Cell cycle regulation of the replication licensing system: Involvement of a Cdk-dependent inhibitor

Journal of Cell Biology

Volumn 136, Issue 1, 1997, Pages 125-135

  Mahbubani, Hiro M ^a   Chong, James P J ^a   Chevalier, Stephane ^a   Thömmes, Pia ^a,b   Blow, J Julian ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 N,N DIMETHYLADENINE; CYCLIN B; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; INITIATION FACTOR; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA REPLICATION; INTERPHASE; METAPHASE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ADENINE; ANIMALS; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; CYCLOHEXIMIDE; DNA REPLICATION; ENZYME INHIBITORS; PROTEIN SYNTHESIS INHIBITORS; XENOPUS;

EID: 0031022391     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.136.1.125     Document Type: Article

References (61)

1. Blow, J.J. 1993. Preventing re-replication of DNA in a single cell cycle: evidence for a Replication Licensing Factor. J. Cell Biol. 122:993-1002.
2. Blow, J.J., and R.A. Laskey. 1986. Initiation of DNA replication in nuclei and purified DNA by a cell-free extract ot Xenopus eggs. Cell. 47:577-587.
3. Blow, J.J., and R.A. Laskey. 1988. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature (Land.). 332:546-548.
4. Blow, J.J., and P. Nurse. 1990. A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts. Cell. 62:855-862.
5. Blow, J.J., and A.M. Sleeman. 1990. Replication of purified DNA in Xenopus egg extract is dependent on nuclear assembly. J. Cell Sci. 95:383-391.
6. Blow, J.J., and J.V. Watson. 1987. Nuclei act as independent and integrated units of replication in a Xenopus cell-free system. EMBO (Eur. Mol. Biol. Organ.) J. 6:1997-2002.
7. Brock, D., R. Bartlett, K. Crawford, and P. Nurse. 1991. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature (Lond.). 349:388-393.
8. Burkhart, R., D. Schulte, D. Hu, C. Musahl, F. Gohring, and R. Knippers. 1995. Interactions of human nuclear proteins P1Mcm3 and P1Cdc46. Eur. J. Biochem. 228:431-438.
9. Chevalier, S., A. Couturier, I. Chartrain, R. Le Guellec, C. Beckhelling, K. Le Guellec, M. Philippe, and C.C. Ford. 1996. Xenopus cyclin E, a nuclear phosphoprotein, accumulates when oocytes gain the ability to initiate DNA replication. J. Cell Sci. 109:1173-1184.
10. Chong, J.P.J., M.H. Mahbubani, C.-Y. Khoo, and J.J. Blow. 1995. Purification of an Mcm-containing complex as a component of the DNA replication licensing system. Nature (Lond.). 375:418-421.
11. Chong, J.P.J., P. Thommes, and J.J. Blow. 1996. The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci. 21:102-106.
12. Chong, J.P.J., P. Thömmes, A. Rowles, H.M. Mahbuhani, and J.J. Blow. 1997. Characterisation of the Xenopus replication licensing system. Methods Enzymol. In press.
13. Coué, M., S.E. Kearsey, and M. Méchali. 1996. Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependend and associated with the control of initiation of DNA replication. EMBO (Eur. Mol. Biol. Organ.) J. 15:1085-1097.
14. Coverley, D., C.S. Downes, P. Romanowski, and R.A. Laskey. 1993. Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor. J. Cell Biol. 122:985-992.
15. Coverley, D., H.R. Wilkinson, and C.S. Downes. 1996. A protein kinase-depeadent block to reinitiation of DNA replication in G2 phase in mammalian cells. Exp. Cell Res. 225:294-300.
16. Crevel, G., and S. Cotterill. 1991. DNA replication in cell-free extracts from Drosophila melanogaster. EMBO (Eur. Mol. Biol. Organ.) J. 10:4361-438.
