. L., Harless, S. M., Lindsley, R. C., Hilbert, D. M. & Cancro, M. P. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J. Immunol. 168, 5993-5996 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5993-5996
    • Hsu, B.L.1    Harless, S.M.2    Lindsley, R.C.3    Hilbert, D.M.4    Cancro, M.P.5
  • 108
    • 0034596831 scopus 로고    scopus 로고
    • Attenuation of apoptosis underlies B-lymphocyte stimulator enhancement of humoral immune response
    • Do, R. K. et al. Attenuation of apoptosis underlies B-lymphocyte stimulator enhancement of humoral immune response. J. Exp Med. 192, 953-964 (2000).
    • (2000) J. Exp Med. , vol.192 , pp. 953-964
    • Do, R.K.1
  • 109
    • 0036794398 scopus 로고    scopus 로고
    • BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
    • Claudio, E., Brown, K., Park, S., Wang, H. & Siebenlist, U. BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells. Nature Immunol. 3, 958-965 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 958-965
    • Claudio, E.1    Brown, K.2    Park, S.3    Wang, H.4    Siebenlist, U.5
  • 110
    • 18644369740 scopus 로고    scopus 로고
    • BAFF/BLyS receptor 3 binds the B-cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-κB2
    • Kayagaki, N. et al. BAFF/BLyS receptor 3 binds the B-cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-κB2. Immunity 17, 515-524 (2002). References 109 and 110 show that BAFF signalling involves a non-classical NF-κB pathway (NEMO-independent processing of NF-κB2) and that this requires the BAFF receptor.
    • (2002) Immunity , vol.17 , pp. 515-524
    • Kayagaki, N.1
  • 111
    • 0034729769 scopus 로고    scopus 로고
    • Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
    • Marsters, S. A. et al. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10, 785-788 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 785-788
    • Marsters, S.A.1
  • 112
    • 15444357762 scopus 로고    scopus 로고
    • Requirement for NF-κK in osteoclast and B-cell development
    • Franzoso, G. et al. Requirement for NF-κK in osteoclast and B-cell development. Genes Dev. 11, 3482-3496 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 3482-3496
    • Franzoso, G.1
  • 113
    • 0036217975 scopus 로고    scopus 로고
    • Origins and functions of B-1 cells with notes on the role of CD5
    • Berland, R. & Wortis, H. H. Origins and functions of B-1 cells with notes on the role of CD5. Annu. Rev. Immunol. 20, 253-300 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 253-300
    • Berland, R.1    Wortis, H.H.2
  • 115
    • 0030740148 scopus 로고    scopus 로고
    • Characterization of the B-lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
    • Chan, V. W., Meng, F., Soriano, P., DeFranco, A. L. & Lowell, C. A. Characterization of the B-lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7, 69-81 (1997).
    • (1997) Immunity , vol.7 , pp. 69-81
    • Chan, V.W.1    Meng, F.2    Soriano, P.3    DeFranco, A.L.4    Lowell, C.A.5
  • 116
    • 0036232606 scopus 로고    scopus 로고
    • The tyrosine kinase Lyn is required for B-cell development beyond the T1 stage in the spleen: Rescue by over-expression of Bcl-2
    • Meade, J., Fernandez, C. & Turner, M. The tyrosine kinase Lyn is required for B-cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2. Eur. J. Immunol. 32, 1029-1034 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1029-1034
    • Meade, J.1    Fernandez, C.2    Turner, M.3
  • 117
    • 0034606219 scopus 로고    scopus 로고
    • Severe B-cell deficiency in mice lacking the Tec-kinase family members Tec and Btk
    • Ellmeier, W. et al. Severe B-cell deficiency in mice lacking the Tec-kinase family members Tec and Btk. J. Exp. Med. 192, 1611-1624 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1611-1624
    • Ellmeier, W.1
  • 118
    • 0033973585 scopus 로고    scopus 로고
    • Positive selection from newly formed to marginal-zone B cells depends on the rate of clonal production, CD19 and Btk
    • Martin, F. & Kearney, J. F. Positive selection from newly formed to marginal-zone B cells depends on the rate of clonal production, CD19 and Btk. Immunity 12, 39-49 (2000). This paper shows that CD19 and BTK have distinct roles in the development of marginal-zone (MZ) and follicular B cells.
