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1
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0027587321
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Activation of the various cyclin/cdc2 protein kinases
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Solomon MJ. Activation of the various cyclin/cdc2 protein kinases. Curr Opin Cell Biol. 5:1993;180-186.
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Curr Opin Cell Biol
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Solomon, M.J.1
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2
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0026027660
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cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: Identification of major phosphorylation sites
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cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J. 10:1991;305-316.
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EMBO J
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Krek, W.1
Nigg, E.2
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3
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0029952160
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Cyclin-dependent kinase 7: At the cross-roads of transcription, DNA repair and cell cycle control?
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Nigg EA. Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control? Curr Opin Cell Biol. 8:1996;312-317.
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Curr Opin Cell Biol
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Nigg, E.A.1
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4
-
-
0029066929
-
KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity
-
of special interest. This paper demonstrates that the closest budding yeast homolog of Cdk7, Kin28, does not function as a Cdc28-activating kinase either in vitro or in vivo. kin28 mutants block transcription (presumably reflecting a role for Kin28 in TFIIH activity) but allow continued Cdc28 phosphorylation even after cyclin synthesis has ceased, showing that the Cdk-activating kinase can phosphorylate monomeric Cdc28 in this organism.
-
Cismowski MJ, Laff GM, Solomon MJ, Reed SI. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. of special interest Mol Cell Biol. 15:1995;2983-2992 This paper demonstrates that the closest budding yeast homolog of Cdk7, Kin28, does not function as a Cdc28-activating kinase either in vitro or in vivo. kin28 mutants block transcription (presumably reflecting a role for Kin28 in TFIIH activity) but allow continued Cdc28 phosphorylation even after cyclin synthesis has ceased, showing that the Cdk-activating kinase can phosphorylate monomeric Cdc28 in this organism.
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(1995)
Mol Cell Biol
, vol.15
, pp. 2983-2992
-
-
Cismowski, M.J.1
Laff, G.M.2
Solomon, M.J.3
Reed, S.I.4
-
5
-
-
0030598908
-
Civ1 (CAK in vivo), a novel Cdk-activating kinase
-
of special interest. A Cdk activating kinase activity was found to copurify with cyclin - Cdc28 complexes from yeast, and was identified as a multicopy suppressor of kin28 mutations. See also annotation [6].
-
Thuret J-Y, Valay J-G, Faye G, Mann C. Civ1 (CAK in vivo), a novel Cdk-activating kinase. of special interest Cell. 86:1996;565-576 A Cdk activating kinase activity was found to copurify with cyclin - Cdc28 complexes from yeast, and was identified as a multicopy suppressor of kin28 mutations. See also annotation [6].
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(1996)
Cell
, vol.86
, pp. 565-576
-
-
Thuret, J.-Y.1
Valay, J.-G.2
Faye, G.3
Mann, C.4
-
6
-
-
0030598865
-
The Cdk-activating kinase (CAK) from budding yeast
-
of special interest. This paper reports the successful purification of a Cdk-activating kinase (CAK) activity from budding yeast lysates. Together with [5], this study provides strong evidence that this kinase (called Cak1) is the physiological CAK in yeast. Cak1 is a 43 kDa protein that is surprisingly highly diverged from other known protein kinases.
-
Kaldis P, Sutton A, Solomon MJ. The Cdk-activating kinase (CAK) from budding yeast. of special interest Cell. 86:1996;553-564 This paper reports the successful purification of a Cdk-activating kinase (CAK) activity from budding yeast lysates. Together with [5], this study provides strong evidence that this kinase (called Cak1) is the physiological CAK in yeast. Cak1 is a 43 kDa protein that is surprisingly highly diverged from other known protein kinases.
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(1996)
Cell
, vol.86
, pp. 553-564
-
-
Kaldis, P.1
Sutton, A.2
Solomon, M.J.3
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7
-
-
0028970682
-
Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin
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Poon RY, Hunter T. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science. 270:1995;90-93.
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(1995)
Science
, vol.270
, pp. 90-93
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Poon, R.Y.1
Hunter, T.2
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8
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0022462146
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+ functions as an inducer in the mitotic control of fission yeast
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+ functions as an inducer in the mitotic control of fission yeast. Cell. 45:1986;145-153.
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(1986)
Cell
, vol.45
, pp. 145-153
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Russell, P.1
Nurse, P.2
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9
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0011992748
-
+, a gene encoding a protein kinase homolog
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+, a gene encoding a protein kinase homolog. Cell. 45:1987;145-153.
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(1987)
Cell
, vol.45
, pp. 145-153
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Russell, P.1
Nurse, P.2
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10
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-
0026035524
-
Mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
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Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell. 64:1991;1111-1122.
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(1991)
Cell
, vol.64
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Lundgren, K.1
Walworth, N.2
Booher, R.3
Dembski, M.4
Kirschner, M.5
Beach, D.6
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11
-
-
0027103630
-
Pyp3 PTPase acts as a mitotic inducer in fission yeast
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Millar JB, Lenaers G, Russell P. Pyp3 PTPase acts as a mitotic inducer in fission yeast. EMBO J. 11:1992;4933-4941.
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EMBO J
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Millar, J.B.1
Lenaers, G.2
Russell, P.3
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13
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0028332528
-
The decision to enter mitosis
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Dunphy WG. The decision to enter mitosis. Trends Cell Biol. 4:1994;202-207.
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(1994)
Trends Cell Biol
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, pp. 202-207
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Dunphy, W.G.1
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15
-
-
0029655570
-
Stockpiling of Cdc25 during a DNA replication checkpoint arrest in Schizosaccharomyces pombe
-
of outstanding interest. This interesting paper shows that the periodicity of cdc25 mRNA arises as a result of periodic destruction of cdc25 mRNA in mitosis, that Cdc25 protein can have at least three distinct activity states depending on the level of phosphorylation, and that Cdc2 activity is required for full activation of Cdc25.
-
Kovelman R, Russell P. Stockpiling of Cdc25 during a DNA replication checkpoint arrest in Schizosaccharomyces pombe. of outstanding interest Mol Cell Biol. 16:1996;86-93 This interesting paper shows that the periodicity of cdc25 mRNA arises as a result of periodic destruction of cdc25 mRNA in mitosis, that Cdc25 protein can have at least three distinct activity states depending on the level of phosphorylation, and that Cdc2 activity is required for full activation of Cdc25.
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(1996)
Mol Cell Biol
, vol.16
, pp. 86-93
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-
Kovelman, R.1
Russell, P.2
-
16
-
-
0030006130
-
Pub1 acts as an E6-AP-like protein ubiquitin ligase in the degradation of cdc25
-
of special interest. Following the accidental discovery of Pub1 in a screen for tyrosine kinases, the authors noticed that pub1 mutants affected size control in fission yeast. Following this lead, they examined the connection between Pub1 and regulators of Cdc2 Y15 phosphorylation, and found that Pub1 was required for Cdc25 ubiquitination and degradation.
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Nefsky B, Beach D. Pub1 acts as an E6-AP-like protein ubiquitin ligase in the degradation of cdc25. of special interest EMBO J. 15:1996;1301-1312 Following the accidental discovery of Pub1 in a screen for tyrosine kinases, the authors noticed that pub1 mutants affected size control in fission yeast. Following this lead, they examined the connection between Pub1 and regulators of Cdc2 Y15 phosphorylation, and found that Pub1 was required for Cdc25 ubiquitination and degradation.
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(1996)
EMBO J
, vol.15
, pp. 1301-1312
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Nefsky, B.1
Beach, D.2
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17
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0027358723
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The HPV16 E6 and E6-AP complex functions as a ubiquitin protein ligase in the ubiquitination of p53
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Scheffner M, Hibregtse JM, Viersta RD, Howley PM. The HPV16 E6 and E6-AP complex functions as a ubiquitin protein ligase in the ubiquitination of p53. Cell. 75:1993;495-505.
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(1993)
Cell
, vol.75
, pp. 495-505
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Scheffner, M.1
Hibregtse, J.M.2
Viersta, R.D.3
Howley, P.M.4
-
18
-
-
0029000155
-
Cell cycle regulation of human WEE1
-
of special interest. This careful study documents the inhibitory hyperphosphorylation of Wee1 during mitosis in HeLa cells, but finds no evidence for the regulation of Wee1 by the DNA-replication checkpoint.
-
McGowan CH, Russell P. Cell cycle regulation of human WEE1. of special interest EMBO J. 14:1995;2166-2175 This careful study documents the inhibitory hyperphosphorylation of Wee1 during mitosis in HeLa cells, but finds no evidence for the regulation of Wee1 by the DNA-replication checkpoint.
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(1995)
EMBO J
, vol.14
, pp. 2166-2175
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McGowan, C.H.1
Russell, P.2
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20
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0029048491
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Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
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Watanabe N, Broome M, Hunter T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14:1995;1878-1891.
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(1995)
EMBO J
, vol.14
, pp. 1878-1891
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Watanabe, N.1
Broome, M.2
Hunter, T.3
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21
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0029039470
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Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity
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Izumi T, Maller JL. Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity. Mol Biol Cell. 6:1995;215-226.
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(1995)
Mol Biol Cell
, vol.6
, pp. 215-226
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Izumi, T.1
Maller, J.L.2
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22
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0027509501
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Phosphorylation and activation of human cdc25-C by cdc2 - Cyclin B and its involvement in the self-amplication of MPF at mitosis
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Hoffmann I, Clarke PR, Marcote MJ, Karsenti E, Draetta G. Phosphorylation and activation of human cdc25-C by cdc2 - cyclin B and its involvement in the self-amplication of MPF at mitosis. EMBO J. 12:1993;53-63.
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EMBO J
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, pp. 53-63
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Hoffmann, I.1
Clarke, P.R.2
Marcote, M.J.3
Karsenti, E.4
Draetta, G.5
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23
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0029821131
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Purification and molecular cloning of PIx1, a cdc25 regulatory kinase from Xenopus egg extracts
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Kumagai A, Dunphy WG. Purification and molecular cloning of PIx1, a cdc25 regulatory kinase from Xenopus egg extracts. Science. 273:1996;1377-1380.
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Science
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, pp. 1377-1380
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Kumagai, A.1
Dunphy, W.G.2
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24
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0024294414
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Regulation of MPF activity in vitro
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Cyert MS, Kirschner MC. Regulation of MPF activity in vitro. Cell. 53:1988;185-195.
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Cell
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Cyert, M.S.1
Kirschner, M.C.2
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25
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0025753691
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A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle
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Cross FR, Tinkelenberg AH. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell. 65:1991;875-883.
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Cell
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Cross, F.R.1
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26
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0026432655
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Positive feedback in the activation of G1 cyclins in yeast
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Dirick L, Nasmyth K. Positive feedback in the activation of G1 cyclins in yeast. Nature. 351:1991;754-757.
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Nature
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Dirick, L.1
Nasmyth, K.2
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28
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0028800378
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CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells
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1-phase cyclin genes in yeast. In contrast to the prevailing positive feedback model, the authors conclude that transcriptional activation of CLN1 and CLN2 is triggered solely by Cln3 - Cdc28 complexes.
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1-phase cyclin genes in yeast. In contrast to the prevailing positive feedback model, the authors conclude that transcriptional activation of CLN1 and CLN2 is triggered solely by Cln3 - Cdc28 complexes.
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(1995)
Genes Dev
, vol.9
, pp. 2780-2794
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Stuart, D.1
Wittenberg, C.2
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29
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0029099463
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Roles and regulation of Cln - Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae
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of outstanding interest. See annotation [28].
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Dirick L, Bohm T, Nasmyth K. Roles and regulation of Cln - Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. of outstanding interest EMBO J. 14:1995;4803-4813 See annotation [28].
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(1995)
EMBO J
, vol.14
, pp. 4803-4813
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Dirick, L.1
Bohm, T.2
Nasmyth, K.3
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30
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0027527033
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Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins
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Amon A, Tyers M, Futcher B, Nasmyth K. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell. 74:1993;993-1007.
