The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: Rescue by over-expression of Bcl-2

European Journal of Immunology

Volumn 32, Issue 4, 2002, Pages 1029-1034

  Meade, Josephine ^a   Fernandez, Claire ^a   Turner, Martin ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

B lymphocyte development; Lyn tyrosine kinase; Transgenic knockout

Indexed keywords

B LYMPHOCYTE ANTIGEN; B7 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN IDIOTYPE; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BCL 2; PROTEIN TYROSINE KINASE;

ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW; CELL COUNT; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CLONAL DELETION; GENES, BCL-2; H-2 ANTIGENS; IMMUNE TOLERANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANTIGEN, B-CELL; RECOMBINANT FUSION PROTEINS; SPLEEN; SRC-FAMILY KINASES;

EID: 0036232606     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200204)32:4<1029::AID-IMMU1029>3.0.CO;2-M     Document Type: Article

References (25)

1. Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression
2. Differential responses of p56lyn and p53lyn, products of alternatively spliced lyn mRNA, on stimulation of B cell antigen receptor
3. Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases
4. Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases
5. Association of B cell antigen receptor with protein tyrosine kinase Lyn
6. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
7. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
8. Characterisation of the B lymphocyte populations in Lyn deficient mice and the role of Lyn in signal initiation and down-regulation
9. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting element of a biochemical pathway regulating BCR signaling and selection
10. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
11. A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals
12. Inhibition of the B cell by CD22: A requirement for Lyn
13. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
14. Peripheral deletion of self-reactive B cells
15. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
16. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
17. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells
18. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating pool
19. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways
20. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
21. Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification
22. Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted lg transgenes
23. B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection
24. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
25. Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice