Genes involved in the initiation of DNA replication in yeast

International Review of Cytology

Volumn 212, Issue , 2002, Pages 133-207

  Calzada, Arturo ^a   Bueno, Avelino ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Cell cycle; DNA replication initiators; Ploidy maintenance; Postreplicative complex; Prereplicative complex; Regulation of DNA replication; Replication origins

Indexed keywords

CELL CYCLE PROTEIN; CELL DNA; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLINE;

CELL CYCLE; DNA REPLICATION; DNA REPLICATION ORIGIN; DNA SYNTHESIS; GENE FUNCTION; GENE SEGREGATION; GENE STRUCTURE; NONHUMAN; PLOIDY; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EUKARYOTA; PROTISTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0036142122     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7696(01)12005-X     Document Type: Chapter

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74. Two steps in the assembly of complexes at yeast replication origins in vivo
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78. 1 transition in Saccharomyces cerevisiae
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82. The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle
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84. Large, complex modular structure of a fission yeast DNA replication origin
85. cdc2 phosphorylation is required for its interaction with cyclin
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87. Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase
88. Initiation of DNA replication in eukaryotic cells
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90. Regulation of transcription by proteins that control the cell cycle
91. Mapping of the human homologue (ORCIL) of the yeast origin recognition complex subunit I gene to chromosome band 1p32
92. Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases
93. Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis
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96. Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division
97. dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila
98. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Skip
99. Dbf4p, an essential S phasepromoting factor, is targeted for degradation by the anaphase-promoting complex
100. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae
101. The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage response
102. DNA replication. Almost licensed
103. The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins
104. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication
105. Replication profile of Saccharomyces cerevisiae chromosome VI
106. Cell cycle regulation of DNA replication initiation proteins in mammalian cells
107. Cell cycle and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase
108. Conserved initiator proteins in eukaryotes
109. A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis
110. Fine mapping of a replication origin of human DNA
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114. A Drosophila homolog of the yeast origin recognition complex
115. Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function
116. The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase
117. Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis
118. 2 phase" in Physarum polycephalum
119. The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1 + gene, encodes a subunit of the Cdc28 protein kinase complex
120. 1 phase in yeast
121. Identification of Cdc45p, an essential factor required for DNA replication
122. mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
123. Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae
124. Genetic control of the cell-division cycle in yeast. I. Detection of mutants
125. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle
126. Cell division from a genetic perspective
127. Genetic control of the cell division cycle in yeast
128. Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5′ end of the lactase gene on chromosome 2q21
129. Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F
130. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
131. An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments
132. Autonomous DNA replication in human cells is affected by the size and the source of the DNA
133. Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex
134. Subcellular localization of yeast CDC46 varies with the cell cycle
135. A group of interacting yeast DNA replication genes
136. DNA polymerase III: Running rings around the fork
137. Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; Patterns of splicing and homology to protein kinases
138. Suc1 + encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe
139. cdt1 is an essential target of the Cdc10/Sct1 transcription factor: Requirement for DNA replication and inhibition of mitosis
140. Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae
141. DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase
142. Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins
143. Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication
144. Characterization of a novel CDC gene (ORC1) partly homologous to CDC6 of Saccharomyces cerevisiae
145. The P1 family: A new class of nuclear mammalian proteins related to the yeast Mcm replication proteins
146. A role for Cdk2 kinase in negatively regulating DNA replication during S phase of the cell cycle
147. A DNA unwinding element and an ARS consensus comprise a replication origin within a yeast chromosome
148. The in vivo replication origin of the yeast 2 microns plasmid
149. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: Human homologue (ORC5L) maps to 7q22
150. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex
151. Biochemical function of mouse minichromosome maintenance 2 protein
152. Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA
153. The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase
154. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein
155. Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe
156. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
157. sud1(+) targets cyclin-dependent kinasephosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast
158. Inhibitory phosphorylation of the APC regulator HctI is controlled by the kinase Cdc28 and the phosphatase Cdc 14
159. Identification and characterization of a human protein kinase related to budding yeast Cdc7p
160. Cell size and budding during starvation of the yeast Saccharomyces cerevisiae
161. A further two mutants defective in initiation of the S phase in the yeast Saccharomyces cerevisiae
162. First the CDKs, now the DDKs
163. The Cdk-activating kinase (CAK) from budding yeast
164. MCM proteins: Evolution, properties, and role in DNA replication
165. The fission yeast cdc18 + gene product couples S phase to START and mitosis
166. Characterization of the yeast Cdc7p/Dbf4p complex purified from insect Cells. Its protein kinase activity is regulated by Rad53p
167. 1/S transition. Structure, chromosomal localization, and expression of mouse gene for S. cerevisiae Cdc7-related kinase
168. Multiple orientation-dependent, synergistically interacting, similar domains in the ribosomal DNA replication origin of the fission yeast, Schizosaccharomyces pombe
169. DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period
170. Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: Physical interaction between PI(MCM3) and CDC46 proteins
171. Mouse MCM proteins: Complex formation and transportation to the nucleus
172. How proteolysis drives the cell cycle
173. Replication in Saccharomyces cerevisiae of plasmid pBR313 carrying DNA from the yeast trpl region
174. 1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5
175. Replication structure of the human beta-globin gene domain
176. Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family
177. Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex
178. The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40S1C1
179. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation
180. 1 to S phase
181. Fission yeast WD-repeat protein pop 1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18
182. Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo- complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase
183. A common set of conserved motifs in a vast variety of putative nucleic acid dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication
184. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system
185. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
186. A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle
187. 1/S transition in mammalian cells
188. 1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
189. Uninterrupted MCM2-7 function required for DNA replication fork progression
190. The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle
191. 1 cyclin Cln2 induced by CDK-dependent phosphorylation
192. CpG islands as gene markers in the human genome
193. Emerging mechanisms of eukaryotic DNA replication initiation
194. Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein
195. Architecture of the yeast origin recognition complex bound to origins of DNA replication
196. ATPase switches controlling DNA replication initiation
197. Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe
198. The roles of Drosophila cyclins A and B in mitotic control
199. Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae
200. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
201. Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes
202. 1 cyclins differ in their intrinsic functional specificities
203. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
204. A proliferation of cyclins
205. Morphogenesis in the yeast cell cycle: Regulation by Cdc28 and cyclins
206. Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system
207. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
208. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
209. Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28
210. Dephosphorylation of threonine 169 of Cdc28 is not required for exit from mitosis but may be necessary for START in Saccharomyces cerevisiae
211. Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification
212. Purification of maturation-promoting factor, an intracellular regulator of early mitotic events
213. The origin recognition complex in silencing, cell cycle progression, and DNA replication
214. Negative regulation of Cdc 18 DNA replication protein by Cdc2
215. Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes
216. The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle
217. Cell cycle control in fission yeast
218. 2 arresting alleles
219. Cell cycle regulation of the replication licensing system: Involvement of a Cdk-dependent inhibitor
220. Mutants of S. cerevisiae defective in the maintenance of minichromosomes
221. Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle
222. XCDT1 is required for the assembly of prereplicative complexes in Xenopus laevis
223. A yeast chromosomal origin of DNA replication defined by multiple functional elements
224. Replicator dominance in a eukaryotic chromosome
225. hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication
226. Sequence analysis of ARS elements in fission yeast
227. Geminin, an inhibitor of DNA replication, is degraded during mitosis
228. 1-specific transcription
229. Negative regulation of FARI at the START of the yeast cell cycle
230. An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae
231. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae
232. A lesion in the DNA replication initiation factor Mcm 10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae
233. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing
234. Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk
235. Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe
236. 2+ suppression, are members of the CDC46/MCM2 family
237. Identification of two Xenopus laevis genes, xMCM2 and xCDC46, with sequence homology to MCM genes involved in DNA replication
238. Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro
239. Cold-sensitive cell-division-cycle mutants of yeast: Isolation, properties, and pseudoreversion studies
240. The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15
241. Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe
242. Identification and reconstitution of the origin recognition complex from Schizosaccharomycespombe
243. 1 phase of the cell cycle by the rum1 + gene
244. Principles of CDK regulation
245. A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins
246. Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex
247. The WHI1 + gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog
248. Cell cycle-dependent phosphorylation of human DNA polymerase alpha
249. Control of the yeast cell cycle by the Cdc28 protein kinase
250. Viewpoint: Putting the cell cycle in order
251. 1 cyclins in yeast
252. Isolation of genes by complementation in yeast: Molecular cloning of a cell-cycle gene
253. The identification of a second cell cycle control on the HO promoter in yeast: Cell cycle regulation of SWI5 nuclear entry
254. Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G(1) transition in mammals
255. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes
256. The structure and function of yeast ARS elements
257. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
258. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
259. p65cdc18 plays a major role controlling the initiation of DNA replication is fission yeast
260. The Cdt1 protein is required to license DNA for replication in fission yeast
261. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis
262. Hierarchy of S-phase-promoting factors: Yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin- dependent kinase activation
263. Genetic control of cell size at cell division in yeast
264. Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe
265. 1 cyclins CLN1 and CLN2 repress the mating factor response pathway at START in the yeast cell cycle
266. 1-phase specificity of arrest by mating factor in budding yeast
267. 1-specific transcription
268. cDNA cloning and expression during development of Drosophila melanogaster MCM3, MCM6 and MCM7
269. Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins
270. Identification of a predominant replication origin in fission yeast
271. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
272. Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly
273. The AAA team: Related ATPases with diverse functions
274. Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae
275. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
276. Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders
277. Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
278. Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle
279. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
280. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1
281. 1, is important for the onset of S phase and for preventing a "reductional" anaphase in the budding yeast Saccharomyces cerevisiae
282. 1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast
283. The one-kilobase DNA fragment upstream of the ardC actin gene of Physarum polycephalum is both a replicator and a promoter
284. A bifunctional gene product involved in two phases of the yeast cell cycle
285. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant
286. Anatomy of a transcription factor important for the start of the cell cycle in Saccharomyces cerevisiae
287. Identification of HsORC4, a member of the human origin of replication recognition complex
288. ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases
289. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators
290. Functional conservation of multiple elements in yeast chromosomal replicators
291. Mammalian cell fusion: Studies on the regulation of DNA synthesis and mitosis
292. Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae
293. CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage
294. 1, function for cyclin-like proteins in yeast
295. 2
296. An origin unwinding activity regulates initiation of DNA replication during mammalian cell cycle
297. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication
298. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
299. Interaction between the origin recognition complex and the replication licensing system in Xenopus
300. Recent developments in the initiation of chromosomal DNA replication: A complex picture emerges
301. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC
302. Conservation of mitotic controls in fission and budding yeasts
303. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase
304. The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae
305. The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast
306. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae
307. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
308. Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApo1alpha-dE2F locus of Drosophila melanogaster
309. Human and Xenopus cDNAs encoding budding yeast Cdc7 related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
310. Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis
311. Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins
312. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
313. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae
314. 1 to S transition in S. cerevisiae
315. Coordinated spindle assembly, and orientation requires Clb5p-dependent kinase in budding yeast
316. Stepwise assembly of initiation proteins at budding yeast replication origins in vitro
317. Characterization of CDC45L: A gene in the 22q1 1.2 deletion region expressed during murine and human development
318. Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p)
319. Regulation of DNA-replication origins during cell-cycle progression
320. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds 1 and cyclin Clb5
321. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
322. Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae
323. 1/S-specific transcription in Saccharomyces cerevisiae
324. Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism
325. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
326. Genetic and molecular analysis of DNA43 and DNA52: Two new cell-cycle genes in Saccharomyces cerevisiae
327. S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28
328. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization
329. Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex
330. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
331. Cell cycle control of DNA replication
332. Isolation and characterisation of a yeast chromosomal replicator
333. Structure of the recA protein-ADP complex
334. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts
335. High-frequency transformation of yeast: Autonomous replication of hybrid DNA molecules
336. Cell cycle-dependent transcription of CLN2 is conferred by multiple distinct cis-acting regulatory elements
337. CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells
338. Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis
339. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae
340. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast
341. The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin
342. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L
343. Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality
344. A fission yeast gene, himI(+)/dfpI(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage
345. Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system
346. Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
347. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
348. Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function
349. Analysis of copy number control elements in the region of the vegetative replication origin of the broad host range plasmid RK2
350. Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein
351. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides
352. Civ1 (CAK in vivo), a novel Cdk-activating kinase
353. A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division
354. Getting started: Regulating the initiation of DNA replication in yeast
355. The activation of DNA replication in yeast
356. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant
357. Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene
358. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p
359. MCM proteins in DNA replication
360. The hexameric eukaryotic MCM helicase: Building symmetry from nonidentical parts
361. 1-phase Cdc28 kinase complexes
362. Proteolysis and the cell cycle: With this RING I do thee destroy
363. 1 cyclins: C1n3 may be an upstream activator of C1n1, C1n2 and other cyclins
364. The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation
365. Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III
366. 1 Cdk required for its degradation and entry into S phase
367. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
368. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
369. Conservation of structure in proton-translocating ATPases of Escherichia coli and mitochondria
370. Regulated chromosomal DNA replication in the absence of a nucleus
371. The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin
372. Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication
373. A human protein related to yeast Cdc6p
374. Control of the yeast cell cycle is associated with assembly/disassembly of the Cdc28 protein kinase complex
375. 1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase
376. Physical mapping of origins of replication in the fission yeast Schizosaccharomyces pombe
377. Inhibition of eukaryotic DNA replication by geminin binding to cdt1
378. Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
379. SRF and MCM1 have related but distinct DNA binding specificities
380. The efficiency and timing of initiation of replication of multiple replicons of Saccharomyces cerevisiae chromosome VI
381. Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function
382. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast
383. Exit from mitosis in budding yeast: Biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20
384. The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity
385. Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle
386. Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity
387. Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae
388. Nuclear accumulation of Saccharomyces cerevisiae Mcm3 is dependent on its nuclear localization sequence
389. Whose end is destruction: Cell division and the anaphasepromoting complex
390. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
391. CDC6 mRNA fluctuates periodically in the yeast cell cycle
392. Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1
393. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin
394. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase
395. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication
396. The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation