Altered T cell signalling in ageing

Mechanisms of Ageing and Development

Volumn 122, Issue 14, 2001, Pages 1613-1637

  Pawelec, G ^a   Hirokawa, K ^a   Fulop T ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Ageing; Signalling; T cell

Indexed keywords

ADAPTOR PROTEIN; B7 ANTIGEN; CD28 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

AGING; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; CELL DIFFERENTIATION; CELL STIMULATION; GENETIC TRANSCRIPTION; HOST RESISTANCE; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE;

AGING; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOLOGIC MEMORY; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 0035975705     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00290-1     Document Type: Review

References (143)

1. Long-term culture of monoclonal human T lymphocytes: Models for immunosenescence?
2. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells
3. Protein kinase C theta: A new essential superstar on the T-cell stage
4. Interleukin/interferon signaling - A 1999 perspective
5. Differential expression of CD28 and CD94/NKG2 on T cells with identical TCR beta variable regions in primary melanoma and sentinel lymph node
6. Induction, binding specificity and function of human ICOS
7. Effect of age on cytokine production in humans
8. Cytokine production by subsets of CD4 memory T cells differing in P-glycoprotein expression: Effects of aging
9. CD28 expression in T cell aging and human longevity
10. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death
11. The T cell activation molecule H4 and the CD28-like molecule ICOS are identical
12. Co-stimulation in T cell responses
13. Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans
14. Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors
15. Proteasome inactivation upon aging and on oxidation-effect of HSP 90
16. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses
17. Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
18. Age-related defect of phospholipase C activity, differential expression of the beta(2) isoform in active T lymphocytes from aged humans
19. Age-dependent variations in the expression of PLC isoforms upon mitogenic stimulation of peripheral blood T cells from healthy donors
20. Mel14(+) CD4(+) T cells from aged mice display functional and phenotypic characteristics of memory cells
21. Changes in thymic function with age and during the treatment of HIV infection
22. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling
23. Decline in CD28(+) T cells in centenarians and in long-term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence
24. Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset
25. Aged T cells are hyporesponsive to costimulation mediated by CD28
26. An age-related decrease in rescue from T cell death following costimulation mediated by CD28
27. Enhancement of common mucosal immunity in aged mice following their supplementation with various antioxidants
28. Diminished heat shock protein synthesis following mitogen stimulation of lymphocytes from aged donors
29. Expansion of cytotoxic CD8(+) CD28(-) T cells in healthy ageing people, including centenarians
30. Early lymphocyte activation in elderly humans: Impaired T and T-dependent B cell responses
31. Generation of CD28(-) cells from long-term-stimulated CD8(+)CD28(+) T cells: A possible mechanism accounting for the increased number of CD8(+)CD28(-) T cells in HIV-1-infected patients
32. Function and dysfunction of CD4(+) T cells in the immune response to melanoma
33. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
34. Phytohemagglutinin-induced proliferation by aged lymphocytes: Reduced expression of high affinity interleukin 2 receptors and interleukin 2 secretion
35. Age-dependent changes in transmembrane signalling -identification of G-proteins in human lymphocytes and polymorphonuclear leukocytes
36. Cellular distribution of protein kinase C isozymes in CD3-mediated stimulation of human T lymphocytes with aging
37. Age-related impairment of p56(Lck) and ZAP-70 activities in human T lymphocytes activated through the TcR/CD3 complex
38. Cyclodextrin modulation of T lymphocyte signal transduction with aging
39. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells
40. Differential tyrosine phosphorylation of zeta chain dimers in mouse CD4 T lymphocytes: Effect of age
41. Increased Zap-70 association with CD3 zeta in CD4 T cells from old mice
42. Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged mice
43. CD28 and LFA-1 contribute to cyclosporin A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways
44. Recent advances in the understanding of interleukin-2 signal transduction
45. Immunophenotypical changes of T lymphocytes in the elderly
46. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
47. Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice
48. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
49. The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter
50. Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas
51. Changes in the amount and level of phosphorylation of p56lck in PBL from aging humans
52. Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation
53. Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice
54. Tissue-specific distribution and age-dependent increase of human CD11b+ T-cells
55. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
56. Diminished cell-cell binding by lymphocytes from healthy, elderly humans: Evidence for altered activation of LFA-1 function with age
57. Possible involvement of proteasome inhibition in aging: Implications for oxidative stress
58. TCR-mediated up-regulation of c-FLIPshort correlates with resistance toward CD95-mediated apoptosis by blocking death-inducing signaling complex activity
59. Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells
60. Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: Effect of age
61. Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells
62. Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes
63. Vascular endothelial cells provide T cells with costimulatory signals via the OX40/gp34 system
64. Age-related changes of cytokine production by murine helper T cell subpopulations
65. TCR V-beta usage and clonality of T cells isolated from progressing and rejected tumor sites before and after in vitro culture
66. Peripheral human CD8(+)CD28(+) T lymphocytes give rise to CD28(-) progeny, but IL-4 prevents loss of CD28 expression
67. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
68. Impaired signal transduction in mitogen activated rat splenic lymphocytes during aging
69. T cell receptor signalling
70. Antigen-independent changes in naive CD4 T cells with aging
71. Interleukin 12-release by mitogen-stimulated mononuclear cells in the elderly
72. Reductions in the activation of ERK and JNK are associated with decreased IL-2 production in T cells from elderly humans stimulated by the TCR/CD3 complex and costimulatory signals
73. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
74. Recently activated T cells are costimulation-dependent in vitro
75. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6
76. The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes
77. Identification of a human recent thymic emigrant phenotype
78. Diminished calcium influx in lectin-stimulated T cells from old mice
79. Lack of B7-2 expression in the germinal centers of aged mice
80. Association of p56(lck) with IL-2 receptor beta-chain is critical for the IL-2-induced activation of p56(lck)
81. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
82. Age-dependent remodeling of peripheral blood CD4(+) CD8(+) T lymphocytes in Cynomolgus monkeys
83. Killer cell activating receptors function as costimulatory molecules on CD4(+)CD28(Null) T cells clonally expanded in rheumatoid arthritis
84. NF-AT components define a family of transcription factors targeted in T-cell activation
85. Expression of the human T cell antigen receptor complex in advanced age
86. The age-related changes in DNA binding activity of AP-1, NF-kappa B, and OCT-1 transcription factors in lymphocytes from rats
87. Age-related decline in activation of calcium/calmodulin-dependent phosphatase calcineurin and kinase CaMK-IV in rat T cells
88. The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT
89. Activation of p21(ras)/MAPK signal transduction molecules decreases with age in mitogen-stimulated T cells from rats
90. Interleukin 10 protects activated human T lymphocytes against growth factor withdrawal-induced cell death but only anti-fas antibody can prevent activation-induced cell death
91. Human T cell clones as a model for immunosenescence
92. Extrathymic T cell differentiation in vitro from human CD34(+) stem cells
93. Longevity in vitro of human CD4+ T helper cell clones derived from young donors and elderly donors, or from progenitor cells: Age-associated differences in cell surface molecule expression and cytokine secretion
94. Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence
95. Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes
96. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappa B signaling, and reduced inflammatory cytokine production in aging
97. Inhibition of IL-2 production by Nil-2-a in murine T cells
98. Age-related tyrosine-specific protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor
99. P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells
100. Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
101. Influence of age on the production of Fos and Jun by influenza virus-exposed T cells
102. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
103. The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation
104. Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation
105. The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells
106. Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo
107. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: Part I-effects of proliferative senescence
108. Expression of c-fos, c-jun and jun-b in peripheral blood lymphocytes from young and elderly adults
109. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling
110. Constitutive activation of NF-kappa B in an animal model of aging
111. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): Differential correlation between adult and pediatric TRECs and naive phenotypes
112. Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals
113. In situ T cells in melanoma
114. ICOS is essential for effective T-helper-cell responses
115. Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction
116. Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice
117. Decreased association of p56(lck) with CD4 may account for lowered tyrosine kinase activity in mitogen-activated human T lymphocytes during aging
118. Age-related impairment of T cell proliferative responses related to the decline of CD28(+) T cell subsets
119. Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging
120. Induction and regulation of NF kappa B during aging: Role of protein kinases
121. Human T-cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor-AP-1
122. Influence of age on the signal transduction of T cells in mice
123. Impairment of signal transduction in T cells from old mice
124. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity
125. Modulation of CD28 expression: Distinct regulatory pathways during activation and replicative senescence
126. Blocking CD40-CD154 and CD80/CD86-CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production
127. Phospholipase D in cellular senescence Bba
128. Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: A flow cytometric analysis
129. Down-regulation of CD28 via Fas (CD95): Influence of CD28 on T-cell apoptosis
130. Functional properties of CD4+CD28- T cells in the aging immune system
131. Characterization of intracellular ionized calcium responsiveness and inisitol phosphate production among resting and stimulated peripheral blood T cells from elderly humans
132. Reduced activation of transcriptional factor-AP-1 among peripheral blood T-cells from elderly humans after PHA stimulation-restorative effect of phorbol diesters
133. Differential expression of the alpha- and beta-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults
134. Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT
135. Age-related reductions in the activation of mitogen-activated protein kinases p44(mapk)/ERK1 and p42(mapk)/ERK2 in human T cells stimulated via ligation of the T cell receptor complex
136. Expression and catalytic activities of protein tyrosine kinases (PTKs) Fyn and Lck in peripheral blood T cells from elderly humans stimulated through the T cell receptor (TCR)/CD3 complex
137. Phosphorylation and coupling of zeta-chains to activated T-cell receptor (TCR)/CD3 complexes from peripheral blood T-cells of elderly humans
138. Age-related impairments in TCR/CD3 activation of ZAP-70 are associated with reduced tyrosine phosphorylations of zeta-chains and p59(Fyn)/p56(Lck) in human T cells
139. Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein
140. Reciprocal expression of P-glycoprotein and TAP1 accompanied by higher expression of MHC class I antigens in T cells of old mice
141. Cluster formation by protein kinase C theta during murine T cell activation: Effect of age
142. Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensions in vitro
143. The proteasome regulates receptor-mediated endocytosis of interleukin-2