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(1993)
Cell
, vol.74
, pp. 993-1007
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Amon, A.1
Tyers, M.2
Futcher, B.3
Nasmyth, K.4
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31
-
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0030061451
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Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2 - Cyclin B kinase activity
-
of outstanding interest. This paper shows that the Cdk inhibitor p21 inhibits entry into mitosis in Xenopus egg extracts, at concentrations that directly inhibit Cdk2, but not Cdc2. The block to mitosis is accompanied by accumulation of Y15-phosphorylated Cdc2 - cyclin complexes, suggesting a requirement for Cdk2 in order to dephosphorylate Cdc2.
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Guadagno TM, Newport JW. Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2 - cyclin B kinase activity. of outstanding interest Cell. 84:1996;73-82 This paper shows that the Cdk inhibitor p21 inhibits entry into mitosis in Xenopus egg extracts, at concentrations that directly inhibit Cdk2, but not Cdc2. The block to mitosis is accompanied by accumulation of Y15-phosphorylated Cdc2 - cyclin complexes, suggesting a requirement for Cdk2 in order to dephosphorylate Cdc2.
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(1996)
Cell
, vol.84
, pp. 73-82
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Guadagno, T.M.1
Newport, J.W.2
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32
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0028791970
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Diversification of cell cycle controls in developing embryos
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of outstanding interest. A lucid and well written account of the different rate-limiting steps in cell cycle progression that predominate in different cells of the developing Drosophila embryo.
-
Edgar B. Diversification of cell cycle controls in developing embryos. of outstanding interest Curr Opin Cell Biol. 7:1995;815-824 A lucid and well written account of the different rate-limiting steps in cell cycle progression that predominate in different cells of the developing Drosophila embryo.
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(1995)
Curr Opin Cell Biol
, vol.7
, pp. 815-824
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Edgar, B.1
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33
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0028109854
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Transcriptional regulation of string (cdc25): A link between developmental programming and the cell cycle
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Edgar BA, Lehman DA, O'Farrell PH. Transcriptional regulation of string (cdc25): a link between developmental programming and the cell cycle. Development. 120:1994;3131-3143.
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(1994)
Development
, vol.120
, pp. 3131-3143
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Edgar, B.A.1
Lehman, D.A.2
O'Farrell, P.H.3
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34
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0025021753
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Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication
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Enoch T, Nurse P. Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell. 60:1990;665-673.
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(1990)
Cell
, vol.60
, pp. 665-673
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Enoch, T.1
Nurse, P.2
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35
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0026482601
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Fission yeast genes involved in coupling mitosis to completion of DNA replication
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Enoch T, Carr AM, Nurse P. Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev. 6:1992;2035-2046.
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(1992)
Genes Dev
, vol.6
, pp. 2035-2046
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Enoch, T.1
Carr, A.M.2
Nurse, P.3
-
36
-
-
0029016412
-
Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors
-
of special interest. The main interest of this paper is a set of careful experiments with nonphosphorylatable Cdc2 mutants that reveal the existence of a Y15-independent pathway which blocks mitosis in checkpoint-arrested extracts. A model involving a putative Cdk inhibitor is proposed (see [44]).
-
Kumagai A, Dunphy WG. Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors. of special interest Mol Biol Cell. 6:1995;199-213 The main interest of this paper is a set of careful experiments with nonphosphorylatable Cdc2 mutants that reveal the existence of a Y15-independent pathway which blocks mitosis in checkpoint-arrested extracts. A model involving a putative Cdk inhibitor is proposed (see [44]).
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(1995)
Mol Biol Cell
, vol.6
, pp. 199-213
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Kumagai, A.1
Dunphy, W.G.2
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37
-
-
0029825066
-
Role of inhibitory CDC2 phosphorylation in radiation induced G2 arrest in human cells
-
of special interest. A study in which a human cell line is created containing a cdc2 allele, with an inducible promoter, whose encoded protein cannot be phosphorylated at T14 and Y15. Expression of this allele does not override the arrest resulting from a block in DNA replication, but it does significantly shorten the cell cycle delay induced by DNA-damage.
-
Jin P, Gu Y, Morgan DO. Role of inhibitory CDC2 phosphorylation in radiation induced G2 arrest in human cells. of special interest J Cell Biol. 134:1996;963-970 A study in which a human cell line is created containing a cdc2 allele, with an inducible promoter, whose encoded protein cannot be phosphorylated at T14 and Y15. Expression of this allele does not override the arrest resulting from a block in DNA replication, but it does significantly shorten the cell cycle delay induced by DNA-damage.
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(1996)
J Cell Biol
, vol.134
, pp. 963-970
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Jin, P.1
Gu, Y.2
Morgan, D.O.3
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38
-
-
0030008450
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Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis
-
of special interest. A complex paper presenting interesting data on the requirements for the function of the DNA-replication checkpoint in A. nidulans. A Cdc2 mutant that cannot be phosphorylated at T14 or Y15 overrides the checkpoint delay induced by low doses of replication inhibitors, while concurrent inactivation of bimE is necessary to override the checkpoint delay induced by high doses of replication inhibitors. The authors suggest that Cdc2 phosphorylation leads to decreased synthesis of NIMA, whereas BIME prevents phosphorylation-dependent activation of NIMA: together, these two actions keep NIMA turned off in checkpoint-arrested cells.
-
Ye XS, Fincher RR, Tang A, O'Donnell K, Osmani SA. Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis. of special interest EMBO J. 15:1996;3599-3610 A complex paper presenting interesting data on the requirements for the function of the DNA-replication checkpoint in A. nidulans. A Cdc2 mutant that cannot be phosphorylated at T14 or Y15 overrides the checkpoint delay induced by low doses of replication inhibitors, while concurrent inactivation of bimE is necessary to override the checkpoint delay induced by high doses of replication inhibitors. The authors suggest that Cdc2 phosphorylation leads to decreased synthesis of NIMA, whereas BIME prevents phosphorylation-dependent activation of NIMA: together, these two actions keep NIMA turned off in checkpoint-arrested cells.
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(1996)
EMBO J
, vol.15
, pp. 3599-3610
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Ye, X.S.1
Fincher, R.R.2
Tang, A.3
O'Donnell, K.4
Osmani, S.A.5
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39
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0026610360
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Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae
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Amon A, Surana U, Muroff I, Nasmyth K. Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature. 355:1992;368-371.
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Nature
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Amon, A.1
Surana, U.2
Muroff, I.3
Nasmyth, K.4
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40
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0026567896
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S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28
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Sorger PK, Murray AW. S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature. 355:1992;365-368.
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Nature
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Sorger, P.K.1
Murray, A.W.2
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41
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0027326257
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Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins
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Booher RN, Deshaies RJ, Kirschner MW. Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J. 12:1993;3417-3426.
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EMBO J
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Booher, R.N.1
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Kirschner, M.W.3
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42
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0027336046
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Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae
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Stueland CS, Lew DJ, Cismowski MJ, Reed SI. Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae. Mol Cell Biol. 13:1993;3744-3755.
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Mol Cell Biol
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Stueland, C.S.1
Lew, D.J.2
Cismowski, M.J.3
Reed, S.I.4
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0026528032
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Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2
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Smythe C, Newport JW. Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. Cell. 68:1992;787-797.
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Smythe, C.1
Newport, J.W.2
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44
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0029670696
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An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts
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of special interest. Identification of a stoichiometric inhibitor of Cdc2 that is associated with membranes in Xenopus extracts.
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Lee TH, Kirschner MW. An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts. of special interest Proc Natl Acad Sci USA. 93:1996;352-356 Identification of a stoichiometric inhibitor of Cdc2 that is associated with membranes in Xenopus extracts.
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Proc Natl Acad Sci USA
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Lee, T.H.1
Kirschner, M.W.2
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45
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0028827253
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The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis
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James SW, Mirabito PM, Scacheri PC, Morris NR. The Aspergillus nidulans bimE (blocked-in-mitosis) gene encodes multiple cell cycle functions involved in mitotic checkpoint control and mitosis. J Cell Sci. 108:1995;3485-3499.
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James, S.W.1
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Scacheri, P.C.3
Morris, N.R.4
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46
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0027202575
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Fission yeast wee1 protein kinase is not required for DNA damage-dependent mitotic arrest
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Barbet NC, Carr AM. Fission yeast wee1 protein kinase is not required for DNA damage-dependent mitotic arrest. Nature. 364:1993;824-827.
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Nature
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Barbet, N.C.1
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47
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