The fission yeast origin recognition complex is constitutively associated with chromatin and is differentially modified through the cell cycle

Journal of Cell Science

Volumn 112, Issue 21, 1999, Pages 3703-3712

  Lygerou, Zoi ^a   Nurse, Paul ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

DNA replication; Nuclear protein; S phase; Schizosaccharomyces pombe

Indexed keywords

PHOSPHOPROTEIN;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL VIABILITY; CHROMATIN; DNA REPLICATION ORIGIN; GEL FILTRATION CHROMATOGRAPHY; IMMUNOPRECIPITATION; INTERPHASE; MITOSIS; MOLECULAR WEIGHT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EUKARYOTA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0032694916     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.112.21.3703     Document Type: Article

References (49)

1. Asano, M. and Wharton, R. P. (1999). E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila. EMBO J. 18, 2435-2448.
2. Baum, B., Nishitani, H., Yanow, S. and Nurse, P. (1998). Cdc18 transcription and proteolysis couple S phase to passage through mitosis. EMBO J. 17, 5689-5698.
3. Bell, S. P. and Stillman, B. (1992). Nucleotide dependent recognition of chromosomal origins of DNA replication by a multi-protein complex. Nature 357, 128-134.
4. Bell, S. P., Kobayashi, R. and Stillman, B. (1993). Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262, 1830-1831.
5. Chuang, R. Y. and Kelly, T. J. (1999). The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. Proc. Nat. Acad. Sci. USA 96, 2656-2661.
6. Clyne, R. K. and Kelly, T. J. (1995). Genetic analysis of an ARS element from the fission yeast Schizosaccharomyces pombe. EMBO J. 12, 6348-6357.
7. Coleman, T. R., Carpenter, P. B. and Dunphy, W. G. (1996). The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87, 53-63.
8. Coxon, A., Maundrell, K. and Kearsey, S. E. (1992). Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome-replication. Nucl. Acids Res. 20, 5571-5577.
9. Diffley, J. F., Cocker, J. H., Dowell, S. J., Harwood, J. and Rowley, A. (1995). Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle. J. Cell Sci. Suppl. 19, 67-72.
10. Donovan, S., Harwood, J., Drury, L. S. and Diffley, J. F. (1997). Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Nat. Acad. Sci. USA 94, 5611-5616.
11. Dubey, D. D., Kim, S., Todorov, I. T. and Huberman, J. A. (1996). Large, complex modular structure of a fission yeast DNA replication origin. Curr. Biol. 6, 467-473.
12. Dutta, A. and Bell, S. P. (1997). Initiation of DNA replication in eukaryotic cells. Annu. Rev. Cell Dev. Biol. 13, 293-332.
13. Foss, M., McNally, F. J., Laurenson, P. and Rine, J. (1993). Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae. Science 262, 1838-1844.
14. Fox, C. A., Loo, S., Dillin, A. and Rine, J. (1995). The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. Genes Dev. 9, 911-924.
15. Gavin, K., Hidaka, M. and Stillman, B. (1995). Conserved initiator proteins in eukaryotes. Science 270, 1667-1677.
16. Gilbert, D. M. (1998). Replication origins in yeast versus metazoa: separation of the haves and the have nots. Curr. Opin. Genet. Dev. 8, 194-199.
17. Gossen, M., Pak, D. T., Hansen, S. K., Acharya, J. K. and Botchan, M. R. (1995). A Drosophila homolog of the yeast origin recognition complex. Science 270, 1674-1677.
18. Grallert, B. and Nurse, P. (1996). The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev. 10, 2644-2654.
19. Hagan, I. M. and Hyams, J. S. (1988). The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 89, 343-357.
20. Harland, R. M. and Laskey, R. A. (1980). Regulated replication of DNA microinjected into eggs of Xenopus laevis. Cell 21, 761-771.
21. Hiraoka, Y., Toda, T. and Yanagida, M. (1984). The NDA3 gene of fission yeast encodes β-tubulin a cold sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Cell 39, 349-358.
22. Ishiai, M., Dean, F. B., Okumura, K., Abe, M., Moon, K. Y., Amin, A. A., Kagotani, K., Taguchi, H., Murakami, Y., Hanaoka, F., et al. (1997). Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. Genomics 46, 294-298.
23. Jallepalli, P. V. and Kelly, T. J. (1997). Cyclin-dependent kinase and initiation at eukaryotic origins: a replication switch? Curr. Opin. Cell Biol. 9, 358-363.
