CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis

Molecular Cell

Volumn 5, Issue 1, 2000, Pages 85-95

  Noton, Elizabeth ^a   Diffley, John F X ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN;

ANAPHASE; ARTICLE; CHROMATID; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURE; DNA REPLICATION; ENZYME INACTIVATION; MITOSIS; NONHUMAN; PROTEIN ASSEMBLY; YEAST;

EID: 0033974957     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80405-0     Document Type: Article

References (56)

1. Amon, A. (1999). The spindle checkpoint. Curr. Opin. Genet. Dev. 9, 69-75.
2. Aparicio, O.M., Weinstein, D.M., and Bell, S.P. (1997). Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM complexes and Cdc45p during S phase. Cell 91, 59-69.
3. Biggins, S., and Murray, A.W. (1999). Sister chromatid cohesion in mitosis. Curr. Opin. Genet. Dev. 9, 230-236.
4. Bousset, K., and Diffley, J.F.X. (1998). The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev. 12, 480-490.
5. Brown, M., Garvik, B., Hartwell, L., Kadyk, L., Seeley, T., and Weinert, T. (1991). Fidelity of mitotic chromosome transmission. Cold Spring Harb. Symp. Quant. Biol. 56, 359-365.
6. Bruschi, C.V., McMillan, J.N., Coglievina, M., and Esposito, M.S. (1995). The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination. Mol. Gen. Genet. 249, 8-18.
7. Bueno, A., and Russell, P. (1992). Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division. EMBO J. 11, 2167-2176.
8. Cocker, J.H., Piatti, S., Santocanale, C., Nasmyth, K., and Diffley, J.F.X. (1996). An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379, 180-182.
9. Dahmann, C., Diffley, J.F.X., and Nasmyth, K.A. (1995). S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of origins to a pre-replicative state. Curr. Biol. 5, 1257-1269.
10. Dani, G.M., and Zakian, V.A. (1983). Mitotic and meiotic stability of linear plasmids in yeast. Proc. Natl. Acad. Sci. U.S.A. 80, 3406-3410.
11. Desdouets, C., Santocanale, C., Drury, L.S., Perkins, G., Foiani, M., Plevani, P., and Diffley, J.F.X. (1998). Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase a. EMBO J. 11, 4139-4146.
12. Detweiler, C.S., and Li, J.J. (1998). Ectopic induction of Clb2 in early G1 phase is sufficient to block prereplicative complex formation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 95, 2384-2389.
13. Diffley, J.F.X. (1995). The initiation of DNA replication in the budding yeast cell division cycle. Yeast 11, 1651-1670.
14. Diffley, J.F.X., Cocker, J.H., Dowell, S.J., and Rowley, A. (1994). Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78, 303-316.
15. Dohmen, R.J., Wu, P., and Varshavsky, A. (1994). Heat-inducible degron: a method for constructing temperature-sensitive mutants. Science 263, 1273-1276.
16. Donovan, S., Harwood, J., Drury, L.S., and Diffley, J.F.X. (1997). Cdc6-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl. Acad. Sci. U.S.A. 94, 5611-5616.
17. Foiani, M., Marini, F., Gamba, D., Lucchini, G., and Plevani, P. (1994). The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol. Cell Biol. 14, 923-933.
18. Godinha Ferreira, M., Santocanale, C., Drury, L.S., and Diffley, J.F.X. (2000). Dbf4p, an essential S phase promoting factor, is targeted for degradation by the Anaphase Promoting Complex. Mol. Cell Biol. 20, 242-248.
19. Guttes, S., and Guttes, E. (1968). Regulation of DNA replication in the nuclei of the slime mold Physarum polycephalum, transplantation of nuclei by plasmodial coalescence. J. Cell Biol. 37, 761-772.
20. Hardy, C. (1996). Characterisation of an essential Orc2p-associated factor that plays a role in DNA replication. Mol. Cell. Biol. 16, 1832-1841.
21. Hardy, C.F.J., and Pautz, A. (1996). A novel role for Cdc5p in DNA replication. Mol. Cell Biol. 16, 6775-6782.
22. Hartwell, L.H., and Smith, D. (1985). Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110, 381-395.
23. Hogan, E., and Koshland, D. (1992). Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 89, 3098-3102.
24. Jaspersen, S.L., Charles, J.F., and Morgan, D.O. (1999). Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227-236.
25. Kitada, K., Johnson, A.L., Johnston, L.H., and Sugino, A. (1993). A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell Biol. 13, 4445-4457.
26. Knapp, D., Bhoite, L., Stillman, D.J., and Nasmyth, K. (1996). The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1. Mol. Cell Biol. 16, 5701-5707.
27. Koepp, D.M., Harper, J.W., and Elledge, S.J. (1999). How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97, 431-434.
28. Kroll, E.S., Hyland, K.M., Hieter, P., and Li, J.J. (1996). Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143, 95-102.
29. Labib, K., Diffley, J.F.X., and Kearsey, S.E. (1999). GI-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus. Nat. Cell Biol. 1, 415-422.
30. Liang, C., and Stillman, B. (1997). Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 11, 3375-3386.
31. Loo, S., Fox, C.A., Rine, J., Kobayashi, R., Stillman, B., and Bell, S. (1995). The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol. Biol. Cell 6, 741-756.
32. McGarry, T.J., and Kirschner, M.W. (1998). Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93, 1043-1053.
33. Mclnerny, C.J., Partridge, J.F., Mikesell, G.E., Creemer, D.P., and Breeden, L.L. (1997). A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription. Genes Dev. 11, 1277-1288.
34. Moll, T., Tebb, G., Surana, U., Robitsch, H., and Nasmyth, K. (1991). The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66, 743-758.
35. Ohi, R., and Gould, K.L. (1999). Regulating the onset of mitosis. Curr. Opin. Cell Biol. 11, 267-273.
36. Palmer, R.E., Hogan, E., and Koshland, D. (1990). Mitotic transmission of artificial chromosomes in cdc mutants of the yeast, Saccharomyces cerevisiae. Genetics 125, 763-774.
37. Perkins, G., and Diffley, J.F.X. (1998). Nucleotide dependent prereplicative complex assembly by Cdc6p, a homologue of eukaryotic and prokaryotic clamp-loaders. Mol. Cell 2, 23-32.
38. Piatti, S., Lengauer, C., and Nasmyth, K. (1995). Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a "reductional" anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14, 3788-3799.
39. Piatti, S., Bohm, T., Cocker, J.H., Diffley, J.F.X., and Nasmyth, K. (1996). Activation of S-phase promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev. 10, 1516-1531.
40. Rao, P.N., and Johnson, R.T. (1970). Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159-164.
41. Santocanale, C., and Diffley, J.F.X. (1996). ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. EMBO J. 15, 6671-6679.
42. Santocanale, C., and Diffley, J.F.X. (1998). A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395, 615-618.
43. Shou, W., Seol, J.H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z.W., Jang, J., Charbonneau, H., and Deshaies, R.J. (1999). Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97, 233-244.
44. Spruck, C.H., Won, K.A., and Reed, S.I. (1999). Deregulated cyclin E induces chromosome instability. Nature 401, 297-300.
45. Tanaka, T., Knapp, D., and Nasmyth, K. (1997). Loading of an Mcm protein onto DNA-replication origins is regulated by Cdc6p and CDKs. Cell 90, 649-660.
46. Toyn, J.H., Johnson, A.L., Donovan, J.D., Toone, W.M., and Johnston, L.H. (1997). The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase. Genetics 145, 85-96.
47. Verma, R., Annan, R.S., Huddleston, M.J., Carr, S.A., Reynard, G., and Deshaies, R.J. (1997). Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278, 455-460.
48. Visintin, R., Craig, K., Hwang, E.S., Prinz, S., Tyers, M., and Amon, A. (1998). The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2, 709-718.
49. Visintin, R., Hwang, E.S., and Amon, A. (1999). Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398, 818-823.
50. Wach, A., Brachat, A., Pohlmann, R., and Philippsen, P. (1994). New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10, 1793-1808.
51. Waga, S., Hannon, G.J., Beach, D., and Stillman, B. (1994). The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369, 574-578.
52. Zachariae, W., and Nasmyth, K. (1999). Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058.
53. Zachariae, W., Schwab, M., Nasmyth, K., and Seufert, W. (1998). Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 282, 1721-1724.
54. Zhou, C., and Jong, A. (1990). CDC6 mRNA fluctuates periodically in the yeast cell cycle. J. Biol. Chem. 265, 19904-19909.
55. Zhou, P., Jiang, W., Weghorst, C.M., and Weinstein, I.B. (1996). Overexpression of cyclin D1 enhances gene amplification. Cancer Res. 56, 36-39.
56. Zwerschke, W., Rottjakob, H.-W., and Küntzel, H. (1994). The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation. J. Biol. Chem. 269, 23351-23356.