    • (2000) Immunity , vol.12 , pp. 39-49
    • Martin, F.1    Kearney, J.F.2
  • 119
    • 0034995180 scopus 로고    scopus 로고
    • The follicular versus marginal-zone B-lymphocyte cell-fate decision is regulated by Aiolos, Btk and CD21
    • Cariappa, A. et al. The follicular versus marginal-zone B-lymphocyte cell-fate decision is regulated by Aiolos, Btk and CD21. Immunity 14, 603-615 (2001). This paper indicates that a strong BCR signal might favour the generation of follicular B cells, whereas a weak BCR signal favours the generation of MZ B cells.
    • (2001) Immunity , vol.14 , pp. 603-615
    • Cariappa, A.1
  • 120
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase
    • Suzuki, H. et al. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3-kinase. Science 283, 390-392 (1999).
    • (1999) Science , vol.283 , pp. 390-392
    • Suzuki, H.1
  • 121
    • 0037018096 scopus 로고    scopus 로고
    • Essential immunoregulatory role for BCAP in B-cell development and function
    • Yamazaki, T. et al. Essential immunoregulatory role for BCAP in B-cell development and function. J. Exp. Med. 195, 535-545 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 535-545
    • Yamazaki, T.1
  • 122
    • 0036312654 scopus 로고    scopus 로고
    • BAFF is a survival and maturation factor for mouse B cells
    • Rolink, A. G., Tschopp, J., Schneider, P. & Melchers, F. BAFF is a survival and maturation factor for mouse B cells. Eur. J. Immunol. 32, 2004-2010 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2004-2010
    • Rolink, A.G.1    Tschopp, J.2    Schneider, P.3    Melchers, F.4
  • 123
    • 0033516689 scopus 로고    scopus 로고
    • Positive selection of natural autoreactive B cells
    • Hayakawa, K. et al. Positive selection of natural autoreactive B cells. Science 285, 113-116 (1999).
    • (1999) Science , vol.285 , pp. 113-116
    • Hayakawa, K.1
  • 124
    • 0035887189 scopus 로고    scopus 로고
    • Homeostasis of peripheral B cells in the absence of B-cell influx from the bone marrow
    • Hao, Z. & Rajewsky, K. Homeostasis of peripheral B cells in the absence of B-cell influx from the bone marrow. J Exp Med. 194, 1151-1164 (2001). This paper shows that blockade of the entry of immature B cells from the bone marrow leads to a gradual decrease in the number of follicular B cells, whereas the levels of MZ and peritoneal B cells remain unchanged in this setting.
    • (2001) J. Exp. Med. , vol.194 , pp. 1151-1164
    • Hao, Z.1    Rajewsky, K.2
  • 125
    • 0036754302 scopus 로고    scopus 로고
    • Blood dendritic cells interact with splenic marginal-zone B cells to initiate T-independent immune responses
    • Balazs, M., Martin, F., Zhou, T. & Kearney, J. Blood dendritic cells interact with splenic marginal-zone B cells to initiate T-independent immune responses. Immunity 17, 341 (2002).
    • (2002) Immunity , vol.17 , pp. 341
    • Balazs, M.1    Martin, F.2    Zhou, T.3    Kearney, J.4
  • 126
    • 0036569215 scopus 로고    scopus 로고
    • Cutting edge commentary: Two B-1 or not to be one
    • Rothstein, T. L. Cutting edge commentary: two B-1 or not to be one. J. Immunol. 168, 4257-4261 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 4257-4261
    • Rothstein, T.L.1
  • 127
    • 0037163059 scopus 로고    scopus 로고
    • + B-1 cells have signaling properties similar to tolerant B cells
    • + peritoneal B cells, and show that it is similar to that of anergic B cells.
    • (2002) J. Biol. Chem. , vol.277 , pp. 30707-30715
    • Wong, S.C.1
  • 128
    • 0029739626 scopus 로고    scopus 로고
    • Immunodeficiency in protein kinase Cβ-deficient mice
    • Leitges, M. et al. Immunodeficiency in protein kinase Cβ-deficient mice. Science 273, 788-791 (1996).
    • (1996) Science , vol.273 , pp. 788-791
    • Leitges, M.1
  • 129
    • 0036533662 scopus 로고    scopus 로고
    • The Rac2 guanosine triphosphatase regulates B-lymphocyte antigen-receptor responses and chemotaxis and is required for establishment of B-1 a and marginal-zone B lymphocytes
    • Croker, B. A. et al. The Rac2 guanosine triphosphatase regulates B-lymphocyte antigen-receptor responses and chemotaxis and is required for establishment of B-1 a and marginal-zone B lymphocytes. J Immunol. 168, 3376-3386 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3376-3386
    • Croker, B.A.1
  • 130
    • 0029094609 scopus 로고
    • Abnormal B-lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal-transduction molecule
    • Engel, P. et al. Abnormal B-lymphocyte development, activation and differentiation in mice that lack or overexpress the CD19 signal-transduction molecule. Immunity 3, 39-50 (1995)
    • (1995) Immunity , vol.3 , pp. 39-50
    • Engel, P.1
  • 131
    • 0029064680 scopus 로고
    • Impairment of T-cell-dependent B-cell responses and B-1-cell development in CD19-deficient mice
    • Rickert, R. C., Rajewsky, K. & Roes, J. Impairment of T-cell-dependent B-cell responses and B-1-cell development in CD19-deficient mice. Nature 376, 352-355 (1995).
    • (1995) Nature , vol.376 , pp. 352-355
    • Rickert, R.C.1    Rajewsky, K.2    Roes, J.3
  • 132
    • 0030499431 scopus 로고    scopus 로고
    • CD22 is both a positive and negative regulator of B-lymphocyte antigen-receptor signal transduction: Altered signaling in CD22-deficient mice
    • Sato, S. et al. CD22 is both a positive and negative regulator of B-lymphocyte antigen-receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5, 551-562 (1996).
    • (1996) Immunity , vol.5 , pp. 551-562
    • Sato, S.1
  • 134
    • 0030972497 scopus 로고    scopus 로고
    • Aiolos, a lymphoid-restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
    • Morgan, B. et al. Aiolos, a lymphoid-restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16, 2004-2013 (1997).
    • (1997) EMBO J. , vol.16 , pp. 2004-2013
    • Morgan, B.1
  • 135
    • 0032191170 scopus 로고    scopus 로고
    • Aiolos regulates B-cell activation and maturation to effector state
    • Wang, J H. et al. Aiolos regulates B-cell activation and maturation to effector state. Immunity 9, 543-553 (1998).
    • (1998) Immunity , vol.9 , pp. 543-553
    • Wang, J.H.1
  • 136
    • 0036180761 scopus 로고    scopus 로고
    • Reduction of marginal-zone B cells in CD22-deficient mice
    • Samardzic, T. et al. Reduction of marginal-zone B cells in CD22-deficient mice. Eur. J. Immunol. 32. 561-567 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 561-567
    • Samardzic, T.1
  • 137
    • 0034232062 scopus 로고    scopus 로고
    • Absence of marginal-zone B cells in Pyk-2-deficient mice defines their role in the humoral response
    • Guinamard, R., Okigaki, M., Schlessinger, J. & Ravetch, J. V. Absence of marginal-zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nature Immunol. 1, 31-36 (2000).
    • (2000) Nature Immunol. , vol.1 , pp. 31-36
    • Guinamard, R.1    Okigaki, M.2    Schlessinger, J.3    Ravetch, J.V.4
  • 138
    • 0032483419 scopus 로고    scopus 로고
    • The α-chemokine, stromal-cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal-transduction pathways
    • Ganiu, R. K. et al. The α-chemokine, stromal-cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal-transduction pathways. J. Biol. Chem. 273, 23169-23175 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 23169-23175
    • Ganiu, R.K.1
  • 139
    • 0034676014 scopus 로고    scopus 로고
    • Nuclear factor-κB is required for the development of marginal-zone B lymphocytes
    • Cariappa, A., Liou, H. C., Horwitz, B. H. & Pillai, S. Nuclear factor-κB is required for the development of marginal-zone B lymphocytes. J. Exp. Med. 192, 1175-1182 (2000). This paper shows that NF-κB is more crucial for the development of MZ B cells than of follicular B cells.
    • (2000) J. Exp. Med. , vol.192 , pp. 1175-1182
    • Cariappa, A.1    Liou, H.C.2    Horwitz, B.H.3    Pillai, S.4
  • 141
    • 0037135158 scopus 로고    scopus 로고
    • Integrin-mediated long-term B-cell retention in the splenic marginal zone
    • 1 integrin, which are required for MZ B-cell localization.
    • (2002) Science , vol.297 , pp. 409-412
    • Lu, T.T.1    Cyster, J.G.2
  • 142
    • 0037092949 scopus 로고    scopus 로고
    • Constitutive nuclear factor-κB activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2-family proteins
    • Bureau, F. et al. Constitutive nuclear factor-κB activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2-family proteins. Blood 99, 3683-3691 (2002).
    • (2002) Blood , vol.99 , pp. 3683-3691
    • Bureau, F.1
  • 143
    • 0037099628 scopus 로고    scopus 로고
    • Delayed cellular maturation and decreased immunoglobulin-κ light chain production in immature B lymphocytes lacking B-cell linker protein
    • Xu, S. & Lam. K. P. Delayed cellular maturation and decreased immunoglobulin-κ light chain production in immature B lymphocytes lacking B-cell linker protein. J. Exp. Med. 196, 197-206 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 197-206
    • Xu, S.1    Lam, K.P.2
  • 144
    • 0035863803 scopus 로고    scopus 로고
    • Cutting edge: Differential sequestration of plasma-membrane-associated B-cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains
    • Chung, J. B., Beumeister, M. A. & Monroe, J. G. Cutting edge: differential sequestration of plasma-membrane-associated B-cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains. J. Immunol. 166. 736-740 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 736-740
    • Chung, J.B.1    Beumeister, M.A.2    Monroe, J.G.3
  • 145
    • 0034547941 scopus 로고    scopus 로고
    • Cutting edge: B-cell antigen receptor signaling occurs outside lipid rafts in immature B cells
    • Sproul, T. W., Malapati, S., Kim, J. & Pierce, S. K. Cutting edge: B-cell antigen receptor signaling occurs outside lipid rafts in immature B cells. J. Immunol. 165, 6020-6023 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 6020-6023
    • Sproul, T.W.1    Malapati, S.2    Kim, J.3    Pierce, S.K.4
  • 146
    • 0028105796 scopus 로고
    • Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes
    • Merino, R., Ding, L., Veis, D. J., Korsmeyer, S. J. & Nunez, G. Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J 13, 683-691 (1994).
    • (1994) EMBO J. , vol.13 , pp. 683-691
    • Merino, R.1    Ding, L.2    Veis, D.J.3    Korsmeyer, S.J.4    Nunez, G.5
  • 147
    • 0031883536 scopus 로고    scopus 로고
    • Long-lived B cells are distinguished by elevated expression of A 1
    • Tomayko, M. M. & Cancro, M. P. Long-lived B cells are distinguished by elevated expression of A1. J. Immunol. 160, 107-111 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 107-111
    • Tomayko, M.M.1    Cancro, M.P.2
  • 148
    • 0027527099 scopus 로고
    • Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice
    • Nakayama, K. et al. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261, 1584-1588 (1993).
    • (1993) Science , vol.261 , pp. 1584-1588
    • Nakayama, K.1
  • 149
    • 0035846955 scopus 로고    scopus 로고
    • CD19-dependent activation of Akt kinase in B lymphocytes
    • Otero, D. C., Omon, S. A. & Rickert, R. C. CD19-dependent activation of Akt kinase in B lymphocytes. J. Biol. Chem, 276, 1474-1478 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 1474-1478
    • Otero, D.C.1    Omon, S.A.2    Rickert, R.C.3
  • 150
    • 0030467610 scopus 로고    scopus 로고
    • CD22 regulates thymus-independent responses and the Iifespan of B cells
    • Otipoby, K. L. et al. CD22 regulates thymus-independent responses and the Iifespan of B cells. Nature 384, 634-637 (1996).
    • (1996) Nature , vol.384 , pp. 634-637
    • Otipoby, K.L.1
  • 151
    • 0033105841 scopus 로고    scopus 로고
    • Antigen-receptor-induced signal-transduction imbalances associated with the negative selection of immature B cells
    • King, L. B., Norvell, A. & Monroe, J. G. Antigen-receptor-induced signal-transduction imbalances associated with the negative selection of immature B cells. J. Immunol. 162, 2655-2662 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 2655-2662
    • King, L.B.1    Norvell, A.2    Monroe, J.G.3
  • 152
    • 0025971175 scopus 로고
    • Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice
    • Yellen, A. J., Glenn, W., Sukhatme, V. P. Cao, X. M. & Monroe, J. G. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated differences in transmembrane signaling in splenic B cells from adult and neonatal mice. J. Immunol. 146, 1446-1454 (1991).
    • (1991) J. Immunol. , vol.146 , pp. 1446-1454
    • Yellen, A.J.1    Glenn, W.2    Sukhatme, V.P.3    Cao, X.M.4    Monroe, J.G.5
  • 154
    • 0037013718 scopus 로고    scopus 로고
    • BCR-mediated signal transduction in immature and mature B cells
    • Koncz, G., Bodor, C., Kovesdi, D., Gati, R. & Sarmay, G. BCR-mediated signal transduction in immature and mature B cells Immunol. Lett. 82, 41-49 (2002).
    • (2002) Immunol. Lett. , vol.82 , pp. 41-49
    • Koncz, G.1    Bodor, C.2    Kovesdi, D.3    Gati, R.4    Sarmay, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.