Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase

Journal of Experimental Medicine

Volumn 188, Issue 7, 1998, Pages 1297-1306

  Jiang, Aimin ^a   Craxton, Andrew ^a   Kurosaki, Tomohiro ^b   Clark, Edward A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

B cell antigen receptor; Btk; Lyn; Mitogen activated protein kinase; Syk

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CHICKEN; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CELL LINE; CHICKENS; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 0032487580     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.7.1297     Document Type: Article

References (58)

1. Campbell, K.S., and J.C. Cambier. 1990. B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO (Eur. Mol. Biol. Organ.) J. 9:441-448.
2. Reth, M. 1992. Antigen receptors on B lymphocytes. Annu. Rev. Immunol. 10:97-121.
3. Bolen, J.B. 1990. Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr. Opin. Immunol. 7:306-311.
4. Sefton, B.M., and M.A. Campbell. 1991. The role of tyrosine protein phosphorylation in lymphocyte activation. Annu. Rev. Cell. Biol. 7:257-274.
5. Law, C.L., A. Craxton, K.L. Otipoby, S.P. Sidorenko, S.J. Klaus, and E.A. Clark. 1996. Regulation of signalling through B-lymphocyte antigen receptors by cell-cell interaction molecules. Immunol. Rev. 153:123-154.
6. Kurosaki, T. 1997. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9:309-318.
7. DeFranco, A.L. 1997. The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunol. 9:296-308.
8. Reth, M., and J. Wienands. 1997. Initiation and processing of signals from the B cell antigen receptor. Annu. Rev. Immunol. 15:453-479.
9. Treisman, R. 1996. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell. Biol. 8:205-215.
10. Su, B., and M. Karin. 1996. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8:402-411.
11. Boulton, T.G., S.H. Nye, D.J. Robbins, N.Y. Ip, E. Radziejewska, S.D. Morgenbesser, R.A. DePinho, N. Panayotatos, M.H. Cobb, and G.D. Yancopoulos. 1991. ERKs: a family of protein-serine/theonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65:663-675.
12. Ahn, N.G., R. Seger, R.L. Bratlien, C.D. Diltz, N.K. Tonks, and E.G. Krebs. 1991. Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J. Biol. Chem. 266:4220-4227.
13. D'Erijard, B., M. Hibi, I.H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R.J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1025-1037.
14. Kyriakis, J.M., P. Banerjee, E. Nikolakaki, T. Dai, E.A. Rubie, M.F. Ahmad, J. Avruch, and J.R. Woodgett. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:156-160.
15. Kallunki, T., B. Su, I. Tsigelny, H.K. Sluss, B. D'Erijard, G. Moore, R. Davis, and M. Karin. 1994. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8:2996-3007.
16. Han, J., J.D. Lee, L. Bibbs, and R.J. Ulevitch. 1994. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265:808-811.
17. Lee, J.C., J.T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Green, D. McNulty, M.J. Blumenthal, J.R. Heys, S.W. Landvatter, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:739-746.
18. Graves, J.D., K.E. Draves, A. Craxton, J. Saklatvala, E.G. Krebs, and E.A. Clark. 1996. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc. Natl. Acad. Sci. USA. 93:13814-13818.
19. Healy, J.I., R.E. Dolmetsch, L.A. Timmerman, J.G. Cyster, M.L. Thomas, G.R. Crabtree, R.S. Lewis, and C.C. Goodnow. 1997. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 6:419-428.
20. 2+ mobilization through distinct pathways. EMBO (Eur. Mol. Biol. Organ.) J. 13:1341-1349.
21. Takata, M., and T. Kurosaki. 1996. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J. Exp. Med. 184:31-40.
22. Chen, C.L., J.E. Lehmeyer, and M.D. Cooper. 1982. Evidence for an IgD homologue on chicken lymphocytes. J. Immunol. 129:2580-2585.
23. Berberich, I., G. Shu, F. Siebelt, J.R. Woodgett, J.M. Kyriakis, and E.A. Clark. 1996. Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBO (Eur. Mol. Biol. Organ.) J. 15:92-101.
24. Rabinovitch, P.S., C.H. June, A. Grossmann, and J.A. Ledbetter. 1986. Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry. J. Immunol. 137:952-961.
25. Casillas, A., C. Hanekom, K. Williams, R. Katz, and A.E. Nel. 1991. Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase. J. Biol. Chem. 266: 19088-19094.
26. Gold, M.R., J.S. Sanghera, J. Stewart, and S.L. Pelech. 1992. Selective activation of p42 mitogen-activated protein (MAP) kinase in murine B lymphoma cell lines by membrane immunoglobulin cross-linking. Evidence for protein kinase C-independent and -dependent mechanisms of activation. Biochem. J. 287:269-276.
27. Wilson, H.A., D. Greenblatt, M. Poenie, F.D. Finkelman, and R.Y. Tsien. 1987. Cross-linkage of B lymphocyte surface immunoglobulin by anti-Ig or antigen induces prolonged oscillation of intracellular ionized calcium. J. Exp. Med. 166:601-606.
28. Thastrup, O., A.P. Dawson, O. Scharff, B. Foder, P.J. Cullen, B.K. Drobak, P.J. Bjerrum, S.B. Christensen, and M.R. Hanley. 1989. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions. 27:17-23.
