The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival

Journal of Experimental Medicine

Volumn 195, Issue 1, 2002, Pages 143-149

  Niiro, Hiroaki ^a   Maeda, Akito ^b   Kurosaki, Tomohiro ^b   Clark, Edward A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Adaptor protein; Cell death; Germinal center; PH domain; Signal transduction

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN BAM 32; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CALCIUM MOBILIZATION; CELL DEATH; CELL SURVIVAL; CHICKEN; GERMINAL CENTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; BLOOD PROTEINS; CALCIUM SIGNALING; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CHICKENS; DNA-BINDING PROTEINS; GERMINAL CENTER; ISOENZYMES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, B-CELL; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0037033384     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20011524     Document Type: Article

References (32)

1. Regulation of B-cell activation and differentiation by the phosphatidytinositol 3-kinase and phospholipase Cγ pathways
2. B cell development: Signal transduction by antigen receptors and their surrogates
3. Genetic analysis or B cell antigen receptor signaling
4. A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase
5. DAPP1: A dual adaptor for phosphotyrosine and 3-phosphoinositides
6. Expression cloning of protein targets for 3-phosphorylated phosphoinositides
7. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells
8. 2+ mobilization through distinct pathways
9. Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B
10. Requirement of phosphotipase C-γ2 activation in surface immunoglobutin M-induced B cell apoptosis
11. Essential role of phospholipase C-γ2 in B cell development and function
12. PtdIns-3,4,5-P3: A regulatory, nexus between tyrosine kinases and sustained calcium signals
13. Phospholipase C-γ as a signal-transducing element
14. Mitogen-activated protein kinase cascades and regulation of gene expression
15. Involvement of guanosine triphosphatases and phospholipase C-γ2 in extracellular signal-regulated kinase, c-jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor
16. Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase
17. B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase
18. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
19. Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin
20. NFATc1 and NFATc2 together control both T and B cell activation and differentiation
21. Transcriptional regulation of B-cell differentiation
22. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-triphosphate receptors in signal transduction through the B-cell antigen receptor
23. Phospholipase C-γ2 couples Bruton's tyrosine kinase to the NF-kB signaling pathway in B tymphocytes
24. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
25. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell response to antigen
26. MEK kinase activity is not necessary, for Raf-1 function
27. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
28. Phosphorylarion of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
29. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
30. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
31. Regulatory and signaling properties of the Vav family
32. Mechanism of antigen-driven selection in germinal centres