Exit from mitosis in budding yeast: Biphasic inactivation of the Cdc28-Clb2 mitotic kinase and the role of Cdc20

Molecular Cell

Volumn 5, Issue 3, 2000, Pages 501-511

  Yeong, Foong May ^a   Lim, Hong Hwa ^a   Padmashree, C G ^a   Surana, Uttam ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; PROTEIN KINASE;

ANAPHASE; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME INACTIVATION; MITOSIS; NONHUMAN; PROTEIN DEGRADATION; SACCHAROMYCES CEREVISIAE; TELOPHASE; YEAST;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0033710410     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80444-X     Document Type: Article

References (45)

1. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
2. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
3. A potential positive feed-back loop controlling CLN1 and CLN2 gene expression at the start of yeast cell cycle
4. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
5. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
6. Cyclin is degraded by the ubiquitin pathway
7. Cdc20 protein contains a destruction box but, unlike Clb2, its proteolysis is not acutely dependent on the activity of anaphase promoting complex
8. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
9. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
10. Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14
11. Structural arrangements of tubulin and actin during the cell cycle of yeast Saccharomyces
12. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
13. Fission yeast Ste9, a homolog of Hct1/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase
14. Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family
15. Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis
16. Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28
17. Cdc20 is essential for APC-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast
18. A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2
19. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
20. Regulation of the APC and the exit from mitosis
21. A general approach to the isolation of cell cycle-regulated genes in the budding yeast Saccharomyces cerevisiae
22. The regulation of Cdc20 proteolysis reveals a role for the APC components Cdc23 and Cdc27 during S phase and early mitosis
23. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
24. The CDC20 gene product of Saccharomyces cerevisiae, a β-transducin homolog, is required for a subset of microtubule-dependent cellular processes
25. The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase
26. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
27. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
28. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
29. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
30. Destruction of the CDC28/CLB mitotic kinase is not required for metaphase to anaphase transition in budding yeast
31. The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression
32. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
33. CDC27Hs colocalizes with CDC16Hs to the centromere and mitotic spindle and is essential for the metaphase to anaphase transition
34. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
35. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
36. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
37. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
38. CDC14 of Saccharomyces cerevisiae
39. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4
40. Pds1p, is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
41. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathways
42. Whose end is destruction: Cell division and the anaphase-promoting complex
43. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae
44. Mass spectrometric analysis of the anaphase complex from budding yeast: Identification of a subunit related to cullins
45. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex