Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28

Molecular and Cellular Biology

Volumn 16, Issue 11, 1996, Pages 6385-6397

  Lim, Hong Hwa ^a   Goh, Phuay Yee ^a   Surana, Uttam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; DEPHOSPHORYLATION; DNA SYNTHESIS; FUNGUS GROWTH; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; FUNGI; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 10244264687     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.11.6385     Document Type: Article

References (55)

1. 2-specific transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:5917-5928.
2. CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature (London) 355:368-371.
3. Atherton-Fessler, S., G. Hannig, and H. Piwnica-Worms. 1993. Reversible tyrosine phosphorylation and cell cycle control. Semin. Cell Biol. 4:433-442.
4. cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83:1159-1169.
5. CDC28 in response to G1 and G2 cyclins. EMBO J. 12:3417-3426.
6. MO15, the catalytic subunit of CDK-activating kinase, during Xenopus oogenesis and embryogenesis. Mol. Biol. Cell 5:921-932.
7. Byers, B. 1981. Cytology of yeast life cycle, p. 59-96. In J. N. Strathern, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces: life cycle and inheritance. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
8. Byers, B., and L. Goetsch. 1974. Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiae. J. Bacteriol. 124: 511-523.
9. Byers, B., and L. Goetsch. 1991. Preparation of yeast cells for thin section electron microscopy. Methods Enzymol. 194:602-608.
10. Clarke, P. R. 1995. CAK-handed kinase activation. Curr. Biol. 5:40-42.
11. Cross, F., and A. H. Tinkelenberg. 1991. A positive feedback loop controlling CLN1 and CLN2 gene expression at the START of yeast cell cycle. Cell 65:875-883.
12. De Bond, H. L., J. Rosenblatt, J. Jancarik, H. D. Jones, D. O. Morgan, and S. H. Kim. 1993. Crystal structure of cyclin-dependent kinase 2. Nature (London) 363:595-602.
13. Draetta, G. 1993. cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation. Trends Cell Biol. 3:287-289.
14. Dunphy, W. G. 1994. The decision to enter mitosis. Trends Cell Biol. 4:202-207.
15. Elledge, S. J., and R. W. Davis. 1990. Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev. 4:740-751.
16. Endow, S. A., S. J. Kang, L. L. Satterwhite, M. D. Rose, V. P. Skeen, and E. D. Salmon. 1994. Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. EMBO J. 13: 2708-2713.
17. Enoch, T., and P. Nurse. 1990. Mutation of fission yeast cell cycle control gene abolishes dependence of mitosis on DNA replication. Cell 60:665-673.
18. Enos, A. P., and N. R. Morris. 1990. Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans. Cell 60:1019-1027.
19. Fesquet, D., J. C. Labbe, J. Derancourt, J. P. Capony, S. Galas, F. Girard, T. Lorca, J. Shuttleworth, M. Doree, and J. C. Cavadore. 1993. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J. 12:3111-3121.
20. Fitch, I., C. Dahman, U. Surana, A. Amon, K. Nasmyth, L. Goetsch, B. Byers, and B. Futcher. 1992. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 3:805-818.
21. Fleig, U. N., and K. L. Gould. 1991. Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation. Semin. Cell Biol. 2:195-204.
22. Ghiara, J. B., H. E. Richardson, K. Sugimoto, M. Henze, D. J. Lew, C. Wittenberg, and S. I. Reed. 1991. A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell 65:163-174.
23. Glover, D. M., M. H. Leibowitz, D. A. McLean, and H. Parry. 1995. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81:95-105.
24. Gould, K., and P. Nurse. 1989. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature (London) 39:39-45.
25. Guacci, V., E. Hogan, and D. Koshland. 1994. Chromosome condensation and sister chromatid pairing in budding yeast. J. Cell Biol. 125:517-530.
26. Hagan, I., J. Hayles, and J. S. Hyams. 1990. Intramitotic controls in the fission yeast Schizosaccharomyces pombe: the effect of cell size on spindle length and the timing of mitotic events. J. Cell Biol. 110:1617-1621.
27. Hagan, I., and M. Yanagida. 1992. Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature (London) 356:74-76.
28. Hoyt, M. A., H. Ling, K. K. Loo, and W. S. Saunders. 1992. Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. J. Cell Biol. 118:109-120.
29. Jeffrey, P. D., A. A. Russo, K. Polyak, E. Gibbs, J. Hurwitz, J. Massague, and N. P. Pavletich. 1995. Mechanism of CDK activation revealed by the structure of a cyclin A-CDK2 complex. Nature (London) 376:313-320.
30. Kilmartin, J. V. 1994. Genetic and biochemical approaches to spindle function and chromosome segregation in eukaryotic microorganisms. Curr. Opin. Cell Biol. 6:50-54.
31. Kilmartin, J. V., and A. E. M. Adams. 1984. Structural arrangements of tubulin and actin during the cell cycle of yeast Saccharomyces. J. Cell Biol. 98:922-933.
32. Koch, C., and K. Nasmyth. 1994. Cell cycle regulated transcription in yeast. Curr. Opin. Cell Biol. 6:451-459.
33. Lew, D. J., and S. I. Reed. 1995. A cell cycle checkpoint monitors cell morphogenesis in budding yeast. J. Cell Biol. 129:739-749.
34. Lundgren, K., N. Walworth, R. Booher, M. Dembski, M. Kirschner, and D. Beach. 1991. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell 64:1111-1122.
35. Meluh, P. B., and M. D. Rose. 1990. KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell 60:1029-1041.
36. Morgan, D. O. 1995. Principles of CDK regulation. Nature (London) 374: 131-134.
37. Nasmyth, K. 1993. Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol. 5:166-179.
38. Nigg, E. A. 1993. Cellular substrates of p34cdc2 and its companion cyclin-dependent kinases. Trends Cell Biol. 3:296-301.
39. Norbury, C., and P. Nurse. 1993. Animal cell cycles and their controls. Annu. Rev. Biochem. 61:441-770.
40. Ohkura, H., I. M. Hagan, and D. M. Glover. 1995. The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring and septum, can drive septum formation in G1 and G2 cells. Genes Dev. 9:1059-1073.
41. Piggott, J. R., R. Rai, and B. L. A. Carter. 1982. A bifunctional gene product involved in two phases of the yeast cell cycle. Nature (London) 298:391-393.
42. Pines, J. 1993. Clear as crystal? Curr. Biol. 3:544-547.
43. Pines, J. 1995. Confirmational change. Nature (London) 376:294-295.
44. Price, C., K. Nasmyth, and T. Schuster. 1991. A general approach to the isolation of cell cycle-regulated genes in the budding yeast Saccharomyces cerevisiae. J. Mol. Biol. 218:543-556.
45. Pringle, J. R., and L. H. Hartwell. 1981. The Saccharomyces cell cycle, p. 97-142. In J. N. Strathern, E. W. Jones, and J. R. Broach (ed.), The molecular biology of the yeast Saccharomyces: life cycle and inheritance. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
46. Roof, D. M., P. B. Meluh, and M. D. Rose. 1992. Kinesin-related proteins required for assembly of the mitotic spindle. J. Cell Biol. 118:95-108.
47. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
48. Saunders, W. S. 1993. Mitotic spindle pole separation. Trends Cell Biol. 3: 432-436.
49. Saunders, W. S., and M. A. Hoyt. 1992. Kinesin-related proteins required for structural integrity of the mitotic spindle. Cell 70:451-458.
50. Schwob, E., and K. Nasmyth. 1993. CLB5 and CLB6, a new pair of B cyclins involved in S phase and mitotic spindle formation in S. cerevisiae. Genes Dev. 7:1160-1175.
51. MO15. EMBO J. 12:3133-3142.
52. CDC28. Nature (London) 355:365-368.
53. Surana, U., A. Amon, C. Dowzer, J. McGrew, B. Byers, and K. Nasmyth. 1993. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12:1969-1978.
54. Surana, U., H. Robitsch, C. Price, T. Schuster, I. Fitch, A. B. Futcher, and K. Nasmyth. 1991. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65:145-161.
55. Tyers, M., G. Tokiwa, and B. Futcher. 1993. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12:1955-1968.