The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

Journal of Immunology

Volumn 168, Issue 7, 2002, Pages 3376-3386

  Croker, Ben A ^a   Tarlinton, David M ^a   Cluse, Leonie A ^a   Tuxen, Alana J ^a   Light, Amanda ^a   Yang, Feng Chun ^a   Williams, David A ^a   Roberts, Andrew W ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; GUANOSINE TRIPHOSPHATASE; RAC2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL KINETICS; CELL MATURATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; MOUSE; NONHUMAN; PERITONEAL CAVITY; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0036533662     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.7.3376     Document Type: Article

References (55)

1. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
2. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
3. Aberrant B cell development and immune response in mice with a compromised BCR complex
4. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool
5. Most peripheral B cells in mice are ligand selected
6. A B-cell receptor-specific selection step governs immature to mature B cell differentiation
7. Mutations affecting either generation or survival of cells influence the pool size of mature B cells
8. Transitional B cells are the target of negative selection in the B cell compartment
9. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
10. CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: Altered signaling in CD22-deficient mice
11. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
12. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
13. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21
14. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk
15. B-1 cells: Unique origins and functions
16. T-independent immune response: New aspects of B cell biology
17. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
18. The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice
19. The phenotype and fate of the antibody-forming cells of the splenic foci
20. Germinal centers: Form and function
21. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes
22. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement
23. B cell antigen receptor engagement inhibits stromal cellderived factor (SDF)-1α chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4
24. Rho GTPases and signaling networks
25. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation
26. The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments
27. A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells
28. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
29. Rac2 stimulates Akt activation affecting BAD/Bcl-xL expression while mediating survival and actin function in primary mast cells
30. Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
31. Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help
32. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
33. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene
34. The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens
35. Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinosital 3-kinase complex in human B cell precursors
36. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
37. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
38. The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection
39. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response
40. Genetic evidence for Lyn as a negative regulator of IL-4 signaling
41. Inhibition of the B cell by CD22: A requirement for Lyn
42. CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes
43. A chemokine-driven positive feedback loop organizes lymphoid follicles
44. A putative chemokine receptor, BLRI, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
45. Self-renewal of B-1 lymphocytes is dependent on CD19
46. CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity
47. CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling
48. CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav
49. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
50. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation
51. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
52. Alymphoplasia (aly)-type nuclear factor κB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system
53. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
54. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response
55. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers