-
2
-
-
37049242573
-
Clonal selection theory
-
Talmage DW. 1959. Clonal selection theory. Science 129:1643-48
-
(1959)
Science
, vol.129
, pp. 1643-1648
-
-
Talmage, D.W.1
-
3
-
-
0030006070
-
Clonal selection and learning in the antibody system
-
Rajewsky K. 1996. Clonal selection and learning in the antibody system. Nature 381:751-58
-
(1996)
Nature
, vol.381
, pp. 751-758
-
-
Rajewsky, K.1
-
4
-
-
0025852445
-
A B cell deficient mouse by targeted disruption of the membrane exons of the immunoglobulin μ chain gene
-
Kitamura D, Roes J, Kuhn R, Rajewsky K. 1991. A B cell deficient mouse by targeted disruption of the membrane exons of the immunoglobulin μ chain gene. Nature 350:423-26
-
(1991)
Nature
, vol.350
, pp. 423-426
-
-
Kitamura, D.1
Roes, J.2
Kuhn, R.3
Rajewsky, K.4
-
5
-
-
0026583842
-
Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion
-
Kitamura D, Rajewsky K. 1992. Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154-56
-
(1992)
Nature
, vol.356
, pp. 154-156
-
-
Kitamura, D.1
Rajewsky, K.2
-
6
-
-
0026652354
-
A critical role of lambda 5 protein in B cell development
-
Kitamura D, Kudo A, Schaal S, Muller W, Melchers F, Rajewsky K. 1992. A critical role of lambda 5 protein in B cell development. Cell 69:823-31
-
(1992)
Cell
, vol.69
, pp. 823-831
-
-
Kitamura, D.1
Kudo, A.2
Schaal, S.3
Muller, W.4
Melchers, F.5
Rajewsky, K.6
-
7
-
-
0027172679
-
B cell development in mice with a defective lambda 5 gene
-
Rolink A, Karasuyama H, Grawunder U, Haasner D, Kudo A, Melchers F. 1993. B cell development in mice with a defective lambda 5 gene. Eur. J. Immunol. 23:1284-88
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 1284-1288
-
-
Rolink, A.1
Karasuyama, H.2
Grawunder, U.3
Haasner, D.4
Kudo, A.5
Melchers, F.6
-
8
-
-
0024980981
-
Antigen receptor tail clue
-
Reth M. 1989. Antigen receptor tail clue. Nature 338:383-84
-
(1989)
Nature
, vol.338
, pp. 383-384
-
-
Reth, M.1
-
9
-
-
0000387536
-
B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn, and Fyn
-
Law DA, Chan VWF, Datta SK, DeFranco AL. 1993. B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn, and Fyn. Curr. Biol. 3:645-57
-
(1993)
Curr. Biol.
, vol.3
, pp. 645-657
-
-
Law, D.A.1
Chan, V.W.F.2
Datta, S.K.3
DeFranco, A.L.4
-
10
-
-
0027290883
-
Signal transduction by immunoglobulin is mediated through Igα and Igβ
-
Sanchez M, Misulovin Z, Burkhardt AL, Mahajan S, Costa T, Franke R, Bolen JB, Nussenzweig M. 1993. Signal transduction by immunoglobulin is mediated through Igα and Igβ. J. Exp. Med. 178:1049-55
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1049-1055
-
-
Sanchez, M.1
Misulovin, Z.2
Burkhardt, A.L.3
Mahajan, S.4
Costa, T.5
Franke, R.6
Bolen, J.B.7
Nussenzweig, M.8
-
11
-
-
0028988692
-
The role of Igβ in precursor B cell transition and allelic excludion
-
Papavasiliou F, Misulovin Z, Suh H, Nussenzweig MC. 1995. The role of Igβ in precursor B cell transition and allelic excludion. Science 268:408-11
-
(1995)
Science
, vol.268
, pp. 408-411
-
-
Papavasiliou, F.1
Misulovin, Z.2
Suh, H.3
Nussenzweig, M.C.4
-
12
-
-
0030914291
-
The immunoglobulin (Ig)α and Igβ cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice
-
Teh Y-M, Neuberger MS. 1997. The immunoglobulin (Ig)α and Igβ cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice. J. Exp. Med. 185:1753-58
-
(1997)
J. Exp. Med.
, vol.185
, pp. 1753-1758
-
-
Teh, Y.-M.1
Neuberger, M.S.2
-
13
-
-
0029913115
-
Regulation of an early developmental checkpoint in the B cell pathway by Igβ
-
Gong S, Nussenzweig MC. 1996. Regulation of an early developmental checkpoint in the B cell pathway by Igβ. Science 272:411-14
-
(1996)
Science
, vol.272
, pp. 411-414
-
-
Gong, S.1
Nussenzweig, M.C.2
-
14
-
-
0030611753
-
The Igα/Igβ heterodimer on μ-negative pro B cells in competent for transducing signals to induce early B cell differentiation
-
Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H. 1997. The Igα/Igβ heterodimer on μ-negative pro B cells in competent for transducing signals to induce early B cell differentiation. Immunity 7:559-70
-
(1997)
Immunity
, vol.7
, pp. 559-570
-
-
Nagata, K.1
Nakamura, T.2
Kitamura, F.3
Kuramochi, S.4
Taki, S.5
Campbell, K.S.6
Karasuyama, H.7
-
15
-
-
0030468487
-
Counterselection against Dμ is mediated through Igα-Igβ
-
Gong S, Sanchez M, Nussenzweig MC. 1996. Counterselection against Dμ is mediated through Igα-Igβ. J. Exp. Med. 184:2079-84
-
(1996)
J. Exp. Med.
, vol.184
, pp. 2079-2084
-
-
Gong, S.1
Sanchez, M.2
Nussenzweig, M.C.3
-
16
-
-
0030058466
-
Aberrant B cell development and immune response in mice with a compromised BCR complex
-
Torres RM, Flaswinkel H, Reth M, Rajewsky K. 1996. Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272:1804-8
-
(1996)
Science
, vol.272
, pp. 1804-1808
-
-
Torres, R.M.1
Flaswinkel, H.2
Reth, M.3
Rajewsky, K.4
-
17
-
-
0342711256
-
In vivo ablation of surface immunogloubulin on mature B cells by inducible gene targeting results in rapid cell death
-
Lam K-P, Kühn R, Rajewsky K. 1997. In vivo ablation of surface immunogloubulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90:1073-83
-
(1997)
Cell
, vol.90
, pp. 1073-1083
-
-
Lam, K.-P.1
Kühn, R.2
Rajewsky, K.3
-
18
-
-
0028784215
-
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
-
Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301-11
-
(1995)
Cell
, vol.83
, pp. 301-311
-
-
Hibbs, M.L.1
Tarlinton, D.M.2
Armes, J.3
Grail, D.4
Hodgson, G.5
Maglitto, R.6
Stacker, S.A.7
Dunn, A.R.8
-
19
-
-
0028806216
-
Impaired proliferation of peripheral B cells and indication of autoimmune disease in Lyn-deficient mice
-
Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mon S, Watanabe T, Yamamoto T. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in Lyn-deficient mice. Immunity 3:549-60
-
(1995)
Immunity
, vol.3
, pp. 549-560
-
-
Nishizumi, H.1
Taniuchi, I.2
Yamanashi, Y.3
Kitamura, D.4
Ilic, D.5
Mon, S.6
Watanabe, T.7
Yamamoto, T.8
-
20
-
-
0030740148
-
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal intiation and down-regulation
-
Chan VWF, Meng F, Soriano P, DeFranco AL, Lowell CA. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal intiation and down-regulation. Immunity 7:69-81
-
(1997)
Immunity
, vol.7
, pp. 69-81
-
-
Chan, V.W.F.1
Meng, F.2
Soriano, P.3
DeFranco, A.L.4
Lowell, C.A.5
-
21
-
-
0032055828
-
Polygenic autoimmune traits: Lyn, CD22 and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
-
Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clark EA, Goodnow CC. 1998. Polygenic autoimmune traits: Lyn, CD22 and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8:497-508
-
(1998)
Immunity
, vol.8
, pp. 497-508
-
-
Cornall, R.J.1
Cyster, J.G.2
Hibbs, M.L.3
Dunn, A.R.4
Otipoby, K.L.5
Clark, E.A.6
Goodnow, C.C.7
-
23
-
-
0030467610
-
CD22 regulates thymus-independent responses and the lifespan of B cells
-
Otipoby KL, Andersson KB, Draves KE, Klaus SJ, Farr AG, Kerner JD, Perlmutter RM, Law C-L, Clark EA. 1996. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384:634-37
-
(1996)
Nature
, vol.384
, pp. 634-637
-
-
Otipoby, K.L.1
Andersson, K.B.2
Draves, K.E.3
Klaus, S.J.4
Farr, A.G.5
Kerner, J.D.6
Perlmutter, R.M.7
Law, C.-L.8
Clark, E.A.9
-
24
-
-
0031080328
-
CD22 is a negative regulator of B cell receptor signaling
-
Nitschke L, Carsetti R, Ocker B, Kohler G, Lamers MC. 1997. CD22 is a negative regulator of B cell receptor signaling. Curr. Biol. 7:133-43
-
(1997)
Curr. Biol.
