Getting started: Regulating the initiation of DNA replication in yeast

Annual Review of Microbiology

Volumn 51, Issue , 1997, Pages 125-149

  Toone, W Mark ^a,b   Aerne, Birgit L ^a   Morgan, Brian A ^a,c   Johnston, Leland H ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cell cycle; Origins; S phase; Start

Indexed keywords

FUNGAL DNA; FUNGAL PROTEIN; PROTEIN KINASE;

CELL CYCLE S PHASE; CELL SIZE; COMPLEX FORMATION; DNA REPLICATION; DNA REPLICATION ORIGIN; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FUNGAL GENETICS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TRANSCRIPTION REGULATION; YEAST;

CARRIER PROTEINS; CELL CYCLE; DNA REPLICATION; GENE EXPRESSION REGULATION, FUNGAL; REPLICATION ORIGIN; S PHASE; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0030751470     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.51.1.125     Document Type: Review

References (103)

1. Amon A, Irniger S, Nasmyth K. 1994. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 77:1037-50
2. Axelrod A, Rine J. 1991. A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:1080-91
3. Bell SP, Kobayashi R, Stillman B. 1993. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262:1844-49
4. Bell SP, Mitchell J, Leber J, Kobayashi R, Stillman B. 1995. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83:563-68
5. Bell SP, Stillman B. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357:128-34
6. Blow JJ, Laskey RA. 1988. A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 332:546-48
7. Breeden L. 1996. Start-specific transcription in yeast. Curr. Top. Microbiol. Immunol. 208:95-127
8. Brewer BJ, Fangman WL. 1987. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell 51:463-71
9. Broach JR, et al. 1983. Localization and sequence analysis of yeast origins of DNA replication. Cold Spring Harb Symp. Quant. Biol. 2:1165-73
10. cdc2 in establishing the dependency of S phase on mitosis. Nature 349:388-93
11. Carpenter PB, Mueller PR, Dunphy WG. 1996. Role for a Xenopus Orc2-related protein in controlling DNA replication. Nature 379:357-60
12. Celniker SE, Sweder K, Srienc F, Bailey JE, Campbell JL. 1984. Deletion mutations affecting autonomously replicating sequence ARSI of Saccharomyces cerevisiae. Mol. Cell. Biol. 4:2455-66
13. Chapman JW, Johnston LH. 1989. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated. Exp. Cell. Res. 180:419-28
14. Chong JP, Mahbubani HM, Khoo CY, Blow JJ. 1995. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375:418-21
15. Chong JPJ, Thommes P, Blow JJ. 1996. The role of MCM/P1 proteins in the licensing of DNA-replication. Trends Biochem. Sci. 21:102-6
16. Cocker JH, Piatti S, Santocanale C, Nasmyth K, Diffley JF. 1996. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature 379:180-82
17. cdc2 mitotic kinase. Cell 83:1001-9
18. Dahmann C, Diffley JFX, Nasmyth KA. 1995. S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol. 5:1257-69
19. Dalton S, Whitbread L. 1995 Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast. Proc. Natl. Acad. Sci. USA 92:2514-18
20. Diffley JFX. 1995. The initiation of DNA-replication in the budding yeast-cell division cycle. Yeast. 11:1651-70
21. Diffley JF, Cocker JH. 1992. Protein-DNA interactions at a yeast replication origin. Nature 357:169-72
22. Diffley JF, Cocker JH, Dowell SJ, Rowley A. 1994. Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78:303-16
23. Diffley JF, Stillman B. 1988. Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. USA 85:2120-244
24. Dillin A, Rine J. 1995. On the origin of a silencer. Trends Biochem. Sci. 20:231-35
25. Dirick L, Bohm T, Nasmyth K. 1995. Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14: 4803-13
26. Dirick L, Moll T, Auer H, Nasmyth K. 1992. A central role for SW16 in modulating cell cycle Start-specific transcription in yeast. Nature 357:508-13
27. SDR25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev. 8:1640-53
28. Dowell SJ, Romanowski P, Diffley JF. 1994. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265:1243-46
29. Ehrenhofer-Murray AE, Gossen M, Pak DTS, Botchan MR, Rine J. 1995. Separation of origin recognition complex functions by cross-species complementation, Science 270:1671-14
30. Epstein CB, Cross FR. 1992. CLB5: a novel B cyclin from budding yeast with a role in S phase. Genes Dev. 6:1695-96
