Cutting edge: Essential role of phospholipase C-γ2 in B cell development and function

Journal of Immunology

Volumn 165, Issue 4, 2000, Pages 1738-1742

  Hashimoto, A ^a   Takeda, K ^a   Inaba, M ^a   Sekimata, M ^a   Kaisho, T ^a   Ikehara, S ^a   Homma, Y ^a   Akira, S ^a   Kurosaki, T ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; B LYMPHOCYTE RECEPTOR; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL MATURATION; ENZYME ACTIVITY; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034663761     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.4.1738     Document Type: Article

References (24)

1. The complexity of signaling pathways activated by the BCR
2. Initiation and processing of signals from the B cell antigen receptor
3. Antigen receptor signaling: Integration of protein tyrosine kinase functions
4. Genetic analysis of B cell antigen receptor signaling
5. 2+ mobilization through distinct pathways
6. A role for Bruton's tyrosine kinase in B cell antigen receptor- mediated activation of phospholipase C-γ2
7. 2+ following B-cell receptor activation
8. Regulation of phosphoinositide-specific phospholipase C isozymes
9. Inositol trisphosphate and calcium signalling
10. Protein kinase C and lipid signaling for sustained cellular responses
11. Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development
12. Inducible gene targeting in mice
13. Defective B cell development and function in Btk-deficient mice
14. Impaired expansion of mouse B cell progenitors lacking Btk
15. Inactivation of BTK by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage
16. 2+ indicators with greatly improved fluorescence properties
17. Antitrinitrophenyl (TNP) plaque assay: Primary response of BALB/c mice to soluble and particulate immunogen
18. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
19. Abnormal development and Function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
20. Requirement for B cell linker protein (BLNK) in B cell development
21. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice
22. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
23. BLNK required for coupling Syk to PLCγ2 and Rac1-JNK in B cells
24. BLNK: Connecting Syk and Btk to calcium signals