Fission yeast WD-repeat protein Pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18

Genes and Development

Volumn 11, Issue 12, 1997, Pages 1548-1560

  Kominami, Kin Ichiro ^a   Toda, Takashi ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

CDK inhibitor; Cell cycle; Fission yeast; Initiation of S phase; Polyploid; Proteasome; Ubiquitin

Indexed keywords

FUNGAL PROTEIN; PROTEASOME; UBIQUITIN;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ANALYSIS; FUNGAL GENETICS; GENE MUTATION; MOLECULAR WEIGHT; NONHUMAN; PLOIDY; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; TEMPERATURE SENSITIVE MUTANT;

SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0030950644     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.12.1548     Document Type: Article

References (58)

1. Bai, C., R. Richman, and S.J. Elledge. 1994. Human cyclin F. EMBO J. 13: 6087-6098.
2. Bai, C., P. Sen, K. Hofmann, L. Ma, M. Goebl, J.W. Harper, and S.J. Elledge. 1996. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86: 263-274.
3. Basi, G., E. Schmid, and K. Maundrell. 1993. TATA box mutations in the Schizosaccharomyces pombe nmt1 promoter affect transcriptional efficiency but not the transcription start point or thiamine repressibility. Gene 123: 131-136.
4. Blondel, M. and C. Mann. 1996. G2 cyclins are required for the degradation of G1 cyclins in yeast. Nature 384: 279-282.
5. cdc2 in establishing the dependency of S phase on mitosis. Nature 349: 388-393.
6. Clurman, B.E., R.J. Sheaff, K. Thress, M. Groudine, and J.M. Roberts. 1996. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes & Dev. 10: 1979-1990.
7. cdc2 mitotic kinase. Cell 83: 1001-1009.
8. Creanor, J. and J.M. Mitchison. 1990. Conditional DNA synthesis after a mitotic block in the double mutant cut1 cdc11 of the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 96: 433-436.
9. Deshaies, R.J. 1995. Make it or break it: The role of ubiquitin-dependent proteolysis in cellular regulation. Trends Cell Biol. 5: 428-434.
10. 1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14: 303-312.
11. 1 transition in Saccharomyces cerevisiae. Genes & Dev. 8: 1640-1653.
12. 1 cyclins. EMBO J. 15: 850-860.
13. Fong, H.K., J.B. Hurley, R.S. Hopkins, R. Miyake-Lye, M.S. Johnson, R.F. Doolitle, and M.I. Simon. 1986. Repetitive segmental structure of the transducin β subunit: Homology with the CDC4 gene and identification of related mRNAs. Proc. Natl. Acad. Sci. 83: 2162-2166.
14. Forsburg, S.A. and P. Nurse. 1991. Identification of a G1 type cyclin puc1 in the fission yeast Schizosaccharomyces pombe. Nature 351: 245-247.
15. Funabiki, H., H. Yamano, K. Kumada, K. Nagao, T. Hunt, and M. Yanagida. 1996. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381: 438-441.
16. Goebl, M.G., J. Yochem, S. Jentsch, J.P. McGrath, A. Varshavsky, and B. Byers 1988. The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 241: 1331-1335.
17. Gordon, C., G. McGurk, P. Dillon, C. Rosen, and N.D. Hastie 1993. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Nature 366: 355-357.
18. + is defective in metaphase to anaphase transition. J. Biol. Chem. 271: 5704-5711.
19. Handeli, S. and H. Weintraub. 1992. The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1. Cell 71: 599-611.
20. Harlow, E. and D. Lane. 1988. Antibodies: A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
21. Hartwell, L.H. and M.B. Kastan. 1994. Cell cycle control and cancer. Science 266: 1821-1828.
22. Hayashi, S. 1996. A Cdc2 dependent checkpoint maintains diploidy in Drosophila. Development 122: 1051-1058.
23. cdc2-mitotic B cyclin complex. Cell 78: 813-822.
24. Heichman, K.A. and J.M. Roberts. 1996. The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Cell 85: 39-48.
25. Hochstrasser, M. 1995. Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr. Biol. 7: 215-223.
26. Jallepalli, P.V. and T.J. Kelly. 1996. Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe. Genes & Dev. 10: 541-552.
27. + gene product couples S phase to START and mitosis. Cell 74: 371-382.
28. King, R.W., R.J. Deshaies, J.-M. Peters, and M.W. Kirschner. 1996. How proteolysis drives the cell cycle? Science 274: 1652-1659.
29. 1-arrest upon nitrogen starvation and is an inhibitor of septum formation. J. Cell Sci. 108: 895-905.
30. 1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271: 1597-1601.
31. rum1 cdk inhibitor. EMBO J. 15: 839-849.
32. 1-to-S-phase transition and indentifies a conserved family of proteins. Mol Cell. Biol 16: 6634-6643.
33. Matsudaira, P. 1987. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J. Biol. Chem. 262: 10035-10038.
34. Molnar, M. and M. Sipiczki. 1993. Polyploidy in the haplontic yeast Schizosaccharomyces pombe: Construction and analysis of strains. Curr. Genet. 24: 45-52.
35. + gene. Nature 367: 236-242.
36. Moreno, S., A. Klar, and P. Nurse. 1991. Molecular genetic analyses of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194: 773-782.
37. + regulates initiation of DNA replication in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. 93: 1666-1670.
38. Neer, E.J., C.J. Schmidt, R. Nambudripad, and T.F. Smith. 1994. The ancient regulatory-protein family of WD-repeat proteins. Nature 371: 297-300.
39. cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83: 397-405.
40. Nugroho, T.T. and M.D. Mendenhall. 1994. An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol. Cell. Biol. 14: 3320-3328.
41. Nurse, P. 1994. Ordering S phase and M phase in the cell cycle. Cell 73: 547-550.
42. Orr-Weaver, T.L. 1994. Developmental modification of the Drosophila cell cycle. Trends Genet. 10: 321-327.
43. Pagano, M., S.W. Tam, A.M. Theodoras, P. Beer-Romero, G.D. Sal, V. Chau, P. Renée, G.F. Draetta, and M. Rolfe. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269: 682-685.
44. Piatti, S., T. Böhm, J.H. Cocker, J.F.X. Diffley, and K. Nasmyth. 1996. Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes & Dev. 10: 1516-1531.
45. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
46. Sanger, F., S. Nicklen, and A.R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. 74: 5463-5467.
47. Schneider, B.L., Q.-H. Yang, and A.B. Futcher. 1996. Linkage of replication to Start by the cdk inhibitor Sic1. Science 272: 560-562.
48. SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79: 233-244. [Erratum 84 1996.]
49. 1 cyclin-dependent kinases. Genes & Dev. 9: 1149-1163.
50. Usui, T., M. Yoshida, K. Abe, H. Osada, K. Isono, and T. Beppu. 1991. Uncoupled cell cycle without mitosis induced by a protein kinase, K-252a. J. Cell Biol. 115: 1275-1282.
51. +, encodes a protein similar to the Caenorhabitis elegans F37A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe. Gene 161: 93-96.
52. + gene regulates spindle pole body duplication and has homology to the budding yeast ESP1. Cell 62:913-925.
53. Waldman, T., C. Lengauer, K.W. Kinzler, and B. Vogelstein. 1996. Uncoupling of S phase and mitosis induced by anti-cancer agents in cells lacking p21. Nature 381: 713-716.
54. Watanabe, Y., S. Shinozaki-Yabana, Y. Chikashige, Y. Hiraoka, and M. Yamamoto 1997. Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast. Nature 386: 187-190.
55. Willems, A.R., S. Lanker, E.E. Patton, K.L. Craig, T.F. Nason, R. Kobayashi, C. Wittenberg, and M. Tyers. 1996. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86: 453-463.
56. Won, K.-A. and S.I. Reed. 1996. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J. 15: 4182-4193.
57. Yamamoto, A., V. Guacci, and D. Koshland. 1996. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. J. Cell Biol. 133: 85-97.
58. Zhou, C., S.H. Huang, and A.Y. Jong. 1989. Molecular cloning of Saccharomyces cerevisiae CDC6 gene. J. Biol. Chem. 264: 9022-9029.