31. Ferguson BM, Brewer BJ, Reynolds AE, Fangman WL. 1991. A yeast origin of replication is activated late in S phase. Cell 65:507-15
32. Foss M, McNally FJ, Laurenson P, Rine J. 1993. Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae. Science 262:1838-44
33. Fox CA, Loo S, Dillin A, Rine J. 1995. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. Genes Dev. 9:911-24
34. Friedman KL, et al. 1996. Multiple determinants controlling activation of yeast replication origins late in S phase. Genes Dev. 10:1595-1607
35. Gavin KA, Hidaka M, Stillman B 1995. Conserved initiator proteins in eukaryotes. Science 270:1667-71
36. Gossen M, Pak DTS, Hansen SK, Acharya JK, Botchan MR. 1995. A Drosophila homolog of the yeast origin recognition complex. Science 270:1674-77
37. Grallert B, Nurse P. 1996. The ORCI homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev. 10:2644-54
38. Hadwiger JA, Wittenberg C, Richardson HE, de Barros-Lopes M, Reed SI. 1989. A family of cyclin homologs that control the G1 phase in yeast. Proc. Natl. Acad. Sci. USA 86:6255-59
39. Hardy CF. 1996. Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol. Cell. Biol. 16:1832-41
40. Hartwell LH. 1976. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104:803-17
41. cdc2-mitotic B cyclin complex. Cell 78:813-22
42. Heichman KA, Roberts JM. 1996. The yeast CDC16 and CDC27 genes restrict DNA-replication to once per cell-cycle. Cell 85:39-48
43. Hennessy KM, Clark CD, Botstein D. 1990. Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev. 4:2252-63
44. Hogan E, Koshland D. 1992. Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 89:3098-3102
45. Hollingsworth RJ, Sclafani RA. 1990. DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase. Proc. Natl. Acad. Sci. USA 87:6272-76
46. Huberman JA, Spotila LD, Nawotka KA, el A-Assouli SM, Davis LR. 1987. The in vivo replication origin of the yeast 2 micron plasmid. Cell 51:473-81
47. Huberman JA, Zhu JG, Davis LR, Newlon CS. 1988. Close association of a DNA replication origin and an ARS element on chromosome III of the yeast, Saccharomyces cerevisiae. Nucleic Acids Res. 16:6373-84
48. Igual JC, Johnson AL, Johnston LH. 1996. Coordinated regulation of gene-expression by the cell-cycle transcription factor Swi4 and the protein-kinase-C map kinase pathway for yeast-cell integrity. EMBO J. 15:5001-13
49. Jackson AL, Pahl PM, Harrison K, Rosamond J, Sclafani RA. 1993. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol. 13:2899-2908
50. Jallepalli PV, Kelly TJ. 1996. Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes Dev. 10:541-52
51. Johnston LH. 1992. Cell cycle control of gene expression in yeast. Trends Cell Biol. 2:353-57
52. Johnston LH, Lowndes NF. 1992. Cell cycle control of DNA synthesis in budding yeast. Nucleic Acids Res. 20:2403-10
53. Johnston LH, Thomas AP. 1982. A further two mutants defective in initiation of the S phase in the yeast Saccharomyces cerevisiae. Mol. Gen. Genet. 186:445-48
54. Johnston LH, Thomas AP. 1982. The isolation of new DNA synthesis mutants in the yeast Sacchammyces cerevisiae. Mol. Gen. Genet. 186:439-44
55. Kitada K, Johnston LH, Sugino T, Sugino A. 1992. Temperature-sensitive cdc7 mutations of Sacchammyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Genetics 131:21-29
56. Koch C, Nasmyth K. 1994. Cell cycle regulated transcription in yeast. Curr. Opin. Cell. Biol. 6:451-59
57. Koonin EV. 1993. A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Wucleic Acids Res. 21:2541-47
58. Kubota Y, Mimura S, Nishimoto S, Takisawa H, Nojima H. 1995. Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81:601-9
59. Laurenson P, Rine J. 1992. Silencers, silencing, and heritable transcriptional states. Microbiol. Rev. 56:543-60
60. Leatherwood J, Lope GA, Russell P. 1996. Interaction of Cdc2 and Cdc18 with a fission yeast Orc2-like protein. Nature 379:360-63
61. Li JJ, Herskowit I. 1993. Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262:1870-74
62. Liang C, Weinreich M, Stillman B. 1995. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 81:667-76
63. Loo S, et al. 1995. The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol. Biol. Cell 6:741-56
64. Loo S, Rine J. 1994. Silencers and domains of generalied repression. Science 264:1768-71
65. Lowndes NF, Johnson AL, Breeden L, Johnston LH. 1992. SW16 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast. Nature 357:505-8