24. Kelly, T. J., Martin, G. S., Forsburg, S. L., Stephen, R. J., Russo, A. and Nurse, P. (1993). The fission yeast cdc18 gene product couples S-phase to start and mitosis. Cell 74, 371-382.
25. Klemm, R. D., Austin, R. J. and Bell, S. P. (1997). Coordinate binding of ATP and origin DNA regulates the ATPase activity of the Origin Recognition Complex. Cell 88, 493-502.
26. Kornberg, A. and Baker, T. A. (1992). DNA Replication. Freeman, New York.
27. Leatherwood, J., Lopez-Girona, A. and Russell, P. (1996). Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein. Nature 379, 360-363.
28. Liang, C., Weinreich, M. and Stillman, B. (1995). ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81, 667-676.
29. Liang, C. and Stillman, B. (1997). Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 11, 3375-3386.
30. Lopez-Girona, A., Mondesert, O., Leatherwood, J. and Russell, P. (1998). Negative regulation of cdc18 DNA replication protein by cdc2. Mol. Biol. Cell 9, 63-73.
31. Micklem, G., Rowley, A., Harwood, J., Nasmyth, K. and Diffley, J. F. (1993). Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366, 87-89.
32. Moreno, S., Klar, A. and Nurse, P. (1991). Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Meth. Enzymol. 194, 795-823.
33. Murakami, Y., Huberman, J. A. and Hurwitz, J. (1996). Identification, purification, and molecular cloning on autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe. Proc. Nat. Acad. Sci. USA 93, 502-507.
34. Muzi-Falconi, M. and Kelly, T. J. (1995). Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc. Nat. Acad. Sci. USA 92, 12475-12479.
35. Nakamura, H., Morita, T. and Sato, C. (1986). Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp. Cell Res. 165, 291-297.
36. Newlon, C. S. (1997). Putting it all together: building a prereplicative complex. Cell 91, 717-720.
37. cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83, 397-405.
38. Pak, D. T., Pflumm, M., Chesnokov, I., Huang, D. W., Kellum, R., Marr, J., Romanowski, P. and Botchan, M. R. (1997). Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell 91, 311-323.
39. Quintana, D. G., Hou, Z., Thome, K. C., Hendricks, M., Saha, P. and Dutta, A. (1997). Identification of HsORC4, a member of the human origin of replication recognition complex. J. Biol. Chem. 272, 28247-28251.
40. Quintana, D. G., Thome, K. C., Hou, Z. H., Ligon, A. H., Morton, C. C. and Dutta, A. (1998). ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases. J. Biol. Chem. 273, 27137-27145.
41. Ritzi, M., Baack, M., Musahl, C., Romanowski, P., Laskey, R. A. and Knippers, R. (1998). Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin. J. Biol. Chem. 273, 24543-24549.
42. Romanowski, P., Madine, M. A., Rowles, A., Blow, J. J. and Laskey, R. A. (1996). The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol. 6, 1416-1425.
43. Rowles, A., Chong, J. P. J., Brown, L., Howell, M., Evan, G. and Blow, J. J. (1996). Interaction beteen the origin recognition complex and the replication licensing system in Xenopus. Cell 87, 287-296.
44. Rowley, A., Dowell, S. J. and Diffley, J. F. (1994). Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. Biochem. Biophys. Acta 1217, 239-256.
45. Royzman, I., Austin, R. J., Bosco, G., Bell, S. P. and Orr-Weaver, T. L. (1999). ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 13, 827-840.
46. Sanchez, J., Murakami, Y., Huberman, J. A. and Hurwitz, J. (1998). Isolation, characterization, and molecular cloning of a protein (Abp2) that binds to a Schizosaccharomyces pombe origin of replication (ars3002). Mol. Cell Biol. 18, 1670-1681.
47. Tugal, T., Zou-Yang, X. H., Gavin, K., Pappin, D., Canas, B., Kobayashi, R., Hunt, T. and Stillman, B. (1998). The orc4p and orc5p subunits of the xenopus and human origin recognition complex are related to ore1p and cdc6p. J. Biol. Chem. 273, 32421-32429.
48. Umesono, K., Toda, T., Hayashi, S. and Yanagida, M. (1983). Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds. J. Mol. Biol. 168, 271-284.
49. Weinreich, M., Liang, C. and Stillman, B. (1999). The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin. Proc. Nat. Acad. Sci. USA 96, 441-446.