17. Dahmann, C., J.F. Diffley, and K.A. Nasmyth. 1995. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol. 5:1257-1269.
18. Dalton, S., and L. Whitbread. 1995. Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast. Proc. Natl. Acad. Sci. USA. 92:2514-2518.
19. Diffley, J.F., J.H. Cocker, S.J. Dowell, and A. Rowley. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell. 78:303-316.
20. Dunphy, W.G., L. Brizuela, D. Beach, and J. Newport. 1988. The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell 54: 423-431.
21. Felix, M.A., J. Pines, T. Hunt, and E. Karsenti. 1989. A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity. EMBO (Eur. Mol. Biol. Organ.) J. 8:3059-3069.
22. Gautier, J., C. Norbury, M. Lohka, P. Nurse, and J. Mailer. 1988. Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell. 54:433-439.
23. Gautier, J., J. Minshull, M. Lohka, M. Glotzer, T. Hunt, and J.L. Maller. 1990. Cyclin is a component of maturation-promoting factor from Xenopus. Cell. 60:487-494.
24. Hayles, J., D. Fisher, A. Woollard, and P. Nurse. 1994. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell. 78:813-822.
25. Hennessy, K.M., C.D. Clark, and D. Botstein. 1990. Subcellular localization of yeast CDC46 varies with the cell cycle. Genes & Dev. 4:2252-2263.
26. Hyrien, O., and M. Méchali. 1993. Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos. EMBO (Eur. Mol. Biol. Organ.) J. 12:4511-4520.
27. CIPI. J. Cell Biol. 130:755-769.
28. Kearsey, S.E., D. Maiorano, E.G. Holmes, and I.T. Todorov. 1996. The role of MCM proteins in the cell cycle control of genome duplication. Bioessays. 18: 183-190.
29. Kimura, H., N. Nozaki, and K. Sugimoto. 1994. DNA polymerase alpha associated protein P1, a m urine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period. EMBO (Eur. Mol. Biol. Organ.) J. 13:4311-4320.
30. Kubota, Y., and H. Takisawa. 1993. Determination of initiation of DNA replication before and after nuclear formation in Xenopus egg cell-free extracts. J. Cell Biol. 123:1321-1331.
31. Kubota, Y., S. Mimura, S. Nishimoto, H. Takisawa, and H. Nojima. 1995. Identification of the yeast MCM3-related protein as a component of Xenopus DNA Replication Licensing Factor. Cell. 81:601-609.
32. Labbé, J.C., J.P. Capony, D. Caput, J.C. Cavadore, J. Derancourt, M. Kaghad, J.M. Lelias, A. Picard, and M. Doree. 1989a. MPF from starfish oocytesat first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO (Eur. Mol. Biol. Organ.) J. 8:3053-3058.
33. Labbé, J.C., A. Picard, G. Peaucellier, J.C. Cavadore, P. Nurse, and M. Dorec. 1989b. Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation. Cell 57: 253-263.
34. Lei, M., Y. Kawasaki, and B.K. Tye. 1996. Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae. Mol. Cell. Biol. 16:5081-5090.
35. Leno, G.H., C.S. Downes, and R.A. Laskey. 1992. The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract. Cell. 69:151-158.
36. 2+ ions on the formation of metaphase chromosomes and sperm pronuclei in cell-free preparations from unactivated Rana pipiens eggs. Dev. Biol. 103:434-442.
37. Luca, F.C., and J.V. Ruderman. 1989. Control of programmed cyclin destruction in a cell-free system. J. Cell Biol. 109:1895-1909.
38. Luca, F.C., E.K. Shibuya, C.E. Dohrmann, and J.V. Ruderman. 1991. Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction. EMBO (Eur. Mol. Biol. Organ.) J. 10:4311-4320.
39. Madine, M.A., C.-Y. Khoo, A.D. Mills, and R.A. Laskey. 1995a. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature (Lond.). 375:421-424.