, vol.7
, pp. 133-143
-
-
Nitschke, L.1
Carsetti, R.2
Ocker, B.3
Kohler, G.4
Lamers, M.C.5
-
25
-
-
0030499431
-
CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
-
Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang MLK, Tedder TF. 1996. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. Immunity 5:551-62
-
(1996)
Immunity
, vol.5
, pp. 551-562
-
-
Sato, S.1
Miller, A.S.2
Inaoki, M.3
Bock, C.B.4
Jansen, P.J.5
Tang, M.L.K.6
Tedder, T.F.7
-
26
-
-
0029012969
-
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP
-
Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, Thomas ML, Fearon DT. 1995. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269:242-44
-
(1995)
Science
, vol.269
, pp. 242-244
-
-
Doody, G.M.1
Justement, L.B.2
Delibrias, C.C.3
Matthews, R.J.4
Lin, J.5
Thomas, M.L.6
Fearon, D.T.7
-
27
-
-
0032550365
-
A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals
-
Nishizumi H, Horikawa K, Mlinaric-Rascan I, Yamamoto T. 1998. A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J. Exp. Med. 187:1343-48
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1343-1348
-
-
Nishizumi, H.1
Horikawa, K.2
Mlinaric-Rascan, I.3
Yamamoto, T.4
-
28
-
-
0032473487
-
Inhibition of the B cell by CD22: A requirement for Lyn
-
Smith KGC, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT. 1998. Inhibition of the B cell by CD22: A requirement for Lyn. J. Exp. Med. 187:807-11
-
(1998)
J. Exp. Med.
, vol.187
, pp. 807-811
-
-
Smith, K.G.C.1
Tarlinton, D.M.2
Doody, G.M.3
Hibbs, M.L.4
Fearon, D.T.5
-
29
-
-
0028889302
-
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
-
Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VLJ. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298-302
-
(1995)
Nature
, vol.378
, pp. 298-302
-
-
Turner, M.1
Mee, P.J.2
Costello, P.S.3
Williams, O.4
Price, A.A.5
Duddy, L.P.6
Furlong, M.T.7
Geahlen, R.L.8
Tybulewicz, V.L.J.9
-
30
-
-
0028783322
-
Syk tyrosine kinase required for mouse viability and B-cell development
-
Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T. 1995. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378:303-6
-
(1995)
Nature
, vol.378
, pp. 303-306
-
-
Cheng, A.M.1
Rowley, B.2
Pao, W.3
Hayday, A.4
Bolen, J.B.5
Pawson, T.6
-
31
-
-
0031456145
-
Syk tyrosine kinases is required for the positive selection of immature B cells into the recirculating B cell pool
-
Turner M, Gulbranson-Judge A, Quinn ME, Walters AE, MacLennan ICM, Tybulewicz VLJ. 1997. Syk tyrosine kinases is required for the positive selection of immature B cells into the recirculating B cell pool. J. Exp. Med. 186:2013-21
-
(1997)
J. Exp. Med.
, vol.186
, pp. 2013-2021
-
-
Turner, M.1
Gulbranson-Judge, A.2
Quinn, M.E.3
Walters, A.E.4
MacLennan, I.C.M.5
Tybulewicz, V.L.J.6
-
32
-
-
0030582773
-
A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
-
Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. 1996. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87:1037-47
-
(1996)
Cell
, vol.87
, pp. 1037-1047
-
-
Forster, R.1
Mattis, A.E.2
Kremmer, E.3
Wolf, E.4
Brem, G.5
Lipp, M.6
-
33
-
-
0027399081
-
Deficient expression of a B cell cytoplasinic tyrosine kinase in human X-linked agammaglobulinemia
-
Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kuhagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON. 1993. Deficient expression of a B cell cytoplasinic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72:279-90
-
(1993)
Cell
, vol.72
, pp. 279-290
-
-
Tsukada, S.1
Saffran, D.C.2
Rawlings, D.J.3
Parolini, O.4
Allen, R.C.5
Klisak, I.6
Sparkes, R.S.7
Kuhagawa, H.8
Mohandas, T.9
Quan, S.10
Belmont, J.W.11
Cooper, M.D.12
Conley, M.E.13
Witte, O.N.14
-
34
-
-
0027441332
-
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
-
Vetrie D, Vorechovsky I, Sideras P, Holland J, Davies A, Flinter F, Hammarstrom L, Kinnon C, Levinsky R, Bobrow M, Smith CIE, Bentley DR. 1993. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361:226-33
-
(1993)
Nature
, vol.361
, pp. 226-233
-
-
Vetrie, D.1
Vorechovsky, I.2
Sideras, P.3
Holland, J.4
Davies, A.5
Flinter, F.6
Hammarstrom, L.7
Kinnon, C.8
Levinsky, R.9
Bobrow, M.10
Smith, C.I.E.11
Bentley, D.R.12
-
35
-
-
0027305921
-
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
-
Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, Cohen RN, Mohr JF, Bazan M, Howard M, Copeland NG, Jenkins NA, Witte ON. 1993. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science 261:358-61
-
(1993)
Science
, vol.261
, pp. 358-361
-
-
Rawlings, D.J.1
Saffran, D.C.2
Tsukada, S.3
Largaespada, D.A.4
Grimaldi, J.C.5
Cohen, R.N.6
Mohr, J.F.7
Bazan, M.8
Howard, M.9
Copeland, N.G.10
Jenkins, N.A.11
Witte, O.N.12
-
36
-
-
0028183398
-
Bruton's tyrosine kinase is a key regulator in B-cell development
-
Rawlings DJ, Witte ON. 1994. Bruton's tyrosine kinase is a key regulator in B-cell development. Immunol. Rev. 138:105-19
-
(1994)
Immunol. Rev.
, vol.138
, pp. 105-119
-
-
Rawlings, D.J.1
Witte, O.N.2
-
37
-
-
0028087195
-
X-linked agammaglobulinemia and other immunoglobulin deficiencies
-
Smith CI, Islam KB, Vorechovsky I, Olerup O, Wallin E, Rabbani H, Baskin B, Hammarstrom L. 1994. X-linked agammaglobulinemia and other immunoglobulin deficiencies. Immunol. Rev. 138:159-83
-
(1994)
Immunol. Rev.
, vol.138
, pp. 159-183
-
-
Smith, C.I.1
Islam, K.B.2
Vorechovsky, I.3
Olerup, O.4
Wallin, E.5
Rabbani, H.6
Baskin, B.7
Hammarstrom, L.8
-
38
-
-
0028847330
-
Impaired expansion of mouse B cell progenitors lacking Btk
-
Kerner JD, Appleby MW, Mohr S, Chien DJ, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301-12
-
(1995)
Immunity
, vol.3
, pp. 301-312
-
-
Kerner, J.D.1
Appleby, M.W.2
Mohr, S.3
Chien, D.J.4
Rawlings, D.J.5
Maliszewski, C.R.6
Witte, O.N.7
Perlmutter, R.M.8
-
39
-
-
0028847329
-
Defective B cell development and function in Btk-deficient mice
-
Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA, Rosen FS, Sideras P. 1995. Defective B cell development and function in Btk-deficient mice. Immunity 3:283-99
-
(1995)
Immunity
, vol.3
, pp. 283-299
-
-
Khan, W.N.1
Alt, F.W.2
Gerstein, R.M.3
Malynn, B.A.4
Larsson, I.5
Rathbun, G.6
Davidson, L.7
Müller, S.8
Kantor, A.B.9
Herzenberg, L.A.10
Rosen, F.S.11
Sideras, P.12
-
40
-
-
0029792213
-
Inactivation of BTK by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage
-
Hendriks RW, de Bruijn MFTR, Mass A, Dingjan GM, Karis A, Grosveld F. 1996. Inactivation of BTK by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO J. 15:4862-72
-
(1996)
EMBO J.
, vol.15
, pp. 4862-4872
-
-
Hendriks, R.W.1
De Bruijn, M.2
Mass, A.3
Dingjan, G.M.4
Karis, A.5
Grosveld, F.6
-
41
-
-
0029864147
-
+ thymocytes, and B cell maturation
-
+ thymocytes, and B cell maturation. J. Exp. Med. 183:1707-18
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1707-1718
-
-
Byth, K.F.1
Conroy, L.A.2
Howlett, S.3
Smith, A.J.H.4
May, J.5
Alexander, D.R.6
Holmes, N.7
-
42
-
-
0027296521
-
Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice
-
Kishihara K, Penninger J, Wallace VA, Kundig TM, Kawai K, Ohashi PS, Thomas ML, Furlonger C, Paige CJ, Mak TW. 1993. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 74:143-56
-
(1993)
Cell
, vol.74
, pp. 143-156
-
-
Kishihara, K.1
Penninger, J.2
Wallace, V.A.3
Kundig, T.M.4
Kawai, K.5
Ohashi, P.S.6
Thomas, M.L.7
Furlonger, C.8
Paige, C.J.9
Mak, T.W.10
-
43
-
-
0030070349
-
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice
-
Benatar T, Carsetti R, Furlonger C, Kamalia N, Mak T, Paige CJ. 1996. Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice. J. Exp. Med. 183:329-34
-
(1996)
J. Exp. Med.
, vol.183
, pp. 329-334
-
-
Benatar, T.1
Carsetti, R.2
Furlonger, C.3
Kamalia, N.4
Mak, T.5
Paige, C.J.6
-
44
-
-
0030023652
-
Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
-
Cyster JG, Healy JI, Kishihara K, Mak TW, Thomas ML, Goodnow CC. 1996. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381:325-28
-
(1996)
Nature
, vol.381
, pp. 325-328
-
-
Cyster, J.G.1
Healy, J.I.2
Kishihara, K.3
Mak, T.W.4
Thomas, M.L.5
Goodnow, C.C.6
-
45
-
-
0028077851
-
Identification of PTP1C mutation as a genetic defect in motheaten and viable motheaten mice: A step toward defining the roles of protein tyrosine phosphtatases in the regulation of hemopoietic cell differentiation and function
-
Bignon JS, Siminovitch KA. 1994. Identification of PTP1C mutation as a genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphtatases in the regulation of hemopoietic cell differentiation and function. Clin. Immunol. Immunopathol. 73:168-79
-
(1994)
Clin. Immunol. Immunopathol.
, vol.73
, pp. 168-179
-
-
Bignon, J.S.1
Siminovitch, K.A.2
-
46
-
-
0023080524
-
Genetically determined murine models of immunodeficiency
-
Shults LD, Sidman CL. 1987. Genetically determined murine models of immunodeficiency. Annu. Rev. Immunol. 5:367-403
-
(1987)
Annu. Rev. Immunol.
, vol.5
, pp. 367-403
-
-
Shults, L.D.1
Sidman, C.L.2
-
47
-
-
0028183404
-
Molecular basis of the motheaten phenotype
-
Tsui FWL, Tsui HW. 1994. Molecular basis of the motheaten phenotype. Immunol. Rev. 136:185-206
-
(1994)
Immunol. Rev.
, vol.136
, pp. 185-206
-
-
Tsui, F.W.L.1
Tsui, H.W.2
-
48
-
-
0028961264
-
Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection
-
Cyster JG, Goodnow CC. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2:13-24
-
(1995)
Immunity
, vol.2
, pp. 13-24
-
-
Cyster, J.G.1
Goodnow, C.C.2
-
50
-
-
0031457622
-
Signaling through scaffold, anchoring, and adaptor proteins
-
Pawson T, Scott JD. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science 278:2075-80
-
(1997)
Science
, vol.278
, pp. 2075-2080
-
-
Pawson, T.1
Scott, J.D.2
-
51
-
-
0032522719
-
Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate
-
Dell' Acqua ML, Faux MC, Thorburn J, Thoburn A, Scott JD. 1998. Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate. EMBO J. 17:2246-60
-
(1998)
EMBO J.
, vol.17
, pp. 2246-2260
-
-
Dell' Acqua, M.L.1
Faux, M.C.2
Thorburn, J.3
Thoburn, A.4
Scott, J.D.5
-
52
-
-
0032101348
-
Membrane compartmentation is required for efficient T cell activation
-
Xavier R, Brennan T, Li Q, McCormack C, Seed B. 1998. Membrane compartmentation is required for efficient T cell activation. Immunity 8:723-32
-
(1998)
Immunity
, vol.8
, pp. 723-732
-
-
Xavier, R.1
Brennan, T.2
Li, Q.3
McCormack, C.4
Seed, B.5
-
53
-
-
0028060150
-
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement
-
Saouaf SJ, Mahajan S, Rowley RB, Kut SA, Fargnoli J, Burkhardt AL, Tsukada S, Witte ON, Bolen JB. 1994. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc. Natl. Acad. Sci. USA 91:9524-28
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 9524-9528
-
-
Saouaf, S.J.1
Mahajan, S.2
Rowley, R.B.3
Kut, S.A.4
Fargnoli, J.5
Burkhardt, A.L.6
Tsukada, S.7
Witte, O.N.8
Bolen, J.B.9
-
55
-
-
0030746106
-
S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
-
Kabouridis PS, Magee AI, Ley SC. 1997. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO J. 16:4983-98
-
(1997)
EMBO J.
, vol.16
, pp. 4983-4998
-
-
Kabouridis, P.S.1
Magee, A.I.2
Ley, S.C.3
-
56
-
-
0028180858
-
+ mobilization through distinct pathways
-
+ mobilization through distinct pathways. EMBO J. 13:1341-49
-
(1994)
EMBO J.
, vol.13
, pp. 1341-1349
-
-
Takata, M.1
Sabe, H.2
Hata, A.3
Inazu, T.4
Homma, Y.5
Nukada, T.6
Yamamura, H.7
Kurosaki, T.8
-
57
-
-
0030018304
-
A role for Bruton's tyrosine kinase in BCR-mediated activation of phospholipase C-γ 2
-
Takata M, Kurosaki T. 1996. A role for Bruton's tyrosine kinase in BCR-mediated activation of phospholipase C-γ 2. J. Exp. Med. 184:31-40
-
(1996)
J. Exp. Med.
, vol.184
, pp. 31-40
-
-
Takata, M.1
Kurosaki, T.2
-
58
-
-
0027300619
-
The when and how of Src regulation
-
Cooper JA, Howell B. 1993. The when and how of Src regulation. Cell. 73:1051-54
-
(1993)
Cell
, vol.73
, pp. 1051-1054
-
-
Cooper, J.A.1
Howell, B.2
-
59
-
-
0029846429
-
CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosine of Lyn in B cells
-
Yanagi S, Sugawara M, Kurosaki M, Sabe H, Yamamura H, Kurosaki T. 1996. CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosine of Lyn in B cells. J. Biol. Chem. 271:30487-92
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 30487-30492
-
-
Yanagi, S.1
Sugawara, M.2
Kurosaki, M.3
Sabe, H.4
Yamamura, H.5
Kurosaki, T.6
-
60
-
-
0031569176
-
Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45 B cells
-
Pao LI, Cambier JC. 1997. Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45 B cells. J. Immunol. 158:2663-69
-
(1997)
J. Immunol.
, vol.158
, pp. 2663-2669
-
-
Pao, L.I.1
Cambier, J.C.2
-
61
-
-
0028073936
-
Functional analysis of Csk in signal transduction through the B-cell antigen receptor
-
Hata A, Sabe H, Kurosaki T, Takata M, Hanafusa H. 1994. Functional analysis of Csk in signal transduction through the B-cell antigen receptor. Mol. Cell. Biol. 14:7306-13
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7306-7313
-
-
Hata, A.1
Sabe, H.2
Kurosaki, T.3
Takata, M.4
Hanafusa, H.5
-
62
-
-
0031066598
-
Molecular targets of CD45 in B cell antigen receptor signal transduction
-
Pao LI, Bedzyk WD, Persin C, Cambier JC. 1997. Molecular targets of CD45 in B cell antigen receptor signal transduction, J. Immunol 158:1116-24
-
(1997)
J. Immunol
, vol.158
, pp. 1116-1124
-
-
Pao, L.I.1
Bedzyk, W.D.2
Persin, C.3
Cambier, J.C.4
-
63
-
-
0025898888
-
Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45
-
Justement LB, Campbell KS, Chien NC, Cambier JC. 1991. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science 252:1839-42
-
(1991)
Science
, vol.252
, pp. 1839-1842
-
-
Justement, L.B.1
Campbell, K.S.2
Chien, N.C.3
Cambier, J.C.4
-
64
-
-
0028219230
-
Negative regulation of apoptotic death in immature B cells by CD45
-
Ogimoto M, Katagiri T, Mashima K, Hasegawa K, Mizuno K, Yakura H. 1994. Negative regulation of apoptotic death in immature B cells by CD45. Int. Immunol. 6:647-54
-
(1994)
Int. Immunol.