66. Lowndes NF, Johnson AL, Johnston LH. 1991. Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated transcription factor. Nature 350:247-50
67. Madine MA, Khoo CY, Mills AD, Laskey RA. 1995. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375:421-24
68. Madine MA, Khoo CY, Mills AD, Mushal C, Laskey RA. 1995. The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts. Curr. Biol. 5:1270-79
69. Marahrens Y, Stillman B. 1992. A yeast chromosomal origin of DNA replication defined by multiple functional elements. Science 255:817-23
70. Marahrens Y, Stillman B. 1994. Replicator dominance in a eukaryotic chromosome. EMBO J. 13:3395-3400
71. McCarroll RM, Fangman WL. 1988. Time of replication of yeast centromeres and telomeres. Cell 54:505-13
72. McNally FJ, Rine J. 1991. A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae. Mol. Cell. Biol. 11:5648-59
73. CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259:216-19
74. Micklem G, Rowley A, Harwood J, Nasmyth K, Diffley JF. 1993. Yeast origin recognition complex is involved in DNA replication and transcriptional silencing. Nature 366:87-89
75. Miller AM, Nasmyth KA. 1984. Role of DNA replication in the repression of silent mating type loci in yeast. Nature 312:247-51
76. + gene. Nature 367:236-342
77. + regulates initiation of DNA replication in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 93:1566-70
78. Nasmyth K. 1993. Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell. Biol. 5:166-79
79. Newlon CS, Theis JF. 1993. The structure and function of yeast ARS elements. Curr. Opin. Genet. Dev. 3:752-58
80. cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83:397-405
81. Piatti S, Lengauer C, Nasmyth K. 1995. Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J. 14:3788-99
82. Rao H, Marahrens Y, Stillman B. 1994. Functional conservation of multiple elements in yeast chromosomal replicators. Mol. Cell Biol. 14:7643-51
83. Rao H, Stillman B. 1995. The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators. Proc. Natl. Acad. Sci. USA 92:2224-28
84. Rao PN, Johnson RT. 1970. Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225:159-64
85. Richardson HE, Wittenberg C, Cross F, Reed SI. 1989. An essential G1 function for cyclin-like proteins in yeast. Cell 59:1127-33
86. Rivier DH, Rine J. 1992. An origin of DNA replication and a transcription silencer require a common element. Science 256:659-63
87. Rowles A, et al. 1996. Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87:287-96
88. Rowley A, Cocker JH, Harwood J, Diffley JF. 1995. Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC. EMBO J. EMBO J. 14:2631-41
89. Rowley A, Dowell SJ, Diffley JF. 1994. Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. Biochem. Biophys. Acta. 1217:239-56
90. Schneider BL, Yang QH, Futcher AB. 1996. Linkage of replication to start by the cdk inhibitor Sic1. Science 272:560-62
91. SICI controls the G1 to S transition in S. cerevisiae. Cell 79:233-44
92. Schwob E, Nasmyth K. 1993. CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7(7A): 1160-75
93. Shore D, Nasmyth K. 1987. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51:721-32
94. Stillman B. 1993. DNA replication. Replicator renaissance. Nature 366:506-7
95. Stillman B. 1994. Initiation of chromosomal DNA replication in eukaryotes. Lessons from lambda. J. Biol. them. 269:7047-50
96. Theis JF, Newlon CS. 1994. Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function. Mol. Cell. Biol. 14:7652-59
97. Toyn JH, Toone WM, Morgan BA, Johnston LH. 1995. The activation of DNA replication in yeast. Trends Biochem. Sci. 20:70-73
98. Tyers M, Tokiwa G, Futcher B. 1993. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12:1955-68
99. Van HJ, Newlon CS. 1990. Mutational analysis of the consensus sequence of a replication origin from yeast chromosome III. Mol. Cell. Biol. 10:3917-25
100. Walker SS, Francesconi SC, Eisenberg S. 1990. A DNA replication enhancer in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87:4665-69
101. CDC28 protein kinase. Cell 62:225-37
102. Van H, Merchant AM, Tye BK. 1993. Cell cycle-regulated nuclear localization of Mcm2 and Mcm3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev. 7:2149-60
103. Yoon HJ, Loo S, Campbell JL. 1993. Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Mol. Biol. Cell. 4:195-208