40. Madine, M.A., C.-Y. Khoo, A.D. Mills, C. Musahl, and R.A. Laskey. 1995b. Nuclear envelope prevents re-replication by restricting binding of MCM3 to chromatin. Curr. Biol. 5:1270-1279.
41. Mahbubani, H.M., T. Paull, J.K. Elder, and J.J. Blow. 1992. DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts. Nucleic Acids Res. 20:1457-1462.
42. Maine, G.T., P. Sinha, and B.K. Tye. 1984. Mutants of 5. cerevisiae defective in the maintenance of minichromosomes. Genetics. 106:365-385.
43. Maiti, A.K., and P. Sinha. 1992. The mcm2 mutation of yeast affects replication, rather than segregation or amplification of the two micron plasmid. J. Mol. Biol. 224:545-558.
44. Moreno, S., and P. Nurse. 1994. Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Nature (Lond.). 367:236-242.
45. Newport, J. 1987. Nuclear reconstitution in vitro: stages of assembly around protein-free DNA. Cell. 48:205-217.
46. Nigg, E.A. 1995. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays. 17:471-480.
47. Piatti, S., T. Bohm, J.H. Cocker, J.F.X. Diffley, and K. Nasmyth. 1996. Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes & Dev. 10:1516-1531.
48. Rempel, R.E., S.B. Sleight, and J.L. Maller. 1995. Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase. J. Bioi. Chem. 270:6843-6855.
49. Rowles, A., J.P.J. Chong, L. Brown, M. Howell, G.I. Evan, and J.J, Blow. 1996. Interaction between the Origin Recognition Complex and the replication licensing system in Xenopus. Cell. 87:287-296.
50. Roy, L.M., K.I. Swenson, D.H. Walker, B.G. Gabrielli, R.S. Li, H. Piwnica Worms, and J.L. Mailer. 1991. Activation of p34cdc2 kinase by cyclin A. J. Cell Bioi. 113:507-514.
51. Sheehan, M.A., A.D. Mills, A.M. Sleeman, R.A. Laskey, and J.J. Blow. 1988. Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs. J. Cell Biol. 106:1-12.
52. Strausfeld, U.P., M. Howell, R. Rempel, J.L. Mailer, T. Hunt, and J.J. Blow. 1994. Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases. Curr. Biol. 4:876-883.
53. Strausfeld, U.P., M. Howell, P. Descombes, S. Chevalier, R.E. Rempel, J. Adamczewski, J.L. Mailer, T. Hunt, and J.J. Blow. 1996. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts. J. Cell Sci. 109:1555-1563.
54. Todorov, IT., R. Pepperkok, R.N. Philipova, S.E. Kearsey, W. Ansorge, and D. Werner. 1994. A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division. J. Cell Sci. 107:253-265.
55. Todorov, IT., A. Attaran, and S.E. Kearsey. 1995. BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication. J. Cell Biol. 129:1433-1445.
56. Treisman, J.E., P.J. Follette, P.H. O'Farrell, and G.M. Rubin. 1995. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes & Dev. 9:1709-1715.
57. Usui, T., M. Yoshida, K. Abe, H. Osada, K. Isono, and T. Beppu. 1991. Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor. K-252a. J. Cell Biol. 115:1275-1282.
58. Vesely, J., L. Havlicek, M. Strand, J.J. Blow, A. Donnella-Deana, L. Pinna, D.S. Letham, J. Kalo, L. Detivaud, S. Leclerc et al. 1994. Inhibition of cyclindependent kinases by purine analogues. Eur. J. Biochem. 224:771-786.
59. Yan, H., and J. Newport. 1995. An analysis of the regulation of DNA synthesis by cdk2, Cip1, and licensing factor. J. Cell Biol. 129:1-15.
60. Yan, H., A.M. Merchant, and B.K. Tye. 1993. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes & Dev. 7: 2149-2160.
61. Zhang, S.C., and Y. Masui. 1992. Activation of Xenopus laevis eggs in the absence of intracellular Ca activity by the protein phosphorylation inhibitor, 6-dimethylaminopurine (6-DMAP). J. Exp. Zool. 262:317-329.