, vol.6
, pp. 647-654
-
-
Ogimoto, M.1
Katagiri, T.2
Mashima, K.3
Hasegawa, K.4
Mizuno, K.5
Yakura, H.6
-
65
-
-
0031025991
-
Three-dimensional structure of the tyrosine kinase c-Src
-
Xu W, Harrison SC, Eck M. 1997. Three-dimensional structure of the tyrosine kinase c-Src. Nature 385:595-602
-
(1997)
Nature
, vol.385
, pp. 595-602
-
-
Xu, W.1
Harrison, S.C.2
Eck, M.3
-
66
-
-
0031034930
-
Crystal structure of the Src family tyrosine kinase Hck
-
Sicheri F, Moarefi I, Kuriyan J. 1997. Crystal structure of the Src family tyrosine kinase Hck, Nature 385:602-9
-
(1997)
Nature
, vol.385
, pp. 602-609
-
-
Sicheri, F.1
Moarefi, I.2
Kuriyan, J.3
-
67
-
-
0028014460
-
Signal transduction by lymphocyte antigen receptors
-
Weiss A, Littman DR. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263-74
-
(1994)
Cell
, vol.76
, pp. 263-274
-
-
Weiss, A.1
Littman, D.R.2
-
68
-
-
0027185152
-
T cell activation by clustered tyrosine kinases
-
Kolanus W, Romeo C, Seed B. 1993. T cell activation by clustered tyrosine kinases. Cell 74:171-83
-
(1993)
Cell
, vol.74
, pp. 171-183
-
-
Kolanus, W.1
Romeo, C.2
Seed, B.3
-
69
-
-
0029952988
-
The syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
-
Chu DH, Spits H, Peyron J-F, Rowley RB, Bolen JB, Weiss A. 1996. The syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 15:6251-61
-
(1996)
EMBO J.
, vol.15
, pp. 6251-6261
-
-
Chu, D.H.1
Spits, H.2
Peyron, J.-F.3
Rowley, R.B.4
Bolen, J.B.5
Weiss, A.6
-
70
-
-
0030795305
-
Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase
-
Latour S, Fournel M, Veillette A. 1997. Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase. Mol. Cell. Biol. 17:4434-11
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4434-4511
-
-
Latour, S.1
Fournel, M.2
Veillette, A.3
-
71
-
-
0026656317
-
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor
-
Hutchcroft JE, Harrison ML, Geablen RL. 1992. Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J. Biol. Chem. 267:8613-19
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 8613-8619
-
-
Hutchcroft, J.E.1
Harrison, M.L.2
Geablen, R.L.3
-
72
-
-
0028783396
-
Role of the Syk autophosphorylation site and SH2 domains in B cell receptor signaling
-
Kurosaki T, Johnson SA, Pao L, Sada K, Yamamura H, Cambier JC. 1995. Role of the Syk autophosphorylation site and SH2 domains in B cell receptor signaling. J. Exp. Med. 182:1815-23
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1815-1823
-
-
Kurosaki, T.1
Johnson, S.A.2
Pao, L.3
Sada, K.4
Yamamura, H.5
Cambier, J.C.6
-
73
-
-
0029068171
-
Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Igα/Igβ immunoreceptor tyrosine activation motif binding and autophosphorylation
-
Rowley RB, Burkhardt AL, Chao HG, Matsueda GR, Bolen JB. 1995. Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Igα/Igβ immunoreceptor tyrosine activation motif binding and autophosphorylation. J. Biol. Chem. 270:11590-94
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11590-11594
-
-
Rowley, R.B.1
Burkhardt, A.L.2
Chao, H.G.3
Matsueda, G.R.4
Bolen, J.B.5
-
74
-
-
84988043558
-
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor
-
Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Kam MK, Theriault K, Zoller MJ, Karas JL. 1995. Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377:32-38
-
(1995)
Nature
, vol.377
, pp. 32-38
-
-
Hatada, M.H.1
Lu, X.2
Laird, E.R.3
Green, J.4
Morgenstern, J.P.5
Lou, M.6
Marr, C.S.7
Phillips, T.B.8
Kam, M.K.9
Theriault, K.10
Zoller, M.J.11
Karas, J.L.12
-
75
-
-
0032079343
-
A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling
-
Latour S, Zhang J, Siraganian RP, Veillette A. 1998. A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling. EMBO J. 17:2584-95
-
(1998)
EMBO J.
, vol.17
, pp. 2584-2595
-
-
Latour, S.1
Zhang, J.2
Siraganian, R.P.3
Veillette, A.4
-
76
-
-
0028355565
-
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
-
Kurosaki T, Takata M, Yamanashi Y, Inazu T, Taniguchi T, Yamamoto T, Yamamura H. 1994. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179:1725-29
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1725-1729
-
-
Kurosaki, T.1
Takata, M.2
Yamanashi, Y.3
Inazu, T.4
Taniguchi, T.5
Yamamoto, T.6
Yamamura, H.7
-
77
-
-
0030968306
-
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130
-
Keshvara LM, Isaacson C, Harrison L, Geahlen RL. 1997. Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J. Biol. Chem. 272:10377-81
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10377-10381
-
-
Keshvara, L.M.1
Isaacson, C.2
Harrison, L.3
Geahlen, R.L.4
-
78
-
-
0030889218
-
The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
-
Ota Y, Samelson LE. 1997. The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. Science 276:418-20
-
(1997)
Science
, vol.276
, pp. 418-420
-
-
Ota, Y.1
Samelson, L.E.2
-
79
-
-
0031858649
-
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-CbI-deficient mice
-
Murphy MA, Schnall RG, Venter DJ, Barnett L, Bertoncello I, Thien CBF, Langdon WY, Bowtell DDL. 1998. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-CbI-deficient mice. Mol. Cell. Biol. 18:4872-82
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 4872-4882
-
-
Murphy, M.A.1
Schnall, R.G.2
Venter, D.J.3
Barnett, L.4
Bertoncello, I.5
Thien, C.B.F.6
Langdon, W.Y.7
Bowtell, D.D.L.8
-
80
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr R, Willson TA, Viney EM, Murray LJL, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387:917-21
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
Willson, T.A.2
Viney, E.M.3
Murray, L.J.L.4
Rayner, J.R.5
Jenkins, B.J.6
Gonda, T.J.7
Alexander, W.S.8
Metcalf, D.9
Nicola, N.A.10
Hilton, D.J.11
-
81
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Maysumoto A, Tanimura S, Ohtsubo M, Miaswa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921-24
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
Masuhara, M.2
Yokouchi, M.3
Suzuki, R.4
Sakamoto, H.5
Mitsui, K.6
Maysumoto, A.7
Tanimura, S.8
Ohtsubo, M.9
Miaswa, H.10
Miyazaki, T.11
Leonor, N.12
Taniguchi, T.13
Fujita, T.14
Kanakura, Y.15
Komiya, S.16
Yoshimura, A.17
-
82
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924-29
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
Narazaki, M.2
Hirata, M.3
Matsumoto, T.4
Minamoto, S.5
Aono, A.6
Nishimoto, N.7
Kajita, T.8
Taga, T.9
Yoshizaki, K.10
Akira, S.11
Kishimoto, T.12
-
83
-
-
0029087567
-
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase
-
Mahajan S, Fargnoli J, Burkhardt AL, Kut SA, Saouaf SJ, Bolen JB. 1995. Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol. Cell. Biol. 15:5304-11
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5304-5311
-
-
Mahajan, S.1
Fargnoli, J.2
Burkhardt, A.L.3
Kut, S.A.4
Saouaf, S.J.5
Bolen, J.B.6
-
84
-
-
0030038840
-
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases
-
Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger A-C, Witte ON, Kinet J-P. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271:822-25
-
(1996)
Science
, vol.271
, pp. 822-825
-
-
Rawlings, D.J.1
Scharenberg, A.M.2
Park, H.3
Wahl, M.I.4
Lin, S.5
Kato, R.M.6
Fluckiger, A.-C.7
Witte, O.N.8
Kinet, J.-P.9
-
85
-
-
0030916169
-
Transphosphorylation of Btk on tyrosine 551 is critical for B cell antigen receptor function
-
Kurosaki T, Kurosaki M. 1997. Transphosphorylation of Btk on tyrosine 551 is critical for B cell antigen receptor function. J. Biol. Chem. 272:15595-98
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15595-15598
-
-
Kurosaki, T.1
Kurosaki, M.2
-
86
-
-
0030740453
-
Xid and Xid-like immunodeficiencies from a signaling point of view
-
Tarakhovsky A. 1997. Xid and Xid-like immunodeficiencies from a signaling point of view. Curr. Opin. Immunol. 9:319-23
-
(1997)
Curr. Opin. Immunol.
, vol.9
, pp. 319-323
-
-
Tarakhovsky, A.1
-
87
-
-
0030152357
-
Regulation of Btk function by a major autophosphorylation site within the SH3 domain
-
Park H, Wahl MI, Afar DEH, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet J-P, Witte ON. 1996. Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4:515-25
-
(1996)
Immunity
, vol.4
, pp. 515-525
-
-
Park, H.1
Wahl, M.I.2
Afar, D.E.H.3
Turck, C.W.4
Rawlings, D.J.5
Tam, C.6
Scharenberg, A.M.7
Kinet, J.-P.8
Witte, O.N.9
-
88
-
-
0031029781
-
Regulatory intramolecular association in a tyrosine kinase of the Tec family
-
Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL. 1997. Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature 385:93-97
-
(1997)
Nature
, vol.385
, pp. 93-97
-
-
Andreotti, A.H.1
Bunnell, S.C.2
Feng, S.3
Berg, L.J.4
Schreiber, S.L.5
-
89
-
-
0032540094
-
Identification and characterization of a novel SH3-domain binding protein, Sab, which prefentially associates with Bruton's Tyrosine kinase (Btk)
-
Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, Hashimoto S, Sekine S, Arai S, Kunikata T, Kurimoto M, Kishimoto T, Tsukada S. 1998. Identification and characterization of a novel SH3-domain binding protein, Sab, which prefentially associates with Bruton's Tyrosine kinase (Btk). Biochem. Biophys. Res. Comm. 245:337-43
-
(1998)
Biochem. Biophys. Res. Comm.
, vol.245
, pp. 337-343
-
-
Matsushita, M.1
Yamadori, T.2
Kato, S.3
Takemoto, Y.4
Inazawa, J.5
Baba, Y.6
Hashimoto, S.7
Sekine, S.8
Arai, S.9
Kunikata, T.10
Kurimoto, M.11
Kishimoto, T.12
Tsukada, S.13
-
90
-
-
10544219605
-
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
-
Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, Scaife R, Margolis RL, Gigg R, Smith CIE, Driscoll PC, Waterfield MD, Panayotou G. 1996. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J. 15:6241-50
-
(1996)
EMBO J.
, vol.15
, pp. 6241-6250
-
-
Salim, K.1
Bottomley, M.J.2
Querfurth, E.3
Zvelebil, M.J.4
Gout, I.5
Scaife, R.6
Margolis, R.L.7
Gigg, R.8
Smith, C.I.E.9
Driscoll, P.C.10
Waterfield, M.D.11
Panayotou, G.12
-
91
-
-
0031471231
-
Phosphatidylinositol 3-kinase-γ activates Bruton's tyrosine kinase in concert with Src family kinases
-
Li Z, Wahl MI, Eguinoa A, Stephens LR, Hawkins PT, Witte ON. 1997. Phosphatidylinositol 3-kinase-γ activates Bruton's tyrosine kinase in concert with Src family kinases. Proc. Natl. Acad. Sci. USA 94:13820-25
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13820-13825
-
-
Li, Z.1
Wahl, M.I.2
Eguinoa, A.3
Stephens, L.R.4
Hawkins, P.T.5
Witte, O.N.6
-
92
-
-
0030826662
-
Src-induced activation of inducible T cell kinase (TTK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase
-
August A, Sadra A, Dupont B, Hanafusa H. 1997. Src-induced activation of inducible T cell kinase (TTK) requires phosphatidylinositol 3-kinase activity and the pleckstrin homology domain of inducible T cell kinase. Proc. Natl. Acad. Sci. USA 94:11227-32
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11227-11232
-
-
August, A.1
Sadra, A.2
Dupont, B.3
Hanafusa, H.4
-
93
-
-
0029670081
-
Phospholipase C-γ 1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk
-
Law C-L, Chandran KA, Sidorenko SP, Clark EA. 1996. Phospholipase C-γ 1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16:1305-15
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1305-1315
-
-
Law, C.-L.1
Chandran, K.A.2
Sidorenko, S.P.3
Clark, E.A.4
-
94
-
-
0028980409
-
Requirement of phospholipase C-γ 2 activation in surface IgM-induced B cell apoptosis
-
Takata M, Homma Y, Kurosaki T. 1995. Requirement of phospholipase C-γ 2 activation in surface IgM-induced B cell apoptosis. J. Exp. Med. 182:907-14
-
(1995)
J. Exp. Med.
, vol.182
, pp. 907-914
-
-
Takata, M.1
Homma, Y.2
Kurosaki, T.3
-
95
-
-
0032127159
-
BLNK: A central linker protein in B cell activation
-
Fu C, Turck C, Kurosaki T, Chan AC. 1998. BLNK: A central linker protein in B cell activation. Immunity 9:93-103
-
(1998)
Immunity
, vol.9
, pp. 93-103
-
-
Fu, C.1
Turck, C.2
Kurosaki, T.3
Chan, A.C.4
-
96
-
-
0032541388
-
SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
-
Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M. 1998. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J. Exp. Med. 188:791-95
-
(1998)
J. Exp. Med.
, vol.188
, pp. 791-795
-
-
Wienands, J.1
Schweikert, J.2
Wollscheid, B.3
Jumaa, H.4
Nielsen, P.J.5
Reth, M.6
-
97
-
-
0032498231
-
LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92:83-92
-
(1998)
Cell
, vol.92
, pp. 83-92
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
Trible, R.P.4
Samelson, L.E.5
-
98
-
-
0032489913
-
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
-
Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Tasken K, Imboden JB, Vaage JT. 1998. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J. Exp. Med. 187:1157-61
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1157-1161
-
-
Weber, J.R.1
Orstavik, S.2
Torgersen, K.M.3
Danbolt, N.C.4
Berg, S.F.5
Ryan, J.C.6
Tasken, K.7
Imboden, J.B.8
Vaage, J.T.9
-
100
-
-
0032055476
-
2+ following B-cell receptor activation
-
2+ following B-cell receptor activation. EMBO J. 17:1973-85
-
(1998)
EMBO J.
, vol.17
, pp. 1973-1985
-
-
Fluckiger, A.-C.1
Li, Z.2
Kato, R.M.3
Wahl, M.I.4
Ochs, H.D.5
Longnecker, R.6
Kinet, J.-P.7
Witte, O.N.8
Scharenberg, A.M.9
Rawlings, D.J.10
-
101
-
-
0032543221
-
T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells
-
Liu K-Q, Bunnell SC, Gurniak CB, Berg LJ. 1998. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J. Exp. Med. 187:1721-27
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1721-1727
-
-
Liu, K.-Q.1
Bunnell, S.C.2
Gurniak, C.B.3
Berg, L.J.4
-
102
-
-
0032518666
-
Activation of phospholipase Cγ by P13-kinase-induced PH domain-mediated membrane targeting
-
Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J. 1998. Activation of phospholipase Cγ by P13-kinase-induced PH domain-mediated membrane targeting. EMBO J. 17:414-22
-
(1998)
EMBO J.
, vol.17
, pp. 414-422
-
-
Falasca, M.1
Logan, S.K.2
Lehto, V.P.3
Baccante, G.4
Lemmon, M.A.5
Schlessinger, J.6
-
103
-
-
0032076954
-
CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav
-
O'Rourke LM, Tooze R, Turner M, Sandoval DM, Carter RH, Tybulewicz VLJ, Fearon DT. 1998. CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. Immunity 8:635-45
-
(1998)
Immunity
, vol.8
, pp. 635-645
-
-
O'Rourke, L.M.1
Tooze, R.2
Turner, M.3
Sandoval, D.M.4
Carter, R.H.5
Tybulewicz, V.L.J.6
Fearon, D.T.7
-
104
-
-
0031007450
-
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B cell antigen receptor
-
Sugawara H, Kurosaki M, Takata M, Kurosaki T. 1997. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B cell antigen receptor. EMBO J. 16:3078-88
-
(1997)
EMBO J.
, vol.16
, pp. 3078-3088
-
-
Sugawara, H.1
Kurosaki, M.2
Takata, M.3
Kurosaki, T.4
-
106
-
-
0032580202
-
Calcium oscillations increase the efficiency and specificity of gene expression
-
Dolmetsch RE, Xu K, Lewis R. 1998. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392:933-36
-
(1998)
Nature
, vol.392
, pp. 933-936
-
-
Dolmetsch, R.E.1
Xu, K.2
Lewis, R.3
-
108
-
-
0029975479
-
Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation
-
Jayaraman T, Ondrias K, Ondriasova E, Marks AR. 1996. Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation. Science 272:1492-94
-
(1996)
Science
, vol.272
, pp. 1492-1494
-
-
Jayaraman, T.1
Ondrias, K.2
Ondriasova, E.3
Marks, A.R.4
-
109
-
-
0028002840
-
Both phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells
-
Gold MR, Aehersold R. 1994. Both phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells. J. Immunol. 152:42-50
-
(1994)
J. Immunol.
, vol.152
, pp. 42-50
-
-
Gold, M.R.1
Aehersold, R.2
-
110
-
-
0030068527
-
Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line
-
Beckwith M, Fenton RG, Katona IM, Longo DL. 1996. Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line. Blood 87:202-10
-
(1996)
Blood
, vol.87
, pp. 202-210
-
-
Beckwith, M.1
Fenton, R.G.2
Katona, I.M.3
Longo, D.L.4
-
111
-
-
0027169534
-
CD19 of B cells as a surrogate kinase insert region to bind phophatidylinositol 3-kinase
-
Tuveson DA, Carter RH, Soltoff SP, Fearon DT. 1993. CD19 of B cells as a surrogate kinase insert region to bind phophatidylinositol 3-kinase. Science 260:986-89
-
(1993)
Science
, vol.260
, pp. 986-989
-
-
Tuveson, D.A.1
Carter, R.H.2
Soltoff, S.P.3
Fearon, D.T.4
-
112
-
-
0028198388
-
Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit
-
Pleiman CM, Hertz WM, Cambier JC. 1994. Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263:1609-12
-
(1994)
Science
, vol.263
, pp. 1609-1612
-
-
Pleiman, C.M.1
Hertz, W.M.2
Cambier, J.C.3
-
113
-
-
0029978202
-
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
-
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G. 1996. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Proc. Natl Acad. Sci. USA 93:1689-93
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1689-1693
-
-
Damen, J.E.1
Liu, L.2
Rosten, P.3
Humphries, R.K.4
Jefferson, A.B.5
Majerus, P.W.6
Krystal, G.7
-
114
-
-
2642684541
-
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
-
Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK. 1998. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes & Dev. 12:1610-20
-
(1998)
Genes & Dev.
