A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells

Molecular and Cellular Biology

Volumn 19, Issue 7, 1999, Pages 5083-5095

  Kumagai, Hiroyuki ^a   Sato, Noriko ^a   Yamada, Masayuki ^a   Mahony, Daniel ^b   Seghezzi, Wolfgang ^b   Lees, Emma ^b   Arai, Ken Ichi ^a,c   Masai, Hisao ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PHOSPHOTRANSFERASE; PROTEIN ASK; REGULATOR PROTEIN; TUBULIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MAMMAL CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

MAMMALIA;

EID: 0033026068     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.7.5083     Document Type: Article

References (41)

1. Bousset, K., and J. F. X. Diffley. 1998. The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev. 15:480-490.
2. Broek, D., R. Bartlett, K. Crawford, and P. Nurse. 1991. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature 349: 338-393.
3. Brown, G. W., and T. J. Kelly. 1998. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast. J. Biol. Chem. 273:22083-22090.
4. Chapman, J. W., and L. H. Johnston. 1989. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated. Exp. Cell Res. 180:419-428.
5. Cho, M. K., et al. Unpublished results.
6. Donaldson, A. D., W. L. Fangman, and B. J. Brewer. 1998. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev. 15:491-500.
7. Dowell, S. J., P. Romanowski, and J. F. X. Diffley. 1994. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265:1243-1246.
8. Dulic, V., E. M. Lees, and S. I. Reed. 1992. Human cyclin E is associated with a periodic G1 protein kinase. Science 257:1958-1961.
9. Fang, F., and J. Newport. 1991. Evidence that G1-S and G2-M are controlled by different cdc2 proteins in higher eukaryotes. Cell 66:731-742.
10. Gietz, D., A. St. Jean, R. A. Woods, and R. H. Schiestl. 1992. Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20:1425.
11. Hardy, C. F. G., and A. Pautz. 1996. A novel role for Cdc5p in DNA replication. Mol. Cell. Biol. 16:6775-6782.
12. Harlow, E., and D. Lane. 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
13. Hartwell, L. H. 1971. Genetic control of the cell cycle in yeast. II. Genes controlling DNA replication and its initiation. J. Mol. Biol. 59:183.
14. Hateboer, G., A. Wobst, B. O. Petersen, L. Le Cam, E. Vigo, C. Sardet, and K. Helin. 1998. Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol. Cell. Biol. 18:6679-6697.
15. Ikeda, M., K. Arai, and H. Masai. 1996. A fusion protein library: an improved method for rapid screening and characterization of DNA binding or interacting proteins. Gene 181:167-174.
16. Ishimi, Y. 1997. A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. J. Biol. Chem. 272:24508-24513.
17. Ishimi, Y., Y. Komamura, Z. You, and H. Kimura. 1998. Biochemical function of mouse minichromosome maintenance 2 protein. J. Biol. Chem. 273: 8369-8375.
18. Jackson, A. L. P., M. B. Pahl, K. Harrison, J. Rosamond, and R. Sclafani. 1993. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol. 13:2899-2908.
19. Jiang, W., and T. Hunter. 1997. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. Proc. Natl. Acad. Sci. USA 94:14320-14325.
20. Kim, J. M., N. Sato, M. Yamada, K. Arai, and H. Masai. 1998. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for S. cerevisiae Cdc7-related kinase. J. Biol. Chem. 273:23248-23257.
21. Kim, J. M., et al. Unpublished results.
22. Koff, A., A. Giordano, D. Desai, K. Yamashita, J. W. Harper, S. Elledge, T. Nishimoto, D. O. Morgan, B. R. Franza, and J. M. Roberts. 1992. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257:1689-1694.
23. Lei, M., Y. Kawasaki, M. R. Young, M. Kihara, A. Sugino, and B. K. Tye. 1997. MCM2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev. 11:3365-3374.
24. +, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J. 14:3094-3104.
25. Masai, H., et al. Unpublished data.
26. McGarry, T. J., and M. W. Kirschner. 1998. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93:1043-1053.
27. Miyake, T. Unpublished results.
28. Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
29. Nigg, E. A. 1995. Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17:471-476.
30. Nurse, P., and Y. Bisset. 1981. Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292:558-560.
31. Ohtani, K., J. DeGregori, and J. R. Nevins. 1995. Regulation of the cyclin E gene by transcription factor E2F1. Proc. Natl. Acad. Sci. USA 92:12146-12150.
32. Ohtani, K., J. DeGregori, G. Leone, D. R. Heraideen, T. J. Kelly, and J. R. Nevins. 1996. Expression of the HsOrc1 gene, a human ORC1 homologue, is regulated by cell proliferation via the E2F transcription factor. Mol. Cell. Biol. 16:6977-6984.
33. Patterson, M. N. S., R. A. Sclafani, W. L. Fangman, and J. Rosamond. 1986. Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae. Mol. Cell. Biol. 6:1590-1598.
34. Sato, N., K. Arai, and H. Masai. 1997. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J. 16:4340-4351.
35. Sclafani, R. A., M. Patterson, J. Rosamond, and W. L. Fangman. 1988. Differential regulation of the yeast CDC7 gene during mitosis and meiosis. Mol. Cell. Biol. 8:293-300.
36. Sherr, C., and J. M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
37. Takebe, Y., M. Seiki, J. Fujisawa, P. Hoy, T. Yokota, K. Arai, M. Yoshida, and N. Arai. 1988. SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8:466-474.
38. Takeda, T., et al. Unpublished results.
39. Takeda, T., et al. Submitted for publication.
40. Williams, R. S., R. V. Shohet, and B. Stillman. 1997. A human protein related to yeast Cdc6p. Proc. Natl. Acad. Sci. USA 94:142-147.
41. Yan, Z., J. DeGregori, R. Shohet, G. Leone, B. Stillman, J. R. Nevins, and R. S. Williams. 1998. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc. Natl. Acad. Sci. USA 95:3603-3608.