Impairment of signal transduction in T cells from old mice

Mechanisms of Ageing and Development

Volumn 93, Issue 1-3, 1997, Pages 131-144

  Utsuyama, Masanori ^a,c   Wakikawa, Atsuko ^a   Tamura, Toshiki ^b   Nariuchi, Hideo ^b   Hirokawa, Katsuiku ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Aging; Signal transduction; T cell

Indexed keywords

DIACYLGLYCEROL; INOSITOL TRISPHOSPHATE; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; T LYMPHOCYTE RECEPTOR;

AGED; ANIMAL CELL; CONFERENCE PAPER; ENZYME PHOSPHORYLATION; FEMALE; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; SENESCENCE; SIGNAL TRANSDUCTION; SPLEEN LYMPHOCYTE; T LYMPHOCYTE;

AGING; ANIMALS; CALCIUM; CLONE CELLS; DIGLYCERIDES; INOSITOL 1,4,5-TRISPHOSPHATE; INTERLEUKIN-2; KINETICS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOLIPASE C; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 0030936949     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01837-4     Document Type: Conference Paper

References (20)

1. T. Makinodan and M.M.B. Kay, Age influence on the immune system. Adv. Immunol., 29 (1980) 287-330.
2. E.A. Goidl, Aging and the Immune Response: Cellular and Humoral Aspect, Marcel Dekker, New York, 1987.
3. K. Hirokawa, M. Utsuyama, M. Kasai and C. Kurashima, Aging and immunity. Acta Pathol. Japan, 42 (1992) 537-548.
4. M. Utsuyama and K. Hirokawa, Age-related changes of splenic T cells in mice: Flow cytometric analysis. Mech. Ageing Dev., 40 (1987) 89-102.
5. T. Fulop Jr., M. Utsuyama and K. Hirokawa, Determination of interleukin 2 receptor number of Con A stimulated human lymphocytes with aging. J. Clin. Lab. Immunol., 34 (1991) 31-36.
6. K. Nakamura, K. Kuramoto, K. Shibasaki, S. Shumiya and K. Ohtsubo, Age-related incidence of spontaneous tumors in SPF C57BL/6 and BDF1 mice. Exp. Animals, 41 (1992) 279-285.
7. M.G. Mage, L.L. McHugh and T.L. Rothstein, Mouse lymphocytes with and without surface immunoglobulin: preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin. J. Immunol. Methods, 15 (1977) 47-56.
8. M. Utsuyama, Z. Varga, K. Fukami, Y. Homma, T. Takenawa and K. Hirokawa, Influence of age on the signal transduction of T cells in mice. Int. Immunol., 5 (1993) 1177-1182.
9. O. Leo, M. Foo, D.H. Sachs, L.E. Samelson and J.A. Bluestone, Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci., 84 (1987) 1374-1378.
10. T. Tamura, H. Nakano, H. Nagase et al., Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production. J. Immunol, 155 (1995) 4692-4701.
11. P.H. Cobbold and T.J. Rink, Fluorescence and bioluminescence measurement of cytoplasmic free calcium. Biochem. J., 248 (1987) 313-328.
12. J.P. Secrist, L. Karzitz and R.E. T-cells antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1. J. Biol. Chem., 296 (1991) 12135-12139.
13. M.O. Borghi, W. Barcellini, G. Ferraro, A. Vismara and P.L. Meroni, Synergisms between different activation pathways in adult and aged human lymphocytes. J. Clin. Lab. Immunol., 29 (1989) 133-139.
14. A. Wakikawa, M. Utsuyama and K. Hirokawa, Altered expression of various receptors on T cells in young and old mice after mitogenic stimulation: a flow cytometric analysis. Mech. Ageing Dev., submitted.
15. Zs. Varga, N. Bressani, A.M. Zaid et al., Cell surface markers, inositol phoshate levels and membrane potential of lymphocytes from young and old human patients. Immunol. Lett., 23 (1990) 275-280.
16. R. Di. Pietro, R.A. Rana, A. Sciscio et al., Age-related events in human active T lymphocytes: changes in the phosphoinositidase C activity. Biochem. Biophys. Res. Comm., 194 (1993) 730-739.
17. R.A. Quadri, O. Plastre, M-A. Phelouzat, A. Arbogast and J. Proust, Age-related tyrosine protein phosphorylation defect in human T lymphocytes activated through CD3, CD4, CD8 or the IL-2 receptor. Mech. Ageing Dev., 88 (1996) 125-138.
18. + current in a T cell cline by stimulation with anti-CD3 antibody. Cell Signal., 8 (1996) 263-267.
19. S. Negoro and H. Hara, The effect of taurine on the age-related decline of the immune response in mice: the restorative effect on the T cell proliferative response to costimulation with ionomycin and phorbol myristate acetate. Adv. Exp. Med. Biol., 315 (1992) 229-239.
20. H. Kawanishi and K. Joseph, Effects of phorbol myristate acetate and ionomycin on in vitro growth of Peyer's patch T and B cells. Mech. Ageing Dev., 65 (1992) 289-300.