, vol.12
, pp. 1610-1620
-
-
Helgason, C.D.1
Damen, J.E.2
Rosten, P.3
Grewal, R.4
Sorensen, P.5
Chappel, S.M.6
Borowski, A.7
Jirik, F.8
Krystal, G.9
Humphries, R.K.10
-
115
-
-
0031033886
-
Co-ligation of the Antigen and Fc receptors give rise to the selective modulation of intracellular signaling in B cells
-
Kiener PA, Liboubin MN, Rohrschneider LR, Ledbetter JA, Nadler SG, Diegel ML. 1997. Co-ligation of the Antigen and Fc receptors give rise to the selective modulation of intracellular signaling in B cells. J. Biol. Chem. 272:3838-44
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3838-3844
-
-
Kiener, P.A.1
Liboubin, M.N.2
Rohrschneider, L.R.3
Ledbetter, J.A.4
Nadler, S.G.5
Diegel, M.L.6
-
116
-
-
0032055485
-
SHIP Modulates immune receptor responses by regulating membrane association of Btk
-
Bolland S, Pearse R, Kurosaki T, Ravetch JV. 1998. SHIP Modulates immune receptor responses by regulating membrane association of Btk. Immunity 8:509-16
-
(1998)
Immunity
, vol.8
, pp. 509-516
-
-
Bolland, S.1
Pearse, R.2
Kurosaki, T.3
Ravetch, J.V.4
-
118
-
-
0028832658
-
Signal transduction in T lymphocytes using a conditional allele of Sos
-
Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR. 1995. Signal transduction in T lymphocytes using a conditional allele of Sos. Proc. Natl. Acad. Sci. USA 92:9810-14
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 9810-9814
-
-
Holsinger, L.J.1
Spencer, D.M.2
Austin, D.J.3
Schreiber, S.L.4
Crabtree, G.R.5
-
119
-
-
0032487507
-
2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor
-
2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J. Exp. Med. 188:1287-95
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1287-1295
-
-
Hashimoto, A.1
Okada, H.2
Jiang, A.3
Kurosaki, M.4
Greenberg, S.5
Clark, E.A.6
Kurosaki, T.7
-
121
-
-
0029768637
-
B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins
-
Ingham RJ, Krebs DL, Barbazuk SM, Turck CW, Hirai H, Matsuda M, Gold MR. 1996. B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins. J. Biol. Chem. 271:32306-14
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32306-32314
-
-
Ingham, R.J.1
Krebs, D.L.2
Barbazuk, S.M.3
Turck, C.W.4
Hirai, H.5
Matsuda, M.6
Gold, M.R.7
-
122
-
-
0029928127
-
Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors
-
Smit L, van der Horst G, Borst J. 1996. Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors. J. Biol. Chem. 271:8564-69
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8564-8569
-
-
Smit, L.1
Van Der Horst, G.2
Borst, J.3
-
123
-
-
0030221148
-
Interactions between Ras proteins and their effectors
-
McCormick F, Wittinghofer A. 1996. Interactions between Ras proteins and their effectors. Curr. Opin. Biotechnol. 7:449-56
-
(1996)
Curr. Opin. Biotechnol.
, vol.7
, pp. 449-456
-
-
McCormick, F.1
Wittinghofer, A.2
-
124
-
-
0029051695
-
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase
-
Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H. 1995. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J. Biol. Chem. 270:19141-50
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19141-19150
-
-
Fukazawa, T.1
Reedquist, K.A.2
Trub, T.3
Soltoff, S.4
Panchamoorthy, G.5
Druker, B.6
Cantley, L.7
Shoelson, S.E.8
Band, H.9
-
125
-
-
0029670779
-
lyn, in the B cell antigen receptor-mediated signaling
-
lyn, in the B cell antigen receptor-mediated signaling. J. Exp. Med. 183:675-80
-
(1996)
J. Exp. Med.
, vol.183
, pp. 675-680
-
-
Tezuka, T.1
Umemori, H.2
Fusaki, N.3
Yagi, T.4
Takata, M.5
Kurosaki, T.6
Yamamoto, T.7
-
126
-
-
0029852837
-
Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells
-
Ota Y, Beitz LO, Scharenberg AM, Donovan JA, Kinet J-P, Samelson LE. 1996. Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. J. Exp. Med. 184:1713-23
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1713-1723
-
-
Ota, Y.1
Beitz, L.O.2
Scharenberg, A.M.3
Donovan, J.A.4
Kinet, J.-P.5
Samelson, L.E.6
-
130
-
-
0031459864
-
dok: A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myclogcnous leukemia progenitor cells
-
dok: a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myclogcnous leukemia progenitor cells. Cell 88:197-204
-
(1997)
Cell
, vol.88
, pp. 197-204
-
-
Carpino, N.1
Wisniewski, D.2
Strife, A.3
Marshak, D.4
Kobayashi, R.5
Stillman, B.6
Clarkson, B.7
-
131
-
-
0031444245
-
Identification of the Abl-and rasGAP-associated 62 kDa protein as a docking protein Dok
-
Yamanashi Y, Baltimore D. 1997. Identification of the Abl-and rasGAP-associated 62 kDa protein as a docking protein Dok. Cell 88:205-11
-
(1997)
Cell
, vol.88
, pp. 205-211
-
-
Yamanashi, Y.1
Baltimore, D.2
-
132
-
-
0028956337
-
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
-
Tarakhovsky A, Turner M, Schaal S, Mee PJ, Duddy LP, Rajewsky K, Tybulewicz VLJ. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374:467-70
-
(1995)
Nature
, vol.374
, pp. 467-470
-
-
Tarakhovsky, A.1
Turner, M.2
Schaal, S.3
Mee, P.J.4
Duddy, L.P.5
Rajewsky, K.6
Tybulewicz, V.L.J.7
-
133
-
-
0028915948
-
Defective signalling through the T-and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
-
Zhang R, Alt FW, Davidzon L, Orkin SH, Swat W. 1995. Defective signalling through the T-and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470-73
-
(1995)
Nature
, vol.374
, pp. 470-473
-
-
Zhang, R.1
Alt, F.W.2
Davidzon, L.3
Orkin, S.H.4
Swat, W.5
-
135
-
-
13144259727
-
Vav is regulator of cytoskeletal reorganization mediated by the T-cell receptor
-
Fischer K-D, Kong Y-Y, Nishina H, Tedford K, Marengere LEM, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. 1998. Vav is regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr. Biol. 8:554-62
-
(1998)
Curr. Biol.
, vol.8
, pp. 554-562
-
-
Fischer, K.-D.1
Kong, Y.-Y.2
Nishina, H.3
Tedford, K.4
Marengere, L.E.M.5
Kozieradzki, I.6
Sasaki, T.7
Starr, M.8
Chan, G.9
Gardener, S.10
Nghiem, M.P.11
Bouchard, D.12
Barbacid, M.13
Bernstein, A.14
Penninger, J.M.15
-
136
-
-
0032493028
-
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
-
Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidzon L, Lweis RS, Alt FW, Crabtree GR. 1998. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr. Biol. 8:563-72
-
(1998)
Curr. Biol.
, vol.8
, pp. 563-572
-
-
Holsinger, L.J.1
Graef, I.A.2
Swat, W.3
Chi, T.4
Bautista, D.M.5
Davidzon, L.6
Lweis, R.S.7
Alt, F.W.8
Crabtree, G.R.9
-
137
-
-
0031033292
-
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
-
Crespo P, Schuebel KE, Ostrom AA, Gutkind JS, Bustelo XR. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385: 169-72
-
(1997)
Nature
, vol.385
, pp. 169-172
-
-
Crespo, P.1
Schuebel, K.E.2
Ostrom, A.A.3
Gutkind, J.S.4
Bustelo, X.R.5
-
138
-
-
0001584956
-
Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
-
Wu J, Motto DG, Koretzky GA, Weiss A. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4:593-602
-
(1996)
Immunity
, vol.4
, pp. 593-602
-
-
Wu, J.1
Motto, D.G.2
Koretzky, G.A.3
Weiss, A.4
-
139
-
-
0030499383
-
Functional and physical interactions of Syk-family kinases with the Vav protooncogene product
-
Deckert M, Tartare-Deckert S, Couture C, Mustelin T, Altman A. 1996. Functional and physical interactions of Syk-family kinases with the Vav protooncogene product. Immunity 5:591-604
-
(1996)
Immunity
, vol.5
, pp. 591-604
-
-
Deckert, M.1
Tartare-Deckert, S.2
Couture, C.3
Mustelin, T.4
Altman, A.5
-
140
-
-
15144353776
-
Role of substrates and products of PI3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
-
Han J, Luby-Phelps K, Das K, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D. 1998. Role of substrates and products of PI3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-60
-
(1998)
Science
, vol.279
, pp. 558-560
-
-
Han, J.1
Luby-Phelps, K.2
Das, K.3
Shu, X.4
Xia, Y.5
Mosteller, R.D.6
Krishna, U.M.7
Falck, J.R.8
White, M.A.9
Broek, D.10
-
141
-
-
0032146170
-
Characterization of the Wiskott-Aldrich syndrome protein and its role in the disease
-
Nonoyama S, Ochs UD. 1998. Characterization of the Wiskott-Aldrich syndrome protein and its role in the disease. Curr. Opin. Immunol. 10:407-12
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 407-412
-
-
Nonoyama, S.1
Ochs, U.D.2
-
142
-
-
0030006284
-
Wiskott-Aldrich syndrome protein, a novel effector for the GTPasa CDC42Hs, is implicated in actin polymerization
-
Symons M, Derry JMJ, Karlark B, Jiang S, Lemahieu V, McCormick F, Francke U, Abo A. 1996. Wiskott-Aldrich syndrome protein, a novel effector for the GTPasa CDC42Hs, is implicated in actin polymerization. Cell 84:723-34
-
(1996)
Cell
, vol.84
, pp. 723-734
-
-
Symons, M.1
Derry, J.M.J.2
Karlark, B.3
Jiang, S.4
Lemahieu, V.5
McCormick, F.6
Francke, U.7
Abo, A.8
-
143
-
-
0026575932
-
The mechanism of action of cyclosporin A and FK506
-
Schreiber SL, Crabtree GR. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today. 13:136-42
-
(1992)
Immunol. Today
, vol.13
, pp. 136-142
-
-
Schreiber, S.L.1
Crabtree, G.R.2
-
144
-
-
0028450096
-
Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4
-
Choi MSK, Brines RD, Holman MJ, Klaus GGB. 1994. Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4. Immunity 1:179-87
-
(1994)
Immunity
, vol.1
, pp. 179-187
-
-
Choi, M.S.K.1
Brines, R.D.2
Holman, M.J.3
Klaus, G.G.B.4
-
145
-
-
0028445321
-
Cyclosporin-A sensitive induction of NF-AT in murine B cells
-
Ventakaraman L, Francis DA, Wang Z, Liu J, Rothstein TL, Sen R. 1994. Cyclosporin-A sensitive induction of NF-AT in murine B cells. Immunity 1:189-96
-
(1994)
Immunity
, vol.1
, pp. 189-196
-
-
Ventakaraman, L.1
Francis, D.A.2
Wang, Z.3
Liu, J.4
Rothstein, T.L.5
Sen, R.6
-
146
-
-
0028286517
-
Cyclosporin A and FK506 inhibit activation-induced death in the murine WEHI-231 B cell line
-
Genestier L, Dearden-Badet MT, Bonnefoy-Berard N, Lizard G, Revillard JP. 1994. Cyclosporin A and FK506 inhibit activation-induced death in the murine WEHI-231 B cell line. Cell Immunol. 155:283-91
-
(1994)
Cell Immunol.
, vol.155
, pp. 283-291
-
-
Genestier, L.1
Dearden-Badet, M.T.2
Bonnefoy-Berard, N.3
Lizard, G.4
Revillard, J.P.5
-
147
-
-
0030459830
-
Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes
-
Graves JD, Draves KE, Craxton A, Saklatvala J, Krebs EG, Clark EA. 1996. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc. Natl. Acad. Sci. USA 93:13814-18
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13814-13818
-
-
Graves, J.D.1
Draves, K.E.2
Craxton, A.3
Saklatvala, J.4
Krebs, E.G.5
Clark, E.A.6
-
148
-
-
0032577673
-
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1
-
Zhu J, Shibasaki F, Price R, Guillemot J-C, Yano T, Dotsch V, Wagner G, Ferrara P, McKeon F. 1998. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 93:851-61
-
(1998)
Cell
, vol.93
, pp. 851-861
-
-
Zhu, J.1
Shibasaki, F.2
Price, R.3
Guillemot, J.-C.4
Yano, T.5
Dotsch, V.6
Wagner, G.7
Ferrara, P.8
McKeon, F.9
-
149
-
-
0030899131
-
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction
-
Beals CR, Clipstone NA, Ho SN, Crabtree GR. 1997. Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes & Dev. 11:824-34
-
(1997)
Genes & Dev.
, vol.11
, pp. 824-834
-
-
Beals, C.R.1
Clipstone, N.A.2
Ho, S.N.3
Crabtree, G.R.4
-
150
-
-
0030890234
-
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
-
Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. 1997. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275:1930-33
-
(1997)
Science
, vol.275
, pp. 1930-1933
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
151
-
-
0029086739
-
Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate
-
Fukuda T, Kitamura D, Taniuchi I, Maekawa Y, Benhamou LE, Sarthou P, Watanabe T. 1995. Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate. Proc. Natl. Acad. Sci. USA 92:7302-6
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7302-7306
-
-
Fukuda, T.1
Kitamura, D.2
Taniuchi, I.3
Maekawa, Y.4
Benhamou, L.E.5
Sarthou, P.6
Watanabe, T.7
-
152
-
-
0030894868
-
Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis
-
Yamanashi Y, FukudaT, Nishizumi H, Inazu T, Higashi K, Kitamura D, Ishida T, Yamamura H, Watanabe T, Yamamoto T. 1997. Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J. Exp. Med. 185:1387-92
-
(1997)
J. Exp. Med.
, vol.185
, pp. 1387-1392
-
-
Yamanashi, Y.1
Nishizumi, H.2
Inazu, T.3
Higashi, K.4
Kitamura, D.5
Ishida, T.6
Yamamura, H.7
Watanabe, T.8
Yamamoto, T.9
-
153
-
-
0029739626
-
Immunodeficiency in protein kinase Cβ-deficient mice
-
Leitges M, Schmedt C, Guinamard R, Davoust J, Schaal S, Stable S, Tarakhovsky A. 1996. Immunodeficiency in protein kinase Cβ-deficient mice. Science 273:788-91
-
(1996)
Science
, vol.273
, pp. 788-791
-
-
Leitges, M.1
Schmedt, C.2
Guinamard, R.3
Davoust, J.4
Schaal, S.5
Stable, S.6
Tarakhovsky, A.7
-
154
-
-
0030273388
-
Protein kinase Cμ (PKCμ) associates with the B cell antigen receptor complex and regulates lymphocyte signaling
-
Sidorenko SP, Law C-L, Klaus SJ, Chandran KA, Takata M, Kurosaki T, Clark EA. 1996. Protein kinase Cμ (PKCμ) associates with the B cell antigen receptor complex and regulates lymphocyte signaling. Immunity 5:353-63
-
(1996)
Immunity
, vol.5
, pp. 353-363
-
-
Sidorenko, S.P.1
Law, C.-L.2
Klaus, S.J.3
Chandran, K.A.4
Takata, M.5
Kurosaki, T.6
Clark, E.A.7
-
155
-
-
0030907987
-
P13K: Downstream AKTion blocks apoptosis
-
Franke TF, Kaplan DR, Cantley LC. 1997. P13K: downstream AKTion blocks apoptosis. Cell 88:435-37
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
156
-
-
0031053360
-
Akt signaling: Linking membrane events to life and death decisions
-
Hammings BA. 1997. Akt signaling: linking membrane events to life and death decisions. Science 275:028-30
-
(1997)
Science
, vol.275
, pp. 28-30
-
-
Hammings, B.A.1
-
157
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
Stokoe D, Stephens LR, Copeland T, Gaffney PRJ, Reese CB, Painter GF, Holmes AB, McCormic F, Hawkins PT. 1997. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567-70
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.J.4
Reese, C.B.5
Painter, G.F.6
Holmes, A.B.7
McCormic, F.8
Hawkins, P.T.9
-
158
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-89
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
159
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-41
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
160
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-89
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
161
-
-
0030783156
-
The search for physiological substrates of MAP and SAP kinases in mammalian cells
-
Cohen P. 1997. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7:353-61
-
(1997)
Trends Cell Biol.
, vol.7
, pp. 353-361
-
-
Cohen, P.1
-
162
-
-
0031909355
-
Cooperation between Syk and Rac I leads to synergistic JNK activation in T lymphocytes
-
Jacinto E, Werlen G, Karin M. 1998. Cooperation between Syk and Rac I leads to synergistic JNK activation in T lymphocytes. Immunity 8:31-41
-
(1998)
Immunity
, vol.8
, pp. 31-41
-
-
Jacinto, E.1
Werlen, G.2
Karin, M.3
-
163
-
-
0032101707
-
Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes
-
Werlen G, Jacinto E, Xia Y, Karin M, 1998. Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101-11
-
(1998)
EMBO J.
, vol.17
, pp. 3101-3111
-
-
Werlen, G.1
Jacinto, E.2
Xia, Y.3
Karin, M.4
-
164
-
-
0029835940
-
Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fcγ RIIB
-
Ono M, Holland S, Tempst P, Ravetch JV. 1996. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fcγ RIIB. Nature 383:263-66
-
(1996)
Nature
, vol.383
, pp. 263-266
-
-
Ono, M.1
Holland, S.2
Tempst, P.3
Ravetch, J.V.4
-
165
-
-
0343307005
-
Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling
-
Ono M, Okada H, Holland S, Yanagi S, Kurosaki T, Ravetch JV. 1997. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling. Cell 90:293-301
-
(1997)
Cell
, vol.90
, pp. 293-301
-
-
Ono, M.1
Okada, H.2
Holland, S.3
Yanagi, S.4
Kurosaki, T.5
Ravetch, J.V.6
-
166
-
-
0032055484
-
3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory
-
Z. L
-
3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory. EMBO J. 17: 1961-72
-
(1998)
EMBO J.
, vol.17
, pp. 1961-1972
-
-
Scharenberg, A.M.1
El-Hillal, O.2
Fruman, D.A.3
Beitz, L.O.4
Lin, S.5
Gout, I.6
Cantley, L.C.7
Rawlings, D.J.8
Kinet, J.-P.9
-
168
-
-
0032478126
-
The paired lg-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1
-
Blery M, Kubagawa H, Chen C-C, Vely F, Cooper MD, Vivier E. 1998. The paired lg-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA 95:2446-51
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2446-2451
-
-
Blery, M.1
Kubagawa, H.2
Chen, C.-C.3
Vely, F.4
Cooper, M.D.5
Vivier, E.6
-
169
-
-
0007955546
-
Requirement of tyrosine phosphatase SHP-1 and SHP-2 for PIR-B-mediated inhibitory signal
-
Maeda A, Kurosaki M, Ono M, Takai T, Kurosaki T. 1998. Requirement of tyrosine phosphatase SHP-1 and SHP-2 for PIR-B-mediated inhibitory signal. J. Exp. Med. 187:1335-60
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1335-1360
-
-
Maeda, A.1
Kurosaki, M.2
Ono, M.3
Takai, T.4
Kurosaki, T.5
-
170
-
-
0025971175
-
Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated difference in trans-membrane signaling in splenic B cells from adult and neonatal mice
-
Yellen AJ, Glenn W, Sukhatme VP, Cao SM, Monroe JG. 1991. Signaling through surface IgM in tolerance-susceptible immature murine B lymphocytes. Developmentally regulated difference in trans-membrane signaling in splenic B cells from adult and neonatal mice. J. Immunol. 146:1446-54
-
(1991)
J. Immunol.
, vol.146
, pp. 1446-1454
-
-
Yellen, A.J.1
Glenn, W.2
Sukhatme, V.P.3
Cao, S.M.4
Monroe, J.G.5
-
171
-
-
0025221021
-
Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction
-
Seyfert VL, McMohan SB, Glenn WD, Yellen AJ, Sukhatme VP, Cao X, Monroe JG. 1990. Methylation of an immediate-early inducible gene as a mechanism for B cell tolerance induction. Science 250:797-800
-
(1990)
Science
, vol.250
, pp. 797-800
-
-
Seyfert, V.L.1
McMohan, S.B.2
Glenn, W.D.3
Yellen, A.J.4
Sukhatme, V.P.5
Cao, X.6
Monroe, J.G.7
-
172
-
-
0026041119
-
Peripheral deletion of self-reactive B cells
-
Russell DM, Dembic Z, Morahan G, Miller JFAP, Bürki K, Nemazee D. 1991. Peripheral deletion of self-reactive B cells. Nature 354:308-11
-
(1991)
Nature
, vol.354
, pp. 308-311
-
-
Russell, D.M.1
Dembic, Z.2
Morahan, G.3
Miller, J.F.A.P.4
Bürki, K.5
Nemazee, D.6
-
173
-
-
0025948793
-
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
-
Hartley SB, Crosbie J, Brink R, Kantor AA, Basten A, Goodnow CC. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens, Nature 353:765-68
-
(1991)
Nature
, vol.353
, pp. 765-768
-
-
Hartley, S.B.1
Crosbie, J.2
Brink, R.3
Kantor, A.A.4
Basten, A.5
Goodnow, C.C.6
-
174
-
-
0026518481
-
A transgenic model of autoimmune hemolytic anemia
-
Okamoto M, Murakami M, Shimizu A, Ozaki S, Tsubata K, Kumagai S, Honjo T. 1992. A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175:71-79
-
(1992)
J. Exp. Med.
, vol.175
, pp. 71-79
-
-
Okamoto, M.1
Murakami, M.2
Shimizu, A.3
Ozaki, S.4
Tsubata, K.5
Kumagai, S.6
Honjo, T.7
-
175
-
-
0028850944
-
The site and stage of anti-DNA B-cell deletion
-
Chen C, Nagy Z, Radic M, Hardy R, Huzar D, Camper SA, Weight M. 1995. The site and stage of anti-DNA B-cell deletion. Nature 373:252-55
-
(1995)
Nature
, vol.373
, pp. 252-255
-
-
Chen, C.1
Nagy, Z.2
Radic, M.3
Hardy, R.4
Huzar, D.5
Camper, S.A.6
Weight, M.7
-
176
-
-
0032559223
-
Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection
-
Melamed D, Benschop RJ, Gambier JC, Nemazec D. 1998. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell 92:173-82
-
(1998)
Cell
, vol.92
, pp. 173-182
-
-
Melamed, D.1
Benschop, R.J.2
Gambier, J.C.3
Nemazec, D.4
-
177
-
-
0030966218
-
Different nuclear signals are activated by the B cell receptor during positive versus nagative signaling
-
Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crahtree GR, Lewis RS, Goodnow CC. 1997. Different nuclear signals are activated by the B cell receptor during positive versus nagative signaling. Immunity 6:419-28
-
(1997)
Immunity
, vol.6
, pp. 419-428
-
-
Healy, J.I.1
Dolmetsch, R.E.2
Timmerman, L.A.3
Cyster, J.G.4
Thomas, M.L.5
Crahtree, G.R.6
Lewis, R.S.7
Goodnow, C.C.8
-
178
-
-
0028127965
-
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells
-
Cooke MP, W. HA, Shokat KM, Zeng Y, Finkelman FD, Linsely PS, Howard M, Goodnow CC. 1994. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179:425-38
-
(1994)
J. Exp. Med.
, vol.179
, pp. 425-438
-
-
Cooke, M.P.1
Ha, W.2
Shokat, K.M.3
Zeng, Y.4
Finkelman, F.D.5
Linsely, P.S.6
Howard, M.7
Goodnow, C.C.8
-
179
-
-
0029847936
-
Evidence for a preformed transducer complex organized by the B cell antigen receptor
-
Wienands J, Larbolette O, Reth M. 1996. Evidence for a preformed transducer complex organized by the B cell antigen receptor. Proc. Natl. Acad. Sci. USA 93:7865-70
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7865-7870
-
-
Wienands, J.1
Larbolette, O.2
Reth, M.3
-
180
-
-
0032503687
-
PtdIns-3,4,5-P3: A regulatory nexus between tirosine kinases and sustained calcium signals
-
Scharenberg AM, Kinet J-P. 1998. PtdIns-3,4,5-P3: a regulatory nexus between tirosine kinases and sustained calcium signals. Cell 94:5-8
-
(1998)
Cell
, vol.94
, pp. 5-8
-
-
Scharenberg, A.M.1
Kinet, J.-P.2
-
182
-
-
0033535614
-
Paired Immunoglobulin-like receptor B (PTR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
-
in press
-
Maeda A, Scharenberg AM, Tsukada S, Bolen JB, Kinet J-P, Kurosaki T. 1999. Paired Immunoglobulin-like receptor B (PTR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene (in press)
-
(1999)
Oncogene
-
-
Maeda, A.1
Scharenberg, A.M.2
Tsukada, S.3
Bolen, J.B.4
Kinet, J.-P.5
Kurosaki, T.6
|