29. Tordai, A., R.A. Franklin, H. Patel, A.M. Gardner, G.L. Johnson, and E.W. Gelfand. 1994. Cross-linking of surface IgM stimulates the Ras/Raf-1/MEK/MAPK cascade in human B lymphocytes. J. Biol. Chem. 269:7538-7543.
30. Williams, S., C. Couture, J. Gilman, T. Jascur, M. Deckert, A. Altman, and T. Mustelin. 1997. Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk. Eur.J. Biochem. 245:84-90.
31. Kawauchi, K., A.H. Lazarus, J.S. Sanghera, G.L. Man, S.L. Pelech, and T.L. Delovitch. 1996. Regulation of BCR-and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities. Mol. Immunol. 33:287-296.
32. 2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J. Exp. Med. 188:1287-1295.
33. Chan, V.W., F. Meng, P. Soriano, A.L. DeFranco, and C.A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 7:69-81.
34. Katsuta, H., S. Tsuji, Y. Niho, T. Kurosaki, and D. Kitamura. 1998. Lyn-mediated down-regulation of B cell antigen receptor signaling: inhibition of protein kinase C activation by Lyn in a kinase-independent fashion. J. Immunol. 160: 1547-1551.
35. Sidorenko, S.P., C.L. Law, S.J. Klaus, K.A. Chandran, M. Takata, T. Kurosaki, and E.A. Clark. 1996. Protein kinase C mu (PKC mu) associates with the B cell antigen receptor complex and regulates lymphocyte signaling. Immunity. 5: 353-363.
36. Schonwasser, D.C., R.M. Marais, C.J. Marshall, and P.J. Parker. 1998. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol. 18:790-798.
37. Cano, E., and L.C. Mahadevan. 1995. Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20: 117-122.
38. Waskiewicz, A.J., and J.A. Cooper. 1995. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell. Biol. 7: 798-805.
39. Moriguchi, T., F. Toyoshima, N. Masuyama, H. Hanafusa, Y. Gotoh, and E. Nishida. 1997. A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO (Eur. Mol. Biol. Organ.) J. 16:7045-7053.
40. Minden, A., A. Lin, F.X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 81:1147-1157.
41. Coso, O.A., M. Chiariello, J.C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J.S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 81:1137-1146.
42. Sutherland, C.L., A.W. Heath, S.L. Pelech, P.R. Young, and M.R. Gold. 1996. Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor. J. Immunol. 157:3381-3390.
43. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and N.-Y. Ben. 1994. JNK is involved in signal integration during co-stimulation of T lymphocytes. Cell. 77:727-736.
44. Jacinto, E., G. Werlen, and M. Karin. 1998. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 8:31-41.
45. Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO (Eur. Mol. Biol. Organ.) J. 17:3101-3111.
46. Kawakami, Y., T. Miura, R. Bissonnette, D. Hata, W.N. Khan, T. Kitamura, Y.-M. Maeda, S.E. Hartman, L. Yao, F.W. Alt, and T. Kawakami. 1997. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc. Natl. Acad. Sci. USA. 94:3938-3942.
47. Gerwins, P., J.L. Blank, and G.L. Johnson. 1997. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 272:8288-8295.
48. Tsukada, S., D.C. Saffran, D.J. Rawlings, O. Parolini, R.C. Allen, I. Klisak, R.S. Sparkes, H. Kubagawa, T. Mohandas, S. Quan, et al. 1993. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell. 72:279-290.
49. Vetrie, D., I. Vorechovsky, P. Sideras, J. Holland, A. Davies, F. Flinter, L. Hammarstrom, C. Kinnon, R. Levinsky, M. Bobrow, et al. 1993. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature. 361:226-233.
50. Yao, L., Y. Kawakami, and T. Kawakami. 1994. The pleckstrin homology domain of Bruton's tyrosine kinase interacts with protein kinase C. Proc. Natl. Acad. Sci. USA. 91:9175-9179.
51. D'Erijard, B., J. Raingeaud, T. Barrett, I.H. Wu, J. Han, R.J. Ulevitch, and R.J. Davis. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 267:682-685.
52. Han, J., J.D. Lee, Y. Jiang, Z. Li, L. Feng, and R.J. Ulevitch. 1996. Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271:2886-2891.
53. Graves, J.D., Y. Gotoh, K.E. Draves, D. Ambrose, D.K.M. Han, M. Wright, J. Chernoff, E.A. Clark, and E.G. Krebs. 1998. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO (Eur. Mol. Biol. Organ). J. 17:2224-2234.
54. Rudel, T., F.T. Zenke, T.H. Chuang, and G.M. Bokoch. 1998. p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells. J. Immunol. 160:7-11.
55. VanParijs, L., and A.K. Abbas. 1998. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science. 280:243-248.
56. Graves, J.D., K.E. Draves, A. Craxton, E.G. Krebs, and E.A. Clark. 1998. A comparison of signaling requirements for apoptosis of human B lymphocytes induced by the B cell receptor and CD95/Fas. J. Immunol. 161:168-174.
57. Takata, M., Y. Homma, and T. Kurosaki. 1995. Requirement of phospholipase C-γ2 activation in surface immunoglobulin M-induced B cell apoptosis. J. Exp. Med. 182:907-914.
58. Uckun, F.M., K.G. Waddick, S. Mahajan, X. Jun, M. Takata, J. Bolen, and T. Kurosaki. 1996. BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells. Science. 273:1096-1100.