Induction and regulation of NFκB during aging: Role of protein kinases

Clinical Immunology and Immunopathology

Volumn 79, Issue 1, 1996, Pages 87-91

  Trebilcock, Gina Uken ^a   Ponnappan, Usha ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 2 RECEPTOR; PROTEIN KINASE; STAUROSPORINE; TRANSCRIPTION FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ONCOPROTEIN; RELB PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELB;

AGING; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; IMMUNE SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

AGING; ANIMALS; ANTIGENS, CD3; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NF-KAPPA B; PROTO-ONCOGENE PROTEINS; T-LYMPHOCYTES; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS;

EID: 0029664882     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0054     Document Type: Article

References (18)

1. Miller, R., Aging and immune function. Int. Rev. Cyt. 124, 187-215, 1991.
2. Negoro, S., Hara, H., Miyata, S., Saiki, O., Tanaka, T., Yoshizaki, K., Igaarashi, T., and Kishimoto, S., Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified Tac-positive T cells. Mech. Aging Dev. 36, 223-241, 1986.
3. Schwab, R., Hausman, P. B., Rinnooy-Kan, E., and Weksler, M. E., Immunological studies of ageing. X. Impaired T lymphocytes and normal monocyte response from elderly humans to the mitogenic antibodies OKT3 and Leu 4. Immunology 55, 677-684, 1985.
4. Nagel, J. E., Chopra, R. K., Chrest, F. J., McCoy, M. T., Schneider, E. L., Holbrook, N. J., and Adler, W. A., Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J. Clin. Invest. 81, 1096-1102, 1988.
5. Crabtree, G. R., Contingent genetic regulatory events in T lymphocyte activation. Science 243, 355-361, 1989.
6. Bohnlein, E., Lowenthal, J. W., Siekevitz, M., Ballar, D. W., Franza, B. R., and Greene, W. C., The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell 53, 827-836, 1988.
7. Shibuya, H., Yoneyama, M., and Taniguchi, T., Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int. Immunol. 1, 43-49, 1989.
8. Baeuerle, P. A., and Baltimore, D., IκB: A specific inhibitor of the NF-κB transcription factor. Science 242, 540-546, 1988.
9. Mizel, S. B., and Shirakawa, F., In vitro activation and nuclear translocation of NF-κB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol. Cell. Biol. 9, 2424-2430, 1989.
10. Beg, A., Finco, T. S., Nantermet, P. V., and Baldwin, A. S., Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB: A mechanism for NFκB activation. Mol. Cell. Biol. 13, 3301-3310, 1993.
11. Sun, S-C., Gaanchi, P. A., Beraud, C., Ballard, D. W., and Greene, W. C., Autoregulation of the NF-kappa B transactivator Rel A (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc. Natl. Acad. Sci. USA 91, 1346-1350, 1994.
12. Dignam, J. D., Lebowitz, R. M., and Roeder, R. G., Accurate transcription initiation by RNA polymerase II in soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489, 1983.
13. Jain, J., McCaffrey, P. G., Valge-Archer, V. E., and Rao, A., Nuclear factor of activated T cells contains Fos and Jun. Nature 356, 801-804, 1992.
14. Bradford, M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254, 1976.
15. Sen, R., and Baltimore, D., Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46, 705-716, 1986.
16. Ghosh, S., and Baltimore, D., Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344, 678-682, 1990.
17. Blank, V., Kourilsky, P., and Israel, A., NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem. Sci. 17, 135-140, 1992.
18. Neumann, M., Grieshammer, T., Chuvpilo, S., Kneitz, B., Lohoff, M., Schimpl, A., Franza, B. R., and Serfling, E., RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO J. 14, 1991-2004, 1995.