Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of Saccharomyces cerevisiae

Molecular Biology of the Cell

Volumn 8, Issue 8, 1997, Pages 1587-1601

  Young, Michael R ^a,b   Tye, Bik K ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL DNA; FUNGAL PROTEIN; NUCLEAR PROTEIN;

ARTICLE; CELL CYCLE PHASE; CHROMATIN; DNA REPLICATION; DNA SYNTHESIS; FUNGAL GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 0030930614     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.8.1587     Document Type: Article

References (36)

1. Ausubel, P.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1992). Short Protocols in Molecular Biology, New York: Greene Publishing Associates and John Wiley & Sons.
2. Bell, S., and Stillman, B. (1992). ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128-134.
3. Blow, J.J. (1993). Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor. J. Cell Biol. 122, 993-1002.
4. Blow, J.J., and Laskey, R.A. (1988). A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 332, 546-548.
5. Chen, Y., and Tye, B.K. (1995). The yeast MCM1 protein is regulated posttranscriptionally by the flux of glycolysis. Mol. Cell. Biol. 15, 4631-4639.
6. Chong, J., Mahbubani, H.M., Khoo, C.Y., and Blow, J.J. (1995). Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418-421.
7. Coue, M., Kearsey, S.E., and Mechali, M. (1996). Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication. EMBO J. 15, 1085-1097.
8. Coverley, D., Downes, C.S., Romanowski, P., and Laskey, R.A. (1993). Reversible effects of nuclear membrane permeabilization on DNA replication: evidence for a positive licensing factor. J. Cell Biol. 122, 985-992.
9. Dalton, S., and Whitbread, L. (1995). Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast. Proc. Natl. Acad. Sci. USA 92, 2514-2518.
10. Diffley, J.F., Cocker, J.H., Dowell, S.J., and Rowley, A. (1994). Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78, 303-316.
11. Gibson, S.I., Surosky, R.T., and Tye, B.K. (1990). The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replication. Mol. Cell. Biol. 10, 5707-5720.
12. Henkel, T., Zabel, U., van Zee, K., Müller, J.M., and Fanning, E. (1992). Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit. Cell 68, 1121-1033.
13. Hennessy, K.M., Clark, C.D., and Botstein, D. (1990). Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev. 4, 2252-2263.
14. Hennessy, K.M., Lee, A., Chen, E., and Botstein, D. (1991). A group of interacting yeast DNA replication genes. Genes Dev. 5, 958-969.
15. Kimura, H., Nazaki, N., and Sugimoto, K. (1994). DNA polymerase α associated protein P1, a murine homolog of yeast Mcm3, changes its intranuclear distribution during the DNA synthetic period. EMBO J. 13, 4311-4320.
16. syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol. Cell. Biol. 16, 1471-1478.
17. 1/S cell cycle transition. Genetics 131, 21-29.
18. Kubota, Y., Mimura, S., Nishimoto, S., Takisawa, H., and Nojima, H. (1995). Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81, 601-609.
19. Lei, M., Kawasaki, Y., and Tye, B.K. (1996). Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in S. cerevisiae. Mol. Cell. Biol. 16, 5081-5090.
20. Li, J., and Herskowitz, I. (1993). Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Science 262, 1870-1874.
21. Madine, M.A., Khoo, C.-Y., Mills, A.D., and Laskey, R.A. (1995). The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts. Curr. Biol. 5, 1270-1279.
22. Maine, G.T., Sinha, P., and Tye, B.-K. (1984). Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106, 365-385.
23. Rao, P.N., and Johnson, R.T. (1970). Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159-164.
24. 1 to S-phase transition. Annu. Rev. Cell Biol. 8, 529-562.
25. Reed, S.I., Hadwiger, J.A., and Lorincz, A.T. (1985). Protein kinase activity assoicated with the product of the yeast cell division cycle gene CDC28. Proc. Natl. Acad. Sci. USA 82, 4055-4059.
26. Rubin, G.M. (1973). The nucleotide sequence of Saccharomyces cerevisiae 5.8S ribosomal ribonucleic acid. J. Biol. Chem. 248, 3860-3875.
27. Sabelli, P., Burgess, S., Kush, A., Young, M., and Shewry, P. (1996). cDNA cloning and characterization of a maize homologue of the MCM proteins required for the initiation of DNA replication. Mol. Gen. Genet. 252, 125-136.
28. Schmidt-Zachmann, M.S., Dargemont, C., Kühn, L., and Nigg, E.A. (1993). Nuclear export of proteins: the role of nuclear retention. Cell 74, 493-504.
29. Springer, P.S., McCombe, W.R., Sundaresan, V., and Martienssen, R.A. (1995). Gene trap tagging of PROLIFERA, an essential MCM2-3-5-like gene in Arabidopsis. Science 268, 877-880.
30. Tan, S., and Richmond, T. (1990). DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 62, 367-377.
31. Todorov, I.T., Attaran, A., and Kearsey, S.E. (1995). BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication. J. Cell Biol. 129, 1433-1445.
32. Toyn, J.H., and Johnston, L.H. (1994). The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. EMBO J. 13, 1103-1113.
33. Treisman, J.E., Follette, P.J., O'Farrell, P.M., and Rubin, G.M. (1995). Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Genes Dev. 9, 1709-1715.
34. Whitbread, L.A., and Dalton, S. (1995). Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication. Gene 155, 113-117.
35. Yan, H., Gibson, S., and Tye, B.K. (1991). Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function. Genes Dev. 5, 944-957.
36. Yan, H., Merchant, A.M., and Tye, B.-K. (1993). Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev. 7, 2149-2160.